Rhinovirus illnesses during infancy predict subsequent childhood wheezing
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Background The contribution of viral respiratory infections during infancy to the development of subsequent wheezing and/or allergic diseases in early childhood is not established.Objective To evaluate these relationships prospectively from birth to 3 years of age in 285 children genetically at high risk for developing allergic respiratory diseases.Methods By using nasal lavage, the relationship of timing, severity, and etiology of viral respiratory infections during infancy to wheezing in the 3rd year of life was evaluated. In addition, genetic and environmental factors that could modify risk of infections and wheezing prevalence were analyzed.Results Risk factors for 3rd year wheezing were passive smoke exposure (odds ratio [OR]=2.1), older siblings (OR=2.5), allergic sensitization to foods at age 1 year (OR=2.0), any moderate to severe respiratory illness without wheezing during infancy (OR=3.6), and at least 1 wheezing illness with respiratory syncytial virus (RSV; OR=3.0), rhinovirus (OR=10) and/or non-rhinovirus/RSV pathogens (OR=3.9) during infancy. When viral etiology was considered, 1st-year wheezing illnesses caused by rhinovirus infection were the strongest predictor of subsequent 3rd year wheezing (OR=6.6; P < .0001). Moreover, 63% of infants who wheezed during rhinovirus seasons continued to wheeze in the 3rd year of life, compared with only 20% of all other infants (OR=6.6; P < .0001).Conclusion In this population of children at increased risk of developing allergies and asthma, the most significant risk factor for the development of preschool childhood wheezing is the occurrence of symptomatic rhinovirus illnesses during infancy that are clinically and prognostically informative based on their seasonal nature.
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RSV interferes with normal repair processes by increasing MMP-2 and MMP-9 activity.
“RSV has also been described as interfering with normal repair processes by increasing MMP-2 and MMP-9 activity (160)”
From The airway epithelium: soldier in the fight against respiratory viruses (2011) · cites this paper as [160]
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Self-citation
- Authors
- Lemanske, R. F., Jackson, D. J., Gangnon, R. E., Evans, M. D., Li, Z., Shult, P. A., Kirk, C. J., Reisdorf, E., Roberg, K. A., Anderson, E. L., Carlson-Dakes, K. T., Adler, K. J., Gilbertson-White, S., Pappas, T. E., DaSilva, D. F., Tisler, C. J., & Gern, J. E.
- Affiliations
- University of Wisconsin–Madison (US)
- Institute for Medical Informatics and Biostatistics (CH)
- Corresponding author
- Lemanske, Robert F.
- Venue
- Journal of Allergy and Clinical Immunology
- Publisher
- Elsevier BV
- Published
- 2005-09
- Volume
- 116
- Issue
- 3
- Pages
- 571-577
- ISSN
- 0091-6749 (ISSN-L)
- OpenAlex
- W2086958200
- Cited by
- 735
- References
- 36
- Citations by year
- 2026: 7 · 2025: 17 · 2024: 14 · 2023: 13 · 2022: 28 · 2021: 22 · 2020: 24 · 2019: 32 · 2018: 28 · 2017: 27 · 2016: 35 · 2015: 37 · 2014: 46 · 2013: 46 · 2012: 52
- FWCI
- 28.16
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Journal of Allergy and Clinical Immunology (publishedVersion)
- PubMed (publishedVersion)
- Iowa Research Online (The University of Iowa) (submittedVersion)
- Funders
- Japan Association for Chemical Innovation
- National Institutes of Health (1P01HL70831-01)
- National Heart, Lung, and Blood Institute (1R01 HL 61879, R01HL061879, 1P01HLPO)
- Topics
- Health Sciences › Medicine › Physiology › Asthma and respiratory diseases
- Health Sciences › Medicine › Epidemiology › Respiratory viral infections research
- Health Sciences › Health Professions › Emergency Medical Services › Pediatric health and respiratory diseases
- Keywords
- rhinovirus infection, childhood wheezing, respiratory viral infections, infancy, respiratory syncytial virus, passive smoking, allergen sensitization, food allergy, preschool children, allergic respiratory diseases, nasal irrigation
- MeSH terms
- Child, Preschool, Common Cold, Humans, Infant, Infant, Newborn, Respiratory Sounds, Rhinovirus, Risk Factors
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