Emerging regulation and functions of autophagy

AMPK and mTOR regulate autophagy through direct phosphorylation of Ulk1

Kim, J., Kundu, M., Viollet, B., & Guan, K.-L. (2011) · Nature Cell Biology · doi:10.1038/ncb2152 · Cited by 7,227 · see citing works

Autophagy in the Pathogenesis of Disease

Levine, B., & Kroemer, G. (2008) · Cell · doi:10.1016/j.cell.2007.12.018 · Cited by 7,069 · see citing works

Autophagy fights disease through cellular self-digestion

Mizushima, N., Levine, B., Cuervo, A. M., & Klionsky, D. J. (2008) · Nature · doi:10.1038/nature06639 · Cited by 6,452 · see citing works

Parkin is recruited selectively to impaired mitochondria and promotes their autophagy

Narendra, D., Tanaka, A., Suen, D.-F., & Youle, R. J. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200809125 · Cited by 4,026 · see citing works

Autophagy regulates lipid metabolism

Singh, R., Kaushik, S., Wang, Y., Xiang, Y., Novak, I., Komatsu, M., Tanaka, K., Cuervo, A. M., & Czaja, M. J. (2009) · Nature · doi:10.1038/nature07976 · Cited by 3,975 · see citing works

Aerobic glycolysis: Meeting the metabolic requirements of cell proliferation

Lunt, S. Y., & Vander Heiden, M. G. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154237 · Cited by 3,057 · see citing works

The Role of Atg Proteins in Autophagosome Formation

Mizushima, N., Yoshimori, T., & Ohsumi, Y. (2011) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-092910-154005 · Cited by 2,978 · see citing works

Phosphorylation of ULK1 (hATG1) by AMP-Activated Protein Kinase Connects Energy Sensing to Mitophagy

Egan, D. F., Shackelford, D. B., Mihaylova, M. M., Gelino, S., Kohnz, R. A., Mair, W., Vasquez, D. S., Joshi, A., Gwinn, D. M., Taylor, R., et al. (2011) · Science · doi:10.1126/science.1196371 · Cited by 2,600 · see citing works

Eaten alive: a history of macroautophagy

Yang, Z., & Klionsky, D. J. (2010) · Nature Cell Biology · doi:10.1038/ncb0910-814 · Cited by 2,096 · see citing works

Autophagosome formation from membrane compartments enriched in phosphatidylinositol 3-phosphate and dynamically connected to the endoplasmic reticulum

Axe, E. L., Walker, S. A., Manifava, M., Chandra, P., Roderick, H. L., Habermann, A., Griffiths, G., & Ktistakis, N. T. (2008) · The Journal of Cell Biology · doi:10.1083/jcb.200803137 · Cited by 1,885 · see citing works

Selective autophagy mediated by autophagic adapter proteins

Johansen, T., & Lamark, T. (2011) · Autophagy · doi:10.4161/auto.7.3.14487 · Cited by 1,730 · see citing works

Deconvoluting the context-dependent role for autophagy in cancer

White, E. (2012) · Nature reviews. Cancer · doi:10.1038/nrc3262 · Cited by 1,698 · see citing works

Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells

Liu, L., Feng, D., Chen, G., Chen, M., Zheng, Q., Song, P., Ma, Q., Zhu, C., Wang, R., Qi, W., et al. (2012) · Nature Cell Biology · doi:10.1038/ncb2422 · Cited by 1,689 · see citing works

mTORC1 Senses Lysosomal Amino Acids Through an Inside-Out Mechanism That Requires the Vacuolar H ⁺ -ATPase

Zoncu, R., Bar-Peled, L., Efeyan, A., Wang, S., Sancak, Y., & Sabatini, D. M. (2011) · Science · doi:10.1126/science.1207056 · Cited by 1,673 · see citing works

PINK1-dependent recruitment of Parkin to mitochondria in mitophagy

Vives-Bauza, C., Zhou, C., Huang, Y., Cui, M., de Vries, R. L. A., Kim, J., May, J., Tocilescu, M. A., Liu, W., Ko, H. S., et al. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0911187107 · Cited by 1,616 · see citing works

