The DOI matches its Crossref record; 103 of the 103 references it cites were found in a registry or an index.
P. aeruginosa Biofilms in CF Infection
Open accessAbstract
Pseudomonas aeruginosa is an opportunistic pathogen of immunocompromised hosts. In cystic fibrosis (CF), P. aeruginosa causes acute and chronic lung infections that result in significant morbidity and mortality. P. aeruginosa possesses several traits that contribute to its ability to colonize and persist in acute and chronic infections. These include high resistance to antimicrobials, ability to form biofilms, plethora of virulence products, and metabolic versatility. In P. aeruginosa, a cell-to-cell communication process termed quorum sensing (QS) regulates many of these factors that contribute to its pathogenesis. Recent evidence suggests that the CF lung environment presents a specialized niche for P. aeruginosa. The relationship of P. aeruginosa QS, biofilm formation, and the CF lung environment is discussed.
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Cites
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Biofilms: Survival Mechanisms of Clinically Relevant Microorganisms
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Self-citationFlagellar and twitching motility are necessary for Pseudomonas aeruginosa biofilm development
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“P. aeruginosa biofilm formation has been divided into various stages, including bacterial attachment and irreversible adhesion to a substratum, microcolony development, maturation of the biofilm demonstrated by the appearance of large structures resembling mushrooms and stalks with water channels, and dispersion of ba…”
BackgroundQuorum-sensing signals indicate that cystic fibrosis lungs are infected with bacterial biofilms
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Cited by
Colvin, K. M., Gordon, V. D., Murakami, K., Borlee, B. R., Wozniak, D. J., Wong, G. C. L., & Parsek, M. R. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1001264 · Cited by 577
Bacterial Biofilm Eradication Agents: A Current Review
Verderosa, A. D., Totsika, M., & Fairfull-Smith, K. E. (2019) · Frontiers in Chemistry · doi:10.3389/fchem.2019.00824 · Cited by 555
Biofilm-Specific Antibiotic Resistance
Mah, T.-F. (2012) · Future Microbiology · doi:10.2217/fmb.12.76 · Cited by 504
Regulation of Bacterial Virulence by Csr (Rsm) Systems
Vakulskas, C. A., Potts, A. H., Babitzke, P., Ahmer, B. M. M., & Romeo, T. (2015) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.00052-14 · Cited by 346
Park, S.-C., Park, Y., & Hahm, K.-S. (2011) · International Journal of Molecular Sciences · doi:10.3390/ijms12095971 · Cited by 327
Metadata
- Authors
- Wagner, V. E., & Iglewski, B. H.
- Venue
- Clinical Reviews in Allergy & Immunology
- Published
- 2008-05-29
- Volume
- 35
- Issue
- 3
- Pages
- 124-134
- ISSN
- 1080-0549 (ISSN-L)
- 1559-0267
- OpenAlex
- W2083456954
- Cited by
- 288
- References
- 103
- FWCI
- 9.80
- Type
- journal article
- Language
- en
- Open access
- hybrid
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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