Nonpharmacologic Treatments for Migraine and Tension-Type Headache: How to Choose and When to Use
Abstract
Opinion statement There are a variety of nonpharmacologic treatments for headache. Educating patients about headache and its management, identifying and managing triggers (via diaries), modifying lifestyles, and understanding the importance of adopting and adhering to interventions (either pharmacologic or nonpharmacologic) are relevant to all persons with headache. In addition, specific nonpharmacologic treatments can be used either alone or in conjunction with ongoing pharmacologic intervention. Strong candidates for nonpharmacologic treatment include individuals with significant headache-related disability, comorbid mood or anxiety disorders, difficulty managing stress or other triggers, medication overuse, and patients who prefer a specific treatment. Behavioral treatments (relaxation, biofeedback, and cognitive-behavioral therapy) possess the most evidence for successful headache management. They have a long history of randomized trials showing efficacy and are considered first-line preventive options. Among complementary and alternative treatments, recent positive findings from randomized trials using acupuncture provide evidence of its potential as a first-line intervention. Other complementary and alternative techniques do not have a consistent base of research to recommend them for headache prevention, but they may be used if the patient prefers this approach or when other first-line interventions (nonpharmacologic or pharmacologic) have not provided adequate results. Among "natural" treatments, both butterbur extract and vitamin B2 have shown efficacy in more than one randomized trial and are thus potentially useful first-line preventive interventions.
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The efficacy of stress-oriented psychotherapeutic interventions, such as acceptance and commitment therapy and mindfulness, has been shown to be poor.
“the efficacy of stress-oriented psychotherapeutic interventions, such as acceptance and commitment therapy and mindfulness, has been shown to be poor [8–18]”
From Protocol and methods for testing the efficacy of well-being therapy in chronic migraine patients: a randomized controlled trial. (2018) · cites this paper as [11]
Current evidence on the efficacy of psychological interventions remains limited and unsatisfactory.
“Current evidence on the efficacy of psychological interventions remains limited and unsatisfactory [8–18]”
From Protocol and methods for testing the efficacy of well-being therapy in chronic migraine patients: a randomized controlled trial. (2018) · cites this paper as [11]
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“05% (alpha), the sample size would be 36 in each group (total 82).(13) For increasing power of our finding we obtained 92 samples for present study.”
BackgroundWang, S., Tian, L., Ma, T., Wong, Y. T., Yan, L. J., Gao, Y., Zhang, D., Hui, S. S., & Xie, Y. J. (2022) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2022/2089139 · Cited by 13 · see citing works
“Referring to other complementary treatments [25], Tai Chi training was expected to reduce one migraine attack each month.”
BackgroundSiahaan, Y. M. T., Hartoyo, V., & Hariyanto, T. I. (2022) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/1440-1681.13700 · Cited by 13 · see citing works
“Some proportions of patients can be successfully managed by nonpharmacologic treatment such as avoiding migraine-specific triggers and by taking a nap.(4) Meanwhile, other patients needs additional interventions such as ingesting drugs to relieve their pain.”
BackgroundKhazraee, H., Bakhtiari, M., Kianimoghadam, A. S., & Hajmanouchehri, R. (2023) · Life · doi:10.3390/life13010131 · Cited by 13 · see citing works
“In addition to pharmacological therapies, other treatment options exist, including psychological interventions [26].”
BackgroundMansueto, G., De Cesaris, F., Geppetti, P., & Cosci, F. (2018) · Trials · doi:10.1186/s13063-018-2944-5 · Cited by 10 · see citing works
Roslyakova, T., Falco, M.-A., & Gauchet, A. (2021) · Psychology & Health · doi:10.1080/08870446.2020.1856844 · Cited by 10 · see citing works
Ohlsen, B. A. (2012) · Journal of Chiropractic Medicine · doi:10.1016/j.jcm.2012.02.003 · Cited by 10 · see citing works
The role of acupuncture in the treatment of migraine
Molsberger, A. F. (2012) · Canadian Medical Association Journal · doi:10.1503/cmaj.112032 · Cited by 10 · see citing works
“, relaxation, biofeedback, and cognitive-behavioural therapy).(1) Riboflavin and coenzyme Q10 significantly decreased the frequency of migraine attacks, and the prophylactic efficacy of magnesium, particularly for children and migraines related to menstruation, has been substantiated.”