Network organization of the human autophagy system

Behrends, C., Sowa, M. E., Gygi, S. P., & Harper, J. W. (2010) · Nature · doi:10.1038/nature09204 · Cited by 1,554 · see citing works

A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

Lee, I. H., Cao, L., Mostoslavsky, R., Lombard, D. B., Liu, J., Bruns, N. E., Tsokos, M., Alt, F. W., & Finkel, T. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0712145105 · Cited by 1,473 · see citing works

Autophagy modulation as a potential therapeutic target for diverse diseases

Rubinsztein, D. C., Codogno, P., & Levine, B. (2012) · Nature Reviews Drug Discovery · doi:10.1038/nrd3802 · Cited by 1,429 · see citing works

Mitochondria Supply Membranes for Autophagosome Biogenesis during Starvation

Hailey, D. W., Rambold, A. S., Satpute‐Krishnan, P., Mitra, K., Sougrat, R., Kim, P. K., & Lippincott‐Schwartz, J. (2010) · Cell · doi:10.1016/j.cell.2010.04.009 · Cited by 1,419 · see citing works

HIF-1: upstream and downstream of cancer metabolism

Semenza, G. L. (2009) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2009.10.009 · Cited by 1,381 · see citing works

Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction

Shi, C.-S., Shenderov, K., Huang, N.-N., Kabat, J., Abu-Asab, M., Fitzgerald, K. A., Sher, A., & Kehrl, J. H. (2012) · Nature Immunology · doi:10.1038/ni.2215 · Cited by 1,367 · see citing works

Toll-like receptor signalling in macrophages links the autophagy pathway to phagocytosis

Sanjuan, M. A., Dillon, C. P., Tait, S. W. G., Moshiach, S., Dorsey, F., Connell, S., Komatsu, M., Tanaka, K., Cleveland, J. L., Withoff, S., et al. (2007) · Nature · doi:10.1038/nature06421 · Cited by 1,347 · see citing works

JNK1-Mediated Phosphorylation of Bcl-2 Regulates Starvation-Induced Autophagy

Wei, Y., Pattingre, S., Sinha, S., Bassik, M., & Levine, B. (2008) · Molecular Cell · doi:10.1016/j.molcel.2008.06.001 · Cited by 1,329 · see citing works

Calpain-mediated cleavage of Atg5 switches autophagy to apoptosis

Yousefi, S., Perozzo, R., Schmid, I., Ziemiecki, A., Schaffner, T. J., Scapozza, L., Brunner, T., & Simon, H. (2006) · Nature Cell Biology · doi:10.1038/ncb1482 · Cited by 1,300 · see citing works

Phosphorylation of the Autophagy Receptor Optineurin Restricts <i>Salmonella</i> Growth

Wild, P., Farhan, H., McEwan, D. G., Wagner, S., Rogov, V. V., Brady, N. R., Richter, B., Korac, J., Waidmann, O., Choudhary, C., et al. (2011) · Science · doi:10.1126/science.1205405 · Cited by 1,298 · see citing works

Atg8, a Ubiquitin-like Protein Required for Autophagosome Formation, Mediates Membrane Tethering and Hemifusion

Nakatogawa, H., Ichimura, Y., & Ohsumi, Y. (2007) · Cell · doi:10.1016/j.cell.2007.05.021 · Cited by 1,215 · see citing works

A subdomain of the endoplasmic reticulum forms a cradle for autophagosome formation

Hayashi, M., Fujita, N., Noda, T., Yamaguchi, A., Yoshimori, T., & Yamamoto, A. (2009) · Nature Cell Biology · doi:10.1038/ncb1991 · Cited by 1,050 · see citing works

Autophagy‐based unconventional secretory pathway for extracellular delivery of IL‐1β

Dupont, N., Jiang, S., Pilli, M., Ornatowski, W., Bhattacharya, D., & Deretic, V. (2011) · The EMBO Journal · doi:10.1038/emboj.2011.398 · Cited by 967 · see citing works

