The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Biological Augmentation of Rotator Cuff Tendon Repair
Open accessAbstract
A histologically normal insertion site does not regenerate following rotator cuff tendon-to-bone repair, which is likely due to abnormal or insufficient gene expression and/or cell differentiation at the repair site. Techniques to manipulate the biologic events following tendon repair may improve healing. We used a sheep infraspinatus repair model to evaluate the effect of osteoinductive growth factors and BMP-12 on tendon-to-bone healing. Magnetic resonance imaging and histology showed increased formation of new bone and fibrocartilage at the healing tendon attachment site in the treated animals, and biomechanical testing showed improved load-to-failure. Other techniques with potential to augment repair site biology include use of platelets isolated from autologous blood to deliver growth factors to a tendon repair site. Modalities that improve local vascularity, such as pulsed ultrasound, have the potential to augment rotator cuff healing. Important information about the biology of tendon healing can also be gained from studies of substances that inhibit healing, such as nicotine and antiinflammatory medications. Future approaches may include the use of stem cells and transcription factors to induce formation of the native tendon-bone insertion site after rotator cuff repair surgery.
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Analysis of the tendon cell fate using Scleraxis, a specific marker for tendons and ligaments
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Functional and Anatomical Results After Rotator Cuff Repair
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A Somitic Compartment of Tendon Progenitors
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Cited by
Docheva, D., Müller, S. A., Majewski, M., & Evans, C. H. (2015) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2014.11.015 · Cited by 693
Alsousou, J., Thompson, M., Hulley, P., Noble, A., & Willett, K. (2009) · The Journal of Bone and Joint Surgery. British volume · doi:10.1302/0301-620x.91b8.22546 · Cited by 600
Platelet rich plasma in arthroscopic rotator cuff repair: a prospective RCT study, 2-year follow-up
Randelli, P., Arrigoni, P., Ragone, V., Aliprandi, A., & Cabitza, P. (2011) · Journal of Shoulder and Elbow Surgery · doi:10.1016/j.jse.2011.02.008 · Cited by 444
Hernigou, P., Flouzat Lachaniette, C. H., Delambre, J., Zilber, S., Duffiet, P., Chevallier, N., & Rouard, H. (2014) · International Orthopaedics · doi:10.1007/s00264-014-2391-1 · Cited by 436
Ljungqvist, A., Jenoure, P., Engebretsen, L., Alonso, J. M., Bahr, R., Clough, A., De Bondt, G., Dvorak, J., Maloley, R., Matheson, G., et al. (2009) · British Journal of Sports Medicine · doi:10.1136/bjsm.2009.064394 · Cited by 431
Metadata
- Authors
- Kovacevic, D., & Rodeo, S. A.
- Venue
- Clinical Orthopaedics & Related Research
- Published
- 2008-03
- Volume
- 466
- Issue
- 3
- Pages
- 622-633
- ISSN
- 0009-921X (ISSN-L)
- OpenAlex
- W2085572225
- Cited by
- 279
- References
- 58
- FWCI
- 17.78
- Type
- journal article
- Language
- en
- Open access
- green
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