BackgroundDerakhshan, A., Manshaei, G., Afshar, H., & Goli, F. (2016) · International journal of body, mind and culture · doi:10.22122/ijbmc.v3i1.55 · Cited by 9 · see citing works
Moore, C., Leaver, A. M., Sibbritt, D. W., & Adams, J. (2019) · Chiropractic & Manual Therapies · doi:10.1186/s12998-019-0254-y · Cited by 9 · see citing works
Barchakh, Z., Valandani, Z. M., & Khorvash, F. (2021) · Practice in Clinical Psychology · doi:10.32598/jpcp.9.1.740.1 · Cited by 8 · see citing works
Recent Approaches and Development of Acupuncture on Chronic Daily Headache
Liu, Y., & Yu, S. (2015) · Current Pain and Headache Reports · doi:10.1007/s11916-015-0535-7 · Cited by 8 · see citing works
Bibliometric Analysis of 100 Most Highly Cited Publications on Acupuncture for Migraine
Song, X., Wang, J., Bai, L., & Zou, W. (2023) · Journal of Pain Research · doi:10.2147/jpr.s396909 · Cited by 7 · see citing works
Marupuru, S., Almatruk, Z., Slack, M. K., & Axon, D. R. (2023) · Clinics and Practice · doi:10.3390/clinpract13030051 · Cited by 6 · see citing works
“According to the US headache consortium, using dietary supplements such as vitamin B12 has a grade I recommendation and Coenzyme Q10 has grade II [38,39].”
MethodMigraine Prevalence and Academic Impact on Medical Students at Alfaisal University
Szabó, A., Mahamud, G., & Ahsan, F. (2024) · Brain and Behavior · doi:10.1002/brb3.70072 · Cited by 5 · see citing works
He, Y., Wu, Y., & Li, X. (2024) · Journal of Pain Research · doi:10.2147/jpr.s489296 · Cited by 5 · see citing works
Pneumothorax after acupuncture.
Huisma, F. F., Konrad, G., & Thomas, S. (2015) · PubMed Central · Cited by 5 · see citing works
Shabani, M., نجات, ح., & Saffarian, M. R. (2019) · International journal of basic science in medicine · doi:10.15171/ijbsm.2019.13 · Cited by 5 · see citing works
He, Y., Wang, X., Liu, M., Li, L., Han, T., Wu, Y., & Li, X. (2025) · Journal of Pain Research · doi:10.2147/jpr.s527987 · Cited by 4 · see citing works
“36,37 Since 2008, the domain of acupuncture for migraines has advanced.”
Complementary and alternative medicine (CAM) approaches to headache
Preter, M., & Lieblich, S. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139206952.013 · Cited by 4 · see citing works
The Relationship of Mental Health, Life Satisfaction and Perfectionism with Migraine Headache
Savari, K. (2013) · Cited by 4 · see citing works
Integrated headache care at the outpatient headache center of the University Hospital of Munich
Rohling, S., Funk, A., Ruscheweyh, R., Schankin, C. J., Straube, A. M., & Kamm, K. (2018) · Clinical and Translational Neuroscience · doi:10.1177/2514183x18786844 · Cited by 4 · see citing works
“It is effective in terms of reducing the frequency of headache attacks and lowering the burden of disease.(27) The reduction of headache activity is even substantial over multiple years.”
