Cited by 162Nutrition and Health in AgingBody Composition Measurement TechniquesFrailty in Older Adults

The DOI matches its Crossref record; 77 of the 77 references it cites were found in a registry or an index.

Clinical Implications of Sarcopenic Obesity in Cancer

Carneiro, Isabella P., Mazurak, Vera C., Prado, Carla M.·2016·Current Oncology Reports

DOI 10.1007/s11912-016-0546-5

Open this paper in CoChat — free account

Abstract

Sarcopenia has been associated with several negative clinical outcomes in cancer. However, the consequences of sarcopenic obesity, a condition of combined sarcopenia and obesity burden, have been less extensively investigated. The aim of this paper was to review the current evidence on the prevalence and clinical implications of sarcopenic obesity in cancer. A total of 14 studies linking sarcopenic obesity to a clinical outcome in cancer were included. There is considerable inconsistency in methods used to evaluate body composition as well as in the criteria used to define sarcopenic obesity, which limits comparison among studies. Therefore, the prevalence of sarcopenic obesity varied substantially: between 1 and 29 % in studies including individuals from all body mass index categories and between 15 and 36 % for those including obese individuals only. Negative clinical outcomes reported to be associated with sarcopenic obesity included higher risk of dose-limiting toxicity, surgical complications, physical disability, and shorter survival.

Integrity signals

Registry

Crossref · 10.1007/s11912-016-0546-5

Cites

77 of 77 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Untitled work
(2000) · PubMed · Cited by 13,173
The Disease Burden Associated With Overweight and Obesity
Must, A. (1999) · JAMA · doi:10.1001/jama.282.16.1523 · Cited by 4,827
Epidemiology of Sarcopenia among the Elderly in New Mexico
Baumgartner, R. N., Koehler, K. M., Gallagher, D., Romero, L., Heymsfield, S. B., Ross, R. R., Garry, P. J., & Lindeman, R. D. (1998) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a009520 · Cited by 4,004
European Guidelines for Obesity Management in Adults
Yumuk, V., Tsigos, C., Fried, M., Schindler, K., Busetto, L., Micic, D., & Toplak, H. (2015) · Obesity Facts · doi:10.1159/000442721 · Cited by 3,432
Adipocytokines: mediators linking adipose tissue, inflammation and immunity
Tilg, H., & Moschen, A. R. (2006) · Nature reviews. Immunology · doi:10.1038/nri1937 · Cited by 3,272
Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: A population-based study
Prado, C. M., Lieffers, J. R., McCargar, L. J., Reiman, T., Sawyer, M. B., Martin, L., & Baracos, V. E. (2008) · The Lancet Oncology · doi:10.1016/s1470-2045(08)70153-0 · Cited by 3,238
Self-citation
Cancer Cachexia in the Age of Obesity: Skeletal Muscle Depletion Is a Powerful Prognostic Factor, Independent of Body Mass Index
Martin, L., Birdsell, L., Macdonald, N., Reiman, T., Clandinin, M. T., McCargar, L. J., Murphy, R. A., Ghosh, S., Sawyer, M. B., & Baracos, V. E. (2013) · Journal of Clinical Oncology · doi:10.1200/jco.2012.45.2722 · Cited by 2,761
The Edmonton Symptom Assessment System (ESAS): A Simple Method for the Assessment of Palliative Care Patients
Bruera, E. D., Kuehn, N., Miller, M. J., Selmser, P., & Macmillan, K. (1991) · Journal of Palliative Care · doi:10.1177/082585979100700202 · Cited by 2,686
A practical and precise approach to quantification of body composition in cancer patients using computed tomography images acquired during routine care
Mourtzakis, M., Prado, C. M. M., Lieffers, J. R., Reiman, T., McCargar, L. J., & Baracos, V. E. (2008) · Applied Physiology, Nutrition, and Metabolism · doi:10.1139/h08-075 · Cited by 2,224
Self-citation
Total body skeletal muscle and adipose tissue volumes: estimation from a single abdominal cross-sectional image
Shen, W., Punyanitya, M., Wang, Z., Gallagher, D., St.-Onge, M.-P., Albu, J., Heymsfield, S. B., & Heshka, S. (2004) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00744.2004 · Cited by 1,692

Show all 77 references

Research works printed but not linked: 1

Canadian Cancer Society. 2014 edition of Canadian cancer statistics. 2014. http://www.cancer.ca/en/cancer-information/cancer-101/canadian-cancer-statistics-publication/?region=on .

