The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.
Diabetes and Depression
Abstract
In a context of the potentially epidemic nature of both diabetes mellitus and depression, and the negative effects reported in cases of comorbidity, this review suggests that the association of the two conditions is multifaceted. Increased risks of prevalent depression and incident depression among diabetic patients have been reported in community studies. Even more consistent is the finding supporting psychosomatic hypotheses regarding the increased risk of diabetes among depressed patients. A recent relevant finding is the increased risk of diabetes reported in depression that is commonly found in the community, namely nonsevere, persistent, untreated depression. In view of the negative implications of the comorbidity of depression and diabetes, the suggestion that all clinically relevant cases of depression found in the community should be treated seems logical. However, new studies seem mandatory to document the efficacy of treatment of depression and the safety of antidepressant use in cases of comorbidity.
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“Depression is a well‐established comorbidity associated with T2DM 79, 80, 81, 82.”
From The Circadian Syndrome: is the Metabolic Syndrome and much more! (2019) · cites this paper as [81]
Citations
Cites
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King, H. O. M., Aubert, R. E., & Herman, W. H. (1998) · Diabetes Care · doi:10.2337/diacare.21.9.1414 · Cited by 6,294
The Prevalence of Comorbid Depression in Adults With Diabetes
Anderson, R. J., Freedland, K. E., Clouse, R. E., & Lustman, P. J. (2001) · Diabetes Care · doi:10.2337/diacare.24.6.1069 · Cited by 3,926
Depression and Type 2 Diabetes Over the Lifespan
Mezuk, B., Eaton, W. W., Albrecht, S., & Golden, S. H. (2008) · Diabetes Care · doi:10.2337/dc08-0985 · Cited by 1,558
Ali, S., Stone, M. A., Peters, J., Davies, M. J., & Khunti, K. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01943.x · Cited by 1,311
Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis
Knol, M. J., Twisk, J. W. R., Beekman, A. T. F., Heine, R. J., Snoek, F. J., & Pouwer, F. (2006) · Diabetologia · doi:10.1007/s00125-006-0159-x · Cited by 974
Examining a Bidirectional Association Between Depressive Symptoms and Diabetes
Golden, S. H. (2008) · JAMA · doi:10.1001/jama.299.23.2751 · Cited by 916
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Relationship of depression to diabetes types 1 and 2: epidemiology, biology, and treatment
Musselman, D. L., Betan, E. J., Larsen, H., & Phillips, L. S. (2003) · Biological Psychiatry · doi:10.1016/s0006-3223(03)00569-9 · Cited by 687
Depression and Risk for Onset of Type II Diabetes: A prospective population-based study
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- Levenson JL: The American Psychiatric Publishing Textbook of Psychosomatic Medicine, edn 1. Washington, DC: American Psychiatric Publishing; 2005.
Cited by
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Items 101–115 of 115
Measures of Psychiatric Changes in Type 1 Diabetes: Depression, Bipolar, and Beyond
CYRANKA, K. M. (2024) · Springer eBooks · doi:10.1007/978-3-031-32046-0_33-1
Sun, H., Cheng, G., Cai, W., & Zuo, B. (2025) · Research Square · doi:10.21203/rs.3.rs-6469342/v1
Paul, A., Laribee, A., Neudecker, M., Luca, S. M. D., & McVoy, M. K. (2025) · Hispanic Journal of Behavioral Sciences · doi:10.1177/07399863251350866
“Additionally, growing evidence indicates that mental and physical health outcomes are oftentimes linked and can often exacerbate the other (Campayo et al., 2011; Ohrnberger et al., 2017; Richard et al., 2023).”
