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Cited by 219Pain Mechanisms and TreatmentsFibromyalgia and Chronic Fatigue Syndrome ResearchPain Management and Treatment

The DOI matches its Crossref record; 80 of the 80 references it cites were found in a registry or an index.

Central sensitization in fibromyalgia and other musculoskeletal disorders

Arendt-Nielsen, Lars, Graven-Nielsen, Thomas·2003·Current Pain and Headache Reports
DOI 10.1007/s11916-003-0034-0
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Abstract

Muscle hyperalgesia and referred pain play an important role in chronic musculoskeletal pain. New knowledge on the involved basic mechanisms and better methods to assess muscle pain in the clinic are needed to revise and optimize treatment regimens. Increased muscle sensitivity is manifested as pain evoked by a normally non-nociceptive stimulus (allodynia), increased pain intensity evoked by nociceptive stimuli (hyperalgesia), or increased referred pain areas with associated somatosensory changes. Some manifestations of sensitization, such as expanded referred muscle pain areas in patients with chronic musculoskeletal pain, can be explained from animal experiments showing extrasegmental spread of sensitization. An important part of the pain manifestations (eg, tenderness and referred pain) related to chronic musculoskeletal disorders may result from peripheral and central sensitization, which may play a role in the transition from acute to chronic pain.

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Crossref · 10.1007/s11916-003-0034-0

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80 of 80 references verified0 citation errors · 0 not checkable

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Research works printed but not linked: 7

  1. Kellgren JH: Observation on referred pain arising from muscle. Clin Sci 1938, 3:175–190.
  2. Bonica JJ: General considerations of acute pain. In The Management of Pain, edn 2. Edited by Bonica JJ. Philadelphia and London: Lea & Febiger; 1990:159–179.
  3. Tuveson B, Lindblom B, Fruhstorfer H: Experimental muscle pain and sensory changes at the site of referred pain. Proceedings of the SASP 22nd Annual Meeting. Reykjavik, Iceland: UtgSted; 1999:77.
  4. Vecchiet L, Giamberardino MA, Marini I: Immediate muscular pain from physical activity. In Pain and Mobility. Edited by Tiengo M, Eccles J, Cuello AC, Ottoson D. New York: Raven Press; 1987:193–218.
  5. Gracely RH, Reid KI: Orofacial pain measurement. In Orofacial Pain and Temporomandibular Disorders: Advances in Pain Research and Therapy, vol 21. Edited by Fricton JR, Dubner R. New York: Raven Press; 1995:117–143.
  6. Jensen K: Quantification of Tenderness by palpation and use of pressure algometers. Advances in Pain Research and Therapy. New York: Raven Press Ltd; 1990:165–180.
  7. Lavigne GJ, Thon MT, Rompré P, et al.: Sensory descriptors from touch to pressure-pain and experimental variables: a psychophysiological study in humans on pressure-pain threshold. Proceedings of the 7th World Congress on Pain: Progress in Pain Research and Management, vol 2. Edited by Gebhart GF, Hammond DL, Jensen TS. Seattle: IASP Press; 1994:831–842.

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Metadata

Authors
Arendt-Nielsen, L., & Graven-Nielsen, T.
Venue
Current Pain and Headache Reports
Publisher
Springer Science and Business Media LLC
Published
2003-10
Volume
7
Issue
5
Pages
355-361
ISSN
  • 1531-3433 (ISSN-L)
  • 1534-3081
DOI
10.1007/s11916-003-0034-0
OpenAlex
W2161320464
Cited by
219
References
80
Citations by year
2026: 5 · 2025: 6 · 2024: 16 · 2023: 8 · 2022: 7 · 2021: 12 · 2020: 8 · 2019: 7 · 2018: 8 · 2017: 8 · 2016: 4 · 2015: 9 · 2014: 6 · 2013: 11 · 2012: 10
FWCI
1.28
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Current Pain and Headache Reports (publishedVersion)
  • PubMed (publishedVersion)
  • VBN Forskningsportal (Aalborg Universitet) (submittedVersion)
Funders
Danmarks Grundforskningsfond
Topics
  • Health Sciences › Medicine › Physiology (medical) › Pain Mechanisms and Treatments
  • Health Sciences › Medicine › Psychiatry and Mental health › Fibromyalgia and Chronic Fatigue Syndrome Research
  • Health Sciences › Medicine › Anesthesiology and Pain Medicine › Pain Management and Treatment
Keywords
central sensitization, fibromyalgia, chronic musculoskeletal pain, muscle hyperalgesia, referred pain, allodynia, transition from acute to chronic pain
MeSH terms
Fibromyalgia, Humans, Musculoskeletal Diseases, Nerve Endings, Neuropeptides, Nociceptors, Pain

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