Adjunctive use of modafinil in bipolar patients: just another stimulant or not?

Shelton, Richard C.; Reddy, Rakesh

doi:10.1007/s11920-008-0082-6

Cited by 11Bipolar Disorder and TreatmentTreatment of Major DepressionSchizophrenia research and treatment

Adjunctive use of modafinil in bipolar patients: just another stimulant or not?

Shelton, Richard C., Reddy, Rakesh·2008·Current Psychiatry Reports

DOI 10.1007/s11920-008-0082-6

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Abstract

Depression is much more common in the life course of people with bipolar disorder than mania or mixed states. Unfortunately, few established treatments are available, and new ones are needed. Modafinil is a novel stimulant approved for treating improving wakefulness in patients with excessive sleepiness associated with narcolepsy, obstructive sleep apnea, and shift-work sleep disorder. Given that bipolar depression is commonly associated with fatigue and somnolence, modafinil is a logical choice. In one recent study of moderate size (n = 85), modafinil was shown to be more effective than placebo in treating bipolar depression. The incidence of cycle induction in this trial was very low (lower than placebo), although isolated case reports of mania, hypomania, or mixed states have been reported. Given the limited options for bipolar depression, modafinil should be considered in patients who have not responded to approved treatments, although more research is needed.

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The final maintaining treatment was buprenorphine, lithium, methylphenidate, and delorazepam together with weekly sessions of third generation Cognitive Behavioural Therapy with integration of Mindfulness and Acceptance and Commitment Therapy.
“The final maintaining treatment was the following: buprenorphine [27, 28], lithium [29], methylphenidate [30, 31], and delorazepam [32] together with weekly sessions of third generation of Cognitive Behavioural Therapy (CBT) with integration of Mindfulness and Acceptance and Commitment Therapy [33] (see Table 1).”
From A Medical Resident with a History of Alcohol Abuse and Suicidal Ideation: A Challenge for Both Psychiatry and Occupational Medicine in the Context of the First Wave of the COVID-19 Pandemic (2022) · cites this paper as [31]

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“The final maintaining treatment was the following: buprenorphine [27, 28], lithium [29], methylphenidate [30, 31], and delorazepam [32] together with weekly sessions of third generation of Cognitive Behavioural Therapy (CBT) with integration of Mindfulness and Acceptance and Commitment Therapy [33] (see Table 1).”
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Authors: Shelton, R. C., & Reddy, R.
Affiliations: Vanderbilt University (US)
Corresponding author: Shelton, Richard C.
ORCID: Shelton, Richard C.
Venue: Current Psychiatry Reports
Publisher: Springer Science and Business Media LLC
Published: 2008-12
Volume: 10
Issue: 6
Pages: 520-524
ISSN: 1523-3812 (ISSN-L)
1535-1645
DOI: 10.1007/s11920-008-0082-6
OpenAlex: W1986003622
Cited by: 11
References: 45
Citations by year: 2023: 2 · 2022: 1 · 2021: 1 · 2018: 1 · 2016: 1 · 2012: 1
FWCI: 0.17
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Current Psychiatry Reports (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Psychiatry and Mental health › Bipolar Disorder and Treatment
Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
Health Sciences › Medicine › Psychiatry and Mental health › Schizophrenia research and treatment
Keywords: modafinil, bipolar depression, adjunctive therapy, stimulants, fatigue, sleepiness, mania, hypomania, mixed states, treatment-resistant depression
MeSH terms: Modafinil, Affect, Central Nervous System Stimulants, Antidepressive Agents, Benzhydryl Compounds, Bipolar Disorder, Humans, Wakefulness, Antimanic Agents, Controlled Clinical Trials as Topic

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Adjunctive use of modafinil in bipolar patients: just another stimulant or not?

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