PTH signaling mediates perilacunar remodeling during exercise
Open accessAbstract
Mechanical loading and release of endogenous parathyroid hormone (PTH) during exercise facilitate the adaptation of bone. However, it remains unclear how exercise and PTH influence the composition of bone and how exercise and PTH-mediated compositional changes influence the mechanical properties of bone. Thus, the primary purpose of this study was to establish compositional changes within osteocytes' perilacunar region of cortical bone following exercise, and evaluate the influence of endogenous PTH signaling on this perilacunar adaptation. Raman spectroscopy, scanning electron microscopy (SEM), and energy dispersive X-ray spectroscopy (EDS) were used to evaluate tissue composition surrounding individual lacuna within the tibia of 19week old male mice exposed to treadmill running for 3weeks. As a result of exercise, tissue within the perilacunar region (within 0-5μm of the lacuna wall) had a lower mineral-to-matrix ratio (MMR) compared to sedentary controls. In addition, exercise also increased the carbonate-to-phosphate ratio (CPR) across both perilacunar and non-perilacunar regions (5-10μm and 10-15μm from the lacuna walls). Tibial post-yield work had a significant negative correlation with perilacunar MMR. Inhibition of PTH activity with PTH(7-34) demonstrated that perilacunar remodeling during exercise was dependent on the cellular response to endogenous PTH. The osteocytes' response to endogenous PTH during exercise was characterized by a significant reduction in SOST expression and significant increase in FGF-23 expression. The potential reduction in phosphate levels due to FGF-23 expression may explain the increase in carbonate substitution. Overall, this is the first study to demonstrate that adaptation in tissue composition is localized around individual osteocytes, may contribute to the changes in whole bone mechanics during exercise, and that PTH signaling during exercise contributes to these adaptations.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The same outcome was observed in cases of excess PTH concentrations both in rats and humans and under PTH modulation after exercise.
“The same outcome was observed in cases of excess PTH concentrations both in rats83 and humans84 and under PTH modulation after exercise.85”
From Bone remodeling: an operational process ensuring survival and bone mechanical competence (2022) · cites this paper as [85]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Bonewald, L. F. (2011) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.320 · Cited by 2,287 · see citing works
BIOMECHANICAL AND MOLECULAR REGULATION OF BONE REMODELING
Robling, A. G., Castillo, A. B., & Turner, C. H. (2006) · Annual Review of Biomedical Engineering · doi:10.1146/annurev.bioeng.8.061505.095721 · Cited by 1,343 · see citing works
Age and bone mass as predictors of fracture in a prospective study.
Hui, S. L., Slemenda, C. W., & Johnston, C. C. (1988) · Journal of Clinical Investigation · doi:10.1172/jci113523 · Cited by 1,169 · see citing works
Raman Assessment of Bone Quality
Morris, M. D., & Mandair, G. S. (2010) · Clinical Orthopaedics and Related Research · doi:10.1007/s11999-010-1692-y · Cited by 518 · see citing works
Self-citationDemonstration of osteocytic perilacunar/canalicular remodeling in mice during lactation
Qing, H., Ardeshirpour, L., Divieti Pajevic, P., Dusevich, V., Jähn, K., Kato, S., Wysolmerski, J., & Bonewald, L. F. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1567 · Cited by 489 · see citing works
Akkuş, O., Adar, F., & Schaffler, M. B. (2003) · Bone · doi:10.1016/j.bone.2003.11.003 · Cited by 449 · see citing works
