Cited by 112Pituitary Gland Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsAdrenal Hormones and Disorders

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Mortality in adults with hypopituitarism: a systematic review and meta-analysis

Jasim, Sina, Alahdab, Fares, Ahmed, Ahmed T., Tamhane, Shrikant, Prokop, Larry J., Nippoldt, Todd B., Murad, M. Hassan·2017·Endocrine

DOI 10.1007/s12020-016-1159-3

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Abstract

Purpose Hypopituitarism is a rare disorder with significant morbidity. To study the evidence on the association of premature mortality and hypopituitarism.Methods A comprehensive search of multiple databases: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus was conducted through August, 2015. Eligible studies that evaluated patients with hypopituitarism and reported mortality estimates were selected following a predefined protocol. Reviewers, independently and in duplicate, extracted data and assessed the risk of bias.Results We included 12 studies (published 1996-2015) that reported on 23,515 patients. Compared to the general population, hypopituitarism was associated with an overall excess mortality (weighted SMR of 1.55; 95 % CI 1.14-2.11), I 2 = 97.8 %, P = 0.000. Risk factors for increased mortality included younger age at diagnosis, female gender, diagnosis of craniopharyngioma, radiation therapy, transcranial surgery, diabetes insipidus and hypogonadism.Conclusion Hypopituitarism may be associated with premature mortality in adults. Risk is particularly higher in women and those diagnosed at a younger age.

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Authors: Jasim, S., Alahdab, F., Ahmed, A. T., Tamhane, S., Prokop, L. J., Nippoldt, T. B., & Murad, M. H.
Affiliations: Mayo Clinic (US)
Corresponding author: Murad, M. Hassan
ORCID: Jasim, Sina
Alahdab, Fares
Ahmed, Ahmed T.
Tamhane, Shrikant
Prokop, Larry J.
Murad, M. Hassan
Venue: Endocrine
Publisher: Springer Science and Business Media LLC
Published: 2016-11-05
Volume: 56
Issue: 1
Pages: 33-42
ISSN: 0969-711X (ISSN-L)
1355-008X
1559-0100
DOI: 10.1007/s12020-016-1159-3
OpenAlex: W2548728043
Cited by: 112
References: 42
Citations by year: 2026: 6 · 2025: 17 · 2024: 14 · 2023: 12 · 2022: 18 · 2021: 12 · 2020: 13 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 1
FWCI: 0.93
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (unspecified)
Locations: Endocrine (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords: hypopituitarism, premature mortality, risk factors, craniopharyngioma, radiotherapy, transcranial surgery, diabetes insipidus, hypogonadism, age at diagnosis, sex differences
MeSH terms: Adult, Age Factors, Craniopharyngioma, Female, Humans, Hypopituitarism, Male, Pituitary Neoplasms, Risk Factors, Sex Factors

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Mortality in adults with hypopituitarism: a systematic review and meta-analysis

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