The DOI matches its Crossref record; 98 of the 98 references it cites were found in a registry or an index.
Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee
Open accessAbstract
Osteoarthritis (OA) is a degenerative and chronic joint disease characterized by clinical symptoms and distortion of joint tissues. It primarily damages joint cartilage, causing pain, swelling, and stiffness around the joint. It is the major cause of disability and pain. The prevalence of OA is expected to increase gradually with the aging population and increasing prevalence of obesity. Many potential therapeutic advances have been made in recent years due to the improved understanding of the underlying mechanisms, diagnosis, and management of OA. Embryonic stem cells and induced pluripotent stem cells differentiate into chondrocytes or mesenchymal stem cells (MSCs) and can be used as a source of injectable treatments in the OA joint cavity. MSCs are known to be the most studied cell therapy products in cell-based OA therapy owing to their ability to differentiate into chondrocytes and their immunomodulatory properties. They have the potential to improve cartilage recovery and ultimately restore healthy joints. However, despite currently available therapies and advances in research, unfulfilled medical needs persist for OA treatment. In this review, we focused on the contents of non-cellular and cellular therapies for OA, and briefly summarized the results of clinical trials for cell-based OA therapy to lay a solid application basis for clinical research.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Multilineage potential of adult human mesenchymal stem cells
Pittenger, M. F., Mackay, A. M., Beck, S. C., Jaiswal, R. K., Douglas, R., Mosca, J. D., Moorman, M. A., Simonetti, D. W., Craig, S., & Marshak, D. R. (1999) · Science · doi:10.1126/science.284.5411.143 · Cited by 21,052
Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors
Takahashi, K., Tanabe, K., Ohnuki, M., Narita, M., Ichisaka, T., Tomoda, K., & Yamanaka, S. (2007) · Cell · doi:10.1016/j.cell.2007.11.019 · Cited by 20,221
Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
Yu, J., Vodyanik, M. A., Smuga-Otto, K., Antosiewicz-Bourget, J., Frane, J. L., Tian, S., Nie, J., Jonsdottir, G. A., Ruotti, V., Stewart, R., et al. (2007) · Science · doi:10.1126/science.1151526 · Cited by 10,310
OARSI guidelines for the non-surgical management of knee osteoarthritis
McAlindon, T. E., Bannuru, R. R., Sullivan, M. C., Arden, N. K., Berenbaum, F., Bierma-Zeinstra, S. M., Hawker, G. A., Henrotin, Y., Hunter, D. J., Kawaguchi, H., et al. (2014) · Osteoarthritis and Cartilage · doi:10.1016/j.joca.2014.01.003 · Cited by 3,110
Kolasinski, S. L., Neogi, T., Hochberg, M. C., Oatis, C., Guyatt, G., Block, J., Callahan, L., Copenhaver, C., Dodge, C., Felson, D., et al. (2020) · Arthritis Care & Research · doi:10.1002/acr.24131 · Cited by 2,516
Epidemiology of Osteoarthritis
Zhang, Y., & Jordan, J. M. (2010) · Clinics in Geriatric Medicine · doi:10.1016/j.cger.2010.03.001 · Cited by 2,316
Mesenchymal stem cell perspective: cell biology to clinical progress
Pittenger, M. F., Discher, D. E., Péault, B. M., Phinney, D. G., Hare, J. M., & Caplan, A. I. (2019) · npj Regenerative Medicine · doi:10.1038/s41536-019-0083-6 · Cited by 2,008
Kolasinski, S. L., Neogi, T., Hochberg, M. C., Oatis, C., Guyatt, G., Block, J., Callahan, L., Copenhaver, C., Dodge, C., Felson, D., et al. (2020) · Arthritis & Rheumatology · doi:10.1002/art.41142 · Cited by 1,965
Martel-Pelletier, J., Barr, A. J., Cicuttini, F. M., Conaghan, P. G., Cooper, C., Goldring, M. B., Goldring, S. R., Jones, G., Teichtahl, A. J., & Pelletier, J.-P. (2016) · Nature Reviews Disease Primers · doi:10.1038/nrdp.2016.72 · Cited by 1,877
Stem cells: past, present, and future
Zakrzewski, W., Dobrzyński, M., Szymonowicz, M., & Rybak, Z. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1165-5 · Cited by 1,834
Cited by
Functional genomic hypothesis generation and experimentation by a robot scientist
King, R. D., Whelan, K. E., Jones, F. M., Reiser, P. G. K., Bryant, C. H., Muggleton, S. H., Kell, D. B., & Oliver, S. G. (2004) · Nature · doi:10.1038/nature02236 · Cited by 662
Psychological interventions for adults with asthma
Yorke, J., Fleming, S. L., & Shuldham, C. (2006) · Cochrane Database of Systematic Reviews · doi:10.1002/14651858.cd002982.pub3 · Cited by 95
Reflexivity and the Practice of Qualitative Research
May, T., & Perry, B. (2014) · The SAGE Handbook of Qualitative Data Analysis · doi:10.4135/9781446282243.n8 · Cited by 74
Tu, J., Zhang, C., Zhang, H., Liang, L., & He, J. (2025) · DIGITAL HEALTH · doi:10.1177/20552076251366390 · Cited by 44
Ion exchange in the synthetic gismondine, zeolite MAP
Allen, S., Carr, S., Chapple, A., Dyer, A., & Heywood, B. (2002) · Physical Chemistry Chemical Physics · doi:10.1039/b111490p · Cited by 43
Metadata
- Authors
- Jang, S., Lee, K., & Ju, J. H.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2021-03-05
- Volume
- 22
- Issue
- 5
- Pages
- 2619
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W3133854280
- Cited by
- 803
- References
- 98
- FWCI
- 54.34
- Type
- journal article
- Language
- en
- Open access
- gold
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee. https://app.cochat.ai/papers/10.3390/ijms22052619
- The paper
- Jang, S., Lee, K., & Ju, J. H. (2021). Recent Updates of Diagnosis, Pathophysiology, and Treatment on Osteoarthritis of the Knee. International Journal of Molecular Sciences. https://doi.org/10.3390/ijms22052619
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
