CoChat
Sign Up
Cited by 9

The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.

Identifying Serum Metabolites and Gut Bacterial Species Associated with Nephrotoxicity Caused by Arsenic and Fluoride Exposure

Tian, Xiaolin, Yan, Xiaoyan, Chen, Xushen, Liu, Penghui, Sun, Zilong, Niu, Ruiyan·2023·Biological Trace Element Research
DOI 10.1007/s12011-023-03568-5
Open this paper in CoChat — free account

Abstract

Co-contamination of arsenic (As) and fluoride (F) is widely distributed in groundwater, which are known risk factors for the nephrotoxicity. Emerging evidence has linked environmentally associated nephrotoxicity with the disturbance of gut microbiota and blood metabolites. In this study, we generated gut microbiota and blood metabolomic profile and identified multiple serum metabolites and gut bacteria species, which were associated with kidney injury on rat model exposed to As and F alone or combined. Combined As and F exposure significantly increased creatinine level. Abnormal autophagosomes and lysosome were observed, and the autophagic genes were enhanced in kidney tissue after single and combined As and F exposure. The metabolome data showed that single and combined As and F exposure remarkably altered the serum metabolites associated with the proximal tubule reabsorption function pathway, with glutamine and alpha-ketoglutarate level decreased in all exposed group. Furthermore, phosphatidylethanolamine (PE), the key contributor of autophagosomes, was decreased significantly in As and F + As exposed groups during the screen of autophagy-animal pathway. Multiple altered gut bacterial microbiota at phylum and species levels post As and F exposure were associated with targeted kidney injury, including p_Bacteroidetes, s_Chromohalobacter_unclassified, s_Halomonas_unclassified, s_Ignatzschineria_unclassified, s_Bacillus_subtilis, and s_Brevundimonas_sp._NA6. Meanwhile, our ana…

Overview

Integrity signals

Registry

Crossref · 10.1007/s12011-023-03568-5

Cites

2 of 2 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Research works printed but not linked: 60

