Anxiety disorders and schizophrenia
Abstract
Anxiety symptoms and disorders have long been described in schizophrenia. This article reviews the epidemiology, phenomenology, and neurobiologic underpinnings of comorbid anxiety symptoms and disorders in schizophrenia. Recent literature was obtained by Medline searches using key words relating to schizophrenia and anxiety symptoms or disorders. There is some evidence that anxiety may be a core symptom dimension in schizophrenia, although further work is required. There is evidence that comorbid obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, and social anxiety disorder are all more common than expected by chance in schizophrenia, although additional work is needed to determine the mechanisms that underlie these associations and their clinical implications. In the interim, however, the data emphasize the importance of assessing and treating comorbid anxiety symptoms and disorders in schizophrenia.
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Depression and anxiety are strongly associated with positive symptoms, negative symptoms, psychotic relapses and impaired social function, and are among the best symptom predictors of quality of life outcomes in people with SSDs.
“Depression and anxiety are strongly associated with positive symptoms,2,3,5–7,9 negative symptoms,2,8 psychotic relapses3,9 and impaired social function,3,5,9 and are among the best symptom predictors of quality of life outcomes in people with SSDs.2–9”
From Dispositional Mindfulness and Psychotic Symptoms in Schizophrenia Spectrum Disorders: The Mediating Roles of Rumination and Negative Emotion (2022) · cites this paper as [4]
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Schizophrenia in Women: Implications for Pregnancy and Postpartum
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Social anxiety in schizophrenia
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- Authors
- Muller, J. E., Koen, L., Seedat, S., Emsley, R. A., & Stein, D. J.
- Affiliations
- Stellenbosch University (ZA)
- Venue
- Current Psychiatry Reports
- Published
- 2004-07
- Volume
- 6
- Issue
- 4
- Pages
- 255-261
- ISSN
- 1523-3812 (ISSN-L)
- 1535-1645
- OpenAlex
- W2055013734
- Cited by
- 42
- References
- 70
- Citations by year
- 2025: 1 · 2024: 2 · 2023: 1 · 2022: 2 · 2021: 5 · 2020: 1 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 3 · 2015: 3 · 2014: 1 · 2013: 4 · 2012: 3
- FWCI
- 0.19
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Psychiatry Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
- Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
- Keywords
- schizophrenia, anxiety disorders, comorbidities, obsessive-compulsive disorder, panic disorder, post-traumatic stress disorder, social anxiety disorder, neurobiology of anxiety, phenomenology
- MeSH terms
- Anxiety Disorders, Brain, Humans, Obsessive-Compulsive Disorder, Phobic Disorders, Schizophrenia, Stress Disorders, Post-Traumatic, Panic Disorder
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
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