Sorted by citations

Sarcopenia – Molecular mechanisms and open questions
Wiedmer, P., Jung, T., Castro, J. P., Pomatto, L. C. D., Sun, P. Y., Davies, K. J. A., & Grune, T. (2020) · Ageing Research Reviews · doi:10.1016/j.arr.2020.101200 · Cited by 524
“chemotherapy tolerance and toxicity (Anandavadivelan et al., 2016; Carneiro et al., 2016; Prado et al., 2008; Yip et al., 2015).”
Sarcopenic obesity: hidden muscle wasting and its impact for survival and complications of cancer therapy
Baracos, V. E., & Arribas, L. (2018) · Annals of Oncology · doi:10.1093/annonc/mdx810 · Cited by 362
“[33] reviewed the clinical implications of SO in cancer reporting negative clinical outcomes associated with SO.”
Background
Diabetes and Sarcopenic Obesity: Pathogenesis, Diagnosis, and Treatments
Wang, M., Tan, Y., Shi, Y., Wang, X., Liao, Z., & Wei, P. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00568 · Cited by 231
A requiem for BMI in the clinical setting
González, M. C., Correia, M. I. T. D., & Heymsfield, S. B. (2017) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0000000000000395 · Cited by 209
Differentiating Sarcopenia and Cachexia Among Patients With Cancer
Peterson, S. J., & Mozer, M. (2016) · Nutrition in Clinical Practice · doi:10.1177/0884533616680354 · Cited by 200
“Other complications associated with sarcopenic obesity include poor functional status, worse postoperative outcomes, prolonged hospitalization, and shorter survival.(47) Among patients with cancer, prevalence of sarcopenia ranges from 12%–51% when diagnosed with both body composition and functional assessment tools an…”
Background
The evolution of body composition in oncology—epidemiology, clinical trials, and the future of patient care: facts and numbers
Brown, J. C., Feliciano, E. M. C., & Caan, B. J. (2018) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12379 · Cited by 180
Impact of Sarcopenic Obesity on Outcomes in Patients Undergoing Hepatectomy for Hepatocellular Carcinoma
Kobayashi, A., Kaido, T., Hamaguchi, Y., Okumura, S., Shirai, H., Yao, S., Kamo, N., Yagi, S., Taura, K., Okajima, H., et al. (2017) · Annals of Surgery · doi:10.1097/sla.0000000000002555 · Cited by 172
The Obesity Paradox in Cancer: Epidemiologic Insights and Perspectives
Lee, D. H., & Giovannucci, E. L. (2019) · Current Nutrition Reports · doi:10.1007/s13668-019-00280-6 · Cited by 156
Adipocytes Sequester and Metabolize the Chemotherapeutic Daunorubicin
Sheng, X., Parmentier, J., Tucci, J., Pei, H., Cortez-Toledo, O., Dieli-Conwright, C. M., Oberley, M. J., Neely, M. N., Orgel, E., Louie, S. G., et al. (2017) · Molecular Cancer Research · doi:10.1158/1541-7786.mcr-17-0338 · Cited by 145
“Furthermore, cancer treatment induces large increases in whole body adiposity (22), Figure 5.”
Background
Nutritional Interventions for Treating Cancer-Related Fatigue: A Qualitative Review
Inglis, J. E., Lin, P., Kerns, S. L., Kleckner, I. R., Kleckner, A. S., Castillo, D. A., Mustian, K. M., & Peppone, L. J. (2019) · Nutrition and Cancer · doi:10.1080/01635581.2018.1513046 · Cited by 137
The Obesity Paradox in Cancer: How Important Is Muscle?
Feliciano, E. M. C., Kroenke, C. H., & Caan, B. J. (2018) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-082117-051723 · Cited by 112
Strategies to Prevent or Remediate Cancer and Treatment-Related Aging
Guida, J., Agurs‐Collins, T., Ahles, T. A., Campisi, J., Dale, W., Demark‐Wahnefried, W., Dietrich, J., Fuldner, R., Gallicchio, L. M., Green, P. A., et al. (2020) · JNCI Journal of the National Cancer Institute · doi:10.1093/jnci/djaa060 · Cited by 113
Sarcopenia and Comorbidity in Gastric Cancer Surgery as a Useful Combined Factor to Predict Eventual Death from Other Causes
Kuwada, K., Kuroda, S., Kikuchi, S., Yoshida, R., Nishizaki, M., Kagawa, S., & Fujiwara, T. (2018) · Annals of Surgical Oncology · doi:10.1245/s10434-018-6354-4 · Cited by 101
“Although SMA divided by the square of height is used for sarcopenia index in many reports, there is concern that this index may be inappropriate for the detection of sarcopenic obesity, which is associated with higher risks of surgical complications, physical disability, and decreased survival.(22) A previous report h…”
Method
A window beneath the skin: how computed tomography assessment of body composition can assist in the identification of hidden wasting conditions in oncology that profoundly impact outcomes
Daly, L. E., Prado, C. M. M., & Ryan, A. M. (2018) · Proceedings of The Nutrition Society · doi:10.1017/s0029665118000046 · Cited by 97
“…can be present at any given BMI, and the prevalence of sarcopenic obesity (sarcopenia and obesity (BMI ≥ 30 kg/m 2 )) has been shown to vary between 1 and 29 % in studies including individuals from all BMI categories, and between 15 and 36 % in studies including obese individuals only (59) .”
BackgroundSelf-citation
Preoperative low skeletal muscle mass as a risk factor for pharyngocutaneous fistula and decreased overall survival in patients undergoing total laryngectomy
Bril, S. I., Pézier, T. F., Tijink, B. M., Janssen, L. M., Braunius, W. W., & de Bree, R. (2019) · Head & Neck · doi:10.1002/hed.25638 · Cited by 92
“The radiological assessment of body composition has increasingly gained attention in oncological research over the last decade.(8,9) Specifically a low skeletal muscle mass (SMM), also termed sarcopenia, has been related to negative outcomes in variety of tumor types and treatments.”
Background
Emerging Therapeutic Strategies in Sarcopenia: An Updated Review on Pathogenesis and Treatment Advances
Najm, A., Niculescu, A.-G., Grumezescu, A. M., & Beuran, M. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084300 · Cited by 86
