The DOI matches its Crossref record; 5 of the 5 references it cites were found in a registry or an index.
The Link Between Periodontal Disease and Rheumatoid Arthritis: An Updated Review
Open accessAbstract
Porphyromonas gingivalis is a leading pathogen in chronic periodontitis, a disease process involving progressive destruction of the tissues that support the teeth. Recently, the organism has been reported to produce a unique bacterial enzyme, P. gingivalis peptidyl-arginine deiminase (PPAD), which has the ability to convert arginine residues in proteins to citrulline. Protein citrullination alters protein structure and function; hence, PPAD may be involved in deregulation of the host's signalling network and immune evasion. Further, accumulating evidence suggests a role for autoimmunity against citrullinated proteins in the development of rheumatoid arthritis (RA). As inflammatory conditions in the lungs of cigarette smokers contribute to the breakdown of immune tolerance to citrullinated epitopes, chronic exposure to citrullinated proteins at periodontitis sites may also predispose susceptible individuals to the development of autoantibodies and the initiation of RA. In this review, we discuss evidence that PPAD may represent a mechanistic link between periodontitis and RA, diseases that are known to be significantly associated at the epidemiological level.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Microbial complexes in subgingival plaque
Socransky, S. S., Haffajee, A. D., Cugini, M. A., Smith, C., & Kent, R. L. (1998) · Journal of Clinical Periodontology · doi:10.1111/j.1600-051x.1998.tb02419.x · Cited by 5,050
Hajishengallis, G., Liang, S., Payne, M. A., Hashim, A., Jotwani, R., Eskan, M. A., McIntosh, M. L., Alsam, A., Kirkwood, K. L., Lambris, J. D., et al. (2011) · Cell Host & Microbe · doi:10.1016/j.chom.2011.10.006 · Cited by 1,154
McGraw, W. T., Potempa, J., Farley, D., & Travis, J. (1999) · Infection and Immunity · doi:10.1128/iai.67.7.3248-3256.1999 · Cited by 378
Self-citationEpidemiologic patterns of chronic and aggressive periodontitis
Demmer, R. T., & Papapanou, P. N. (2010) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00326.x · Cited by 286
Mangat, P., Wegner, N., Venables, P. J., & Potempa, J. (2010) · Arthritis Research & Therapy · doi:10.1186/ar3000 · Cited by 111
Self-citation
Cited by
Periodontitis: from microbial immune subversion to systemic inflammation
Hajishengallis, G. (2015) · Nature Reviews Immunology · doi:10.1038/nri3785 · Cited by 3,046
Porphyromonas gingivalis: Major Periodontopathic Pathogen Overview
Mysak, J., Podzimek, S., Sommerova, P., Lyuya-Mi, Y., Bartova, J., Janatova, T., Prochazkova, J., & Duskova, J. (2014) · Journal of Immunology Research · doi:10.1155/2014/476068 · Cited by 585
The Type IX Secretion System (T9SS): Highlights and Recent Insights into Its Structure and Function
Lasica, A. M., Ksiazek, M., Madej, M., & Potempa, J. (2017) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2017.00215 · Cited by 312
Self-citationZhang, Z., Liu, D., Liu, S., Zhang, S., & Pan, Y. (2021) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2020.585917 · Cited by 265
Oral microbiota and cancer development
Tuominen, H., & Rautava, J. (2021) · Pathobiology · doi:10.1159/000510979 · Cited by 238
Metadata
- Authors
- Koziel, J., Mydel, P., & Potempa, J.
- Venue
- Current Rheumatology Reports
- Published
- 2014-01-24
- Volume
- 16
- Issue
- 3
- Pages
- 408-408
- ISSN
- 1523-3774 (ISSN-L)
- 1534-6307
- OpenAlex
- W2168670867
- Cited by
- 236
- References
- 5
- FWCI
- 31.73
- Type
- journal article
- Language
- en
- Open access
- hybrid
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: The Link Between Periodontal Disease and Rheumatoid Arthritis: An Updated Review. https://app.cochat.ai/papers/10.1007/s11926-014-0408-9
- The paper
- Koziel, J., Mydel, P., & Potempa, J. (2014). The Link Between Periodontal Disease and Rheumatoid Arthritis: An Updated Review. Current Rheumatology Reports. https://doi.org/10.1007/s11926-014-0408-9
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