Laube, J., Araujo, T. S., & Taw, L. B. (2020) · Global Advances in Health and Medicine · doi:10.1177/2164956120905817 · Cited by 3 · see citing works
“Mind–body approaches for CM and CTTH have been increasingly studied and supported, specifically cognitive behavioral therapy, stress management training, and biofeedback.(21,22) The efficacy of these approaches may be because many CDH patients also suffer from psychiatric comorbid diagnoses including anxiety, depressi…”
MethodPsychologische Therapie der Migräne: Systematische Übersicht
Fritsche, G., Kröner‐Herwig, B., Kropp, P. A., Niederberger, U., & Haag, G. (2013) · Der Schmerz · Cited by 3 · see citing works
Management of medication overuse headache
D’Amico, D., Grazzi, L., & Tepper, S. J. (2024) · Handbook of clinical neurology · doi:10.1016/b978-0-12-823357-3.00026-4 · Cited by 2 · see citing works
Effectiveness of Cognitive Behavioural Therapy in Adolescents
Sagar, R., Mehta, M., & Sahu, A. (2015) · Springer eBooks · doi:10.1007/978-81-322-2241-5_19 · Cited by 1 · see citing works
Lysk, S., Pach, D., Tissen‐Diabaté, T., Scholler, S., & Witt, C. M. (2025) · Headache The Journal of Head and Face Pain · doi:10.1111/head.70009 · Cited by 1 · see citing works
Behavioral approaches to headache: A practical guide for non-mental health providers
Gittleman, M. (2012) · Techniques in Regional Anesthesia and Pain Management · doi:10.1053/j.trap.2012.11.009 · Cited by 1 · see citing works
Psychological Approaches to Headache
Seng, E. K., & Baskin, S. M. (2015) · Elsevier eBooks · doi:10.1016/b978-0-12-800901-7.00019-7 · Cited by 1 · see citing works
Dodick, D. W., & Silberstein, S. D. (2016) · doi:10.1093/med/9780199793617.003.0009 · Cited by 1 · see citing works
Rajabi, S., & Abbasi, Z. (2015) · Cited by 1 · see citing works
Common Pitfalls in the Evaluation and Management of Headache: Case-Based Learning
Loder, E., Burch, R. C., & Rizzoli, P. B. (2014) · Cited by 1 · see citing works
The organizations of specialized medical care for patients with headache
Baiushkina, L. I. (2019) · Journal of clinical practice · doi:10.17816/clinpract102108-113 · Cited by 1 · see citing works
“Оно эффективно в отношении уменьшения частоты приступов головной боли и снижения бремени болезни [33].”
Martelletti, P. (2022) · Springer eBooks · doi:10.1007/978-3-030-97359-9_4 · Cited by 1 · see citing works
Mirror, Mirror On the Wall: What effectiveness research shows us about headache care
Ahn, A. H., & Kairalla, J. A. (2011) · Pain · doi:10.1016/j.pain.2011.03.009 · Cited by 1 · see citing works
“Because these alterations are typically more challenging than medical prophylaxis, successful treatment requires multiple disciplines to work closely [7], and can include physical therapy, nutrition, psychology, psychiatry, otolaryngology, endodontic dentistry, sleep medicine, gynecology, pain medicine, and neurosurge…”
BackgroundSonty, N. (2013) · Cambridge University Press eBooks · doi:10.1017/cbo9781139206952.011
Headache Triggers and Causality Editorial: A Research Roadmap and Clinical Caution
Seng, E. K. (2013) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12073
Varkey, E. (2012)
Bernstein, C. A., Bernstein, C. A., & Bernstein, C. A. (2012) · Springer eBooks · doi:10.1007/978-1-4419-7113-5_8
Pitfallsin nonpharmacologic treatment of headache
Loder, E., Burch, R. C., & Rizzoli, P. B. (2014) · Cambridge University Press eBooks · doi:10.1017/cbo9781139519335.010
Gonzalez, R. A., Watson, E. C., Denton, F. N., Steinberg, T. C., & Hua, W. (2016) · Open Medicine Journal · doi:10.2174/1874220301603010113
“[105] Nicholson RA, Buse DC, Andrasik F, Lipton RB.”