Association of Body Composition with Long-Term Survival in Non-metastatic Rectal Cancer Patients
Han, J., Ryu, H., Park, I. J., Kim, K. W., Shin, Y., Kim, S. O., Lim, S., Kim, C. W., Yoon, Y. S., Lee, J. L., et al. (2019) · Cancer Research and Treatment · doi:10.4143/crt.2019.249 · Cited by 74
Implication of Obesity and Gut Microbiome Dysbiosis in the Etiology of Colorectal Cancer
Singh, S., Sharma, P., Sarma, D. K., Kumawat, M., Tiwari, R. R., Verma, V., Nagpal, R., & Kumar, M. (2023) · Cancers · doi:10.3390/cancers15061913 · Cited by 83
Vascular Impairment, Muscle Atrophy, and Cognitive Decline: Critical Age-Related Conditions
de Lima, E. P., Tanaka, M., Lamas, C. B., Quesada, K. R., Detregiachi, C. R. P., Araújo, A. C., Guiguer, É. L., Catharin, V. M. C. S., de Castro, M. V. M., Baldi, E., et al. (2024) · Biomedicines · doi:10.3390/biomedicines12092096 · Cited by 81
CT Body Composition of Sarcopenia and Sarcopenic Obesity: Predictors of Postoperative Complications and Survival in Patients with Locally Advanced Esophageal Adenocarcinoma
Fehrenbach, U., Wuensch, T., Gabriel, P., Segger, L., Yamaguchi, T., Auer, T. A., Beetz, N. L., Denecke, C., Kröll, D., Raakow, J., et al. (2021) · Cancers · doi:10.3390/cancers13122921 · Cited by 75
Low skeletal muscle mass is a strong predictive factor for surgical complications and a prognostic factor in oral cancer patients undergoing mandibular reconstruction with a free fibula flap
Ansari, E., Chargi, N., van Gemert, J. T. M., van Es, R. J. J., Dieleman, F. J., Rosenberg, A. J. W. P., Cann, E. M. V., & de Bree, R. (2019) · Oral Oncology · doi:10.1016/j.oraloncology.2019.104530 · Cited by 74
Immediate versus delayed exercise in men initiating androgen deprivation: effects on bone density and soft tissue composition
Taaffe, D. R., Galvao, D. A., Spry, N. A., Joseph, D. J., Chambers, S. K., Gardiner, R. A., Hayne, D., Cormie, P., Shum, D., & Newton, R. U. (2018) · British Journal of Urology · doi:10.1111/bju.14505 · Cited by 68
Interobserver agreement of skeletal muscle mass measurement on head and neck CT imaging at the level of the third cervical vertebra
Bril, S. I., Wendrich, A. W., Swartz, J. E., Wegner, I., Pameijer, F. A., Smid, E. J., Bol, G. H., Pothen, A. J., & de Bree, R. (2019) · European Archives of Oto-Rhino-Laryngology · doi:10.1007/s00405-019-05307-w · Cited by 67
The Role of Sarcopenic Obesity in Cancer and Cardiovascular Disease: A Synthesis of the Evidence on Pathophysiological Aspects and Clinical Implications
Silveira, É. A., Filho, R. R. D. S., Spexoto, M. C. B., Haghighatdoost, F., Sarrafzadegan, N., & de Oliveira, C. M. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094339 · Cited by 59
Screening for low muscularity in colorectal cancer patients: a valid, clinic‐friendly approach that predicts mortality
Feliciano, E. M. C., Avrutin, E., Caan, B. J., Boroian, A., & Mourtzakis, M. (2018) · Journal of Cachexia Sarcopenia and Muscle · doi:10.1002/jcsm.12317 · Cited by 57
Prevalence and prognostic value of sarcopenic obesity in patients with cancer: A systematic review and meta-analysis
Gao, Q., Hu, K., Gao, J., Shang, Y., Mei, F., Zhao, L., Chen, F., & Ma, B. (2022) · Nutrition · doi:10.1016/j.nut.2022.111704 · Cited by 57
Sarcopenia related to neoadjuvant chemotherapy and perioperative outcomes in resected gastric cancer: a multi-institutional analysis
Mirkin, K. A., Luke, F. E., Gangi, A., Pimiento, J. M., Jeong, D. K., Hollenbeak, C. S., & Wong, J. Y. (2017) · Journal of Gastrointestinal Oncology · doi:10.21037/jgo.2017.03.02 · Cited by 53
“There is evidence that sarcopenic obesity is a unique combination with compound burdens on outcomes, but there are conflicting reports regarding the association between sarcopenic obesity and postoperative outcomes (14).”
BackgroundInfluential
Prevalence and significance of sarcopenia in multiple myeloma patients undergoing autologous hematopoietic cell transplantation
Williams, A., Baruah, D., Patel, J. J., Szabó, A., Chhabra, S., Dhakal, B., Hari, P., Janz, S., Stolley, M. R., & D’Souza, A. (2020) · Bone Marrow Transplantation · doi:10.1038/s41409-020-01008-9 · Cited by 52
Sarcopenic obesity: What about in the cancer setting?
Cappellari, G. G., Brasacchio, C., Laudisio, D., Lubrano, C., Pivari, F., Barrea, L., Muscogiuri, G., Savastano, S., & Colao, A. (2022) · Nutrition · doi:10.1016/j.nut.2022.111624 · Cited by 49
To fast, or not to fast before chemotherapy, that is the question
on behalf of the AIOM-SINPE-FAVO Working Group, Caccialanza, R., Cereda, E., Lorenzo, F. D., Farina, G., & Pedrazzoli, P. (2018) · BMC Cancer · doi:10.1186/s12885-018-4245-5 · Cited by 48
“Completed and ongoing human trials have only considered the exclusion of patients with low body mass index and weight loss [14–16], which overlooks the issue of sarcopenic obesity and its negative clinical implications [22].”
Skeletal muscle mass is an imaging biomarker for decreased survival in patients with oropharyngeal squamous cell carcinoma
Chargi, N., Bril, S. I., Swartz, J. E., Wegner, I., Willems, S. M., & de Bree, R. (2019) · Oral Oncology · doi:10.1016/j.oraloncology.2019.104519 · Cited by 46
Clinical significance of sarcopenia in the treatment of patients with primary hepatic malignancies, a systematic review and meta-analysis
Zhang, G., Meng, S., Li, R., Ye, J., & Zhao, L. (2017) · Oncotarget · doi:10.18632/oncotarget.19687 · Cited by 44
“In recent years, studies have shown that sarcopenia is prevalent in patients with certain cancers [2, 3], and evidence has revealed its prognostic significance in oncologic patients [4–10].”
Background
