The DOI matches its Crossref record; 75 of the 75 references it cites were found in a registry or an index.
Raman Assessment of Bone Quality
Open accessAbstract
BACKGROUND: Progress in the diagnosis and prediction of fragility fractures depends on improvements to the understating of the compositional contributors of bone quality to mechanical competence. Raman spectroscopy has been used to evaluate alterations to bone composition associated with aging, disease, or injury. QUESTIONS/PURPOSES: In this survey we will (1) review the use of Raman-based compositional measures of bone quality, including mineral-to-matrix ratio, carbonate-to-phosphate ratio, collagen quality, and crystallinity; (2) review literature correlating Raman spectra with biomechanical and other physiochemical measurements and with bone health; and (3) discuss prospects for ex vivo and in vivo human subject measurements. METHODS: ISI Web of Science was searched for references to bone Raman spectroscopy in peer-reviewed journals. Papers from other topics have been excluded from this review, including those on pharmaceutical topics, dental tissue, tissue engineering, stem cells, and implant integration. RESULTS: Raman spectra have been reported for human and animal bone as a function of age, biomechanical status, pathology, and other quality parameters. Current literature supports the use of mineral-to-matrix ratio, carbonate-to-phosphate ratio, and mineral crystallinity as measures of bone quality. Discrepancies between reports arise from the use of band intensity ratios rather than true composition ratios, primarily as a result of differing collagen band selections. CONCLUSIONS: Raman spectroscopy shows promise for evaluating the compositional contributors of bone quality in ex vivo specimens, although further validation is still needed. Methodology for noninvasive in vivo assessments is still under development.
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Cites
Molecular Mechanisms of Stress-Responsive Changes in Collagen and Elastin Networks in Skin
Aziz, J., Shezali, H., Radzi, Z., Yahya, N. A., Abu Kassim, N. H., Czernuszka, J., & Rahman, M. T. (2016) · Skin Pharmacology and Physiology · doi:10.1159/000447017 · Cited by 7,323
Stone, K. L., Seeley, D. G., Lui, L.-Y., Cauley, J. A., Ensrud, K., Browner, W. S., Nevitt, M. C., & Cummings, S. R. (2003) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2003.18.11.1947 · Cited by 1,051
Clinical Use of Bone Densitometry: Scientific Review
Cummings, S. R., Bates, D., & Black, D. M. (2002) · JAMA · doi:10.1001/jama.288.15.1889 · Cited by 817
Penel, G., Leroy, G., Rey, C., & Bres, E. (1998) · Calcified Tissue International · doi:10.1007/s002239900561 · Cited by 636
The skeletal attachment of tendons—tendon ‘entheses’
Benjamin, M., Kumai, T., Milz, S., Boszczyk, B. M., Boszczyk, A. A., & Ralphs, J. R. (2002) · Comparative Biochemistry and Physiology Part A: Molecular & Integrative Physiology · doi:10.1016/s1095-6433(02)00138-1 · Cited by 622
Spectroscopic Characterization of Collagen Cross-Links in Bone
Paschalis, E. P., Verdelis, K., Doty, S. B., Boskey, A. L., Mendelsohn, R., & Yamauchi, M. (2001) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.2001.16.10.1821 · Cited by 517
Akkus, O., Adar, F., & Schaffler, M. B. (2004) · Bone · doi:10.1016/j.bone.2003.11.003 · Cited by 447
Application of vibrational spectroscopy to the study of mineralized tissues (review)
Carden, A., & Morris, M. D. (2000) · Journal of Biomedical Optics · doi:10.1117/1.429994 · Cited by 431
Self-citationFTIR microspectroscopic analysis of human osteonal bone
Paschalis, E. P., DiCarlo, E., Betts, F., Sherman, P., Mendelsohn, R., & Boskey, A. L. (1996) · Calcified Tissue International · doi:10.1007/bf00369214 · Cited by 397
Carbonate Assignment and Calibration in the Raman Spectrum of Apatite
Awonusi, A., Morris, M. D., & Tecklenburg, M. M. J. (2007) · Calcified Tissue International · doi:10.1007/s00223-007-9034-0 · Cited by 381
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Cited by
Bone composition: relationship to bone fragility and antiosteoporotic drug effects
Boskey, A. L. (2013) · BoneKEy Reports · doi:10.1038/bonekey.2013.181 · Cited by 424
Mirzaali, M. J., Schwiedrzik, J. J., Thaiwichai, S., Best, J. P., Michler, J., Zysset, P. K., & Wolfram, U. (2016) · Bone · doi:10.1016/j.bone.2015.11.018 · Cited by 325
Proteins in Art, Archaeology, and Paleontology: From Detection to Identification
Dallongeville, S., Garnier, N., Rolando, C., & Tokarski, C. (2016) · Chemical Reviews · doi:10.1021/acs.chemrev.5b00037 · Cited by 172
Advanced Glycation Endproducts and Bone Material Properties in Type 1 Diabetic Mice
Rubin, M. R., Paschalis, E. P., Poundarik, A., Sroga, G. E., McMahon, D. J., Gamsjaeger, S., Klaushofer, K., & Vashishth, D. (2016) · PLOS ONE · doi:10.1371/journal.pone.0154700 · Cited by 90
PTH signaling mediates perilacunar remodeling during exercise
Gardinier, J. D., Al-Omaishi, S., Morris, M. D., & Kohn, D. H. (2016) · Matrix Biology · doi:10.1016/j.matbio.2016.02.010 · Cited by 69
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Metadata
- Authors
- Morris, M. D., & Mandair, G. S.
- Venue
- Clinical Orthopaedics & Related Research
- Published
- 2011-08
- Volume
- 469
- Issue
- 8
- Pages
- 2160-2169
- ISSN
- 0009-921X (ISSN-L)
- OpenAlex
- W1965505631
- Cited by
- 511
- References
- 75
- FWCI
- 8.37
- Type
- journal article
- Language
- en
- Open access
- green
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