BackgroundFermo, O. P., & Rosenberg, J. D. (2016) · doi:10.1002/9781118777374.ch5
Efficacy of the Comprehensive Headache Clinic at the Bangkok Hospital: The First 6 Months’ Report
Jindawong, N., & Vongvaivanich, K. (2013) · THE BANGKOK MEDICAL JOURNAL · doi:10.31524/bkkmedj.2013.02.005
Mayhami, K., Moradi, O., Dadgar, M., & Ezatpour, E. E.-D. (2019) · Shenakht Journal of Psychology and Psychiatry · doi:10.29252/shenakht.6.2.27
Psychophysiological Features of Primary Headache: New Findings and Some Confirmation
Pruneti, C. A. (2020) · Archives in Neurology & Neuroscience · doi:10.33552/ann.2020.08.000676
“Despite the limitations, important methodological and design indications are obtained and, therefore, the development of further research on the population characterized by primary headache is suggested in which, in addition to considering more representative samples from the numerical point of view, the inclusion cri…”
BackgroundBruni, O. (2020) · Springer eBooks · doi:10.1007/978-3-030-54359-4_12
Taylor, F. R., Cooper, W. M., Kaniecki, R. G., Ward, T. N., & Roberts, J. (2015) · Headache The Journal of Head and Face Pain · doi:10.1111/head.12520
Martelletti, P. (2023) · Springer eBooks · doi:10.1007/978-3-031-20894-2_1
Editorial: Cognitive schemas in primary headache disorders
Özge, A., Valeriani, M., Uludüz, D., & Guidetti, V. (2023) · Frontiers in Neurology · doi:10.3389/fneur.2023.1240559
Advances in migraine treatment - a review
Słychan, K., Frańczuk, A., Makłowicz, A., Szpulak, A., Kopczyńska, E., Głoskowska, J., Grzelka, M., Kuleta, K., Łęska, A. E., & Kejna, P. (2024) · Quality in Sport · doi:10.12775/qs.2024.21.54055
A Randomized Trial of Cervical Stabilization Exercise Training Via Telerehabilitation for Migraine
Düşgün, E. S., Karahan, N., & Celenay, S. T. (2025) · Pain Management Nursing · doi:10.1016/j.pmn.2025.08.001
- Authors
- Nicholson, R. A., Buse, D. C., Andrasik, F., & Lipton, R. B.
- Affiliations
- Saint Louis University (US)
- Albert Einstein College of Medicine (US)
- University of Memphis (US)
- Corresponding author
- Nicholson, Robert A.
- Venue
- Current Treatment Options in Neurology
- Published
- 2010-11-16
- Volume
- 13
- Issue
- 1
- Pages
- 28-40
- ISSN
- 1092-8480 (ISSN-L)
- 1534-3138
- OpenAlex
- W2079068522
- Cited by
- 88
- References
- 50
- Citations by year
- 2025: 4 · 2024: 4 · 2023: 6 · 2022: 3 · 2021: 4 · 2020: 9 · 2019: 4 · 2018: 4 · 2017: 2 · 2016: 5 · 2015: 11 · 2014: 7 · 2013: 11 · 2012: 11
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Current Treatment Options in Neurology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Migraine and Headache Studies
- Health Sciences › Health Professions › Complementary and Manual Therapy › Temporomandibular Joint Disorders
- Health Sciences › Medicine › Epidemiology › Traumatic Brain Injury Research
- Keywords
- migraine, tension-type headache, non-pharmacological treatment, headache prevention, behavior therapy, biofeedback, relaxation training, cognitive behavioral therapy, acupuncture, complementary and alternative medicine, riboflavin, medication overuse headache, headache triggers, lifestyle modification, patient education, medication adherence
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