Wallace, B. A., & Cumming, R. G. (2000) · Calcified Tissue International · doi:10.1007/s00223001089 · Cited by 433 · see citing works
Contribution of collagen and mineral to the elastic-plastic properties of bone
Burstein, A. H., Zika, J. M., Heiple, K. G., & Klein, L. (1975) · Journal of Bone and Joint Surgery · doi:10.2106/00004623-197557070-00013 · Cited by 391 · see citing works
Bone tissue compositional differences in women with and without osteoporotic fracture
McCreadie, B. R., Morris, M. D., Chen, T.-C., Rao, D. S., Finney, W. F., Widjaja, E., & Goldstein, S. A. (2006) · Bone · doi:10.1016/j.bone.2006.06.008 · Cited by 255 · see citing works
Self-citationBoskey, A. (2003) · Osteoporosis International · doi:10.1007/s00198-003-1468-2 · Cited by 237 · see citing works
Holmbeck, K., Bianco, P., Pidoux, I., Inoué, S., Billinghurst, R. C., Wu, W. K. K., Chrysovergis, K., Yamada, S. S., Birkedal‐Hansen, H., & Poole, A. R. (2004) · Journal of Cell Science · doi:10.1242/jcs.01581 · Cited by 231 · see citing works
Tang, S. Y., Herber, R., Ho, S. P., & Alliston, T. N. (2012) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.1646 · Cited by 228 · see citing works
Boskey, A. L., Wright, T. M., & Blank, R. D. (1999) · Journal of Bone and Mineral Research · doi:10.1359/jbmr.1999.14.3.330 · Cited by 207 · see citing works
Carden, A., Rajachar, R. M., Morris, M. D., & Kohn, D. H. (2003) · Calcified Tissue International · doi:10.1007/s00223-002-1039-0 · Cited by 201 · see citing works
Self-citationRelationships Among Carbonated Apatite Solubility, Crystallite Size, and Microstrain Parameters
Baig, A. A., Fox, J. L., Young, R. A., Wang, Z., Hsu, J., Higuchi, W. I., Chhettry, A., Zhuang, H., & Otsuka, M. (1999) · Calcified Tissue International · doi:10.1007/pl00005826 · Cited by 199 · see citing works
Blaber, E. A., Dvorochkin, N., Lee, C., Alwood, J. S., Yousuf, R., Pianetta, P., Globus, R. K., Burns, B. P., & Almeida, E. A. C. (2013) · PLoS ONE · doi:10.1371/journal.pone.0061372 · Cited by 196 · see citing works
Donnelly, E. L., Boskey, A. L., Baker, S. P., & van der Meulen, M. C. H. (2009) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.32442 · Cited by 194 · see citing works
Raman Spectroscopic Imaging Markers for Fatigue-Related Microdamage in Bovine Bone
Timlin, J. A., Carden, A., Morris, M. D., Rajachar, R. M., & Kohn, D. H. (2000) · Analytical Chemistry · doi:10.1021/ac9913560 · Cited by 187 · see citing works
Self-citationDifferential effect of treadmill exercise on three cancellous bone sites in the young growing rat
Iwamoto, J., Yeh, J. K., & Aloia, J. F. (1999) · Bone · doi:10.1016/s8756-3282(98)00189-6 · Cited by 169 · see citing works
Sclerostin Regulates Release of Bone Mineral by Osteocytes by Induction of Carbonic Anhydrase 2
Kogawa, M., Wijenayaka, A. R., Ormsby, R. T., Thomas, G. P., Anderson, P., Bonewald, L. F., Findlay, D. M., & Atkins, G. J. (2013) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2003 · Cited by 153 · see citing works
Osteocyte Remodeling of the Perilacunar and Pericanalicular Matrix
Qing, H., & Bonewald, L. F. (2009) · International Journal of Oral Science · doi:10.4248/ijos.09019 · Cited by 152 · see citing works
Huang, T., Lin, S., Chang, F. L., Hsieh, S. S., Liu, S., & Yang, R. (2003) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01076.2002 · Cited by 139 · see citing works
Scott, J. P. R., Sale, C., Greeves, J. P., Casey, A. E., Dutton, J. J., & Fraser, W. D. (2010) · Journal of Applied Physiology · doi:10.1152/japplphysiol.00764.2010 · Cited by 136 · see citing works
FGF-23 and secondary hyperparathyroidism in chronic kidney disease
Silver, J., & Naveh‐Many, T. (2013) · Nature Reviews Nephrology · doi:10.1038/nrneph.2013.147 · Cited by 129 · see citing works