Phenotypes of Sarcopenic Obesity: Exploring the Effects on Peri-Muscular Fat, the Obesity Paradox, Hormone-Related Responses and the Clinical Implications
Alalwan, T. A. (2020) · Geriatrics · doi:10.3390/geriatrics5010008 · Cited by 44
“[119] conducted a meta-analysis including 14 studies linking sarcopenic obesity to clinical outcomes in cancer patients and concluded that sarcopenic obesity was associated with increased surgical complications.”
Pre‐operative core muscle index in combination with hypoalbuminemia is associated with poor prognosis in advanced ovarian cancer
Conrad, L. B., Awdeh, H., Acosta‐Torres, S., Conrad, S. A., Bailey, A. A., Miller, D. S., & Lea, J. S. (2018) · Journal of Surgical Oncology · doi:10.1002/jso.24990 · Cited by 42
The relationship between body-mass index and overall survival in non-small cell lung cancer by sex, smoking status, and race: A pooled analysis of 20,937 International lung Cancer consortium (ILCCO) patients
Jiang, M., Fares, A. F., Shepshelovich, D., Yang, P., Christiani, D. C., Zhang, J., Shiraishi, K., Ryan, B. M., Chen, C., Schwartz, A. G., et al. (2020) · Lung Cancer · doi:10.1016/j.lungcan.2020.11.029 · Cited by 43
Phase angle is associated with sarcopenic obesity in post-stroke patients
Yoshimura, Y., Wakabayashi, H., Nagano, F., Matsumoto, A., Shimazu, S., Shiraishi, A., Kido, Y., Bise, T., Hori, K., & Yoneda, K. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.08.018 · Cited by 43
Do Cancer and Cancer Treatments Accelerate Aging?
Bhatia, R., Holtan, S. G., Jurdi, N. E., Prizment, A. E., & Blaes, A. H. (2022) · Current Oncology Reports · doi:10.1007/s11912-022-01311-2 · Cited by 41
Association of body composition with risk of overall and site‐specific cancers: A population‐based prospective cohort study
He, Q., Xia, B., Liu, A., Li, M., Zhou, Z., Cheung, E. C., Kuo, Z. C., Wang, B., Li, F., Tang, Y., et al. (2021) · International Journal of Cancer · doi:10.1002/ijc.33697 · Cited by 39
Obesidad sarcopénica: un nuevo reto en la clínica práctica
Ciudin, A., Simó-Servat, A., Palmas-Candia, F. X., & Barahona, M. J. (2020) · Endocrinología Diabetes y Nutrición · doi:10.1016/j.endinu.2020.03.004 · Cited by 44
Sarcopenic obesity: A new challenge in the clinical practice
Ciudin, A., Simó-Servat, A., Palmas-Candia, F. X., & Barahona, M. J. (2020) · Endocrinología Diabetes y Nutrición (English ed ) · doi:10.1016/j.endien.2020.03.007 · Cited by 37
Obesity and lung cancer—a narrative review
Vedire, Y., Kalvapudi, S., & Yendamuri, S. (2023) · Journal of Thoracic Disease · doi:10.21037/jtd-22-1835 · Cited by 40
“Sarcopenic obesity is a condition of combined skeletal muscle depletion in obese patients (63).”
Under-Recognizing Malnutrition in Hospitalized Obese Populations: The Real Paradox
Sharma, K., Mogensen, K. M., & Robinson, M. K. (2019) · Current Nutrition Reports · doi:10.1007/s13668-019-00288-y · Cited by 36
Fasting in oncology: a word of caution
Caccialanza, R., Aprile, G., Cereda, E., & Pedrazzoli, P. (2019) · Nature reviews. Cancer · doi:10.1038/s41568-018-0098-0 · Cited by 34
Challenges in identifying malnutrition in obesity; An overview of the state of the art and directions for future research
Mwala, N. N., Borkent, J. W., van der Meij, B. S., & de van der Schueren, M. A. E. (2024) · Nutrition Research Reviews · doi:10.1017/s095442242400012x · Cited by 34
“Although sarcopenic obesity, particularly the secondary form, associated with specific comorbidities such as cancer or rheumatoid arthritis, can occur in individuals under 65 years, the primary form is more prevalent and particularly observed in those aged 65 and older (35,37,38) .”
Background
Role of bone marrow adipocytes in leukemia and chemotherapy challenges
Samimi, A., Ghanavat, M., Shahrabi, S., Azizidoost, S., & Saki, N. (2019) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-019-03031-6 · Cited by 32
Relationship between Handgrip Strength and Muscle Mass in Female Survivors of Breast Cancer: A Mediation Analysis
Benavides-Rodriguez, L. E., García‐Hermoso, A., Rodrigues-Bezerra, D., Izquierdo, M., Correa‐Bautista, J. E., & Ramírez‐Vélez, R. (2017) · Nutrients · doi:10.3390/nu9070695 · Cited by 32
Sarcopenic Obesity in Cancer Patients: Focus on Pathogenesis
Raffaello, W. M., & Kurniawan, A. (2020) · Indonesian Journal of Cancer · doi:10.33371/ijoc.v14i3.720 · Cited by 32
Perspective: Creating the Evidence Base for Nutritional Support in Childhood Cancer in Low- and Middle-Income Countries: Priorities for Body Composition Research
Murphy‐Alford, A. J., Prasad, M., Slone, J. S., Stein, K., & Tolar-Peterson, T. (2019) · Advances in Nutrition · doi:10.1093/advances/nmz095 · Cited by 31
“and children with sarcopenic obesity (increased FM and decreased FFM) tend to receive drug doses that are possibly higher than what their depleted FFM can metabolize (79).”
Background
The nutritional needs of older cancer survivors
Kleckner, A. S., & Magnuson, A. M. (2021) · Journal of Geriatric Oncology · doi:10.1016/j.jgo.2021.12.007 · Cited by 28
Body composition and nutritional status in malignant pleural mesothelioma: implications for activity levels and quality of life
Jeffery, E., Lee, G., Newton, R. U., Lyons‐Wall, P., McVeigh, J. A., Nowak, A. K., Cheah, H. M., Nguyen, B., Fitzgerald, D. B., Creaney, J., et al. (2019) · European Journal of Clinical Nutrition · doi:10.1038/s41430-019-0418-9 · Cited by 27
Sarcopenic obesity and therapeutic outcomes in gastrointestinal surgical oncology: A meta-analysis
Wang, P., Wang, S., Ma, Y., Li, H., Liu, Z., Lin, G., Li, X., Yang, F., & Qiu, M. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.921817 · Cited by 29