  1. Pi K, Wang Y, Xie X, Su C, Ma T, Li J, Liu Y (2015) Hydrogeochemistry of co-occurring geogenic arsenic, fluoride and iodine in groundwater at Datong Basin, northern China. J Hazard Mater 300:652–661. https://doi.org/10.1016/j.jhazmat.2015.07.080 · DOI
  2. Rahaman MS, Rahman MM, Mise N, Sikder MT, Ichihara G, Uddin MK, Kurasaki M, Ichihara S (2021) Environmental arsenic exposure and its contribution to human diseases, toxicity mechanism and management. Environ Pollut 289:117940. https://doi.org/10.1016/j.envpol.2021.117940 · DOI
  3. Nagendra AH, Bose B, Shenoy PS (2021) Recent advances in cellular effects of fluoride: an update on its signalling pathway and targeted therapeutic approaches. Mol Biol Rep 48(7):5661–5673. https://doi.org/10.1007/s11033-021-06523-6 · DOI
  4. Levin-Schwartz Y, Politis M, Gennings C, Tamayo-Ortiz M, Flores D, Amarasiriwardena C, Pantic I, Tolentino M, Estrada-Gutierrez G, Lamadrid-Figueroa H, Tellez-Rojo M, Baccarelli A, Wright R, Sanders A (2021) Nephrotoxic metal mixtures and preadolescent kidney function. Children (Basel) 8(8):673. https://doi.org/10.3390/children8080673 · DOI
  5. Khan KM, Chakraborty R, Bundschuh J, Bhattacharya P, Parvez F (2020) Health effects of arsenic exposure in Latin America: an overview of the past eight years of research. Sci Total Environ 710:136071. https://doi.org/10.1016/j.scitotenv.2019.136071 · DOI
  6. Dharmaratne RW (2019) Exploring the role of excess fluoride in chronic kidney disease: a review. Hum Exp Toxicol 38(3):269–279. https://doi.org/10.1177/0960327118814161 · DOI
  7. Lu K, Abo RP, Schlieper KA, Graffam ME, Levine S, Wishnok JS, Swenberg JA, Tannenbaum SR, Fox JG (2014) Arsenic exposure perturbs the gut microbiome and its metabolic profile in mice: an integrated metagenomics and metabolomics analysis. Environ Health Perspect 122(3):284–291. https://doi.org/10.1289/ehp.1307429 · DOI
  8. Xue J, Lai Y, Chi L, Tu P, Leng J, Liu CW, Ru H, Lu K (2019) Serum metabolomics reveals that gut microbiome perturbation mediates metabolic disruption induced by arsenic exposure in mice. J Proteome Res 18(3):1006–1018. https://doi.org/10.1021/acs.jproteome.8b00697 · DOI
  9. Coryell M, McAlpine M, Pinkham NV, McDermott TR, Walk ST (2018) The gut microbiome is required for full protection against acute arsenic toxicity in mouse models. Nat Commun 9(1):5424. https://doi.org/10.1038/s41467-018-07803-9 · DOI
  10. Wang HW, Miao CY, Liu J, Zhang Y, Zhu SQ, Zhou BH (2020) Fluoride-induced rectal barrier damage and microflora disorder in mice. Environ Sci Pollut Res Int 27(7):7596–7607. https://doi.org/10.1007/s11356-019-07201-8 · DOI
  11. Liu J, Wang HW, Lin L, Miao CY, Zhang Y, Zhou BH (2019) Intestinal barrier damage involved in intestinal microflora changes in fluoride-induced mice. Chemosphere 234:409–418. https://doi.org/10.1016/j.chemosphere.2019.06.080 · DOI · Paper page
  12. Yan X, Chen X, Tian X, Qiu Y, Wang J, Yu G, Dong N, Feng J, Xie J, Nalesnik M, Niu R, Xiao B, Song G, Quinones S, Ren X (2021) Co-exposure to inorganic arsenic and fluoride prominently disrupts gut microbiota equilibrium and induces adverse cardiovascular effects in offspring rats. Sci Total Environ 767:144924. https://doi.org/10.1016/j.scitotenv.2020.144924 · DOI
