The DOI matches its Crossref record; 129 of the 129 references it cites were found in a registry or an index.
The Latest Neuroimaging Findings in Borderline Personality Disorder
Abstract
Borderline personality disorder (BPD) is a severe mental disorder, characterized by pronounced deficits in emotion regulation, cognitive disturbances including dissociation, impulsivity, and interpersonal disturbances. Over the last decades, neuroimaging has become one of the most important methods to investigate neurobiological alterations possibly underlying core features of BPD. The aim of our article is to provide an overview of the latest neuroimaging research in BPD focusing on functional and structural MRI studies published since 2010. Findings of these studies are depicted and discussed referring to central domains of BPD psychopathology. On a neurochemical level, altered function in neurotransmitter systems including the serotonin, glutamate, and GABA systems was observed in patients with BPD. On a neural level, individuals with BPD showed structural and functional abnormalities in a fronto-limbic network including regions involved in emotion processing (e.g., amygdala, insula) and frontal brain regions implicated in regulatory control processes (e.g., anterior cingulate cortex, medial frontal cortex, orbitofrontal cortex, and dorsolateral prefrontal cortex). Limbic hyperreactivity and diminished recruitment of frontal brain regions may yield a link between disturbed emotion processing and other core features of BPD such as impulsivity and interpersonal disturbances. To clarify whether findings are specific to BPD, comparisons with other clinical groups are needed.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In BPD, deficits in interpersonal trust, tolerance of aloneness, and recognition of conventional norms of social cooperation/fairness also have been documented and shown to be associated with altered patterns of anterior cingulate, temporal lobe, and insula activation [97, 149].”
From Complex PTSD and borderline personality disorder (2021) · cites this paper as [97]
Citations
Cites
Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR)
American Psychiatric Association (2000) · doi:10.1176/appi.books.9780890423349 · Cited by 11,069
Saliency, switching, attention and control: a network model of insula function
Menon, V., & Uddin, L. Q. (2010) · Brain Structure and Function · doi:10.1007/s00429-010-0262-0 · Cited by 5,592
Burden and consequences of child maltreatment in high-income countries
Gilbert, R., Widom, C. S., Browne, K., Fergusson, D., Webb, E., & Janson, S. (2009) · The Lancet · doi:10.1016/s0140-6736(08)61706-7 · Cited by 3,876
The neural basis of economic decision-making in the Ultimatum Game.
Sanfey, A. G., Rilling, J. K., Aronson, J. A., Nystrom, L. E., & Cohen, J. D. (2003) · Science · doi:10.1126/science.1082976 · Cited by 3,375
International Affective Picture System (IAPS) : Technical Manual and Affective Ratings
Lang, P. J. (1995) · Medical Entomology and Zoology · Cited by 2,870
Psychiatric Aspects of Impulsivity
Moeller, F. G., Barratt, E. S., Dougherty, D. M., Schmitz, J. M., & Swann, A. C. (2001) · American Journal of Psychiatry · doi:10.1176/appi.ajp.158.11.1783 · Cited by 2,747
Rethinking feelings: an fMRI study of the cognitive regulation of emotion
Ochsner, K. N., Bunge, S. A., Gross, J. J., & Gabrieli, J. D. E. (2002) · Journal of Cognitive Neuroscience · doi:10.1162/089892902760807212 · Cited by 2,520
Subcortical and cortical brain activity during the feeling of self-generated emotions
Damasio, A. R., Grabowski, T. J., Bechara, A., Damasio, H., Ponto, L. L. B., Parvizi, J., & Hichwa, R. D. (2000) · Nature Neuroscience · doi:10.1038/79871 · Cited by 2,117
Ochsner, K. N., Ray, R. D., Cooper, J. C., Robertson, E. R., Chopra, S., Gabrieli, J. D. E., & Gross, J. J. (2004) · NeuroImage · doi:10.1016/j.neuroimage.2004.06.030 · Cited by 2,113
Evenden, J. L. (1999) · Psychopharmacology · doi:10.1007/pl00005481 · Cited by 2,044
Research works printed but not linked: 5
- Lis E, Greenfield B, Henry M, Guile JM, Dougherty G. Neuroimaging and genetics of borderline personality disorder: a review. J Psychiatry Neurosci. 2007;32(3):162–73.