“Several reviews have described these issues (9, 10, 40), however, quantitative analyses have not been conducted.”
Background
Sarcopenic obesity in cancer
Jurdana, M., & Čemažar, M. (2024) · Radiology and Oncology · doi:10.2478/raon-2024-0011 · Cited by 27
“5,6,8 Levels of IL -6 and TNF-α are further increased by the hormone leptin, reducing the anabolic pathway of IGF-1 and enhancing lipotoxicity.”
BackgroundInfluential
Is Sarcopenic Obesity an Indicator of Poor Prognosis in Gastric Cancer Surgery? A Cohort Study in a Western Population
Gonçalves, V. R., Landi, F., Castro, S., Mast, R., Conde, N. R., Gantxegi, A., Pradell, J., Cano, M. L., & Armengol, M. (2020) · Journal of Gastrointestinal Surgery · doi:10.1007/s11605-020-04716-1 · Cited by 26
Increasing quality of life in pulmonary arterial hypertension: is there a role for nutrition?
Vinke, P., Jansen, S. M., Witkamp, R. F., & van Norren, K. (2018) · Heart Failure Reviews · doi:10.1007/s10741-018-9717-9 · Cited by 25
“The combination of immobility and the inability to use fat can lead to a sarcopenic obesity phenotype (high BMI, lowmuscle mass), a malnourished phenotype that is also more and more encountered in cancer [64] and is associated with increased morbidity and mortality in this disease.”
Background
Is sarcopenia and sarcopenic obesity associated with clinical and pathological outcomes in patients undergoing radical nephroureterectomy?
Kocher, N. J., Jafri, S., Balabhadra, S., Lehman, E. B., Gardner, J. A., Vijay, K., Sarwani, N. I., & Raman, J. D. (2017) · Urologic Oncology Seminars and Original Investigations · doi:10.1016/j.urolonc.2017.12.004 · Cited by 24
Amino acid kinetics and the response to nutrition in patients with cancer
van der Meij, B. S., Teleni, L., ENGELEN, M. P. K. J., & Deutz, N. E. P. (2018) · International Journal of Radiation Biology · doi:10.1080/09553002.2018.1466209 · Cited by 24
Impact of Lean Body Mass–Based Oxaliplatin Dose Calculation on Neurotoxicity in Adjuvant Treatment of Stage III Colon Cancer: Results of the Phase II Randomized LEANOX Trial
Assénat, E., Abdelghani, M. B., Gourgou, S., Perrier, H., Akouz, F. K., Desgrippes, R., Galais, M., Janiszewski, C., Mazard, T., Rinaldi, Y., et al. (2025) · Journal of Clinical Oncology · doi:10.1200/jco-24-02754 · Cited by 29
Prognostic Value of Third Cervical Vertebra Skeletal Muscle Index in Oral Cavity Cancer: A Retrospective Study
Chang, S., Hsu, C., Tsai, Y., Chang, G., Tsai, M., Huang, E. I., & Tsai, Y. (2021) · The Laryngoscope · doi:10.1002/lary.29390 · Cited by 22
The prognostic value of skeletal muscle index on clinical and survival outcomes after cytoreduction and HIPEC for peritoneal metastases from colorectal cancer: A systematic review and meta-analysis
Giorgio, A. D., Rotolo, S., Cintoni, M., Rinninella, E., Pulcini, G., Schena, C. A., Ferracci, F., Grassi, F., Raoul, P. C., Moroni, R., et al. (2021) · European Journal of Surgical Oncology · doi:10.1016/j.ejso.2021.10.008 · Cited by 22
Isatuximab, carfilzomib, lenalidomide, and dexamethasone in patients with newly diagnosed, transplantation-eligible multiple myeloma (SKylaRk): a single-arm, phase 2 trial
O’Donnell, E., Mo, C. C., Yee, A. J., Nadeem, O., Laubach, J. P., Rosenblatt, J. M., Munshi, N. C., Midha, S., Cirstea, D. D., Chrysafi, P., et al. (2024) · The Lancet Haematology · doi:10.1016/s2352-3026(24)00070-x · Cited by 22
Nutrition, Cancer and Personalized Medicine
Flores-Pérez, J. A., Oliva, F. D. L. R., Yacab, R. A., & Meneses-García, A. (2019) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-24100-1_11 · Cited by 20
Sarcopenic obesity: patterns and paradoxes
Drapkina, O. M., Budnevsky, A. V., Ovsyannikov, Е. S., Васильевна, К. А., & Дробышева, Е. С. (2021) · Russian Journal of Preventive Medicine · doi:10.17116/profmed20212401173 · Cited by 20
Association between Body Mass Index and Survival Outcome in Metastatic Cancer Patients Treated by Immunotherapy: Analysis of a French Retrospective Cohort
Collet, L., Delrieu, L., Bouhamama, A., Crochet, H., Swalduz, A., Nerot, A., Marchal, T., Chabaud, S., & Heudel, P. (2021) · Cancers · doi:10.3390/cancers13092200 · Cited by 21
The impact of skeletal muscle abnormalities on tolerance to adjuvant chemotherapy and radiation and outcome in patients with endometrial cancer
Ganju, R. G., Tennapel, M. J., Spoozak, L. A., Chen, A. M., & Hoover, A. C. (2019) · Journal of Medical Imaging and Radiation Oncology · doi:10.1111/1754-9485.12935 · Cited by 18
“For example, a recent review showed rates of sarcopenia ranging from 11 to 74% overall and from 1 to 36% in the setting of obesity; among 14 included studies, seven different definitions for sarcopenia and five different definitions for obesity were used.(17) There is scarce literature assessing measures of skeletal m…”
Background
Technical Note: Automatic segmentation of CT images for ventral body composition analysis
Fu, Y., Ippolito, J. E., Ludwig, D. R., Nizamuddin, R., Li, H. H., & Yang, D. (2020) · Medical Physics · doi:10.1002/mp.14465 · Cited by 18
Obesity, cancer, and response to immune checkpoint inhibitors: Could the gut microbiota be the mechanistic link?
Delaye, M., Rousseau, A., Mailly-Giacchetti, L., Assoun, S., Sokol, H., & Neuzillet, C. (2023) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2023.108442 · Cited by 19
Correlation between muscle mass and quality around the hip and of psoas muscles at L3 level using unenhanced CT scans
Zannoni, S., Albano, D., Jannone, M. L., Messina, C., & Sconfienza, L. M. (2020) · Skeletal Radiology · doi:10.1007/s00256-020-03475-z · Cited by 18
Muscle weakness as an additional criterion for grading sarcopenia‐related prognosis in patients with cancer