Measures of Psychiatric Changes in Type 1 Diabetes: Depression, Bipolar, and Beyond
CYRANKA, K. M. (2025) · Springer eBooks · doi:10.1007/978-3-031-73363-5_33
Al-Mamun, F., Hasan, M., Quadros, S., Kaggwa, M. M., Mubarak, M., Sikder, M. T., Hossain, M. S., Muhit, M., Moonajilin, M. S., Gozal, D., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26592017
Financial hardship from medical bills and depression among adults with diabetes in the United States
Alharbi, H., & Popovici, I. (2025) · Journal of Pharmaceutical Health Services Research · doi:10.1093/jphsr/rmaf016
Development of Psychosomatic Medicine in Spain
Gómez-Reino, I., Farré, J. M., Parramón, G., & Lobo, A. (2026) · Springer eBooks · doi:10.1007/978-3-032-11824-0_43
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Psilocibina en depresión: mecanismos neurobiológicos y cambios cognitivos
Arias, A. V., Ramírez, M. C., López, A. H., & Becerra-Hernández, L. V. (2026) · Acta neurológica colombiana · doi:10.22379/anc.v42i1.1926
Li, Y., Chen, H., Lu, Y., Zhong, S., & Wu, X. (2026) · Frontiers in Pharmacology · doi:10.3389/fphar.2026.1792796 · Cited by 1
“In addition to classic metabolic disorders, there is growing evidence indicating a significant association between diabetes and neurological diseases (Campayo et al., 2011).”
Ming, X., Zhang, H., Xue, K., Cui, Z., Wang, D., Wei, Z., Gao, S., & Li, K. (2026) · BMC Public Health · doi:10.1186/s12889-026-27164-z
“Depression is a major health challenge for middle-aged and older adults globally [14–16].”
Exploring the molecular determinants of behavioral changes induced by ketamine at the nanoscale
Uyttersprot, F. (2024) · theses.fr (ABES) · doi:10.70675/df438baaz92d0z488aza38cz4227b46c9acb
Kruk, M. E., Kapoor, N. R., Arsenault, C., Carai, S., Daray, F. M., Doubova, S. V., Ettman, C. K., Garcia, P. J., Getachew, T., García‐Elorrio, E., et al. (2026) · PLoS Medicine · doi:10.1371/journal.pmed.1004745
Gautam, K., Prasad, S., & Singh, P. (2026) · Naunyn-Schmiedeberg s Archives of Pharmacology · doi:10.1007/s00210-026-05429-z
“…its underlying pathophysiology remains incompletely understood due to the interplay of multiple biological systems, including neurotransmitter imbalance, oxidative stress, neuroinflammation, and impaired neuroplasticity (Campayo et al. 2011; Lee and Bae 2017; Cobley et al. 2018; Wang et al. 2024).”
Sun, X., Chen, X., Liu, J., Bai, J., Li, L., Wa, Z., Zeng, M., Fu, J., Yao, Y., Shen, F., et al. (2026) · Journal of Visualized Experiments · doi:10.3791/70295 · Cited by 1
Metadata
- Authors
- Campayo, A., Gómez-Biel, C. H., & Lobo, A.
- Corresponding author
- Campayo, Antonio
- ORCID
- Campayo, Antonio
- Venue
- Current Psychiatry Reports
- Published
- 2010-10-30
- Volume
- 13
- Issue
- 1
- Pages
- 26-30
- ISSN
- 1523-3812 (ISSN-L)
- 1535-1645
- OpenAlex
- W2037135066
- Cited by
- 116
- References
- 39
- Citations by year
- 2026: 9 · 2025: 20 · 2024: 15 · 2023: 9 · 2022: 10 · 2021: 5 · 2020: 5 · 2019: 4 · 2018: 7 · 2017: 8 · 2016: 3 · 2015: 6 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 0.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Psychiatry Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Education
- Health Sciences › Medicine › Pharmacology (medical) › Treatment of Major Depression
- Health Sciences › Medicine › Psychiatry and Mental health › Mental Health Treatment and Access
- Keywords
- diabetes mellitus, depression, comorbidities, untreated depression, psychosomatic mechanisms, antidepressant safety, antidepressant efficacy, depression treatment
- MeSH terms
- Depression, Depressive Disorder, Diabetes Mellitus, Humans, Comorbidity, Prevalence
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