The DOI matches its Crossref record; 196 of the 196 references it cites were found in a registry or an index.
Biologics for tendon repair
Open accessAbstract
Tendon injuries are common and present a clinical challenge to orthopedic surgery mainly because these injuries often respond poorly to treatment and require prolonged rehabilitation. Therapeutic options used to repair ruptured tendons have consisted of suture, autografts, allografts, and synthetic prostheses. To date, none of these alternatives has provided a successful long-term solution, and often the restored tendons do not recover their complete strength and functionality. Unfortunately, our understanding of tendon biology lags far behind that of other musculoskeletal tissues, thus impeding the development of new treatment options for tendon conditions. Hence, in this review, after introducing the clinical significance of tendon diseases and the present understanding of tendon biology, we describe and critically assess the current strategies for enhancing tendon repair by biological means. These consist mainly of applying growth factors, stem cells, natural biomaterials and genes, alone or in combination, to the site of tendon damage. A deeper understanding of how tendon tissue and cells operate, combined with practical applications of modern molecular and cellular tools could provide the long awaited breakthrough in designing effective tendon-specific therapeutics and overall improvement of tendon disease management.
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Cites
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TENDON INJURY AND TENDINOPATHY: HEALING AND REPAIR
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Cited by
Havis, E., & Duprez, D. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21051664 · Cited by 494
Extracellular matrix-derived biomaterials in engineering cell function
Xing, H., Lee, H., Luo, L., & Kyriakides, T. R. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2019.107421 · Cited by 302
“In engineering orthopedic soft tissue, specifically skeletal muscle and tendon, synthetic materials, collagen matrix, and acellular dermal matrix have been extensively investigated (Docheva et al., 2015; Wolf et al., 2015).”
BackgroundZhou, Y., Zhang, J., Wu, H., Hogan, M. V., & Wang, J. H.-C. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0172-4 · Cited by 187
Scaffold-Mediated Immunoengineering as Innovative Strategy for Tendon Regeneration
Russo, V., El Khatib, M., Prencipe, G., Cerveró-Varona, A., Citeroni, M. R., Mauro, A., Berardinelli, P., Faydaver, M., Haidar-Montes, A. A., Turriani, M., et al. (2022) · Cells · doi:10.3390/cells11020266 · Cited by 49
Aeberhard, P., Grognuz, A., Peneveyre, C., McCallin, S., Hirt‐Burri, N., Antons, J., Pioletti, D., Raffoul, W., & Applegate, L. A. (2020) · Artificial Organs · doi:10.1111/aor.13581 · Cited by 43
Metadata
- Authors
- Docheva, D., Müller, S. A., Majewski, M., & Evans, C. H.
- Venue
- Advanced Drug Delivery Reviews
- Publisher
- Elsevier BV
- Published
- 2015-04
- Volume
- 84
- Pages
- 222-239
- ISSN
- 0169-409X (ISSN-L)
- OpenAlex
- W1972930867
- Cited by
- 693
- References
- 196
- FWCI
- 6.46
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
