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Cited by 133Schizophrenia research and treatmentAnxiety, Depression, Psychometrics, Treatment, Cognitive ProcessesMental Health and Psychiatry

Anxiety and Schizophrenia: The Interaction of Subtypes of Anxiety and Psychotic Symptoms

Huppert, Jonathan D., Smith, Thomas E.·2005·CNS Spectrums
DOI 10.1017/s1092852900019714
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Abstract

Objective: To examine the interaction of specific anxiety subtypes and psychosis. Introduction: Accumulating evidence suggests that anxiety and its disorders play a significant role in patients with schizophrenia, but few studies have examined multiple types of anxiety and how they interact with different symptoms of schizophrenia. Methods: Thirty-two patients diagnosed with schizophrenia or schizoaffective disorder were assessed through self-report measures and interviewer rating scales to examine symptoms of psychosis and anxiety. Results: A majority of patients (62%) were diagnosed with at least one comorbid anxiety disorder. Obsessive-compulsive symptoms and social anxiety symptoms were related to positive symptoms, bizarre behavior, and quality of life (QOL). Furthermore, panic and social anxiety were related to suspiciousness/paranoia. No consistent relationship was found with negative symptoms. Finally, severity of anxiety disorders was negatively correlated with the severity of formal thought disorder. Discussion: This is one of the first studies to simultaneously examine the interrelationships of different types of anxiety symptoms and psychotic symptoms. The present findings are consistent with the studies that have suggested relationships between panic and paranoia and comorbid anxiety disorders and impaired QOL. These data suggest that further research into anxiety in schizophrenia, including the cognitive and neurobiological correlates, may help elucidate the mechanisms involved in the manifestation of these psychopathologies Conclusion: Anxiety disorders are common in patients with schizophrenia. The presence of such symptoms may influence the presence of core psychotic symptoms and QOL. More information is needed in terms of the relationship between treatment of these symptoms and changes in psychotic symptoms and/or relapse prevention.

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  • Depression and anxiety are strongly associated with positive symptoms, negative symptoms, psychotic relapses and impaired social function, and are among the best symptom predictors of quality of life outcomes in people with SSDs.

    “Depression and anxiety are strongly associated with positive symptoms,2,3,5–7,9 negative symptoms,2,8 psychotic relapses3,9 and impaired social function,3,5,9 and are among the best symptom predictors of quality of life outcomes in people with SSDs.2–9”

    From Dispositional Mindfulness and Psychotic Symptoms in Schizophrenia Spectrum Disorders: The Mediating Roles of Rumination and Negative Emotion (2022) · cites this paper as [6]

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Authors
Huppert, J. D., & Smith, T. E.
Affiliations
University of Pennsylvania (US)
ORCID
Venue
CNS Spectrums
Publisher
Cambridge University Press (CUP)
Published
2005-09
Volume
10
Issue
9
Pages
721-731
ISSN
  • 1092-8529 (ISSN-L)
  • 2165-6509
DOI
10.1017/s1092852900019714
OpenAlex
W1457595327
Cited by
133
References
63
Citations by year
2026: 2 · 2025: 3 · 2024: 7 · 2023: 6 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 1 · 2018: 5 · 2017: 9 · 2016: 6 · 2015: 5 · 2014: 7 · 2013: 13 · 2012: 13
FWCI
2.20
Type
journal article
Language
en
Open access
closed
Licence
www.cambridge.org/core/terms (unspecified, 3354 d)
Locations
  • CNS Spectrums (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (5k07mh001359-02)
  • National Institute of Mental Health (K07-MH01359)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Anxiety, Depression, Psychometrics, Treatment, Cognitive Processes
  • Social Sciences › Arts and Humanities › Philosophy › Mental Health and Psychiatry
Keywords
schizophrenia, anxiety disorders, schizoaffective disorder, comorbidities, obsessive-compulsive symptoms, social anxiety, panic, paranoia, positive symptoms, negative symptoms, formal thought disorder, quality of life, psychotic symptoms
MeSH terms
Adult, Anxiety, Depression, Female, Humans, Male, Middle Aged, Obsessive-Compulsive Disorder, Phobic Disorders, Psychotic Disorders, Quality of Life, Surveys and Questionnaires, Schizophrenia

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