Sarcopenic obesity and 10-year cardiovascular disease risk scores in cancer survivors and non-cancer participants using a nationwide survey
Open accessAbstract
OBJECTIVE: To evaluate the associations of combinations of sarcopenia and adiposity phenotypes with 10-year cardiovascular disease (CVD) risk scores in cancer survivors and non-cancer participants. METHODS: In 19,019 individuals including 1023 cancer survivors free of CVD who were aged ≥30 years from the Korea National Health and Nutrition Examination Survey, combination groups of sarcopenia, obesity and abdominal obesity based on handgrip strength, BMI and waist circumference, respectively, were generated and 10-year CVD risk scores based on Framingham risk model were determined. RESULTS AND CONCLUSION: After adjusting for socio-demographic factors, health behaviours, dietary intake of nutrients and time since cancer diagnosis and current cancer therapy (in cancer survivors), cancer survivors with sarcopenic non-obesity, non-sarcopenic abdominal obesity or sarcopenic abdominal obesity had, respectively, 84%, 85% and 3.61-fold higher odds for ≥10% CVD risk scores compared with cancer survivors without those phenotypes. In non-cancer participants, sarcopenia, obesity, abdominal obesity and combinations of those phenotypes had higher odds from 1.37 (in those with obesity) to 4.24 (in those with sarcopenic abdominal obesity) for ≥10% CVD risk scores compared with reference phenotypes. In conclusion, cancer survivors and non-cancer participants with sarcopenia, obesity, abdominal obesity or combination of those phenotypes had increased 10-year CVD risk scores.
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Sarcopenic obesity significantly increases risk of cardiovascular risk factors including insulin resistance, metabolic syndrome, and adverse glycolipid metabolism, even in context of divergent comorbidities such as cancer and peritoneal dialysis.
“Sarcopenic obesity significantly increases the risk of cardiovascular risk factors including insulin resistance (IR), metabolic syndrome, and adverse glycolipid metabolism (16, 42–44), even in the context of divergent comorbidities such as cancer and peritoneal dialysis (45, 46).”
From Sarcopenic obesity: epidemiology, pathophysiology, cardiovascular disease, mortality, and management (2023) · cites this paper as [45]
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Sarcopenic obesity: epidemiology, pathophysiology, cardiovascular disease, mortality, and management
Wei, S., Nguyen, T. T., Zhang, Y., Ryu, D., & Gariani, K. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1185221 · Cited by 291 · see citing works
- Authors
- Lee, K.
- Affiliations
- Inje University (KR)
- Corresponding author
- Lee, Kayoung
- ORCID
- Lee, Kayoung
- Venue
- European Journal of Cancer Care
- Publisher
- Wiley
- Published
- 2020-11-11
- Volume
- 30
- Issue
- 2
- Pages
- e13365-e13365
- ISSN
- 0961-5423 (ISSN-L)
- 1365-2354
- OpenAlex
- W3103639772
- Cited by
- 8
- References
- 28
- Citations by year
- 2024: 3 · 2023: 1 · 2022: 3 · 2021: 1
- FWCI
- 0.75
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- European Journal of Cancer Care (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Research Foundation
- National Research Foundation of Korea (2017S1A5B8066096, NRF-2017S1A5B8066096)
- Topics
- Health Sciences › Medicine › Physiology › Nutrition and Health in Aging
- Health Sciences › Medicine › Oncology › Cancer Risks and Factors
- Health Sciences › Medicine › Geriatrics and Gerontology › Frailty in Older Adults
- Keywords
- sarcopenic obesity, sarcopenia, obesity, abdominal obesity, cardiovascular risk, cancer survivors, Framingham risk equation, grip strength, waist circumference, body mass index, Korea National Health and Nutrition Examination Survey
- MeSH terms
- Cancer Survivors, Cardiovascular Diseases, Humans, Neoplasms, Nutrition Surveys, Obesity, Risk Factors, Body Mass Index, Hand Strength, Sarcopenia
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