Autophagy, Immunity, and Microbial Adaptations

Deretic, V. P., & Levine, B. (2009) · Cell Host & Microbe · doi:10.1016/j.chom.2009.05.016 · Cited by 868 · see citing works

Mitochondria-Anchored Receptor Atg32 Mediates Degradation of Mitochondria via Selective Autophagy

Okamoto, K., Kondo‐Okamoto, N., & Ohsumi, Y. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.013 · Cited by 867 · see citing works

Subversion of Cellular Autophagosomal Machinery by RNA Viruses

Jackson, W. T., Giddings, T. H., Taylor, M. P., Mulinyawe, S. B., Rabinovitch, M., Kopito, R. R., & Kirkegaard, K. (2005) · PLoS Biology · doi:10.1371/journal.pbio.0030156 · Cited by 820 · see citing works

Differential Regulation of Distinct Vps34 Complexes by AMPK in Nutrient Stress and Autophagy

Kim, J., Kim, Y. C., Fang, C., Russell, R. C., Kim, J. H., Fan, W., Liu, R., Zhong, Q., & Guan, K. (2013) · Cell · doi:10.1016/j.cell.2012.12.016 · Cited by 806 · see citing works

Ubiquitination and selective autophagy

Shaid, S., Brandts, C. H., Serve, H., & Dikic, I. (2013) · Cell Death &amp; Differentiation · doi:10.1038/cdd.2012.72 · Cited by 800 · see citing works

Atg32 Is a Mitochondrial Protein that Confers Selectivity during Mitophagy

Kanki, T., Wang, K., Cao, Y., Baba, M., & Klionsky, D. J. (2009) · Developmental Cell · doi:10.1016/j.devcel.2009.06.014 · Cited by 798 · see citing works

HDAC6 controls autophagosome maturation essential for ubiquitin‐selective quality‐control autophagy

Lee, J., Koga, H., Kawaguchi, Y., Tang, W., Wong, E., Gao, Y., Pandey, U. B., Kaushik, S., Tresse, E., Lu, J., et al. (2010) · The EMBO Journal · doi:10.1038/emboj.2009.405 · Cited by 756 · see citing works

Extracellular M. tuberculosis DNA Targets Bacteria for Autophagy by Activating the Host DNA-Sensing Pathway

Watson, R. O., Manzanillo, P. S., & Cox, J. S. (2012) · Cell · doi:10.1016/j.cell.2012.06.040 · Cited by 755 · see citing works

Akt-Mediated Regulation of Autophagy and Tumorigenesis Through Beclin 1 Phosphorylation

Wang, R. C., Wei, Y., An, Z., Zou, Z., Xiao, G., Bhagat, G., White, M., Reichelt, J., & Levine, B. (2012) · Science · doi:10.1126/science.1225967 · Cited by 728 · see citing works

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

Matsumoto, G., Wada, K., Okuno, M., Kurosawa, M., & Nukina, N. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.07.039 · Cited by 692 · see citing works

Hierarchy of Atg proteins in pre‐autophagosomal structure organization

Suzuki, K., Kubota, Y., Sekito, T., & Ohsumi, Y. (2007) · Genes to Cells · doi:10.1111/j.1365-2443.2007.01050.x · Cited by 691 · see citing works

Caspase-mediated cleavage of Beclin-1 inactivates Beclin-1-induced autophagy and enhances apoptosis by promoting the release of proapoptotic factors from mitochondria

Wirawan, E., Walle, L. V., Kersse, K., Cornelis, S., Claerhout, S., Vanoverberghe, I., Roelandt, R., Rycke, R. M. D., Verspurten, J., Declercq, W., et al. (2010) · Cell Death and Disease · doi:10.1038/cddis.2009.16 · Cited by 680 · see citing works

3D tomography reveals connections between the phagophore and endoplasmic reticulum

