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Intestinal barrier damage involved in intestinal microflora changes in fluoride-induced mice

Liu, Jing, Wang, Hong-wei, Lin, Lin, Miao, Cheng-yi, Zhang, Yan, Zhou, Bian-hua·2019·Chemosphere
DOI 10.1016/j.chemosphere.2019.06.080
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Abstract

Intestinal microflora play an important role in maintaining the homeostasis of the intestinal microenvironment, but fluoride-induced changes in intestinal mechanical barrier and intestinal microflora have not been well studied. Given this paucity of information, this study aims to determine the effects of high fluoride level on intestinal mechanical barrier and intestinal microflora in the cecum of mice. Seventy-two female 21-day-old Kunming mice were randomly assigned to three groups and raised for 70 days. Changes in intestinal pathomorphology and intestinal epithelial cell proliferation were observed by haematoxylin and eosin-staining and Brdu measurement, respectively. The distribution of goblet cells, glycoproteins and mast cells was analysed through Alcian blue and periodic acid-Schiff (AB-PAS) staining, Periodic Acid-Schiff (PAS) staining, and toluidine blue staining. Results showed that excessive fluoride damaged the structure of the cecal tissues, inhibited epithelial cell proliferation and decreased the relative distribution of goblet cells, glycoproteins and mast cells that are involved in defense responses. Intestinal microflora sequencing analysis revealed that the composition of the diversity and composition of intestinal microflora was altered by excessive fluoride based on 16S rRNA amplicon sequencing. The relative abundance of Firmicutes (P = 0.03174), Bacteroidetes (P = 0.04462), Actinobacteria (P = 0.01085) and Spirochacteria (P = 0.04084) was significantly…

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Metadata

Authors
Liu, J., Wang, H.-W., Lin, L., Miao, C.-Y., Zhang, Y., & Zhou, B.-H.
ORCID
Wang, Hong-wei
Venue
Chemosphere
Publisher
Elsevier BV
Published
2019-11
Volume
234
Pages
409-418
ISSN
0045-6535
DOI
10.1016/j.chemosphere.2019.06.080
Cited by
100
References
3
Language
en
Licence
Funders
National Natural Science Foundation of China

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