  13. Qiu Y, Chen X, Yan X, Wang J, Yu G, Ma W, Xiao B, Quinones S, Tian X, Ren X (2020) Gut microbiota perturbations and neurodevelopmental impacts in offspring rats concurrently exposure to inorganic arsenic and fluoride. Environ Int 140:105763. https://doi.org/10.1016/j.envint.2020.105763 · DOI
  14. Knauf F, Brewer JR, Flavell RA (2019) Immunity, microbiota and kidney disease. Nat Rev Nephrol 15(5):263–274. https://doi.org/10.1038/s41581-019-0118-7 · DOI
  15. Meijers B, Evenepoel P, Anders HJ (2019) Intestinal microbiome and fitness in kidney disease. Nat Rev Nephrol 15(9):531–545. https://doi.org/10.1038/s41581-019-0172-1 · DOI
  16. Ticinesi A, Milani C, Guerra A, Allegri F, Lauretani F, Nouvenne A, Mancabelli L, Lugli GA, Turroni F, Duranti S, Mangifesta M, Viappiani A, Ferrario C, Dodi R, Dall’Asta M, Del Rio D, Ventura M, Meschi T (2018) Understanding the gut-kidney axis in nephrolithiasis: an analysis of the gut microbiota composition and functionality of stone formers. Gut 67(12):2097–2106. https://doi.org/10.1136/gutjnl-2017-315734 · DOI
  17. Margiotta E, Caldiroli L, Callegari ML, Miragoli F, Zanoni F, Armelloni S, Rizzo V, Messa P, Vettoretti S (2021) Association of sarcopenia and gut microbiota composition in older patients with advanced chronic kidney disease, investigation of the interactions with uremic toxins, inflammation and oxidative stress. Toxins (Basel) 13(7):472. https://doi.org/10.3390/toxins13070472 · DOI
  18. Wang X, Yang S, Li S, Zhao L, Hao Y, Qin J, Zhang L, Zhang C, Bian W, Zuo L, Gao X, Zhu B, Lei XG, Gu Z, Cui W, Xu X, Li Z, Zhu B, Li Y, Chen S, Guo H, Zhang H, Sun J, Zhang M, Hui Y, Zhang X, Liu X, Sun B, Wang L, Qiu Q, Zhang Y, Li X, Liu W, Xue R, Wu H, Shao D, Li J, Zhou Y, Li S, Yang R, Pedersen OB, Yu Z, Ehrlich SD, Ren F (2020) Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents. Gut 69(12):2131–2142. https://doi.org/10.1136/gutjnl-2019-319766 · DOI
  19. Huang Y, Zhou J, Wang S, Xiong J, Chen Y, Liu Y, Xiao T, Li Y, He T, Li Y, Bi X, Yang K, Han W, Qiao Y, Yu Y, Zhao J (2020) Indoxyl sulfate induces intestinal barrier injury through IRF1-DRP1 axis-mediated mitophagy impairment. Theranostics 10(16):7384–7400. https://doi.org/10.7150/thno.45455 · DOI
  20. Bundschuh J, Farias B, Martin R, Storniolo A, Bhattacharya P, Cortes J, Bonorino G, Albouy R (2004) Groundwater arsenic in the Chaco-Pampean Plain, Argentina: case study from Robles county, Santiago del Estero Province. Appl Geochem19(2):231–243. https://doi.org/10.1016/j.apgeochem.2003.09.009 · DOI
  21. Sivasankar V, Darchen A, Omine K, Sakthivel R (2016) Fluoride: a world ubiquitous compound, its chemistry, and ways of contamination. In: Surface Modified Carbons as Scavengers for Fluoride from Water pp 5–32. Springer, Cham. https://doi.org/10.1007/978-3-319-40686-2_2 · DOI
  22. Tian X, Feng J, Dong N, Lyu Y, Wei C, Li B, Ma Y, Xie J, Qiu Y, Song G, Ren X, Yan X (2019) Subchronic exposure to arsenite and fluoride from gestation to puberty induces oxidative stress and disrupts ultrastructure in the kidneys of rat offspring. Sci Total Environ 686:1229–1237. https://doi.org/10.1016/j.scitotenv.2019.04.409 · DOI
  23. Calzada E, Onguka O, Claypool SM (2016) Phosphatidylethanolamine metabolism in health and disease. Int Rev Cell Mol Biol 321:29–88. https://doi.org/10.1016/bs.ircmb.2015.10.001 · DOI
  24. Rajapakse S, Shivanthan MC, Selvarajah M (2016) Chronic kidney disease of unknown etiology in Sri Lanka. Int J Occup Environ Health 22(3):259–264. https://doi.org/10.1080/10773525.2016.1203097 · DOI
