Trace Elements Homeostatic Imbalance in Psoriasis: A Meta-Analysis
Abstract
Studies point out that trace elements take vital roles in immunological and inflammatory reactions, such as psoriasis, while the conclusions are controversial. The purpose of this study was to analyze the existing literatures and explore the relationship between the risk of psoriasis and four trace elements zinc (Zn), copper (Cu), iron (Fe), and selenium (Se). We identified 42 studies through the databases PubMed, Embase, Cochrane Library, Google Scholar, and Web of knowledge. After the meta-analysis, the serum zinc, iron, and selenium levels showed no remarkable difference between psoriasis and controls. The people with psoriasis showed a higher level of zinc in lesion tissue (standard mean difference (SMD) = 14.43; 95% confidence interval (CI), 7.89-20.97; P < 0.0001), and a higher level of serum copper than controls (SMD = 18.23; 95% CI, 5.06-31.40; P = 0.007). Our findings indicated that the trace element of copper and zinc levels are in a homeostatic imbalance in psoriasis patients when compared with controls, which raise the question whether this imbalance can be taken as the therapy target for psoriasis.
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Trace elements are closely related to skin immunity and inflammation, and homeostasis of copper and zinc ions in psoriasis patients may be a potential target for treating psoriasis.
“Trace elements are closely related to skin immunity and inflammation, and the homeostasis of copper and zinc ions in psoriasis patients may be a potential target for treating psoriasis [59].”
From Diet and Skin Aging—From the Perspective of Food Nutrition (2020) · cites this paper as [59]
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References 70 · Cited by 20
- Authors
- Chen, W., Zhou, X., & Zhu, W.
- Affiliations
- Central South University (CN)
- Corresponding author
- Zhou, Xingchen
- Zhu, Wu
- Venue
- Biological Trace Element Research
- Published
- 2019-01-15
- Volume
- 191
- Issue
- 2
- Pages
- 313-322
- ISSN
- 0163-4984 (ISSN-L)
- 1559-0720
- OpenAlex
- W2909971255
- Cited by
- 20
- References
- 70
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 3 · 2023: 3 · 2021: 3 · 2020: 4
- FWCI
- 0.24
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Biological Trace Element Research (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Natural Science Foundation of China (NO. 81773329)
- Natural Science Youth Foundation of China (NO. 81803118)
- Topics
- Health Sciences › Nursing › Nutrition and Dietetics › Trace Elements in Health
- Life Sciences › Immunology and Microbiology › Immunology › Psoriasis: Treatment and Pathogenesis
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Heavy Metal Exposure and Toxicity
- Keywords
- psoriasis, trace elements, zinc, copper, iron, selenium, trace element homeostasis, serum trace element levels, serum copper, psoriasis risk factors
- MeSH terms
- Copper, Humans, Psoriasis, Selenium, Trace Elements, Zinc
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