Insulin signaling in heart muscle: Lessons from genetically engineered mouse models

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Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene

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Growth retardation and increased apoptosis in mice with homozygous disruption of the akt1 genePreprint

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The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus

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Dwarfism, impaired skin development, skeletal muscle atrophy, delayed bone development, and impeded adipogenesis in mice lacking Akt1 and Akt2Preprint

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The cardiac phenotype induced by PPARα overexpression mimics that caused by diabetes mellitus

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The conserved phosphoinositide 3‐kinase pathway determines heart size in mice

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Regulation of Myocardial Contractility and Cell Size by Distinct PI3K-PTEN Signaling Pathways

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Akt/Protein Kinase B Promotes Organ Growth in Transgenic Mice

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Phosphoinositide 3-kinase(p110α) plays a critical role for the induction of physiological, but not pathological, cardiac hypertrophy

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Myocardial Protection by Insulin at Reperfusion Requires Early Administration and Is Mediated via Akt and p70s6 Kinase Cell-Survival Signaling

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Adaptation and Maladaptation of the Heart in Diabetes: Part I

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Nitric Oxide Mediates the Antiapoptotic Effect of Insulin in Myocardial Ischemia-Reperfusion

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Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4

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Akt induces enhanced myocardial contractility and cell size in vivo in transgenic mice

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IRS-2 pathways integrate female reproduction and energy homeostasis

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Impaired Cardiac Efficiency and Increased Fatty Acid Oxidation in Insulin-Resistant <i>ob/ob</i> Mouse Hearts

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Phenotypic Spectrum Caused by Transgenic Overexpression of Activated Akt in the Heart

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The Insulin-like Growth Factor 1 Receptor Induces Physiological Heart Growth via the Phosphoinositide 3-Kinase(p110α) Pathway

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Altered metabolism causes cardiac dysfunction in perfused hearts from diabetic (db/db) mice

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The lipid phosphatase SHIP2 controls insulin sensitivity

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Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression

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Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heart

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Caveolin-1-deficient mice show insulin resistance and defective insulin receptor protein expression in adipose tissue

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Altered thymic positive selection and intracellular signals in Cbl-deficient mice

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Insulin signaling coordinately regulates cardiac size, metabolism, and contractile protein isoform expression

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Starvation and diabetes increase the amount of pyruvate dehydrogenase kinase isoenzyme 4 in rat heart

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Insulin-like Growth Factor I as aÈCardiac Hormone: Physiological and Pathophysiological Implications in Heart Disease

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Mice mutant for Egfr and Shp2 have defective cardiac semilunar valvulogenesis

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Hypoglycaemia, liver necrosis and perinatal death in mice lacking all isoforms of phosphoinositide 3-kinase p85α

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Caveolin-3 Knock-out Mice Develop a Progressive Cardiomyopathy and Show Hyperactivation of the p42/44 MAPK Cascade

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A Role for Peroxisome Proliferator-activated Receptor α (PPARα) in the Control of Cardiac Malonyl-CoA Levels

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Caveolin-1/3 Double-Knockout Mice Are Viable, but Lack Both Muscle and Non-Muscle Caveolae, and Develop a Severe Cardiomyopathic Phenotype

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Minimally invasive aortic banding in mice: effects of altered cardiomyocyte insulin signaling during pressure overload

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Glucose transport in the heart

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Caveolin-1 null mice develop cardiac hypertrophy with hyperactivation of p42/44 MAP kinase in cardiac fibroblasts

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Responses of GLUT4-Deficient Hearts to Ischemia Underscore the Importance of Glycolysis

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Akt Signaling Mediates Postnatal Heart Growth in Response to Insulin and Nutritional Status

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Endothelial Replacement and Angiogenesis in Arteriosclerotic Lesions of Allografts Are Contributed by Circulating Progenitor Cells

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Transcriptional effects of chronic Akt activation in the heart

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Streptozotocin-induced Changes in Cardiac Gene Expression in the Absence of Severe Contractile Dysfunction

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Deficiency of PDK1 in cardiac muscle results in heart failure and increased sensitivity to hypoxia

