The DOI matches its Crossref record; 49 of the 49 references it cites were found in a registry or an index.
Mechanisms of Osteoarthritis (OA) Pain
Open accessAbstract
PURPOSE OF REVIEW: Osteoarthritis (OA) is a major cause of pain and disability worldwide. There is, however, a relatively poor correlation between the severity of OA based on plain radiograph changes and symptoms. In this review, we consider the mechanisms of pain in OA. RECENT FINDINGS: It is now widely recognised that OA is a disease of the whole joint. Data from large observational studies which have used magnetic resonance imaging (MRI) suggest that pain in OA is associated with a number of structural factors including the presence of bone marrow lesions (BMLs) and also synovitis. There is evidence also of alterations in nerve processing and that both peripheral and central nerve sensitisation may contribute to pain in OA. Identification of the causes of pain in an individual patient may be of benefit in helping to better target with appropriate therapy to help reduce their symptoms and improve function.
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Cites
Osteoarthritis: A disease of the joint as an organ
Loeser, R. F., Goldring, S. R., Scanzello, C. R., & Goldring, M. B. (2012) · Arthritis & Rheumatism · doi:10.1002/art.34453 · Cited by 3,076
TRP channels as cellular sensors
Clapham, D. E. (2003) · Nature · doi:10.1038/nature02196 · Cited by 2,779
Epidemiology of Osteoarthritis
Zhang, Y., & Jordan, J. M. (2010) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2010.03.001 · Cited by 2,316
Guccione, A. A., Felson, D. T., Anderson, J. J., Anthony, J. M., Zhang, Y., Wilson, P. W., Kelly-Hayes, M., Wolf, P. A., Kreger, B. E., & Kannel, W. B. (1994) · American Journal of Public Health · doi:10.2105/ajph.84.3.351 · Cited by 1,584
Self-citationThe individual and socioeconomic impact of osteoarthritis
Hunter, D. J., Schofield, D., & Callander, E. (2014) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2014.44 · Cited by 1,238
From the gate to the neuromatrix
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Synovitis in osteoarthritis: current understanding with therapeutic implications
Mathiessen, A., & Conaghan, P. G. (2017) · Arthritis Research & Therapy · doi:10.1186/s13075-017-1229-9 · Cited by 1,065
The Association of Bone Marrow Lesions with Pain in Knee Osteoarthritis
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Self-citationNerve growth factor contributes to the generation of inflammatory sensory hypersensitivity
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Metadata
- Authors
- O’Neill, T. W., & Felson, D. T.
- Venue
- Current Osteoporosis Reports
- Published
- 2018-08-28
- Volume
- 16
- Issue
- 5
- Pages
- 611-616
- ISSN
- 1544-1873 (ISSN-L)
- 1544-2241
- OpenAlex
- W2889131448
- Cited by
- 334
- References
- 49
- FWCI
- 15.23
- Type
- journal article
- Language
- en
- Open access
- hybrid
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