The DOI matches its Crossref record; 29 of the 29 references it cites were found in a registry or an index.
Insomnia Disorder and Brain’s Default-Mode Network
Abstract
Purpose of review Insomnia disorder (ID) is a prevalent sleep disorder that significantly compromises the physical and mental health of individuals. This article reviews novel approaches in the study of brain networks and impaired function in ID through the application of modern neuroimaging techniques such as functional magnetic resonance imaging (fMRI). Recent findings The default-mode network (DMN) is presumed to be correlated with self-referential information processing, and it appears to be altered or unbalanced in insomnia. A growing body of evidence suggests the lack of deactivation of brain regions comprising the DMN when insomnia patients are at rest. Moreover, core areas of the DMN demonstrate greater activation in insomnia patients when compared to healthy controls in self-referential related tasks. Despite the few studies on the topic, underpinning the correlation between abnormal DMN activity and ID deserves further attention in the future. Implications for therapeutics are briefly outlined.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“Notably, this elevation relates positively to the degree of objective sleep disturbance, consistent with a disorder of 24-hour hyperarousal rather than simply sleep loss [25].”
From Pre-Sleep Anxiety: Mechanisms and Therapeutic Approaches in Clinical Practice. (2026) · cites this paper as [25]
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders
American Psychiatric Association (2013) · doi:10.1176/appi.books.9780890425596 · Cited by 116,369
A default mode of brain function
Raichle, M. E., MacLeod, A. M., Snyder, A. Z., Powers, W. J., Gusnard, D. A., & Shulman, G. L. (2001) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.98.2.676 · Cited by 12,190
Exploring the brain network: A review on resting-state fMRI functional connectivity
van den Heuvel, M. P., & Hulshoff Pol, H. E. (2010) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2010.03.008 · Cited by 3,326
The International Classification of Sleep Disorders: Diagnostic and Coding Manual
(1991) · Annals of Internal Medicine · doi:10.7326/0003-4819-115-5-413_1 · Cited by 2,416
The hyperarousal model of insomnia: A review of the concept and its evidence
Riemann, D., Spiegelhalder, K., Feige, B., Voderholzer, U., Berger, M., Perlis, M., & Nissen, C. (2010) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2009.04.002 · Cited by 1,789
Default Mode Network Activity and Connectivity in Psychopathology
Whitfield-Gabrieli, S., & Ford, J. M. (2012) · Annual Review of Clinical Psychology · doi:10.1146/annurev-clinpsy-032511-143049 · Cited by 1,465
Opportunities and limitations of intrinsic functional connectivity MRI
Buckner, R. L., Krienen, F. M., & Yeo, B. T. T. (2013) · Nature Neuroscience · doi:10.1038/nn.3423 · Cited by 912
Functional Neuroimaging Evidence for Hyperarousal in Insomnia
Nofzinger, E. A., Buysse, D. J., Germain, A., Price, J. C., Miewald, J. M., & Kupfer, D. J. (2004) · American Journal of Psychiatry · doi:10.1176/appi.ajp.161.11.2126 · Cited by 752
How psychotherapy changes the brain – the contribution of functional neuroimaging
Linden, D. E. J. (2006) · Molecular Psychiatry · doi:10.1038/sj.mp.4001816 · Cited by 491
A neurobiological model of insomnia
Buysse, D. J., Germain, A., Hall, M. H., Monk, T. H., & Nofzinger, E. A. (2011) · Drug Discovery Today Disease Models · doi:10.1016/j.ddmod.2011.07.002 · Cited by 188
Cited by
Sorted by citations
Sleep spindles: mechanisms and functions
Fernandez, L. M. J., & Lüthi, A. (2020) · Physiological Reviews · doi:10.1152/physrev.00042.2018 · Cited by 716
Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia
Pinto, A. M., Geenen, R., Wager, T. D., Lumley, M. A., Häuser, W., Kosek, E., Ablin, J. N., Amris, K., Branco, J., Buskila, D., et al. (2022) · Nature Reviews Rheumatology · doi:10.1038/s41584-022-00873-6 · Cited by 161
Self-citationCoping With COVID-19: Mindfulness-Based Approaches for Mitigating Mental Health Crisis
Antonova, E., Schlosser, K., Pandey, R., & Kumari, V. (2021) · Frontiers in Psychiatry · doi:10.3389/fpsyt.2021.563417 · Cited by 89
“The DMN hyperactivity and over-connectivity has been observed in schizophrenia and depression (49), predicted the post-traumatic stress disorder (50), and is altered in insomnia disorder (51), amongst other psychopathologies (we mention most relevant to the impact of COVID-19 on mental health).”
BackgroundNeuroimaging insights into the link between depression and Insomnia: A systematic review
Bagherzadeh‐Azbari, S., Khazaie, H., Zarei, M., Spiegelhalder, K., Walter, M., Leerssen, J., Someren, E. J. W. V., Sepehry, A. A., & Tahmasian, M. (2019) · Journal of Affective Disorders · doi:10.1016/j.jad.2019.07.089 · Cited by 89
TMS-EEG: An emerging tool to study the neurophysiologic biomarkers of psychiatric disorders
Cao, K.-X., Ma, M.-L., Wang, C.-Z., Iqbal, J., Si, J., Xue, Y.-X., & Yang, J. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2021.108574 · Cited by 91
Metadata
- Authors
- Marques, D. R., Gomes, A. A., Caetano, G., & Castelo-Branco, M.
- Affiliations
- University of Aveiro (PT)
- University of Coimbra (PT)
- University of Lisbon (PT)
- Corresponding author
- Marques, Daniel Ruivo
- Venue
- Current Neurology and Neuroscience Reports
- Published
- 2018-06-09
- Volume
- 18
- Issue
- 8
- Pages
- 45-45
- ISSN
- 1528-4042 (ISSN-L)
- 1534-6293
- OpenAlex
- W2807404538
- Cited by
- 112
- References
- 29
- Citations by year
- 2026: 16 · 2025: 25 · 2024: 18 · 2023: 19 · 2022: 14 · 2021: 9 · 2020: 4 · 2019: 5 · 2018: 2
- FWCI
- 0.79
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Neurology and Neuroscience Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
- Life Sciences › Neuroscience › Cognitive Neuroscience › Functional Brain Connectivity Studies
- Life Sciences › Neuroscience › Cognitive Neuroscience › Sleep and Wakefulness Research
- Keywords
- insomnia, default mode network, self-referential processing, functional MRI, sleep disorders, brain network dysfunction
- MeSH terms
- Adult, Brain, Brain Mapping, Cognition, Female, Humans, Sleep Initiation and Maintenance Disorders, Magnetic Resonance Imaging, Male, Nerve Net, Neural Pathways
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