Ylä‐Anttila, P., Vihinen, H., Jokitalo, E., & Eskelinen, E. (2009) · Autophagy · doi:10.4161/auto.5.8.10274 · Cited by 670 · see citing works

Autophagy Gene-Dependent Clearance of Apoptotic Cells during Embryonic Development

Qu, X., Zou, Z., Sun, Q., Luby‐Phelps, K., Cheng, P., Hogan, R. N., Gilpin, C. J., & Levine, B. (2007) · Cell · doi:10.1016/j.cell.2006.12.044 · Cited by 655 · see citing works

Spatial Coupling of mTOR and Autophagy Augments Secretory Phenotypes

Narita, M., Young, A. R. J., Arakawa, S., Samarajiwa, S. A., Nakashima, T., Yoshida, S., Hong, S., Berry, L. S., Reichelt, S., Ferreira, M., et al. (2011) · Science · doi:10.1126/science.1205407 · Cited by 594 · see citing works

DAP‐kinase‐mediated phosphorylation on the BH3 domain of beclin 1 promotes dissociation of beclin 1 from Bcl‐XL and induction of autophagy

Zalckvar, E., Berissi, H., Mizrachy, L., Idelchuk, Y., Koren, I., Eisenstein, M., Sabanay, H., Pinkas‐Kramarski, R., & Kimchi, A. (2009) · The EMBO Reports · doi:10.1038/embor.2008.246 · Cited by 592 · see citing works

The Atg5–Atg12 conjugate associates with innate antiviral immune responses

Jounai, N., Takeshita, F., Kobiyama, K., Sakaue-Sawano, A., Miyawaki, A., Xin, K.-Q., Ishii, K. J., Kawai, T., Akira, S., Suzuki, K., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0704014104 · Cited by 562 · see citing works

Atg8‐family interacting motif crucial for selective autophagy

Noda, N. N., Ohsumi, Y., & Inagaki, F. (2010) · FEBS Letters · doi:10.1016/j.febslet.2010.01.018 · Cited by 556 · see citing works

Canonical and non-canonical autophagy: variations on a common theme of self-eating?

Codogno, P., Mehrpour, M., & Proikas‐Cezanne, T. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3249 · Cited by 545 · see citing works

Spermidine and resveratrol induce autophagy by distinct pathways converging on the acetylproteome

Morselli, E., Mariño, G., Bennetzen, M. V., Eisenberg, T., Megalou, E. V., Schroeder, S., Cabrera, S., Bénit, P., Rustin, P., Criollo, A., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201008167 · Cited by 495 · see citing works

Mechanisms of Autophagosome Biogenesis

Rubinsztein, D. C., Shpilka, T., & Elazar, Z. (2012) · Current Biology · doi:10.1016/j.cub.2011.11.034 · Cited by 489 · see citing works

Autophagy Proteins Regulate the Secretory Component of Osteoclastic Bone Resorption

DeSelm, C. J., Miller, B. C., Zou, W., Beatty, W. L., van Meel, E., Takahata, Y., Klumperman, J., Tooze, S. A., Teitelbaum, S. L., & Virgin, H. W. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.08.016 · Cited by 487 · see citing works

Image-based genome-wide siRNA screen identifies selective autophagy factors

Orvedahl, A., Sumpter, R., Xiao, G., Ng, A., Zou, Z., Tang, Y., Narimatsu, M., Gilpin, C. J., Sun, Q., Roth, M. G., et al. (2011) · Nature · doi:10.1038/nature10546 · Cited by 486 · see citing works

Apoptosis blocks Beclin 1-dependent autophagosome synthesis: an effect rescued by Bcl-xL

Luo, S., & Rubinsztein, D. C. (2009) · Cell Death and Differentiation · doi:10.1038/cdd.2009.121 · Cited by 481 · see citing works

Autophagy machinery mediates macroendocytic processing and entotic cell death by targeting single membranes

Florey, O., Kim, S. E., Sandoval, C. P., Haynes, C. M., & Overholtzer, M. (2011) · Nature Cell Biology · doi:10.1038/ncb2363 · Cited by 459 · see citing works

