The DOI matches its Crossref record; 121 of the 121 references it cites were found in a registry or an index.
Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis
Open accessAbstract
Osteoarthritis (OA) is a whole joint disease, in which thinning and disappearance of cartilage is a critical determinant in OA progression. The rupture of cartilage homeostasis whatever its cause (aging, genetic predisposition, trauma or metabolic disorder) induces profound phenotypic modifications of chondrocytes, which then promote the synthesis of a subset of factors that induce cartilage damage and target other joint tissues. Interestingly, among these factors are numerous components of the inflammatory pathways. Chondrocytes produce cytokines, chemokines, alarmins, prostanoids, and adipokines and express numerous cell surface receptors for cytokines and chemokines, as well as Toll-like receptors. These receptors activate intracellular signaling pathways involved in inflammatory and stress responses of chondrocytes in OA joints. This review focuses on mechanisms responsible for the maintenance of cartilage homeostasis and highlights the role of inflammatory processes in OA progression.
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Cites
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Self-citationOsteoarthritis: New Insights. Part 1: The Disease and Its Risk Factors
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Polycystins 1 and 2 mediate mechanosensation in the primary cilium of kidney cells
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Osteoarthritis as an inflammatory disease (osteoarthritis is not osteoarthrosis!)
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Self-citationThe role of synovitis in pathophysiology and clinical symptoms of osteoarthritis
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Self-citationBlagojevic, M., Jinks, C., Jeffery, A., & Jordan, K. P. (2010) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2009.08.010 · Cited by 1,397
Deletion of active ADAMTS5 prevents cartilage degradation in a murine model of osteoarthritis
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A Framework for the in Vivo Pathomechanics of Osteoarthritis at the Knee
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Cited by
Martel-Pelletier, J., Barr, A. J., Cicuttini, F. M., Conaghan, P. G., Cooper, C., Goldring, M. B., Goldring, S. R., Jones, G., Teichtahl, A. J., & Pelletier, J.-P. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.72 · Cited by 1,877
Self-citationGoldring, S. R., & Goldring, M. B. (2016) · Nature Reviews Rheumatology · doi:10.1038/nrrheum.2016.148 · Cited by 896
Self-citationRecent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee
Jang, S., Lee, K., & Ju, J. H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22052619 · Cited by 803
Modern-day environmental factors in the pathogenesis of osteoarthritis
Berenbaum, F., Wallace, I. J., Lieberman, D. E., & Felson, D. T. (2018) · Nature Reviews Rheumatology · doi:10.1038/s41584-018-0073-x · Cited by 323
Self-citationCollins, K. H., Herzog, W., MacDonald, G. Z., Reimer, R. A., Rios, J. L., Smith, I. C., Zernicke, R. F., & Hart, D. A. (2018) · Frontiers in Physiology · doi:10.3389/fphys.2018.00112 · Cited by 308
Metadata
- Authors
- Houard, X., Goldring, M. B., & Berenbaum, F.
- Venue
- Current Rheumatology Reports
- Published
- 2013-09-27
- Volume
- 15
- Issue
- 11
- Pages
- 375-375
- ISSN
- 1523-3774 (ISSN-L)
- 1534-6307
- OpenAlex
- W2028212402
- Cited by
- 338
- References
- 121
- FWCI
- 18.90
- Type
- journal article
- Language
- en
- Open access
- green
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