The DOI matches its Crossref record; 105 of the 106 references it cites were found in a registry or an index.
The pathophysiology of essential tremor and parkinson's tremor
Abstract
We review recent evidence about the pathophysiology of essential tremor and tremor in Parkinson's disease. We believe that a network perspective is necessary to understand this common neurological symptom, and that knowledge of cerebral network dysfunction in tremor disorders will help to develop new therapies. Both essential tremor and Parkinson's tremor are associated with increased activity in the cerebellothalamocortical circuit. However, different pathophysiological mechanisms lead to tremulous activity within this circuit. In Parkinson's disease, evidence suggests that dopaminergic dysfunction of the pallidum triggers increased activity in the cerebellothalamocortical circuit. In essential tremor, GABAergic dysfunction of the cerebellar dentate nucleus and brain stem, possibly caused by neurodegeneration in these regions, may lead to tremulous activity within the cerebellothalamocortical circuit. In both disorders, network parameters such as the strength and directionality of interregional coupling are crucially altered. Exciting new research uses these network parameters to develop network-based therapies, such as closed-loop deep brain stimulation and transcranial magnetic or direct current stimulation.
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In the citing paper
“and meanwhile 25% Parkinsonian cases lack resting tremor (Helmich et al., 2013).”
From A Novel Posture for Better Differentiation Between Parkinson's Tremor and Essential Tremor (2018) · cites this paper as Helmich et al., 2013
In the citing paper
“While both of the arms are rested, the increased mechanical resonance in the arms by straining the forearm muscles and tendons may activated the proprioceptive feedback pathway regulated by the Golgi tendon organ, which senses changes in muscle tension and modulates the stretch reflex with afferent Ib fibers together (Prochazka and Gorassini, 1998; Helmich et al., 2013).”
From A Novel Posture for Better Differentiation Between Parkinson's Tremor and Essential Tremor (2018) · cites this paper as Helmich et al., 2013
Citations
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Self-citationLong-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus
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Connectivity profile of thalamic deep brain stimulation to effectively treat essential tremor
Al‐Fatly, B., Ewert, S., Kübler, D., Kroneberg, D., Horn, A., & Kühn, A. A. (2019) · Brain · doi:10.1093/brain/awz236 · Cited by 177
Parkinson’s disease as a system-level disorder
Caligiore, D., Helmich, R. C. G., Hallett, M., Moustafa, A. A., Timmermann, L., Toni, I., & Baldassarre, G. (2016) · npj Parkinson s Disease · doi:10.1038/npjparkd.2016.25 · Cited by 174
Self-citationThe cerebral basis of Parkinsonian tremor: A network perspective
Helmich, R. C. G. (2017) · Movement Disorders · doi:10.1002/mds.27224 · Cited by 164
Self-citationThe Cerebral Network of Parkinson's Tremor: An Effective Connectivity fMRI Study
Dirkx, M. F., den Ouden, H. E. M., Aarts, E., Timmer, M. H. M., Bloem, B. R., Toni, I., & Helmich, R. C. G. (2016) · Journal of Neuroscience · doi:10.1523/jneurosci.3634-15.2016 · Cited by 159
Self-citationMotor network disruption in essential tremor: a functional and effective connectivity study
Buijink, A. W. G., van der Stouwe, A. M. M., Broersma, M., Sharifi, S., Groot, P. F. C., Speelman, J. D., Maurits, N. M., & van Rootselaar, A. (2015) · Brain · doi:10.1093/brain/awv225 · Cited by 151
Metadata
- Authors
- Helmich, R. C., Toni, I., Deuschl, G., & Bloem, B. R.
- Affiliations
- Radboud University Nijmegen (NL)
- Christian-Albrechts-Universität zu Kiel (DE)
- Corresponding author
- Helmich, Rick C.
- Venue
- Current Neurology and Neuroscience Reports
- Published
- 2013-07-27
- Volume
- 13
- Issue
- 9
- Pages
- 378-378
- ISSN
- 1528-4042 (ISSN-L)
- 1534-6293
- OpenAlex
- W2032330693
- Cited by
- 294
- References
- 106
- Citations by year
- 2026: 13 · 2025: 37 · 2024: 33 · 2023: 27 · 2022: 30 · 2021: 25 · 2020: 16 · 2019: 23 · 2018: 22 · 2017: 22 · 2016: 15 · 2015: 16 · 2014: 10 · 2013: 3
- FWCI
- 1.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Neurology and Neuroscience Reports (publishedVersion)
- PubMed (publishedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Topics
- Health Sciences › Medicine › Clinical Neurology › Deep Brain Stimulation and Movement Disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Motor Control and Adaptation
- Life Sciences › Neuroscience › Neurology › Transcranial Magnetic Stimulation Studies
- Keywords
- essential tremor, Parkinson's disease, tremor pathophysiology, dopaminergic dysfunction, globus pallidus, GABAergic dysfunction, cerebellar dentate nucleus, brainstem, closed-loop deep brain stimulation, transcranial magnetic stimulation, direct current stimulation
- MeSH terms
- Animals, Electric Stimulation Therapy, gamma-Aminobutyric Acid, Humans, Movement Disorders, Nerve Net, Parkinson Disease, Essential Tremor
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