Activity-Dependent Neuroprotective Protein Modulates Its Own Gene Expression
Abstract
We investigated whether activity-dependent neuroprotective protein (ADNP) could autoregulate its own expression. Both the endogenous ADNP gene and reporter gene constructs were analysed in response to overexpression of ADNP, supplied either as wild-type ADNP or a mutant form lacking the NAP motif, a motif which has neuroprotective properties. Overexpression of these two forms of ADNP resulted in both decreased endogenous ADNP expression and repressed ADNP promoter-directed reporter gene activity. Chromatin immunoprecipitation demonstrated the ability of ADNP to bind to its own promoter which is consistent with its action as a repressor of both promoter-supported and endogenous ADNP expression.
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Because ADNP expression is controlled by an autoregulatory negative feedback loop, the overall upregulation might result from the mutant protein's inability to bind the ADNP promoter.
“Since ADNP expression is under control of an autoregulatory negative feedback loop33, the overall upregulation might be a consequence of the inability of the mutant protein to bind the ADNP promoter.”
From A SWI/SNF-related autism syndrome caused by de novo mutations in ADNP (2014) · cites this paper as [33]
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A SWI/SNF-related autism syndrome caused by de novo mutations in ADNP
Helsmoortel, C., Vulto-van Silfhout, A. T., Coe, B. P., Vandeweyer, G., Rooms, L., van den Ende, J., Schuurs-Hoeijmakers, J. H. M., Marcelis, C. L., Willemsen, M. H., Vissers, L. E. L. M., et al. (2014) · Nature Genetics · doi:10.1038/ng.2899 · Cited by 354 · see citing works
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- Authors
- Aboonq, M. S., Vasiliou, S. A., Haddley, K., Quinn, J. P., & Bubb, V. J.
- Affiliations
- University of Liverpool (GB)
- Corresponding author
- Bubb, Vivien J.
- Venue
- Journal of Molecular Neuroscience
- Published
- 2011-06-07
- Volume
- 46
- Issue
- 1
- Pages
- 33-39
- ISSN
- 0895-8696 (ISSN-L)
- 1559-1166
- OpenAlex
- W2049741427
- Cited by
- 23
- References
- 31
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 3 · 2021: 1 · 2020: 1 · 2019: 1 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2 · 2014: 3
- FWCI
- 0.60
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Molecular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Biotechnology and Biological Sciences Research Council
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nuclear Receptors and Signaling
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Genomics and Chromatin Dynamics
- Keywords
- ADNP, transcriptional repression, promoter binding, neuroprotection
- MeSH terms
- Gene Expression Regulation, HeLa Cells, Humans, Nerve Tissue Proteins, Neurons, Promoter Regions, Genetic, Genes, Reporter, Homeodomain Proteins, Cell Line, Tumor
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