Unconventional secretion of Acb1 is mediated by autophagosomes

Duran, J. M., Anjard, C., Stefan, C., Loomis, W. F., & Malhotra, V. (2010) · Journal of Cell Biology · doi:10.1083/jcb.200911154 · Cited by 433 · see citing works

Anticancer Targets in the Glycolytic Metabolism of Tumors: A Comprehensive Review

Porporato, P. E., Dhup, S., Dadhich, R. K., Copetti, T., & Sonveaux, P. (2011) · Frontiers in Pharmacology · doi:10.3389/fphar.2011.00049 · Cited by 424 · see citing works

Autophagosome-Independent Essential Function for the Autophagy Protein Atg5 in Cellular Immunity to Intracellular Pathogens

Zhao, Z., Fux, B., Goodwin, M., Dunay, I. R., Strong, D. W., Miller, B. C., Cadwell, K., Delgado, M. A., Ponpuak, M., Green, K. G., et al. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.10.003 · Cited by 413 · see citing works

Coronaviruses Hijack the LC3-I-Positive EDEMosomes, ER-Derived Vesicles Exporting Short-Lived ERAD Regulators, for Replication

Reggiori, F., Monastyrska, I., Verheije, M. H., Calí, T., Ulaşlı, M., Bianchi, S., Bernasconi, R., de Haan, C. A. M., & Molinari, M. (2010) · Cell Host & Microbe · doi:10.1016/j.chom.2010.05.013 · Cited by 383 · see citing works

GSK3-TIP60-ULK1 Signaling Pathway Links Growth Factor Deprivation to Autophagy

Lin, S.-Y., Li, T. Y., Liu, Q., Zhang, C., Li, X., Chen, Y., Zhang, S.-M., Lian, G., Liu, Q., Ruan, K., et al. (2012) · Science · doi:10.1126/science.1217032 · Cited by 365 · see citing works

Selective Subversion of Autophagy Complexes Facilitates Completion of the Brucella Intracellular Cycle

Starr, T., Child, R., Wehrly, T. D., Hansen, B. T., Hwang, S., López-Otı́n, C., Virgin, H. W., & Celli, J. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2011.12.002 · Cited by 341 · see citing works

Regulation of the autophagy protein LC3 by phosphorylation

Cherra, S. J., Kulich, S. M., Uechi, G. T., Balasubramani, M., Mountzouris, J. A., Day, B. W., & Chu, C. T. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.201002108 · Cited by 341 · see citing works

Unconventional secretion of Pichia pastoris Acb1 is dependent on GRASP protein, peroxisomal functions, and autophagosome formation

Manjithaya, R. R., Anjard, C., Loomis, W. F., & Subramani, S. E. (2010) · The Journal of Cell Biology · doi:10.1083/jcb.200911149 · Cited by 337 · see citing works

LC3C, Bound Selectively by a Noncanonical LIR Motif in NDP52, Is Required for Antibacterial Autophagy

von Muhlinen, N., Akutsu, M., Ravenhill, B. J., Foeglein, Á., Bloor, S., Rutherford, T. J., Freund, S. M. V., Komander, D., & Randow, F. (2012) · Molecular Cell · doi:10.1016/j.molcel.2012.08.024 · Cited by 332 · see citing works

LC3 and GATE-16 N Termini Mediate Membrane Fusion Processes Required for Autophagosome Biogenesis

Weidberg, H., Shpilka, T., Shvets, E., Abada, A., Shimron, F., & Elazar, Z. (2011) · Developmental Cell · doi:10.1016/j.devcel.2011.02.006 · Cited by 326 · see citing works

The Tor and PKA signaling pathways independently target the Atg1/Atg13 protein kinase complex to control autophagy

Stephan, J. S., Yeh, Y.-Y., Ramachandran, V., Deminoff, S. J., & Herman, P. K. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0903316106 · Cited by 306 · see citing works

