Bacterial biofilm in upper respiratory tract infections

Morris, David P.

doi:10.1007/s11908-007-0030-3

Cited by 37Bacterial biofilms and quorum sensingOtolaryngology and Infectious DiseasesMicrobial infections and disease research

Bacterial biofilm in upper respiratory tract infections

Morris, David P.·2007·Current Infectious Disease Reports

DOI 10.1007/s11908-007-0030-3

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Abstract

The upper respiratory tract is of easy access to pathogens, and although it has evolved a number of defensive barriers to avoid invasion, acute and chronic infections of the ears, nose, and throat are common and present a huge challenge to the healthcare system. Though most infections are viral, mild, and self-limiting, bacterial infection is responsible for considerable morbidity and has potential for life-threatening sequelae. Biofilms form when free-floating planktonic organisms adhere to a surface. Within a polymicrobial, biofilm organisms interact, exchanging metabolites, enzymes, and genetic material. The colony is protected, allowing bacteria to thrive in otherwise unfavorable conditions. A role for the biofilm in upper respiratory tract infections has been proposed because infections often run a persistent, remitting course, samples are sometimes difficult to culture, and resistance to medical management is common. This review presents recently published evidence of bacterial biofilms in established upper respiratory tract infections.

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“It has been shown that the RSV fusion protein interacts with TLR4, which then signals through MyD88 to induce immune responses in airway epithelial cells (28, 92, 103, 152), and a recent study demonstrated RSV interaction with TLR2 and TLR6, promoting a proinflammatory response (190).”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [190]

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Biofilm Dispersal: Mechanisms, Clinical Implications, and Potential Therapeutic Uses
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Authors: Morris, D. P.
Affiliations: Dalhousie University (CA)
Corresponding author: Morris, David P.
ORCID: Morris, David P.
Venue: Current Infectious Disease Reports
Publisher: Springer Science and Business Media LLC
Published: 2007-04-27
Volume: 9
Issue: 3
Pages: 186-192
ISSN: 1523-3847 (ISSN-L)
1534-3146
DOI: 10.1007/s11908-007-0030-3
OpenAlex: W1966127816
Cited by: 37
References: 58
Citations by year: 2025: 1 · 2024: 2 · 2023: 2 · 2022: 1 · 2021: 3 · 2020: 11 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 1 · 2015: 2 · 2014: 1 · 2013: 1 · 2012: 2
FWCI: 0.66
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Infectious Disease Reports (publishedVersion)
PubMed (publishedVersion)
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bacterial biofilms and quorum sensing
Health Sciences › Medicine › Infectious Diseases › Otolaryngology and Infectious Diseases
Life Sciences › Immunology and Microbiology › Microbiology › Microbial infections and disease research
Keywords: bacterial biofilms, upper respiratory tract infection, polymicrobial interactions, persistent infection, antibiotic resistance, biofilm-associated infections, co-infection

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Bacterial biofilm in upper respiratory tract infections

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