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Cited by 645

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Respiratory Syncytial Virus—A Comprehensive Review

Open access
Borchers, Andrea T., Chang, Christopher, Gershwin, M. Eric, Gershwin, Laurel J.·2013·Clinical Reviews in Allergy & Immunology
DOI 10.1007/s12016-013-8368-9
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Abstract

Respiratory syncytial virus (RSV) is amongst the most important pathogenic infections of childhood and is associated with significant morbidity and mortality. Although there have been extensive studies of epidemiology, clinical manifestations, diagnostic techniques, animal models and the immunobiology of infection, there is not yet a convincing and safe vaccine available. The major histopathologic characteristics of RSV infection are acute bronchiolitis, mucosal and submucosal edema, and luminal occlusion by cellular debris of sloughed epithelial cells mixed with macrophages, strands of fibrin, and some mucin. There is a single RSV serotype with two major antigenic subgroups, A and B. Strains of both subtypes often co-circulate, but usually one subtype predominates. In temperate climates, RSV infections reflect a distinct seasonality with onset in late fall or early winter. It is believed that most children will experience at least one RSV infection by the age of 2 years. There are several key animal models of RSV. These include a model in mice and, more importantly, a bovine model; the latter reflects distinct similarity to the human disease. Importantly, the prevalence of asthma is significantly higher amongst children who are hospitalized with RSV in infancy or early childhood. However, there have been only limited investigations of candidate genes that have the potential to explain this increase in susceptibility. An atopic predisposition appears to predispose to subsequent development of asthma and it is likely that subsequent development of asthma is secondary to the pathogenic inflammatory response involving cytokines, chemokines and their cognate receptors. Numerous approaches to the development of RSV vaccines are being evaluated, as are the use of newer antiviral agents to mitigate disease. There is also significant attention being placed on the potential impact of co-infection and defining the natural history of RSV. Clearly, more research is required to define the relationships between RSV bronchiolitis, other viral induced inflammatory responses, and asthma.

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Metadata

Authors
Borchers, A. T., Chang, C., Gershwin, M. E., & Gershwin, L. J.
Venue
Clinical Reviews in Allergy & Immunology
Publisher
Springer Science and Business Media LLC
Published
2013-04-12
Volume
45
Issue
3
Pages
331-379
ISSN
  • 1080-0549 (ISSN-L)
  • 1559-0267
DOI
10.1007/s12016-013-8368-9
OpenAlex
W2063095964
Cited by
645
References
12
FWCI
16.21
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Respiratory Syncytial Virus—A Comprehensive Review. https://app.cochat.ai/papers/10.1007/s12016-013-8368-9
The paper
Borchers, A. T., Chang, C., Gershwin, M. E., & Gershwin, L. J. (2013). Respiratory Syncytial Virus—A Comprehensive Review. Clinical Reviews in Allergy & Immunology. https://doi.org/10.1007/s12016-013-8368-9

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.