Cereda, E., Tancredi, R. J., Klersy, C., Lobascio, F., Crotti, S., Masi, S., Cappello, S., Stobäus, N., Tank, M., Cutti, S., et al. (2021) · Cancer Medicine · doi:10.1002/cam4.4362 · Cited by 16
Poor Muscle Status, Dietary Protein Intake, Exercise Levels, Quality of Life and Physical Function in Women with Metastatic Breast Cancer at Chemotherapy Commencement and during Follow-Up
Parkinson, J., Bandera, A., Crichton, M., Shannon, C., Woodward, N. E., Hodgkinson, A., Millar, L., Teleni, L., & van der Meij, B. S. (2023) · Current Oncology · doi:10.3390/curroncol30010054 · Cited by 16
Diagnosis and prevalence of sarcopenic obesity in patients with colorectal cancer: A scoping review
Saino, Y., Kawase, F., Nagano, A., Ueshima, J., Kobayashi, H., Murotani, K., Inoue, T., Nagami, S., Suzuki, M., & Maeda, K. (2023) · Clinical Nutrition · doi:10.1016/j.clnu.2023.06.025 · Cited by 16
Potential roles of sex-linked differences in obesity and cancer immunotherapy: revisiting the obesity paradox
Vick, L. V., Rosario, S. R., Riess, J. W., Canter, R. J., Mukherjee, S., Monjazeb, A. M., & Murphy, W. J. (2024) · npj Metabolic Health and Disease · doi:10.1038/s44324-024-00007-4 · Cited by 15
“Additional studies have suggested that obesity with consideration of factors, such as ratio of lean body mass or presence of sarcopenia, could be better determinants in predicting therapy outcomes 19,20 .”
Background
Clinical screening and identification of sarcopenic obesity in adults with advanced knee osteoarthritis
Godziuk, K., Woodhouse, L. J., Prado, C. M. M., & Forhan, M. A. (2020) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2020.08.005 · Cited by 16
Self-citation
Current colorectal cancer chemotherapy dosing limitations and novel assessments to personalize treatments
Arafat, Y., Loft, M., Cao, K., Reid, F. S. W., Kosmider, S., Lee, M., Gibbs, P., Faragher, I. G., & Yeung, J. M. C. (2022) · ANZ Journal of Surgery · doi:10.1111/ans.18046 · Cited by 14
“Some studies have reported that patients with reduced muscle density (sarcopenia) and who are obese are at the highest risk of developing DLT.(4) Overall, there is growing evidence that chemotherapy treatment dosing based on body composition, rather than BSA, reflects more accurately on drug distribution in different…”
Background
Post-diagnosis weight trajectories and mortality among women with breast cancer
Puklin, L. S., Li, F., Cartmel, B., Zhao, J., Sanft, T. B., Lisevick, A. B., Winer, E. P., Lustberg, M. B., Spiegelman, D. L., Sharifi, M., et al. (2023) · npj Breast Cancer · doi:10.1038/s41523-023-00603-5 · Cited by 16
“This condition may affect 12 – 40% of breast cancer patients and is associated with poorer functional status and lower survival rates 54,55 .”
Background
Enhanced recovery in liver surgery
Day, R., & Aloia, T. (2019) · Journal of Surgical Oncology · doi:10.1002/jso.25420 · Cited by 10
“Obesity does not exclude the possibility of malnutrition and sarcopenic obesity is an increasingly recognized entity.(21) Several risk screening tools are available and include the Nutritional Risk Score and the Malnutrition Universal Screening Tool.”
Background
Impact of Body Composition in Overweight and Obese Patients With Localised Renal Cell Carcinoma
Darbas, T., Forestier, G., Léobon, S., Pestre, J., Jésus, P., Lachâtre, D., Tubiana-Mathieu, N., Descazeaud, A., & Deluche, É. (2020) · In Vivo · doi:10.21873/invivo.12115 · Cited by 14
The Association between the Preoperative Prognostic Nutritional Index and the Controlling Nutritional Status Score on Tumor Stage, Chemotherapeutic Response and Overall Survival in Ovarian Cancer
Karakaş, S., Demirayak, G., Önder, A. B., Özdemir, İ. A., Comba, C., Çaypınar, S. S., Yıldız, Ş., Afşar, S., Baghaki, H. S., Yıldız, G. Ö., et al. (2022) · Nutrition and Cancer · doi:10.1080/01635581.2021.2022170 · Cited by 13
“by the presence of sarcopenic obesity which is defined as the coexistence of obesity with low skeletal muscle mass and function with a prevalence of 15%– 36% in cancer patients (27).”
Background
Monitoring potentially modifiable lifestyle factors in cancer survivors: A narrative review on currently available methodologies and innovations for large-scale surveillance
Derksen, J. W. G., Beijer, S., Koopman, M., Verkooijen, H. M., van de Poll-Franse, L. V., & May, A. M. (2018) · European Journal of Cancer · doi:10.1016/j.ejca.2018.06.017 · Cited by 13
The role of sarcopenic obesity in high‐grade endometrial cancer
Donkers, H., Fasmer, K. E., McGrane, J., Pijnenborg, J. M. A., Bekkers, R. L. M., Haldorsen, I. S., & Galaal, K. A. (2021) · International Journal of Gynecology & Obstetrics · doi:10.1002/ijgo.13591 · Cited by 12
Myeloma extracellular vesicle-derived RAGE increases inflammatory responses and myotube atrophy in multiple myeloma through activation of the TLR4/NF-κB p65 pathway
Wu, Y., Yao, X., Shi, X., Xu, Z., Ren, J., Shi, M., Li, M., Liu, J., & Du, X. (2024) · Apoptosis · doi:10.1007/s10495-023-01920-7 · Cited by 10
“Sarcopenia is thought to be associated with poor prognosis in some solid malignancies [5].”
Resveratrol as a potential therapeutic agent for sarcopenic obesity: Insights from in vivoperiments
Yi, L., Wu, Y., Zhong, Y., Wu, Y., Ye, H., Luo, Y., Li, X., Ma, Y., & Wang, M. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.117396 · Cited by 12
Sarcopenia is a Predictive Factor for Postoperative Morbidity and Mortality in Patients Having Radical Gastrectomy for Cancer
Beuran, M., Tache, C., Ciubotaru, C., Vartic, M., Hostiuc, S., Prodan, A., Sartelli, M., Griffiths, E. A., Hernandez, M., & Negoi, I. (2018) · Chirurgia · doi:10.21614/chirurgia.113.5.678 · Cited by 12