  25. Chouhan S, Flora SJ (2010) Arsenic and fluoride: two major ground water pollutants. Indian J Exp Biol 48(7):666–678
  26. Tian X, Xie J, Chen X, Dong N, Feng J, Gao Y, Tian F, Zhang W, Qiu Y, Niu R, Ren X, Yan X (2020) Deregulation of autophagy is involved in nephrotoxicity of arsenite and fluoride exposure during gestation to puberty in rat offspring. Arch Toxicol 94(3):749–760. https://doi.org/10.1007/s00204-019-02651-y · DOI
  27. Wu M, Lao YZ, Tan HS, Lu G, Ren Y, Zheng ZQ, Yi J, Fu WW, Shen HM, Xu HX (2019) Oblongifolin C suppresses lysosomal function independently of TFEB nuclear translocation. Acta Pharmacol Sin 40(7):929–937. https://doi.org/10.1038/s41401-018-0167-7 · DOI
  28. Zhang X, Wei M, Fan J, Yan W, Zha X, Song H, Wan R, Yin Y, Wang W (2021) Ischemia-induced upregulation of autophagy preludes dysfunctional lysosomal storage and associated synaptic impairments in neurons. Autophagy 17(6):1519–1542. https://doi.org/10.1080/15548627.2020.1840796 · DOI
  29. Liu P, Xue Y, Zheng B, Liang Y, Zhang J, Shi J, Chu X, Han X, Chu L (2020) Crocetin attenuates the oxidative stress, inflammation and apoptosisin arsenic trioxide-induced nephrotoxic rats: Implication of PI3K/AKT pathway. Int Immunopharmacol 88:106959. https://doi.org/10.1016/j.intimp.2020.106959 · DOI
  30. Li H, Fan J, Zhao Y, Yang J, Xu H, Manthari RK, Cheng X, Wang J, Wang J (2021) Calcium alleviates fluoride-induced kidney damage via FAS/FASL, TNFR/TNF, DR5/TRAIL pathways in rats. Ecotoxicol Environ Saf 226:112851. https://doi.org/10.1016/j.ecoenv.2021.112851 · DOI
  31. Zhan F, Wang X, Zhang J, Yi S, He P (2022) Glutamine alleviates the renal dysfunction associated with gentamicin-induced acute kidney injury in Sprague-Dawley rats. Biotechnol Appl Biochem 69(1):323–329. https://doi.org/10.1002/bab.2111 · DOI
  32. Guo L, Chen S, Ou L, Li S, Ye ZN, Liu HF (2022) Disrupted alpha-ketoglutarate homeostasis: understanding kidney diseases from the view of metabolism and beyond. Diabetes Metab Syndr Obes 15:1961–1974. https://doi.org/10.2147/dmso.s369090 · DOI
  33. Gatica D, Chiong M, Lavandero S, Klionsky DJ (2015) Molecular mechanisms of autophagy in the cardiovascular system. Circ Res 116(3):456–467. https://doi.org/10.1161/circresaha.114.303788 · DOI · Paper page
  34. Zhao Y, Li Y, Wang J, Manthari RK, Wang J (2018) Fluoride induces apoptosis and autophagy through the IL-17 signaling pathway in mice hepatocytes. Arch Toxicol 92(11):3277–3289. https://doi.org/10.1007/s00204-018-2305-x · DOI
  35. Patel D, Witt SN (2017) Ethanolamine and phosphatidylethanolamine: partners in health and disease. Oxid Med Cell Longev 2017:4829180. https://doi.org/10.1155/2017/4829180 · DOI
  36. Guan ZZ, Xiao KQ, Zeng XY, Long YG, Cheng YH, Jiang SF, Wang YN (2000) Changed cellular membrane lipid composition and lipid peroxidation of kidney in rats with chronic fluorosis. Arch Toxicol 74(10):602–608. https://doi.org/10.1007/s002040000177 · DOI
  37. Wang YN, Xiao KQ, Liu JL, Dallner G, Guan ZZ (2000) Effect of long term fluoride exposure on lipid composition in rat liver. Toxicology 146(2–3):161–169. https://doi.org/10.1016/s0300-483x(00)00167-0 · DOI