The Autophagy Protein Atg12 Associates with Antiapoptotic Bcl-2 Family Members to Promote Mitochondrial Apoptosis

Rubinstein, A. D., Eisenstein, M., Ber, Y., Bialik, S., & Kimchi, A. (2011) · Molecular Cell · doi:10.1016/j.molcel.2011.10.014 · Cited by 303 · see citing works

ATG12 Conjugation to ATG3 Regulates Mitochondrial Homeostasis and Cell Death

Radoshevich, L., Murrow, L., Chen, N., Fernandez, E., Roy, S., Fung, C., & Debnath, J. (2010) · Cell · doi:10.1016/j.cell.2010.07.018 · Cited by 290 · see citing works

Warburg Meets Autophagy: Cancer-Associated Fibroblasts Accelerate Tumor Growth and Metastasis via Oxidative Stress, Mitophagy, and Aerobic Glycolysis

Pavlides, S., Vera, I., Gândara, R., Sneddon, S., Pestell, R. G., Mercier, I., Martinez‐Outschoorn, U., Whitaker‐Menezes, D., Howell, A., Sotgia, F., et al. (2011) · Antioxidants and Redox Signaling · doi:10.1089/ars.2011.4243 · Cited by 289 · see citing works

miR-375 Inhibits Autophagy and Reduces Viability of Hepatocellular Carcinoma Cells Under Hypoxic Conditions

Chang, Y., Yan, W., He, X., Zhang, L., Li, C., Huang, H., Nace, G., Geller, D. A., Lin, J., & Tsung, A. (2012) · Gastroenterology · doi:10.1053/j.gastro.2012.04.009 · Cited by 288 · see citing works

Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy

Itakura, E., Kishi-Itakura, C., Koyama-Honda, I., & Mizushima, N. (2012) · Journal of Cell Science · doi:10.1242/jcs.094110 · Cited by 286 · see citing works

Liver autophagy contributes to the maintenance of blood glucose and amino acid levels

Ezaki, J., Matsumoto, N., Takeda‐Ezaki, M., Komatsu, M., Takahashi, K., Hiraoka, Y., Taka, H., Fujimura, T., Takehana, K., Yoshida, M., et al. (2011) · Autophagy · doi:10.4161/auto.7.7.15371 · Cited by 282 · see citing works

Trs85 directs a Ypt1 GEF, TRAPPIII, to the phagophore to promote autophagy

Lynch-Day, M. A., Bhandari, D., Menon, S., Huang, J., Cai, H., Bartholomew, C. R., Brumell, J. H., Ferro‐Novick, S., & Klionsky, D. J. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000063107 · Cited by 278 · see citing works

Regulation of Autophagy by the p300 Acetyltransferase

Lee, I. H., & Finkel, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m807135200 · Cited by 276 · see citing works

Non‐autophagic roles of autophagy‐related proteins

Subramani, S. E., & Malhotra, V. (2013) · EMBO Reports · doi:10.1038/embor.2012.220 · Cited by 276 · see citing works

Pex3‐anchored Atg36 tags peroxisomes for degradation in Saccharomyces cerevisiae

Motley, A. M., Nuttall, J. M., & Hettema, E. H. (2012) · The EMBO Journal · doi:10.1038/emboj.2012.151 · Cited by 267 · see citing works

Function and Molecular Mechanism of Acetylation in Autophagy Regulation

Yi, C., Ma, M., Ran, L., Zheng, J., Tong, J., Zhu, J., Ma, C., Sun, Y., Zhang, S., Feng, W., et al. (2012) · Science · doi:10.1126/science.1216990 · Cited by 258 · see citing works

Nondegradative Role of Atg5-Atg12/ Atg16L1 Autophagy Protein Complex in Antiviral Activity of Interferon Gamma

Hwang, S., Maloney, N. S., Bruinsma, M. W., Goel, G., Duan, E., Zhang, L., Shrestha, B., Diamond, M., Dani, A., Sosnovtsev, S. V., et al. (2012) · Cell Host & Microbe · doi:10.1016/j.chom.2012.03.002 · Cited by 249 · see citing works