- Brodmann K. Vergleichende Lokalisationslehre der Grosshirnrinde in ihren Prinzipien dargestellt auf Grund des Zellenbaues. Leipzig: J. A. Barth; 1909.
- Krause-Utz A, Veer IM, Rombouts SARB, Bohus M, Elzinga B, Schmahl C. Amygdala and anterior cingulate resting-state functional connectivity in borderline personality disorder patients with a history of interpersonal trauma. under review.
- Donegan NH, Sanislow CA, Blumberg HP, Fulbright RK, Lacadie C, Skudlarski P, et al. Amygdala hyperreactivity in borderline personality disorder: implications for emotional dysregulation. Biol Psychiatry. 2003;54(11):1284–93. · DOI
- Krause-Utz A, Schmahl C. Neurobiological differentiation between borderline patients with and without post-traumatic stress disorder. Eur Psych Rev. 2010;3(2):63–8.
Cited by
Sorted by citations
Schulze, L., Schmahl, C., & Niedtfeld, I. (2016) · Biological Psychiatry · doi:10.1016/j.biopsych.2015.03.027 · Cited by 48
Self-citationThe Stigma of Personality Disorders
Sheehan, L. L., Nieweglowski, K., & Corrigan, P. W. (2016) · Current Psychiatry Reports · doi:10.1007/s11920-015-0654-1 · Cited by 320
Complex PTSD and borderline personality disorder
Ford, J. D., & Courtois, C. A. (2021) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/s40479-021-00155-9 · Cited by 209
“In BPD, deficits in interpersonal trust, tolerance of aloneness, and recognition of conventional norms of social cooperation/fairness also have been documented and shown to be associated with altered patterns of anterior cingulate, temporal lobe, and insula activation [97, 149].”
BackgroundMorawetz, C., Bode, S., Baudewig, J., & Heekeren, H. R. (2016) · Social Cognitive and Affective Neuroscience · doi:10.1093/scan/nsw169 · Cited by 224
Complex PTSD, affect dysregulation, and borderline personality disorder
Ford, J. D., & Courtois, C. A. (2014) · Borderline Personality Disorder and Emotion Dysregulation · doi:10.1186/2051-6673-1-9 · Cited by 182
Metadata
- Authors
- Krause-Utz, A., Winter, D., Niedtfeld, I., & Schmahl, C.
- Affiliations
- Heidelberg University (DE)
- Corresponding author
- Schmahl, Christian
- Venue
- Current Psychiatry Reports
- Published
- 2014-02-05
- Volume
- 16
- Issue
- 3
- Pages
- 438-438
- ISSN
- 1523-3812 (ISSN-L)
- 1535-1645
- OpenAlex
- W2012062688
- Cited by
- 235
- References
- 129
- Citations by year
- 2026: 13 · 2025: 16 · 2024: 12 · 2023: 14 · 2022: 11 · 2021: 17 · 2020: 36 · 2019: 18 · 2018: 15 · 2017: 20 · 2016: 26 · 2015: 22 · 2014: 9
- FWCI
- 3.82
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Psychiatry Reports (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Social Sciences › Psychology › Clinical Psychology › Personality Disorders and Psychopathology
- Life Sciences › Neuroscience › Cognitive Neuroscience › Neural and Behavioral Psychology Studies
- Social Sciences › Psychology › Clinical Psychology › Psychopathy, Forensic Psychiatry, Sexual Offending
- Keywords
- borderline personality disorder, neuroimaging, emotion regulation, emotional processing, fronto-limbic network, amygdala, insula, anterior cingulate cortex, dorsolateral prefrontal cortex, impulsivity, interpersonal problems, serotonin, glutamate, GABA, structural MRI, functional MRI
- MeSH terms
- Borderline Personality Disorder, Brain Mapping, Humans, Magnetic Resonance Imaging, Neural Pathways, Neuroimaging, Connectome
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