  38. Li Y, Liu Y, Yi J, Li Y, Yang B, Shang P, Mehmood K, Bilal RM, Zhang H, Chang YF, Tang Z, Wang Y, Li Y (2021) The potential risks of chronic fluoride exposure on nephrotoxic via altering glucolipid metabolism and activating autophagy and apoptosis in ducks. Toxicology 461:152906. https://doi.org/10.1016/j.tox.2021.152906 · DOI
  39. Kim C, Ashrap P, Watkins DJ, Mukherjee B, Rosario-Pabón ZY, Vélez-Vega CM, Alshawabkeh AN, Cordero JF, Meeker JD (2021) Maternal metals/metalloid blood levels are associated with lipidomic profiles among pregnant women in Puerto Rico. Front Public Health 9:754706. https://doi.org/10.3389/fpubh.2021.754706 · DOI
  40. Du X, Zhang J, Zhang X, Schramm KW, Nan B, Huang Q, Tian M, Shen H (2021) Persistence and reversibility of arsenic-induced gut microbiome and metabolome shifts in male rats after 30-days recovery duration. Sci Total Environ 776:145972. https://doi.org/10.1016/j.scitotenv.2021.145972 · DOI
  41. Kahrstrom CT, Pariente N, Weiss U (2016) Intestinal microbiota in health and disease. Nature 535(7610):47 · DOI
  42. Colombo I, Aiello-Battan F, Elena R, Ruiz A, Petraglia L, Musso CG (2021) Kidney-gut crosstalk in renal disease. Ir J Med Sci 190(3):1205–1212. https://doi.org/10.1007/s11845-020-02437-7 · DOI
  43. Sun N, Zhu B, Xin J, Li L, Gan B, Cao X, Fang J, Pan K, Jing B, Zeng Y, Lv C, Zhao L, Zeng D, Xu P, Wang H, Ni X (2022) Psychoactive effects of Lactobacillus johnsonii BS15 on preventing memory dysfunction induced by acute ethanol exposure through modulating intestinal microenvironment and improving alcohol metabolic level. Front Microbiol 13:847468. https://doi.org/10.3389/fmicb.2022.847468 · DOI
  44. Fu R, Niu R, Zhao F, Wang J, Cao Q, Yu Y, Liu C, Zhang D, Sun Z (2022) Exercise alleviated intestinal damage and microbial disturbances in mice exposed to fluoride. Chemosphere 288(Pt 3):132658. https://doi.org/10.1016/j.chemosphere.2021.132658 · DOI · Paper page
  45. Niu S, Zhu X, Zhang J, Ma Y, Lang X, Luo L, Li W, Zhao Y, Zhang Z (2022) Arsenic trioxide modulates the composition and metabolic function of the gut microbiota in a mouse model of rheumatoid arthritis. Int Immunopharmacol 111:109159. https://doi.org/10.1016/j.intimp.2022.109159 · DOI
  46. Chen F, Luo Y, Li C, Wang J, Chen L, Zhong X, Zhang B, Zhu Q, Zou R, Guo X, Zhou Y, Guo L (2021) Sub-chronic low-dose arsenic in rice exposure induces gut microbiome perturbations in mice. Ecotoxicol Environ Saf 227:112934. https://doi.org/10.1016/j.ecoenv.2021.112934 · DOI
  47. Zhao M, Chen C, Yuan Z, Li W, Zhang M, Cui N, Duan Y, Zhang X, Zhang P (2021) Dietary Bacillus subtilis supplementation alleviates alcohol-induced liver injury by maintaining intestinal integrity and gut microbiota homeostasis in mice. Exp Ther Med 22(5):1312. https://doi.org/10.3892/etm.2021.10747 · DOI
  48. Liu Y, Yin F, Huang L, Teng H, Shen T, Qin H (2021) Long-term and continuous administration of Bacillus subtilis during remission effectively maintains the remission of inflammatory bowel disease by protecting intestinal integrity, regulating epithelial proliferation, and reshaping microbial structure and function. Food Funct 12(5):2201–2210. https://doi.org/10.1039/d0fo02786c · DOI
  49. Choi J, Kwon H, Kim YK, Han PL (2022) Extracellular vesicles from gram-positive and gram-negative probiotics remediate stress-induced depressive behavior in mice. Mol Neurobiol 59(5):2715–2728. https://doi.org/10.1007/s12035-021-02655-9 · DOI