Autophagy and senescence in cancer-associated fibroblasts metabolically supports tumor growth and metastasis, via glycolysis and ketone production

Capparelli, C., Guido, C., Whitaker‐Menezes, D., Bonuccelli, G., Balliet, R. M., Pestell, T. G., Goldberg, A. F., Pestell, R. G., Howell, A., Sneddon, S., et al. (2012) · Cell Cycle · doi:10.4161/cc.20718 · Cited by 235 · see citing works

Multiple roles of the cytoskeleton in autophagy

Monastyrska, I., Rieter, E., Klionsky, D. J., & Reggiori, F. (2009) · Biological reviews/Biological reviews of the Cambridge Philosophical Society · doi:10.1111/j.1469-185x.2009.00082.x · Cited by 223 · see citing works

Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation

Deretic, V. P., Jiang, S., & Dupont, N. (2012) · Trends in Cell Biology · doi:10.1016/j.tcb.2012.04.008 · Cited by 218 · see citing works

Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion

Bruns, C., McCaffery, J. M., Curwin, A. J., Durán, J. M., & Malhotra, V. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201106098 · Cited by 205 · see citing works

Autophagy: Regulation and role in disease

Meijer, A. J., & Codogno, P. (2009) · Critical Reviews in Clinical Laboratory Sciences · doi:10.1080/10408360903044068 · Cited by 199 · see citing works

Maturing reticulocytes internalize plasma membrane in glycophorin A–containing vesicles that fuse with autophagosomes before exocytosis

Griffiths, R. E., Kupzig, S., Cogan, N. M., Mankelow, T. J., Betin, V. M. S., Trakarnsanga, K., Massey, E., Lane, J. D., Parsons, S. F., & Anstee, D. J. (2012) · Blood · doi:10.1182/blood-2011-09-376475 · Cited by 182 · see citing works

Metabolic Profiling of Hypoxic Cells Revealed a Catabolic Signature Required for Cell Survival

Frezza, C., Zheng, L., Tennant, D. A., Papkovsky, D. B., Hedley, B. A., Kalna, G., Watson, D. G., & Gottlieb, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0024411 · Cited by 177 · see citing works

The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against<i>Salmonella</i>

Kageyama, S., Omori, H., Saitoh, T., Sone, T., Guan, J.-L., Akira, S., Imamoto, F., Noda, T., & Yoshimori, T. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e10-11-0893 · Cited by 175 · see citing works

Starvation Induced Cell Death in Autophagy-Defective Yeast Mutants Is Caused by Mitochondria Dysfunction

Suzuki, S. W., Onodera, J., & Ohsumi, Y. (2011) · PLoS ONE · doi:10.1371/journal.pone.0017412 · Cited by 169 · see citing works

The Three Musketeers of Autophagy: phosphorylation, ubiquitylation and acetylation

McEwan, D. G., & Đikić, I. (2011) · Trends in Cell Biology · doi:10.1016/j.tcb.2010.12.006 · Cited by 161 · see citing works

Autophagy: More Than a Nonselective Pathway

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Astrocyte dysfunction triggers neurodegeneration in a lysosomal storage disorder

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Glycogen Synthase Kinase-3 (GSK3) Inhibition Induces Prosurvival Autophagic Signals in Human Pancreatic Cancer Cells

Marchand, B., Arsenault, D., Raymond-Fleury, A., Boisvert, F., & Boucher, M. (2015) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.616714 · Cited by 166 · see citing works

Atg5-independent autophagy regulates mitochondrial clearance and is essential for iPSC reprogramming

Ma, T., Li, J., Xu, Y., Chen, Y., Xu, T., Wang, H., Liu, K., Cao, N., Nie, B., Zhu, S., et al. (2015) · Nature Cell Biology · doi:10.1038/ncb3256 · Cited by 167 · see citing works

Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization

Hernández‐Tiedra, S., Fabriàs, G., Dávila, D., Salanueva, Í. J., Casas, J., Montes, L. R., Antón, Z., García-Taboada, E., Salazar‐Roa, M., Lorente, M., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1213927 · Cited by 162 · see citing works

GFRA1 promotes cisplatin-induced chemoresistance in osteosarcoma by inducing autophagy

Kim, M., Jung, J.-Y., Choi, S., Lee, H., Morales, L. D., Koh, J.-T., Kim, S. H., Choi, Y.-D., Choi, C., Slaga, T. J., et al. (2016) · Autophagy · doi:10.1080/15548627.2016.1239676 · Cited by 160 · see citing works

Melatonin and Autophagy in Aging-Related Neurodegenerative Diseases

Luo, F., Sandhu, A. F., Rungratanawanich, W., Williams, G. E., Akbar, M. D., Zhou, S., Song, B., & Wang, X. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21197174 · Cited by 158 · see citing works

Reactive oxygen species (ROS) in cancer pathogenesis and therapy: An update on the role of ROS in anticancer action of benzophenanthridine alkaloids

Khan, A. Q., Rashid, K., AlAmodi, A. A., Agha, M. V., Akhtar, S., Hakeem, I., Raza, S. S., & Shahab Uddin, M. S. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.112142 · Cited by 160 · see citing works

Inflammatory Bowel Disease: Updates on Molecular Targets for Biologics

Katsanos, K. H., & Papadakis, K. A. (2017) · Gut and Liver · doi:10.5009/gnl16308 · Cited by 156 · see citing works

Autophagy: roles in intestinal mucosal homeostasis and inflammation

Haq, S., Grondin, J. A., Banskota, S., & Khan, W. I. (2019) · Journal of Biomedical Science · doi:10.1186/s12929-019-0512-2 · Cited by 159 · see citing works

Autophagy, a key mechanism of oncogenesis and resistance in leukemia

Auberger, P., & Puissant, A. (2016) · Blood · doi:10.1182/blood-2016-07-692707 · Cited by 153 · see citing works

The role of autophagy in hepatocellular carcinoma: friend or foe

Liu, L., Liao, J., He, X., & Li, P. (2017) · Oncotarget · doi:10.18632/oncotarget.17202 · Cited by 155 · see citing works

The lysosomal membrane protein LAMP2A promotes autophagic flux and prevents SNCA-induced Parkinson disease-like symptoms in the Drosophila brain

Issa, A.-R., Sun, J., Petitgas, C., Mesquita, A., Dulac, A., Robin, M., Mollereau, B., Jenny, A., Chérif‐Zahar, B., & Birman, S. (2018) · Autophagy · doi:10.1080/15548627.2018.1491489 · Cited by 152 · see citing works

Long-term live imaging reveals cytosolic immune responses of host hepatocytes against Plasmodium infection and parasite escape mechanisms

Prado, M., Eickel, N., Niz, M. D., Heitmann, A., Agop‐Nersesian, C., Wacker, R., Schmuckli‐Maurer, J., Caldelari, R., Janse, C. J., Khan, S. M., et al. (2015) · Autophagy · doi:10.1080/15548627.2015.1067361 · Cited by 152 · see citing works

Osteocyte apoptosis: the roles and key molecular mechanisms in resorption-related bone diseases

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Autophagy in kidney disease and aging: lessons from rodent models

Lenoir, O., Tharaux, P., & Huber, T. B. (2016) · Kidney International · doi:10.1016/j.kint.2016.04.014 · Cited by 150 · see citing works

1 Autophagy: New emerging functions and concepts

Boya, P., Reggiori, F., & Codogno, P. (2016)

Autophagy: machinery and regulation

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Autophagy in cells of the blood.

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The nonautophagic functions of autophagy-related proteins

Shang, J.-N., Yu, C.-G., Li, R. Q., Xi, Y., Jian, Y. J., Xu, N., & Chen, S. (2023) · Autophagy · doi:10.1080/15548627.2023.2254664 · Cited by 30 · see citing works

Autophagy at the crossroads of metabolism and cellular defense

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