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Cited by 176Forensic Toxicology and Drug AnalysisAutopsy Techniques and OutcomesHistorical and Scientific Studies

The DOI matches its Crossref record; 17 of the 17 references it cites were found in a registry or an index.

Postmortem toxicology

Skopp, Gisela·2010·Forensic Science, Medicine, and Pathology
DOI 10.1007/s12024-010-9150-4
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Abstract

Results from toxicological analyses in death investigations are used to determine whether foreign substances were a cause of death, whether they contributed to death, or whether they caused impairment. Drug concentrations are likely to change during pre-terminal stages due to altered pharmacokinetics, to treatment during resuscitation or in the intensive care unit, to concomitant illness or to the presence of drug tolerance. The potential for postmortem changes must be considered in all but a few drugs. Formation of new entities as well as degradation of drugs may occur, especially in putrefied corpses; in addition, body fluids and tissues may be severely affected by autolysis and putrefaction. Specimens should be selected based on individual case history and on their availability. Analytical procedures should be performed in accordance with a proper quality assurance program for toxicological investigations. Problems are most likely to occur during the isolation and identification of a drug. Interpretation of analytical results is often limited by the inadequate information provided in a particular case.

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Registry

Crossref · 10.1007/s12024-010-9150-4

Cites

17 of 17 references verified0 citation errors · 0 not checkable

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Citations

Cites

Show all 16 references

Research works printed but not linked: 4

  1. Madea R, Dettmeyer R, unter Mitarbeit von Mußhoff F. Basiswissen Rechtsmedizin. Berlin, Heidelberg: Springer; 2007. pp. 182–217.
  2. Tiess D. Asservierung, Exhumierung, Thanatochemie. In: Madea B, Brinkmann B (Hrsg). Handbuch gerichtliche Medizin, Bd. 2. Berlin, Heidelberg, New York: Springer. pp. 70–88.
  3. Ludewig R. Akute Vergiftungen. Ratgeber zur Erkennung, Verlauf, Behandlung und Verhütung toxikologischer Notfälle. Stuttgart: 9. Aufl., Wissenschaftliche Verlagsgesellschaft mbH; 1999. pp. 31–37.
  4. Skopp G, v. Meyer, L. Empfehlungen der Gesellschaft für Toxikologische und Forensische Chemie (GTFCh) zur Asservierung von Obduktionsmaterial für forensisch-toxikologische Untersuchungen. Toxichem + Krimtech 2004;71:101–7.

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Metadata

Authors
Skopp, G.
Affiliations
Heidelberg University (DE)
Corresponding author
Skopp, Gisela
ORCID
Skopp, Gisela
Venue
Forensic Science, Medicine, and Pathology
Publisher
Springer Science and Business Media LLC
Published
2010-03-04
Volume
6
Issue
4
Pages
314-325
ISSN
  • 1547-769X (ISSN-L)
  • 1556-2891
DOI
10.1007/s12024-010-9150-4
OpenAlex
W4240389001
Semantic Scholar
b995434b824e829ec5fc3e4adb7e2415f36efd0f
Cited by
176
References
16
Citations by year
2026: 6 · 2025: 8 · 2024: 15 · 2023: 17 · 2022: 17 · 2021: 13 · 2020: 14 · 2019: 6 · 2018: 12 · 2017: 12 · 2016: 9 · 2015: 11 · 2014: 7 · 2013: 15 · 2012: 7
FWCI
11.35
Type
journal article
Language
en
Open access
closed
Licence
www.springer.com/tdm (tdm)
Locations
  • Forensic Science Medicine and Pathology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Toxicology › Forensic Toxicology and Drug Analysis
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Autopsy Techniques and Outcomes
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Historical and Scientific Studies
Keywords
postmortem toxicology, postmortem changes, drug degradation, putrefaction, autolysis, pharmacokinetics, drug tolerance, specimen selection, death investigation, drug identification
MeSH terms
Autopsy, Body Fluids, Cause of Death, Drug Therapy, Humans, Pharmacokinetics, Poisoning, Postmortem Changes, Specimen Handling, Reproducibility of Results, Substance Abuse Detection, Artifacts, Substance-Related Disorders, Forensic Toxicology

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