The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Mortality in adults with hypopituitarism: a systematic review and meta-analysis
Abstract
Purpose Hypopituitarism is a rare disorder with significant morbidity. To study the evidence on the association of premature mortality and hypopituitarism.Methods A comprehensive search of multiple databases: MEDLINE, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, and Scopus was conducted through August, 2015. Eligible studies that evaluated patients with hypopituitarism and reported mortality estimates were selected following a predefined protocol. Reviewers, independently and in duplicate, extracted data and assessed the risk of bias.Results We included 12 studies (published 1996-2015) that reported on 23,515 patients. Compared to the general population, hypopituitarism was associated with an overall excess mortality (weighted SMR of 1.55; 95 % CI 1.14-2.11), I 2 = 97.8 %, P = 0.000. Risk factors for increased mortality included younger age at diagnosis, female gender, diagnosis of craniopharyngioma, radiation therapy, transcranial surgery, diabetes insipidus and hypogonadism.Conclusion Hypopituitarism may be associated with premature mortality in adults. Risk is particularly higher in women and those diagnosed at a younger age.
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“Left untreated, anterior pituitary deficiencies are associated with decreased health and quality of life [55-59].”
From Neuroendocrine Disruptions Following Head Injury (2023) · cites this paper as [56]
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“undiagnosed and untreated deficiencies confer increased morbidity and mortality, which can be reversed by appropriate hormone replacement.”
From Neuroendocrine Disruptions Following Head Injury (2023) · cites this paper as [56]
Citations
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Clinical Biology of the Pituitary Adenoma
Melmed, S. K., Kaiser, U. B., Lopes, M. B. S., Bertherat, J. Y., Syro, L. V., Raverot, G., Reincke, M., Johannsson, G., Beckers, A. M., Fleseriu, M., et al. (2022) · Endocrine Reviews · doi:10.1210/endrev/bnac010 · Cited by 362
Yuen, K. C. J., Biller, B. M. K., Radovick, S., Carmichael, J. D., Jasim, S., Pantalone, K. M., & Hoffman, A. R. (2019) · Endocrine Practice · doi:10.4158/gl-2019-0405 · Cited by 298
Self-citationFleseriu, M., Christ‐Crain, M., Langlois, F., Gadelha, M. R., & Melmed, S. K. (2024) · The Lancet · doi:10.1016/s0140-6736(24)00342-8 · Cited by 129
Functioning Pituitary Adenomas – Current Treatment Options and Emerging Medical Therapies
Varlamov, E. V., McCartney, S., & Fleseriu, M. (2019) · touchREVIEWS in Endocrinology · doi:10.17925/ee.2019.15.1.30 · Cited by 87
Cossu, G., Jouanneau, E., Cavallo, L. M., Elbabaa, S. K., Giammattei, L., Starnoni, D., Barges-Coll, J., Cappabianca, P., Beneš, V., Başkaya, M. K., et al. (2020) · Acta Neurochirurgica · doi:10.1007/s00701-020-04265-1 · Cited by 90
Metadata
- Authors
- Jasim, S., Alahdab, F., Ahmed, A. T., Tamhane, S., Prokop, L. J., Nippoldt, T. B., & Murad, M. H.
- Affiliations
- Mayo Clinic (US)
- Corresponding author
- Murad, M. Hassan
- Venue
- Endocrine
- Published
- 2016-11-05
- Volume
- 56
- Issue
- 1
- Pages
- 33-42
- ISSN
- 0969-711X (ISSN-L)
- 1355-008X
- 1559-0100
- OpenAlex
- W2548728043
- Cited by
- 112
- References
- 42
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 14 · 2023: 12 · 2022: 18 · 2021: 12 · 2020: 13 · 2019: 8 · 2018: 6 · 2017: 4 · 2016: 1
- FWCI
- 0.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- hypopituitarism, premature mortality, risk factors, craniopharyngioma, radiotherapy, transcranial surgery, diabetes insipidus, hypogonadism, age at diagnosis, sex differences
- MeSH terms
- Adult, Age Factors, Craniopharyngioma, Female, Humans, Hypopituitarism, Male, Pituitary Neoplasms, Risk Factors, Sex Factors
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