Gadeleta, S. J., Boskey, A. L., Paschalis, E. P., Carlson, C. S., Menschik, F., Baldini, T. H., Peterson, M., & Rimnac, C. M. (2000) · Bone · doi:10.1016/s8756-3282(00)00362-8 · Cited by 127 · see citing works
Iwamoto, J., Shimamura, C., Takeda, T., Abe, H., Ichimura, S., Satō, Y., & Toyama, Y. (2004) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-003-0443-5 · Cited by 114 · see citing works
Observations of microdamage around osteocyte lacunae in bone
Reilly, G. C. (2000) · Journal of Biomechanics · doi:10.1016/s0021-9290(00)00090-7 · Cited by 113 · see citing works
Nyman, J. S., Lynch, C. C., Perrien, D. S., Thiolloy, S., O’Quinn, E. C., Patil, C. A., Bi, X., Pharr, G. M., Mahadevan-Jansen, A. M., & Mundy, G. R. (2010) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.326 · Cited by 111 · see citing works
Effect of Physical Activity on Calcium Homeostasis and Calciotropic Hormones: A Review
Maı̈moun, L., & Sultan, C. (2009) · Calcified Tissue International · doi:10.1007/s00223-009-9277-z · Cited by 109 · see citing works
Iwasaki, Y., Kazama, J. J., Yamato, H., & Fukagawa, M. (2011) · Bone · doi:10.1016/j.bone.2011.03.672 · Cited by 89 · see citing works
Microstructure and nanomechanical properties in osteons relate to tissue and animal age
Koltsov, J. C. B., Gourion‐Arsiquaud, S., Havill, L. M., Baker, S. P., Boskey, A. L., & van der Meulen, M. C. H. (2010) · Journal of Biomechanics · doi:10.1016/j.jbiomech.2010.10.018 · Cited by 82 · see citing works
PTH Signaling During Exercise Contributes to Bone Adaptation
Gardinier, J. D., Mohamed, F. F., & Kohn, D. H. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2432 · Cited by 73 · see citing works
Self-citationA method for isolating high quality RNA from mouse cortical and cancellous bone
Kelly, N. H., Schimenti, J. C., Ross, F. P., & van der Meulen, M. C. H. (2014) · Bone · doi:10.1016/j.bone.2014.07.022 · Cited by 69 · see citing works
Bone Chemical Structure Response to Mechanical Stress Studied by High Pressure Raman Spectroscopy
de Carmejane, O., Morris, M. D., Davis, M. K., Stixrude, L. P., Tecklenburg, M. M. J., Rajachar, R. M., & Kohan, D. H. (2005) · Calcified Tissue International · doi:10.1007/s00223-004-0168-z · Cited by 69 · see citing works
Self-citationExercise Alters Mineral and Matrix Composition in the Absence of Adding New Bone
Kohn, D. H., Sahar, N. D., Wallace, J. M., Gölcük, K., & Morris, M. D. (2008) · Cells Tissues Organs · doi:10.1159/000151452 · Cited by 68 · see citing works
Self-citationAge-specific profiles of tissue-level composition and mechanical properties in murine cortical bone
Raghavan, M., Sahar, N. D., Kohn, D. H., & Morris, M. D. (2012) · Bone · doi:10.1016/j.bone.2011.12.026 · Cited by 68 · see citing works
Self-citationHesse, B., Langer, M., Varga, P., Pacureanu, A., Dong, P., Schrof, S., Männicke, N., Suhonen, H., Olivier, C., Maurer, P., et al. (2014) · PLoS ONE · doi:10.1371/journal.pone.0088481 · Cited by 55 · see citing works
Clarke, M. V., Russell, P. K., Findlay, D. M., Sastra, S., Anderson, P. H., Skinner, J. P., Atkins, G. J., Zajac, J. D., & Davey, R. A. (2015) · Endocrinology · doi:10.1210/en.2015-1345 · Cited by 54 · see citing works
Hoshi, A., Watanabe, H., Chiba, M., & Inaba, Y. (1998) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.185.15 · Cited by 51 · see citing works
Sano, H., Kikuta, J., Furuya, M., Kondo, N., Endo, N., & Ishii, M. (2015) · Bone · doi:10.1016/j.bone.2015.01.013 · Cited by 50 · see citing works
Britz, H. M., Carter, Y., Jokihaara, J., Leppänen, O., Järvinen, T. L. N., Belev, G. S., & Cooper, D. M. L. (2012) · Bone · doi:10.1016/j.bone.2012.08.112 · Cited by 47 · see citing works