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Insulin Signaling in Microdomains of the Plasma Membrane

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Skeletal Muscle Cells and Adipocytes Differ in Their Reliance on TC10 and Rac for Insulin-Induced Actin Remodeling

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Differential Effects of Rosiglitazone and Metformin on Adipose Tissue Distribution and Glucose Uptake in Type 2 Diabetic Subjects

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Reperfusion-Activated Akt Kinase Prevents Apoptosis in Transgenic Mouse Hearts Overexpressing Insulin-Like Growth Factor-1

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Mechanism of Enhanced Cardiac Function in Mice with Hypertrophy Induced by Overexpressed Akt

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Mice Deficient in the Insulin-regulated Membrane Aminopeptidase Show Substantial Decreases in Glucose Transporter GLUT4 Levels but Maintain Normal Glucose Homeostasis

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An increase in the myocardial PCr/ATP ratio in GLUT4 null mice

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Preservation of glucose metabolism in hypertrophic GLUT4-null hearts

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Regulation of Insulin-Responsive Aminopeptidase Expression and Targeting in the Insulin-Responsive Vesicle Compartment of Glucose Transporter Isoform 4-Deficient Cardiomyocytes

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Tissue-specific regulation of protein synthesis by insulin and free fatty acids

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Cardiovascular Actions of Insulin

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Interaction of Cardiovascular Risk Factors with Myocardial Ischemia/Reperfusion Injury, Preconditioning, and Postconditioning

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Cardiac remodeling in obesity

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Metabolic stress–induced activation of FoxO1 triggers diabetic cardiomyopathy in mice

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Renin-angiotensin-aldosterone system and oxidative stress in cardiovascular insulin resistance

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Insulin Stimulates Mitochondrial Fusion and Function in Cardiomyocytes via the Akt-mTOR-NFκB-Opa-1 Signaling Pathway

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Recipes for Creating Animal Models of Diabetic Cardiovascular Disease

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Cardiomyocyte-Specific BMAL1 Plays Critical Roles in Metabolism, Signaling, and Maintenance of Contractile Function of the Heart

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Insulin says NO to cardiovascular disease

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Akt2 Regulates Cardiac Metabolism and Cardiomyocyte Survival

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Diabetic cardiomyopathy: mechanisms and therapeutic targets

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Influence of the Cardiomyocyte Circadian Clock on Cardiac Physiology and Pathophysiology

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Angiotensin-(1–7) stimulates the phosphorylation of JAK2, IRS-1 and Akt in rat heart in vivo: role of the AT1 and Mas receptors

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Feed-forward signaling of TNF-α and NF-κB via IKK-β pathway contributes to insulin resistance and coronary arteriolar dysfunction in type 2 diabetic mice

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The nuclear and mitochondrial sirtuins, Sirt6 and Sirt3, regulate each other's activity and protect the heart from developing obesity‐mediated diabetic cardiomyopathy

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NO-Rich Diet for Lifestyle-Related Diseases

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Diabetic Inhibition of Preconditioning- and Postconditioning-Mediated Myocardial Protection against Ischemia/Reperfusion Injury

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Dietary nitrite supplementation improves insulin resistance in type 2 diabetic KKAy mice

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Heart Failure and Loss of Metabolic Control

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Loss of insulin signaling may contribute to atrial fibrillation and atrial electrical remodeling in type 1 diabetes

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Insulin signaling pathways and cardiac growth

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Factors controlling the activity of the SERCA2a pump in the normal and failing heart

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Impairment of insulin-stimulated Akt/GLUT4 signaling is associated with cardiac contractile dysfunction and aggravates I/R injury in STZ-diabetic Rats

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Altered parasympathetic nervous system regulation of the sinoatrial node in Akita diabetic mice

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GENDER DISPARITY OF STREPTOZOTOCIN‐INDUCED INTRINSIC CONTRACTILE DYSFUNCTION IN MURINE VENTRICULAR MYOCYTES: ROLE OF CHRONIC ACTIVATION OF AKT

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