  50. Wang R, Lin F, Ye C, Aihemaitijiang S, Halimulati M, Huang X, Jiang Z, Li L, Zhang Z (2023) Multi-omics analysis reveals therapeutic effects of Bacillus subtilis-fermented Astragalus membranaceus in hyperuricemia via modulation of gut microbiota. Food Chem 399:133993. https://doi.org/10.1016/j.foodchem.2022.133993 · DOI
  51. Chan KC, Kok KE, Huang KF, Weng YL, Chung YC (2020) Effects of fermented red bean extract on nephropathy in streptozocin-induced diabetic rats. Food Nutr Res 64:4272. https://doi.org/10.29219/fnr.v64.4272 · DOI
  52. Zhu A, Yang X, Bai L, Hou Y, Guo C, Zhao D, Wen M, Jiang P, Liu Y, Huang Y, Li C, Meng H (2020) Analysis of microbial changes in the tonsillar formalin-fixed paraffin-embedded tissue of Chinese patients with IgA nephropathy. Pathol Res Pract 216(11):153174. https://doi.org/10.1016/j.prp.2020.153174 · DOI
  53. Ryan MP, Pembroke JT (2018) Brevundimonas spp: Emerging global opportunistic pathogens. Virulence 9(1):480–493. https://doi.org/10.1080/21505594.2017.1419116 · DOI
  54. Paramasivam V, Paez A, Verma A, Landry D, Braden GL (2021) Brevundimonas vesicularis peritonitis in a chronic peritoneal dialysis patient. Case Rep Nephrol Dial 11(3):314–320. https://doi.org/10.1159/000517140 · DOI
  55. Mondal P, Chattopadhyay A (2020) Environmental exposure of arsenic and fluoride and their combined toxicity: A recent update. J Appl Toxicol 40(5):552–566. https://doi.org/10.1002/jat.3931 · DOI
  56. Flora SJ, Mittal M, Mishra D (2009) Co-exposure to arsenic and fluoride on oxidative stress, glutathione linked enzymes, biogenic amines and DNA damage in mouse brain. J Neurol Sci 285(1–2):198–205. https://doi.org/10.1016/j.jns.2009.07.001 · DOI
  57. Ma Y, Ma Z, Yin S, Yan X, Wang J (2017) Arsenic and fluoride induce apoptosis, inflammation and oxidative stress in cultured human umbilical vein endothelial cells. Chemosphere 167:454–461. https://doi.org/10.1016/j.chemosphere.2016.10.025 · DOI
  58. Ma Y, Niu R, Sun Z, Wang J, Luo G, Zhang J, Wang J (2012) Inflammatory responses induced by fluoride and arsenic at toxic concentration in rabbit aorta. Arch Toxicol 86(6):849–856. https://doi.org/10.1007/s00204-012-0803-9 · DOI
  59. Flora SJ, Pachauri V, Mittal M, Kumar D (2011) Interactive effect of arsenic and fluoride on cardio-respiratory disorders in male rats: possible role of reactive oxygen species. Biometals 24(4):615–628. https://doi.org/10.1007/s10534-011-9412-y · DOI
  60. Liu P, Li R, Tian X, Zhao Y, Li M, Wang M, Ying X, Yuan J, Xie J, Yan X, Lyu Y, Wei C, Qiu Y, Tian F, Zhao Q, Yan X (2021) Co-exposure to fluoride and arsenic disrupts intestinal flora balance and induces testicular autophagy in offspring rats. Ecotoxicol Environ Saf 222:112506. https://doi.org/10.1016/j.ecoenv.2021.112506 · DOI · Paper page

Cited by

Sorted by citations

See all 9

Metadata

Authors
Tian, X., Yan, X., Chen, X., Liu, P., Sun, Z., & Niu, R.
Venue
Biological Trace Element Research
Publisher
Springer Science and Business Media LLC
Published
2023-01-24
Volume
201
Issue
10
Pages
4870-4881
ISSN
  • 0163-4984
  • 1559-0720
DOI
10.1007/s12011-023-03568-5
Cited by
9
References
2
Language
en
Licence
Funders
  • Shanxi Graduate Education Innovation Program (2020BY051)
  • National Natural Science Foundation of China (82173644)

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review