Extracellular vesicles-mediated signaling in the osteosarcoma microenvironment: Roles and potential therapeutic targets
Open accessAbstract
Osteosarcoma (OS) is the most common non-hematologic malignant tumor of bone in children. It is usually characterized by a high risk of developing lung metastasis and poor prognosis. Extracellular vesicles (EVs) are cell-derived nanoparticles with a small size of 50-200 nm in diameter. As a communicator, the contents of the EVs secreted via either fusing with lysosomes for degradation and recycling or fusing with the cell plasma membrane into the extracellular environment, which play an important role in regulating the tumor microenvironment of OS and mediating the Wnt/β-catenin and TGF-β signalings. Increasing evidences suggest that EVs have significant role in OS growth, progression, metastasis and drug resistance. In this study, the roles of EVs in the physiology and pathogenesis of OS and the potential attractive therapeutic target for the treatment of OS were reviewed.
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The dialogue between osteosarcoma cells and their microenvironment is crucial for tumour growth at the bone site and involves direct interactions among mesenchymal, vascular and immune cells, soluble factors such as chemokines and cytokines, and extracellular vesicles.
“The dialogue between osteosarcoma cells and their microenvironment is crucial for tumour growth at the bone site and is associated with direct interaction among mesenchymal, vascular and immune cells (depending on cell differentiation level) 45 , the interaction of cells with soluble factors such as chemokines and cytokines 46 , and the interaction of cells with extracellular vesicles 47 .”
From Osteosarcoma (2022) · cites this paper as [47]
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Retracted
- Authors
- Lan, M., Zhu, X.-P., Cao, Z.-Y., Liu, J.-M., Lin, Q., & Liu, Z.-L.
- Affiliations
- First Affiliated Hospital of Nanchang University (CN)
- Johns Hopkins University (US)
- Corresponding author
- Lin, Qing
- Venue
- Journal of Bone Oncology
- Publisher
- Elsevier BV
- Published
- 2018-09
- Volume
- 12
- Pages
- 101-104
- ISSN
- 2212-1366 (ISSN-L)
- 2212-1374
- PMC
- PMC6111053
- OpenAlex
- W2886912880
- Cited by
- 19
- References
- 56
- Citations by year
- 2025: 1 · 2024: 1 · 2022: 7 · 2021: 1 · 2020: 6 · 2019: 2
- FWCI
- 0.22
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of bone oncology (publishedVersion, cc-by-nc-nd)
- Europe PMC (PubMed Central) (publishedVersion, cc-by-nc-nd)
- PubMed Central (publishedVersion, cc-by-nc-nd)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Department of Science and Technology Program of Jiangxi Province (20162BCB22022, 20162BCB23057)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Sarcoma Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
- Keywords
- osteosarcoma, extracellular vesicles, tumor microenvironment, Wnt/β-catenin signaling, TGF-beta signaling, lung metastasis, drug resistance, therapeutic target, bone cancer
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