Wallace, J. M., Ron, M. S., & Kohn, D. H. (2009) · Calcified Tissue International · doi:10.1007/s00223-009-9228-8 · Cited by 46 · see citing works
Self-citationInbred Strain-Specific Effects of Exercise in Wild Type and Biglycan Deficient Mice
Wallace, J. M., Gölcük, K., Morris, M. D., & Kohn, D. H. (2009) · Annals of Biomedical Engineering · doi:10.1007/s10439-009-9881-0 · Cited by 37 · see citing works
Self-citationMcNerny, E., Gardinier, J. D., & Kohn, D. H. (2015) · Bone · doi:10.1016/j.bone.2015.07.030 · Cited by 27 · see citing works
Self-citation
Flagged first, then by citations
Cited by
Sorted by citations
Bone remodeling: an operational process ensuring survival and bone mechanical competence
Bolamperti, S., Villa, I., & Rubinacci, A. (2022) · Bone Research · doi:10.1038/s41413-022-00219-8 · Cited by 482 · see citing works
Exercise and bone health across the lifespan
Santos, L., Elliott-Sale, K. J., & Sale, C. (2017) · Biogerontology · doi:10.1007/s10522-017-9732-6 · Cited by 256 · see citing works
Physical Activity-Dependent Regulation of Parathyroid Hormone and Calcium-Phosphorous Metabolism
Lombardi, G., Ziemann, E., Banfi, G., & Corbetta, S. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21155388 · Cited by 131 · see citing works
The Mechanosensory Role of Osteocytes and Implications for Bone Health and Disease States
Choi, J. U. A., Kijas, A. W., Lauko, J., & Rowan, A. E. (2022) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.770143 · Cited by 127 · see citing works
Delgado-Calle, J., Tu, X., Pacheco-Costa, R., McAndrews, K., Edwards, R., Pellegrini, G. G., Kuhlenschmidt, K., Olivos, N., Robling, A., Peacock, M., et al. (2017) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3011 · Cited by 114 · see citing works
Kohrt, W. M., Wherry, S. J., Wolfe, P., Sherk, V. D., Wellington, T., Swanson, C. M., Weaver, C. M., & Boxer, R. S. (2018) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3428 · Cited by 105 · see citing works
Kaya, S., Basta‐Pljakic, J., Şeref-Ferlengez, Z., Majeska, R. J., Cardoso, L., Bromage, T. G., Zhang, Q., Flach, C. R., Mendelsohn, R., Yakar, S., et al. (2016) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3044 · Cited by 102 · see citing works
YAP and TAZ Mediate Osteocyte Perilacunar/Canalicular Remodeling
Kegelman, C. D., Coulombe, J. C., Jordan, K. M., Horan, D. J., Qin, L., Robling, A. G., Ferguson, V. L., Bellido, T., & Boerckel, J. D. (2019) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.3876 · Cited by 95 · see citing works
How Physical Activity across the Lifespan Can Reduce the Impact of Bone Ageing: A Literature Review
Faienza, M. F., Lassandro, G., Chiarito, M., Valente, F., Ciaccia, L., & Giordano, P. (2020) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph17061862 · Cited by 95 · see citing works
An Overview of FGF-23 as a Novel Candidate Biomarker of Cardiovascular Risk
Vázquez‐Sánchez, S., Poveda, J., Navarro‐García, J. A., González‐Lafuente, L., Rodríguez‐Sánchez, E., Ruilope, L. M., & Ruiz‐Hurtado, G. (2021) · Frontiers in Physiology · doi:10.3389/fphys.2021.632260 · Cited by 74 · see citing works
Control of Bone Matrix Properties by Osteocytes
Creecy, A., Damrath, J. G., & Wallace, J. M. (2021) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.578477 · Cited by 68 · see citing works
Heveran, C. M., Rauff, A., King, K. B., Carpenter, R. D., & Ferguson, V. L. (2018) · Bone · doi:10.1016/j.bone.2018.01.018 · Cited by 57 · see citing works
Bone adaptation in response to treadmill exercise in young and adult mice
Gardinier, J. D., Rostami, N., Juliano, L., & Zhang, C. (2018) · Bone Reports · doi:10.1016/j.bonr.2018.01.003 · Cited by 58 · see citing works
