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Cited by 1,787Neurological disorders and treatmentsObsessive-Compulsive Spectrum DisordersBotulinum Toxin and Related Neurological Disorders

Long-term suppression of tremor by chronic stimulation of the ventral intermediate thalamic nucleus

Benabid, A.L., Pollak, P., Hoffmann, D., Gervason, C., Hommel, M., Perret, J.E., de Rougemont, J., Gao, D.M.·1991·The Lancet
DOI 10.1016/0140-6736(91)91175-t
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Abstract

The usefulness of high-frequency stimulation of the ventral intermediate nucleus (Vim) as the first neurosurgical procedure in disabling tremor was assessed in 26 patients with Parkinson's disease and 6 with essential tremor. 7 of these patients had already undergone thalamotomy contralateral to the stimulated side, and 11 others had bilateral Vim stimulation at the same time. Chronic stimulating electrodes connected to a pulse generator were implanted in the Vim. Tremor amplitude at rest, during posture holding, and during action and intention manoeuvres was assessed by means of accelerometry. Of the 43 thalami stimulated, 27 showed complete relief from tremor and 11 major improvement (88%). The improvement was maintained for up to 29 months (mean follow-up 13 [SD 9] months). Adverse effects were mild and could be eradicated by reduction or cessation of stimulation. This reversibility and adaptability, allowing control of side-effects, make thalamic stimulation preferable to thalamotomy, especially when treatment of both sides of the brain is needed.

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Crossref · 10.1016/0140-6736(91)91175-t

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  • Tremor suppression by high frequency stimulation or lesioning at these sites need not necessarily imply interference with a pacemaker circuit, and could potentially arise from interference with the pacemaker circuit's outflow or mechanisms amplifying this outflow.

    “The fact that tremor may be suppressed by high frequency stimulation, or indeed lesioning, at these sites (Benabid et al., 1991; Lenz et al., 1995; Krack et al., 1998; Fasano et al., 2012) need not necessarily imply interference with a pacemaker circuit, and could potentially arise from interference with the pacemaker circuit’s outflow or mechanisms amplifying this outflow.”

    From The nature of tremor circuits in parkinsonian and essential tremor (2014) · cites this paper as Benabid et al., 1991

  • The clinical effects of high frequency stimulation of the subthalamic nucleus and ventrolateral thalamus on parkinsonian tremor suggest that the two sites are essential components of the tremor circuit.

    “The clinical effects of high frequency stimulation of the two targets on parkinsonian tremor would further suggest that the two sites are essential components of the tremor circuit (Benabid et al., 1991; Krack et al., 1998).”

    From The nature of tremor circuits in parkinsonian and essential tremor (2014) · cites this paper as Benabid et al., 1991

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Authors
Benabid, A. L., Pollak, P., Hoffmann, D., Gervason, C., Hommel, M., Perret, J. E., de Rougemont, J., & Gao, D. M.
Affiliations
  • Inserm (FR)
  • Medical College of Jinzhou Medical University (CN)
Corresponding author
Pollak, P.
ORCID
Venue
The Lancet
Publisher
Elsevier BV
Published
1991-02
Volume
337
Issue
8738
Pages
403-406
ISSN
  • 0099-5355 (ISSN-L)
  • 0140-6736
DOI
10.1016/0140-6736(91)91175-t
OpenAlex
W2062865989
Cited by
1,787
References
0
Citations by year
2026: 42 · 2025: 45 · 2024: 51 · 2023: 42 · 2022: 58 · 2021: 69 · 2020: 85 · 2019: 70 · 2018: 75 · 2017: 69 · 2016: 76 · 2015: 79 · 2014: 71 · 2013: 78 · 2012: 76
FWCI
6.93
Type
journal article
Language
en
Open access
closed
Licence
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
Locations
  • The Lancet (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Neurology › Neurological disorders and treatments
  • Social Sciences › Psychology › Clinical Psychology › Obsessive-Compulsive Spectrum Disorders
  • Health Sciences › Medicine › Neurology › Botulinum Toxin and Related Neurological Disorders
Keywords
ventral intermediate nucleus, deep brain stimulation, tremor suppression, Parkinson's disease, essential tremor, thalamotomy, accelerometry
MeSH terms
Aged, Electric Stimulation, Electrodes, Implanted, Evaluation Studies as Topic, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neurosurgery, Thalamic Nuclei, Time Factors, Tremor

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