Increased serum levels of fetuin B in patients with coronary artery disease
Abstract
Background Recent evidence indicates a pivotal role for fetuin B, one of the cystatin superfamily of cysteine protease inhibitors, in the pathogenesis of metabolic diseases. This study investigated whether serum fetuin B levels are associated with the presence of coronary artery disease.Methods Serum fetuin B levels were assessed in 87 patients with coronary artery disease (41 with acute coronary syndromes and 46 with stable angina pectoris) and 87 healthy controls using an enzyme-linked immunosorbent assay. The association of serum fetuin B levels with cardiac risk factors was analyzed.Results Serum fetuin B levels were significantly higher in patients with coronary artery disease than those in healthy controls (90.7 ± 32.1 vs. 110.0 ± 32.7 μg/ml, P < 0.001), extremely elevated in group with acute coronary syndromes (115.0 ± 35.2 μg/ml). Pearson correlation analysis showed that serum fetuin B levels were positively associated with the levels of total cholesterol (r = 0.276, P < 0.001), low-density lipoprotein cholesterol (r = 0.363, P < 0.001), and fasting blood glucose (r = 0.159, P < 0.05). In addition, multiple logistic regression analyses revealed that fetuin B was independently associated with the presence of coronary artery disease (OR, 1.019; 95% CI, 1.009 to 1.029; P < 0.001) and acute coronary syndromes (OR, 1.017; 95% CI, 1.006 to 1.028; P < 0.01).Conclusions Our data revealed that high fetuin B levels are associated with the presence of coronary artery disease and acute coronary syndromes, and that fetuin B may serve as a potential biomarker for coronary artery disease.
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Fetuin-B positively correlates with LDL-c levels.
“Finally, fetuin-B also negatively impacts metabolism because its serum level is higher in patients with coronary artery disease, especially in those with the acute coronary syndrome, and it still positively correlates with LDL-c levels [114].”
From Adipokines, Myokines, and Hepatokines: Crosstalk and Metabolic Repercussions (2021) · cites this paper as [114]
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- Authors
- Zhu, K., Wang, Y., Shu, P., Zhou, Q., Zhu, J., Zhou, W., Du, C., Xu, C., Liu, X., & Tang, L.
- Affiliations
- First Affiliated Hospital Zhejiang University (CN)
- Affiliated Hangzhou First People's Hospital, Westlake University, School of Medicine (CN)
- The University of Texas at Dallas (US)
- Zhejiang University (CN)
- Zhejiang Hospital (CN)
- Wenzhou Medical University (CN)
- Corresponding author
- Tang, Lijiang
- Venue
- Endocrine
- Published
- 2017-08-19
- Volume
- 58
- Issue
- 1
- Pages
- 97-105
- ISSN
- 0969-711X (ISSN-L)
- 1355-008X
- 1559-0100
- OpenAlex
- W2746057256
- Cited by
- 33
- References
- 31
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 4 · 2023: 7 · 2022: 2 · 2021: 6 · 2020: 3 · 2019: 3 · 2018: 2
- FWCI
- 1.71
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Endocrine (publishedVersion)
- PubMed (publishedVersion)
- Funders
- the Major Program for the Zhejiang Science and Technology Agency (2012C13018-1)
- the Program of Zhejiang Health Department (201353645)
- the Medical and Health Science Program of Zhejiang (2015KYB158)
- Topics
- Health Sciences › Medicine › Epidemiology › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes, Cardiovascular Risks, and Lipoproteins
- Keywords
- fetuin-B, coronary artery disease, acute coronary syndrome, stable angina, cystatin superfamily, cysteine protease inhibitors, serum biomarkers, LDL cholesterol, total cholesterol, fasting blood glucose, cardiovascular risk factors
- MeSH terms
- Aged, Aged, 80 and over, Angina Pectoris, Blood Glucose, Cholesterol, Coronary Artery Disease, Female, Humans, Cholesterol, HDL, Cholesterol, LDL, Male, Middle Aged, Risk Factors, ROC Curve, Biomarkers, Acute Coronary Syndrome, Fetuin-B
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