Self-citationYan, Y., Wang, L., Ge, L., & Pathak, J. L. (2020) · Current Osteoporosis Reports · doi:10.1007/s11914-020-00564-9 · Cited by 57 · see citing works
The Osteocyte as the New Discovery of Therapeutic Options in Rare Bone Diseases
Pathak, J. L., Bravenboer, N., & Klein‐Nulend, J. (2020) · Frontiers in Endocrinology · doi:10.3389/fendo.2020.00405 · Cited by 53 · see citing works
Lacunar-canalicular bone remodeling: Impacts on bone quality and tools for assessment
Vahidi, G., Rux, C. J., Sherk, V. D., & Heveran, C. M. (2020) · Bone · doi:10.1016/j.bone.2020.115663 · Cited by 46 · see citing works
Varley, I., Hughes, D. C., Greeves, J. P., Stellingwerff, T., Ranson, C., Fraser, W. D., & Sale, C. (2017) · Journal of science and medicine in sport · doi:10.1016/j.jsams.2017.10.038 · Cited by 44 · see citing works
Tunnels in the rock: Dynamics of osteocyte morphogenesis
Moharrer, Y., & Boerckel, J. D. (2021) · Bone · doi:10.1016/j.bone.2021.116104 · Cited by 43 · see citing works
Tirado‐Cabrera, I., Martín‐Guerrero, E., Heredero‐Jiménez, S., Ardura, J. A., & Gortázar, A. R. (2022) · Journal of Cellular Physiology · doi:10.1002/jcp.30849 · Cited by 36 · see citing works
Heitman, K., Alexander, M. S., & Faul, C. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25105117 · Cited by 39 · see citing works
Dzik, K. P., Grzywacz, T., Łuszczyk, M., Kujach, S., Flis, D. J., & Kaczor, J. J. (2022) · Scientific Reports · doi:10.1038/s41598-022-05783-x · Cited by 39 · see citing works
Examining the influence of PTH(1-34) on tissue strength and composition
Gardinier, J. D., Al-Omaishi, S., Rostami, N., Morris, M. D., & Kohn, D. H. (2018) · Bone · doi:10.1016/j.bone.2018.09.019 · Cited by 24 · see citing works
Self-citationZhou, Y., Hellberg, M., Hellmark, T., Höglund, P., & Clyne, N. (2020) · BMC Nephrology · doi:10.1186/s12882-020-01881-y · Cited by 23 · see citing works
Loss of the PTH/PTHrP receptor along the osteoblast lineage limits the anabolic response to exercise
Gardinier, J. D., Daly‐Seiler, C. S., Rostami, N., Kundal, S., & Zhang, C. (2019) · PLoS ONE · doi:10.1371/journal.pone.0211076 · Cited by 22 · see citing works
Self-citationOrtinau, L. C., Linden, M. A., Dirkes, R. K., Rector, R. S., & Hinton, P. S. (2017) · Bone · doi:10.1016/j.bone.2017.07.010 · Cited by 20 · see citing works
Rux, C. J., Vahidi, G., Darabi, A., Cox, L. M., & Heveran, C. M. (2022) · Bone · doi:10.1016/j.bone.2022.116327 · Cited by 20 · see citing works
Osteocyte Remodeling of the Lacunar-Canalicular System: What’s in a Name?
Heveran, C. M., & Boerckel, J. D. (2022) · Current Osteoporosis Reports · doi:10.1007/s11914-022-00766-3 · Cited by 18 · see citing works
Sakamoto, E., Kitase, Y., Fitt, A. J., Zhu, Z., Awad, K. R., Brotto, M. A. P., White, K. E., Welc, S. S., Bergwitz, C., & Bonewald, L. F. (2024) · Cell Reports · doi:10.1016/j.celrep.2024.114397 · Cited by 18 · see citing works
Taylor, E. A., Donnelly, E. L., Yao, X., Johnson, M. L., Amugongo, S. K., Kimmel, D. B., & Lane, N. E. (2019) · Calcified Tissue International · doi:10.1007/s00223-019-00634-w · Cited by 18 · see citing works
McGregor, N. E., Walker, E. C., Chan, A. S. M., Poulton, I. J., Cho, H., Windahl, S. H., & Sims, N. A. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4484 · Cited by 18 · see citing works
Damrath, J. G., Moe, S. M., & Wallace, J. M. (2020) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.4574 · Cited by 18 · see citing works
Regulatory cellular and molecular networks in the bone microenvironment during aging
Zhang, L., Wang, Z., Zhang, Y., Ji, R., Li, Z., Zou, J., & Gao, B. (2024) · Life Medicine · doi:10.1093/lifemedi/lnae019 · Cited by 18 · see citing works
Borer, K. T., Zheng, Q., Jafari, A., Javadi, S., & Kernozek, T. W. (2019) · Nutrients · doi:10.3390/nu11071494 · Cited by 13 · see citing works
Bolger, M. W., Romanowicz, G. E., & Kohn, D. H. (2019) · Current Opinion in Biomedical Engineering · doi:10.1016/j.cobme.2019.09.011 · Cited by 12 · see citing works
Self-citationMapping the Response of Human Osteocytes in Native Matrix to Mechanical Loading Using RNA Sequencing
Zhang, C., van Essen, H. W., Sie, D., Micha, D., Pals, G., Klein‐Nulend, J., & Bravenboer, N. (2023) · JBMR Plus · doi:10.1002/jbm4.10721 · Cited by 10 · see citing works
Buskermolen, J., Meijden, K. V. D., Furrer, R., Mons, D. J., van Essen, H. W., Heijboer, A. C., Lips, P. T. A. M., Jaspers, R. T., & Bravenboer, N. (2019) · PeerJ · doi:10.7717/peerj.6184 · Cited by 9 · see citing works
Wu, X., Ai, Y., He, Y., Ma, D., Li, X., Huang, X., Cheng, R., & Wang, B. (2025) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2025.1562764 · Cited by 8 · see citing works
Fluorescent mapping of osteocyte-driven bone formation at pre-osteocyte and mature osteocyte lacunae
Ford, S., Tiedemann, K., Shapiro, R., Komarova, S. V., Jähn, K., & Zimmermann, E. A. (2025) · Acta Biomaterialia · doi:10.1016/j.actbio.2025.09.040 · Cited by 7 · see citing works
Aging decreases osteocyte lacunar-canalicular turnover in female C57BL/6 mice
Vahidi, G., Boone, C., Hoffman, F., & Heveran, C. M. (2023) · Bone · doi:10.1016/j.bone.2024.117163 · Cited by 6 · see citing works
Romanowicz, G. E., Terhune, A. H., Bielajew, B. J., Sexton, B., Lynch, M. A., Mandair, G. S., McNerny, E., & Kohn, D. H. (2022) · Bone Reports · doi:10.1016/j.bonr.2022.101629 · Cited by 7 · see citing works
Self-citationEffects of acute- and long-term aerobic exercises at different intensities on bone in mice
Hatakeyama, J., Inoue, S., Li, C., Takamura, D., Jiang, H., Kuroki, H., & Moriyama, H. (2024) · Journal of Bone and Mineral Metabolism · doi:10.1007/s00774-023-01491-2 · Cited by 6 · see citing works
Purinergic signaling through the P2Y2 receptor regulates osteocytes’ mechanosensitivity
Chougule, A., Zhang, C., Vinokurov, N., Mendez, D., Vojtisek, E., Shi, C., Zhang, J., & Gardinier, J. D. (2024) · The Journal of Cell Biology · doi:10.1083/jcb.202403005 · Cited by 6 · see citing works
Self-citationBolger, M. W., Tekkey, T., & Kohn, D. H. (2023) · Calcified Tissue International · doi:10.1007/s00223-023-01098-9 · Cited by 6 · see citing works
Self-citationMechanical loading modulates phosphate related genes in rat bone
Nepal, A. K., van Essen, H. W., Reijnders, C. M. A., Lips, P. T. A. M., & Bravenboer, N. (2023) · PLoS ONE · doi:10.1371/journal.pone.0282678 · Cited by 5 · see citing works
Benlidayı, İ. C., Gupta, L., Parihar, J., Lanis, A., & Alexanderson, H. (2024) · International Journal of Rheumatic Diseases · doi:10.1111/1756-185x.15402 · Cited by 5 · see citing works
The Evolving Role of PTH Signaling in Osteocytes
Kiryaman, G., Enabulele, I., Banville, M., & Pajevic, P. D. (2025) · Endocrinology · doi:10.1210/endocr/bqaf034 · Cited by 5 · see citing works
Yee, C. S., Meliadis, C., Kaya, S., Chang, W., & Alliston, T. N. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1342938 · Cited by 4 · see citing works
Bolger, M. W., Tekkey, T., & Kohn, D. H. (2024) · JBMR Plus · doi:10.1093/jbmrpl/ziad017 · Cited by 4 · see citing works
Self-citationMok, J., Brown, C. C., Moore, A. E. B., Min, S. S., & Hampson, G. (2018) · Endocrine Research · doi:10.1080/07435800.2018.1454461 · Cited by 3 · see citing works
Kitase, Y., Vallejo, J. A., Dallas, S. L., Xie, Y., Dallas, M., Tiede-Lewis, L. M., Moore, D., Meljanac, A., Kumar, C., Zhao, C., et al. (2022) · Aging · doi:10.18632/aging.204390 · Cited by 3 · see citing works
Dev, I., Mehmood, S., Pleshko, N. L., Iyad Obeid, A., & Querido, W. (2024) · Journal of Structural Biology X · doi:10.1016/j.yjsbx.2024.100111 · Cited by 3 · see citing works
Migotsky, N., Brodt, M. D., Cheverud, J. M., & Silva, M. J. (2022) · Bone Reports · doi:10.1016/j.bonr.2022.101615 · Cited by 3 · see citing works
Osteocytes remodel bone by TGF-β-induced YAP/TAZ signalingPreprint
Kegelman, C. D., Coulombe, J. C., Jordan, K. M., Horan, D. J., Qin, L., Robling, A. G., Ferguson, V. L., Bellido, T., & Boerckel, J. D. (2019) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/611913 · Cited by 3 · see citing works
McGoldrick, S. J., Woo, B., & Kohn, D. H. (2025) · Journal of Biomedical Materials Research Part B Applied Biomaterials · doi:10.1002/jbm.b.35612 · Cited by 1 · see citing works
Self-citationOsteocyte Mechanobiology in Aging and Disease
Donahue, H. J., Friendman, M. J., & Genetos, D. C. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-817931-4.00001-7 · Cited by 1 · see citing works
Lister, M. (2018) · ChesterRep (University of Chester)
Rux, C. J., Vahidi, G., Darabi, A., Cox, L. M., & Heveran, C. M. (2021) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2021.09.21.461298
Rouzbayani, N., Fathi, M., & Rahmati, M. (2022) · Armaghane Danesh · doi:10.52547/armaghanj.27.4.442
Aging decreases osteocyte lacunar-canalicular turnover in female C57BL/6 micePreprint
Vahidi, G., Boone, J. C., Hoffman, F., & Heveran, C. M. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.12.15.571934
Tirado‐Cabrera, I., Pizarro‐Gómez, J., Heredero‐Jiménez, S., Martín‐Guerrero, E., Ardura, J. A., & de Gortázar, M. A. R. (2024) · Revista de Osteoporosis y Metabolismo Mineral · doi:10.20960/revosteoporosmetabminer.00035
fazeli, V., Motamedi, P., Rajabi, H., & Khaledi, N. (2023) · Research in Sport Medicine and Technology · doi:10.61186/jsmt.21.26.129
Osorio, R., Aguilera, F. S., Fernández-Romero, E., Toledano, R., Osorio, M. T., Manuel, T., & Osorio, E. (2026) · Journal of Dentistry · doi:10.1016/j.jdent.2026.106340
Kitase, Y., Prideaux, M., Bellido, T., Pajevic, P. D., & Bonewald, L. F. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-13683-2.00043-8
Akhtar, S., & Al-Suhaimi, E. A. (2026) · Microscopy Research and Technique · doi:10.1002/jemt.70175
- Authors
- Gardinier, J. D., Al-Omaishi, S., Morris, M. D., & Kohn, D. H.
- Affiliations
- Henry Ford Health (US)
- University of Michigan (US)
- Corresponding author
- Kohn, David H.
- Venue
- Matrix Biology
- Publisher
- Elsevier BV
- Published
- 2016-05
- Volume
- 52-54
- Pages
- 162-175
- ISSN
- 0945-053X (ISSN-L)
- PMC
- PMC4875803
- OpenAlex
- W2286575445
- Cited by
- 69
- References
- 44
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 11 · 2023: 6 · 2022: 10 · 2021: 4 · 2020: 8 · 2019: 12 · 2018: 6 · 2017: 3 · 2016: 2
- FWCI
- 9.33
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Matrix Biology (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (DE07057, AR064668, AR056657)
- Topics
- Health Sciences › Medicine › Orthopedics and Sports Medicine › Bone health and osteoporosis research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Bone Metabolism and Diseases
- Health Sciences › Medicine › Nephrology › Parathyroid Disorders and Treatments
- Keywords
- parathyroid hormone signaling, physical activity, bone remodeling, osteocytes, mineral-to-matrix ratio, carbonate substitution, fibroblast growth factor 23, sclerostin, bone mechanical properties, tibia, mechanical loading
- MeSH terms
- Fibroblast Growth Factor-23, Animals, Biomechanical Phenomena, Exercise Test, Male, Microscopy, Electron, Scanning, Parathyroid Hormone, Physical Conditioning, Animal, Spectrometry, X-Ray Emission, Spectrum Analysis, Raman, Tibia, Signal Transduction, Bone Remodeling, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review