“and sarcopenia in patients with gastrectomy older than 60 years (24).”
Sarcopenic Obesity in Non-Alcoholic Fatty Liver Disease—The Union of Two Culprits
Ali, S. E., & Nguyen, M. H. (2021) · Life · doi:10.3390/life11020119 · Cited by 12
Sarcobesity Index Predicts Poor Disease-Specific Survival After Resection for Colorectal Cancer
Conti, C., Turri, G., Gecchele, G., Conci, S., Zamboni, G. A., Ruzzenente, A., Guglielmi, A., & Pedrazzani, C. (2022) · Journal of Surgical Research · doi:10.1016/j.jss.2022.06.029 · Cited by 11
Body composition assessment with ultrasound muscle measurement: optimization through the use of semi-automated tools in colorectal cancer
Palmas-Candia, F. X., Mucarzel, F., Ricart, M., Lluch, A., Zabalegui, A., Melián, J. M., Guerra, R., Rodríguez-Martínez, A., Rosón, N., Ciudin, A., et al. (2024) · Frontiers in Nutrition · doi:10.3389/fnut.2024.1372816 · Cited by 11
Disentangling the obesity paradox in upper gastrointestinal cancers: Weight loss matters more than body mass index
Kumar, S., Mahmud, N., Goldberg, D. S., Datta, J., & Kaplan, D. E. (2021) · Cancer Epidemiology · doi:10.1016/j.canep.2021.101912 · Cited by 11
The Prevalence of Sarcopenic Obesity in Postmenopausal Women with a History of Breast Cancer Depending on Adopted Methodology – A Case–Control Study
Kałędkiewicz, E., Milewska, M., Pańczyk, M., & Szostak-Węgierek, D. E. (2020) · Journal of Multidisciplinary Healthcare · doi:10.2147/jmdh.s274660 · Cited by 11
What is the most useful body composition parameter for predicting toxicities of preoperative chemotherapy for gastric cancer?
Hashimoto, T., Kurokawa, Y., Takahashi, T., Saito, T., Yamashita, K., Tanaka, K., Makino, T., Yamasaki, M., Motoori, M., Kimura, Y., et al. (2019) · Surgery Today · doi:10.1007/s00595-019-01915-5 · Cited by 11
Development and application of the Cancer Cachexia Staging Index for the diagnosis and staging of cancer cachexia
Wang, J., Tan, S., Xu, J., Li, S., Yan, M., Yang, F., Huang, Q., Zhang, Z., Zhang, Y., Han, J. S., et al. (2023) · Nutrition · doi:10.1016/j.nut.2023.112114 · Cited by 10
Effect of exercise therapy on sarcopenia in pancreatic cancer: a study protocol for a randomised controlled trial
Yoh, K., Nishikawa, H., Enomoto, H., Ishii, N. K., Iwata, Y., Ishii, A., Yuri, Y., Miyamoto, Y., Hasegawa, K., Nakano, C., et al. (2018) · BMJ Open Gastroenterology · doi:10.1136/bmjgast-2017-000194 · Cited by 10
Magnetic Resonance Imaging of Adipose Tissue in Metabolic Dysfunction
Franz, D., Syväri, J., Weidlich, D., Baum, T. H., Rummeny, E. J., & Karampinos, D. C. (2018) · RöFo - Fortschritte auf dem Gebiet der Röntgenstrahlen und der bildgebenden Verfahren · doi:10.1055/a-0612-8006 · Cited by 10
“Studies found that cancer patients with coexisting sarcopenic obesity showed poorer survival rates compared to other patients [75].”
Result
Association of preoperative low skeletal muscle mass with postoperative complications after selective neck dissection
Ansari, E., Chargi, N., van Es, R. J. J., Dieleman, F. J., Cann, E. M. V., & de Bree, R. (2022) · International Journal of Oral and Maxillofacial Surgery · doi:10.1016/j.ijom.2022.02.008 · Cited by 10
Association between Scored Patient-Generated Subjective Global Assessment and Skeletal Muscle Determined by Computed Tomography in Patients with Cervical Cancer
Pereira, F. D. O., Mota, A. P., Aredes, M. A., Chaves, G. V., & Cardoso, I. C. R. (2019) · Nutrition and Cancer · doi:10.1080/01635581.2019.1645866 · Cited by 10
“5 (1-29) CT(3) SMI (categorized)(1) No myopenia 138 (76.”
Sarcopenic obesity and 10-year cardiovascular disease risk scores in cancer survivors and non-cancer participants using a nationwide survey
Lee, K. (2021) · European Journal of Cancer Care · doi:10.1111/ecc.13365 · Cited by 8
Prognostic Impact of Sarcopenic Obesity on Postoperative Outcomes in Colorectal Cancer Patients Undergoing Surgery: A Systematic Review and Meta-Analysis
Kopuz, T. N. Y., Yıldız, H. F., Er, S., & Fisunoğlu, M. (2025) · Nutrition and Cancer · doi:10.1080/01635581.2025.2450843 · Cited by 8
An in-depth analysis on the effects of body composition in patients receiving neoadjuvant chemotherapy for urothelial cell carcinoma
MacDonald, L., Rendon, R. A., Thana, M., Wood, L. A., Macfarlane, R. J., Bell, D., Duplisea, J. J., & Mason, R. J. (2024) · Canadian Urological Association Journal · doi:10.5489/cuaj.8542 · Cited by 8
Consumo de Alimentos Ultraprocessados por Mulheres Sobreviventes do Câncer de Mama
Sales, J. D. N., Barbosa, M. C., Bezerra, I. N., & Verde, S. M. M. L. (2020) · Revista Brasileira de Cancerologia · doi:10.32635/2176-9745.rbc.2020v66n3.1092 · Cited by 8
Computed tomography body composition and clinical outcomes following lung transplantation in cystic fibrosis
Jennerich, A. L., Downey, L., Goss, C. H., Kapnadak, S. G., Pryor, J. B., & Ramos, K. J. (2023) · BMC Pulmonary Medicine · doi:10.1186/s12890-023-02398-4 · Cited by 9
Prediagnostic adult body mass index change and esophageal adenocarcinoma survival
Loehrer, E. A., Giovannucci, E. L., Betensky, R. A., Shafer, A., & Christiani, D. C. (2020) · Cancer Medicine · doi:10.1002/cam4.3015 · Cited by 8
Impact of Sarcopenia on Survival in Patients With Early-Stage Lung Cancer Treated With Stereotactic Body Radiation Therapy
Taylor, J. M., Song, A. J., David, A. R., Chen, V. E., Lü, B., & Werner‐Wasik, M. (2020) · Cureus · doi:10.7759/cureus.10712 · Cited by 8
“While the authors conclude there is a high degree of heterogeneity in how sarcopenic obesity is defined, there is evidence to suggest that cancer patients with sarcopenic obesity have shorter survivals [29].”
Background

