Anti-TGF-β Antibody Combined with Dendritic Cells Produce Antitumor Effects in Osteosarcoma
Open accessAbstract
BACKGROUND: We previously reported the combination of tumor cryotreatment with dendritic cells to promote antitumor immunity. The effect of the combination treatment with dendritic cells and antitransforming growth factor-β (anti-TGF-β) antibody on the elimination of regulatory T cells and the inhibition of tumor growth was investigated. QUESTIONS/PURPOSES: The effects of the combination treatment with dendritic cells and anti-TGF-β antibody on the enhancement of systemic immune responses and inhibition of metastatic tumor growth were investigated in a murine osteosarcoma (LM8) model. MATERIALS AND METHODS: To evaluate activation of the immune response, we established the following three groups of C3H mice (60 mice total): (1) excision only; (2) tumor excision and administration of anti-TGF-β antibody; and (3) tumor excision and administration of dendritic cells exposed to cryotreated tumor lysates with anti-TGF-β antibody. RESULTS: The mice that received dendritic cells exposed to cryotreated tumor lysates with anti-TGF-β antibody showed increased numbers of CD8(+) T lymphocytes, reduced regulatory T lymphocytes in the metastatic lesion, and inhibition of metastatic growth. The combined therapy group showed reduced numbers of regulatory T lymphocytes in the spleen and high serum interferon γ level. CONCLUSIONS: The control of the inhibitory condition induced by regulatory T cells is important to improve the suppression of the cytotoxic lymphocytes. Combining dendritic cells with anti-TGF-β antibody enhanced the systemic immune response. CLINICAL RELEVANCE: We suggest that our immunotherapy could be developed further to improve the treatment of osteosarcoma.
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Combined DCs and anti-TGF-β antibodies enhanced systemic immune responses in mice models.
“Kawano et al. suggested that combined DCs and anti-TGF-β antibodies to treat osteosarcoma and detected enhanced systematic immune responses in mice models [149].”
From Advances on immunotherapy for osteosarcoma (2024) · cites this paper as [149]
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- Authors
- Kawano, M., Itonaga, I., Iwasaki, T., Tsuchiya, H., & Tsumura, H.
- Affiliations
- Oita University (JP)
- Kanazawa University (JP)
- Corresponding author
- Kawano, Masanori
- Venue
- Clinical Orthopaedics & Related Research
- Published
- 2012-08
- Volume
- 470
- Issue
- 8
- Pages
- 2288-2294
- ISSN
- 0009-921X (ISSN-L)
- PMC
- PMC3392369
- OpenAlex
- W1999506915
- Cited by
- 51
- References
- 26
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 6 · 2022: 6 · 2021: 4 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 1 · 2016: 4 · 2015: 3 · 2013: 2
- FWCI
- 0.70
- Type
- journal article
- Language
- en
- Open access
- hybrid
- doi.org
- Licence
- cc-by
- Locations
- Clinical Orthopaedics and Related Research (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Immunology › Immunotherapy and Immune Responses
- Health Sciences › Medicine › Oncology › Cancer Immunotherapy and Biomarkers
- Life Sciences › Immunology and Microbiology › Immunology › T-cell and B-cell Immunology
- Keywords
- osteosarcoma, anti-TGF-beta antibody, dendritic cells, cancer immunotherapy, regulatory T cells, CD8+ T cells, interferon-gamma, tumor lysate, metastasis suppression
- MeSH terms
- Animals, Antibodies, Monoclonal, Bone Neoplasms, Combined Modality Therapy, Dendritic Cells, Female, Mice, Inbred C3H, Osteosarcoma, Tumor Cells, Cultured, Transforming Growth Factor beta, Treatment Outcome, CD8-Positive T-Lymphocytes, Cancer Vaccines, Xenograft Model Antitumor Assays, Mice
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