Authors: Carneiro, I. P., Mazurak, V. C., & Prado, C. M.
Affiliations: University of Alberta (CA)
Corresponding author: Prado, Carla M.
ORCID: Mazurak, Vera C.
Prado, Carla M.
Venue: Current Oncology Reports
Publisher: Springer Science and Business Media LLC
Published: 2016-08-19
Volume: 18
Issue: 10
Pages: 62-62
ISSN: 1523-3790 (ISSN-L)
1534-6269
DOI: 10.1007/s11912-016-0546-5
OpenAlex: W2518082324
Cited by: 162
References: 77
Citations by year: 2026: 9 · 2025: 13 · 2024: 15 · 2023: 19 · 2022: 15 · 2021: 23 · 2020: 22 · 2019: 19 · 2018: 17 · 2017: 9 · 2016: 1
FWCI: 1.80
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Current Oncology Reports (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Physiology (medical) › Nutrition and Health in Aging
Health Sciences › Medicine › Physiology (medical) › Body Composition Measurement Techniques
Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
Keywords: sarcopenic obesity, sarcopenia, obesity, cancer, body composition, prevalence, dose-limiting toxicity, surgical complications, physical disability, survival, clinical outcomes
MeSH terms: Antineoplastic Combined Chemotherapy Protocols, Body Composition, Dose-Response Relationship, Drug, Humans, Neoplasms, Obesity, Prevalence, Survival Analysis, Treatment Outcome, Sarcopenia

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Clinical Implications of Sarcopenic Obesity in Cancer

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks