Activity-dependent neuroprotective protein (ADNP) exhibits striking sexual dichotomy impacting on autistic and Alzheimer’s pathologies

Analyzing real-time PCR data by the comparative CT method

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De novo mutations in schizophrenia implicate synaptic networks

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Complete Sequence of a Novel Protein Containing a Femtomolar‐Activity‐Dependent Neuroprotective Peptide

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Cloning and Characterization of the Human Activity-dependent Neuroprotective Protein

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Autophagy has a key role in the pathophysiology of schizophrenia

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Activity-dependent neuroprotective protein: a novel gene essential for brain formation

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Activity-Dependent Neuroprotective Protein Snippet NAP Reduces Tau Hyperphosphorylation and Enhances Learning in a Novel Transgenic Mouse Model

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A Neuronal Microtubule-Interacting Agent, NAPVSIPQ, Reduces Tau Pathology and Enhances Cognitive Function in a Mouse Model of Alzheimer’s Disease

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Activity-dependent neuroprotective protein (ADNP) differentially interacts with chromatin to regulate genes essential for embryogenesis

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Mnk kinase pathway: Cellular functions and biological outcomes

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Activity-dependent Neuroprotective Protein Constitutes a Novel Element in the SWI/SNF Chromatin Remodeling Complex

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The NAP motif of activity-dependent neuroprotective protein (ADNP) regulates dendritic spines through microtubule end binding proteins

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Decreased serum levels of transforming growth factor-β1 in patients with autism

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Ageing and the regulation of protein synthesis: a balancing act?

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NAP protects memory, increases soluble tau and reduces tau hyperphosphorylation in a tauopathy model

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Effect of the neuroprotective peptide davunetide (AL-108) on cognition and functional capacity in schizophrenia

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A mutation affecting the sodium/proton exchanger, SLC9A6, causes mental retardation with tau deposition

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Depletion of MAP2 expression and laminar cytoarchitectonic changes in dorsolateral prefrontal cortex in adult autistic individuals

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Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1

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Heterozygous Ambra1 Deficiency in Mice: A Genetic Trait with Autism-Like Behavior Restricted to the Female Gender

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The rescue of microtubule-dependent traffic recovers mitochondrial function in Parkinson's disease

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The SWI/SNF Chromatin Remodeling Subunit BAF57 Is a Critical Regulator of Estrogen Receptor Function in Breast Cancer Cells

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ADNP Differential Nucleus/Cytoplasm Localization in Neurons Suggests Multiple Roles in Neuronal Differentiation and Maintenance

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Addressing Alzheimers Disease Tangles: From NAP to AL-108

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Activity-dependent neuroprotector homeobox protein: A candidate protein identified in serum as diagnostic biomarker for Alzheimer's disease

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The ADNP Derived Peptide, NAP Modulates the Tubulin Pool: Implication for Neurotrophic and Neuroprotective Activities

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Intranasal administration of NAP, a neuroprotective peptide, decreases anxiety-like behavior in aging mice in the elevated plus maze

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Selective deletion of forebrain glycogen synthase kinase 3β reveals a central role in serotonin-sensitive anxiety and social behaviour

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NAP (davunetide) rescues neuronal dysfunction in a Drosophila model of tauopathy

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Activity-Dependent Neurotrophic Factor-9 and NAP Promote Neurite Outgrowth in Rat Hippocampal and Cortical Cultures

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Effects of Davunetide on N-acetylaspartate and Choline in Dorsolateral Prefrontal Cortex in Patients with Schizophrenia

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Activity-dependent neuroprotective protein (ADNP) expression level is correlated with the expression of the sister protein ADNP2: Deregulation in schizophrenia

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Prohibitin and the SWI/SNF ATPase subunit BRG1 are required for effective androgen antagonist-mediated transcriptional repression of androgen receptor-regulated genes

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Sexual dimorphism of activity-dependent neuroprotective protein in the mouse arcuate nucleus

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NAP (davunetide) enhances cognitive behavior in the STOP heterozygous mouse—A microtubule-deficient model of schizophrenia

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Novel Marker for the Onset of Frontotemporal Dementia: Early Increase in Activity-Dependent Neuroprotective Protein (ADNP) in the Face of Tau Mutation

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The Synaptic Protein Neuroligin-1 Interacts with the Amyloid β-Peptide. Is There a Role in Alzheimer’s Disease?

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The Translational Repression Mediated by the Platelet-derived Growth Factor 2/c-sis mRNA Leader Is Relieved during Megakaryocytic Differentiation

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Novel Evolutionary-conserved Role for the Activity-dependent Neuroprotective Protein (ADNP) Family That Is Important for Erythropoiesis

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A novel missense mutation (Leu46Val) of PAX6 found in an autistic patient

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Expression of Activity-Dependent Neuroprotective Protein in the Immune System: Possible Functions and Relevance to Multiple Sclerosis

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ZMIZ1 Preferably Enhances the Transcriptional Activity of Androgen Receptor with Short Polyglutamine Tract

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Protection Against Tauopathy by the Drug Candidates NAP (Davunetide) and D-SAL: Biochemical, Cellular and Behavioral Aspects

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A sex-specific association of common variants of neuroligin genes (NLGN3 and NLGN4X) with autism spectrum disorders in a Chinese Han cohort

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Tracking a refined eIF4E-binding motif reveals Angel1 as a new partner of eIF4E

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NAP Alpha-Aminoisobutyric Acid (IsoNAP)

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Novel Tubulin and Tau Neuroprotective Fragments Sharing Structural Similarities with the Drug Candidate NAP (Davuentide)

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Activity-Dependent Neuroprotective Protein Modulates Its Own Gene Expression

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Protein Synthesis in Rat Brain Microvessels Decreases with Aging

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Chapter 20. Davunetide (NAP) Pharmacology: Neuroprotection and Tau

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P3‐428: Activity‐dependent neuroprotective protein (ADNP) is regulated in the brains of mouse models of human tauopathies: Toward davunetide replacement therapy

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Maternal immune activation: Implications for neuropsychiatric disorders

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Deficient autophagy in microglia impairs synaptic pruning and causes social behavioral defects

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Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications

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Genetics and genomics of autism spectrum disorder: embracing complexity

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Decreased peripheral brain-derived neurotrophic factor levels in Alzheimer’s disease: a meta-analysis study (N=7277)

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Discovery of autism/intellectual disability somatic mutations in Alzheimer’s brains: mutated ADNP cytoskeletal impairments and repair as a case study

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ADNP/NAP dramatically increase microtubule end-binding protein–Tau interaction: a novel avenue for protection against tauopathy

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Activity-dependent neuroprotective protein deficiency models synaptic and developmental phenotypes of autism-like syndrome

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Tauopathy in the young autistic brain: novel biomarker and therapeutic target

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Sexual divergence in microtubule function: the novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory

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Sex-Dependent Effects of Perinatal Inflammation on the Brain: Implication for Neuro-Psychiatric Disorders

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Novel ADNP Syndrome Mice Reveal Dramatic Sex-Specific Peripheral Gene Expression With Brain Synaptic and Tau Pathologies

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Premature primary tooth eruption in cognitive/motor-delayed ADNP-mutated children

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Erratum: Premature primary tooth eruption in cognitive/motor-delayed ADNP-mutated children

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The autism/neuroprotection-linked ADNP/NAP regulate the excitatory glutamatergic synapse

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Introducing ADNP and SIRT1 as new partners regulating microtubules and histone methylation

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ADNP Plays a Key Role in Autophagy: From Autism to Schizophrenia and Alzheimer's Disease

Sragovich, S., Wagner, A. M., & Gozes, I. (2017) · BioEssays · doi:10.1002/bies.201700054 · Cited by 62 · see citing works

What we can learn from a genetic rodent model about autism

Möhrle, D., Fernández, M. C., Peñagarikano, O., Frick, A., Allman, B. L., & Schmid, S. (2019) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2019.12.015 · Cited by 59 · see citing works

Blood-Borne Activity-Dependent Neuroprotective Protein (ADNP) is Correlated with Premorbid Intelligence, Clinical Stage, and Alzheimer’s Disease Biomarkers

Malishkevich, A., Marshall, G. A., Schultz, A. P., Sperling, R. A., Aharon‐Peretz, J., & Gozes, I. (2016) · Journal of Alzheimer s Disease · doi:10.3233/jad-150799 · Cited by 60 · see citing works

Proteomics of autism and Alzheimer’s mouse models reveal common alterations in mTOR signaling pathway

Mencer, S., Kartawy, M., Lendenfeld, F. V., Soluh, H., Tripathi, M. K., Халиулин, И. Г., & Amal, H. (2021) · Translational Psychiatry · doi:10.1038/s41398-021-01578-2 · Cited by 55 · see citing works

The autism-mutated ADNP plays a key role in stress response

Sragovich, S., Ziv, Y., Vaisvaser, S., Shomron, N., Hendler, T., & Gozes, I. (2019) · Translational Psychiatry · doi:10.1038/s41398-019-0569-4 · Cited by 51 · see citing works

The Eight and a Half Year Journey of Undiagnosed AD: Gene Sequencing and Funding of Advanced Genetic Testing Has Led to Hope and New Beginnings

Gozes, I., Patterson, M. C., Dijck, A. V., Kooy, R. F., Peeden, J., Eichenberger, J. A., Zawacki-Downing, A., & Bedrosian‐Sermone, S. (2017) · Frontiers in Endocrinology · doi:10.3389/fendo.2017.00107 · Cited by 50 · see citing works

Chromatin remodeler Activity-Dependent Neuroprotective Protein (ADNP) contributes to syndromic autism

D’Incal, C. P., Rossem, K. E. V., Man, K. D., Konings, A., Dijck, A. V., Rizzuti, L., Vitriolo, A., Testa, G., Gozes, I., Berghe, W. V., et al. (2023) · Clinical Epigenetics · doi:10.1186/s13148-023-01450-8 · Cited by 51 · see citing works

Sexual dimorphism of AMBRA1-related autistic features in human and mouse

Mitjans, M., Begemann, M., Ju, A., Dere, E., Wüstefeld, L., Hofer, S., Hassouna, I. A., Balkenhol, J., Oliveira, B., der Auwera, S. V., et al. (2017) · Translational Psychiatry · doi:10.1038/tp.2017.213 · Cited by 45 · see citing works

Mutations in ADNP affect expression and subcellular localization of the protein

Cappuyns, E., Huyghebaert, J., Vandeweyer, G., & Kooy, R. F. (2018) · Cell Cycle · doi:10.1080/15384101.2018.1471313 · Cited by 41 · see citing works

The Compassionate Side of Neuroscience: Tony Sermone’s Undiagnosed Genetic Journey—ADNP Mutation

Gozes, I., Helsmoortel, C., Vandeweyer, G., der Aa, N. V., Kooy, R. F., & Bedrosian‐Sermone, S. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0586-6 · Cited by 41 · see citing works

The ADNP Syndrome and CP201 (NAP) Potential and Hope

Gozes, I. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.608444 · Cited by 39 · see citing works

Proteomic phenotype of cerebral organoids derived from autism spectrum disorder patients reveal disrupted energy metabolism, cellular components, and biological processes

Ilieva, M. S., Aldana, B. I., Vinten, K. T., Hohmann, S. S., Woofenden, T. W., Lukjanska, R., Waagepetersen, H. S., & Michel, T. M. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01627-2 · Cited by 37 · see citing works

Adnp-mutant mice with cognitive inflexibility, CaMKIIα hyperactivity, and synaptic plasticity deficits

Cho, H., Yoo, T., Moon, H., Kang, H., Yang, Y., Kang, M., Yang, E., Lee, D., Hwang, D., Kim, H., et al. (2023) · Molecular Psychiatry · doi:10.1038/s41380-023-02129-5 · Cited by 36 · see citing works

The cytoplasmic localization of ADNP through 14-3-3 promotes sex-dependent neuronal morphogenesis, cortical connectivity, and calcium signaling

Bennison, S. A., Blazejewski, S. M., Liu, X., Hacohen-Kleiman, G., Sragovich, S., Zoidou, S., Touloumi, O., Grigoriadis, N., Gozes, I., & Toyo-oka, K. (2023) · Molecular Psychiatry · doi:10.1038/s41380-022-01939-3 · Cited by 42 · see citing works

Atypical Auditory Brainstem Response and Protein Expression Aberrations Related to ASD and Hearing Loss in the Adnp Haploinsufficient Mouse Brain

Hacohen-Kleiman, G., Barnea, O. Y., Touloumi, O., Lagoudaki, R., Avraham, K. B., Grigoriadis, N., & Gozes, I. (2019) · Neurochemical Research · doi:10.1007/s11064-019-02723-6 · Cited by 35 · see citing works

Molecular causes of sex‐specific deficits in rodent models of neurodevelopmental disorders

Mossa, A., & Manzini, M. C. (2019) · Journal of Neuroscience Research · doi:10.1002/jnr.24577 · Cited by 36 · see citing works

Cellular and animal models of skin alterations in the autism-related ADNP syndrome

Mollinedo, P., Kapitansky, O., González‐Lamuño, D., Zaslavsky, A., Real, P. J., Gozes, I., Gandarillas, A., & Fernández-Luna, J. L. (2019) · Scientific Reports · doi:10.1038/s41598-018-36859-2 · Cited by 34 · see citing works

Distinct Impairments Characterizing Different ADNP Mutants Reveal Aberrant Cytoplasmic-Nuclear Crosstalk

Ganaiem, M., Karmon, G., Ivashko‐Pachima, Y., & Gozes, I. (2022) · Cells · doi:10.3390/cells11192994 · Cited by 33 · see citing works

Convergence of spectrums: neuronal gene network states in autism spectrum disorder

Sullivan, J. M., Rubeis, S. D., & Schaefer, A. (2019) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2019.04.011 · Cited by 30 · see citing works

Medial prefrontal cortex circuitry and social behaviour in autism

Mediane, D. H., Basu, S., Cahill, E., & Anastasiades, P. G. (2024) · Neuropharmacology · doi:10.1016/j.neuropharm.2024.110101 · Cited by 33 · see citing works

Molecular mechanisms for targeted ASD treatments

Basilico, B., Morandell, J., & Novarino, G. (2020) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2020.06.004 · Cited by 30 · see citing works

Reciprocal control of translation and transcription in autism spectrum disorder

Longo, F., & Klann, E. (2021) · EMBO Reports · doi:10.15252/embr.202052110 · Cited by 27 · see citing works

A convergent mechanism of high risk factors ADNP and POGZ in neurodevelopmental disorders

Conrow‐Graham, M., Williams, J. B., Martin, J. A., Zhong, P., Cao, Q., Rein, B. A., & Yan, Z. (2022) · Brain · doi:10.1093/brain/awac152 · Cited by 28 · see citing works

Davunetide sex-dependently boosts memory in prodromal Alzheimer’s disease

Gozes, I., Blatt, J., & Lobyntseva, A. (2024) · Translational Psychiatry · doi:10.1038/s41398-024-03118-0 · Cited by 27 · see citing works

Activity-dependent neuroprotective protein (ADNP)-end-binding protein (EB) interactions regulate microtubule dynamics toward protection against tauopathy

Ivashko‐Pachima, Y., & Gozes, I. (2020) · Progress in molecular biology and translational science · doi:10.1016/bs.pmbts.2020.07.008 · Cited by 25 · see citing works

Unexpected gender differences in progressive supranuclear palsy reveal efficacy for davunetide in women

Gozes, I., Shapira, G., Lobyntseva, A., & Shomron, N. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02618-9 · Cited by 26 · see citing works

Integrative proteogenomic analyses of human tumours identifies ADNP as a novel oncogenic mediator of cell cycle progression in high-grade serous ovarian cancer with poor prognosis

Karagoz, K., Mehta, G. A., Khella, C. A., Khanna, P., & Gatza, M. L. (2019) · EBioMedicine · doi:10.1016/j.ebiom.2019.11.009 · Cited by 25 · see citing works

Age and Sex-Dependent ADNP Regulation of Muscle Gene Expression Is Correlated with Motor Behavior: Possible Feedback Mechanism with PACAP

Kapitansky, O., Sragovich, S., Jaljuli, I., Hadar, A., Giladi, E., & Gozes, I. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21186715 · Cited by 21 · see citing works

Activity-dependent neuroprotective protein (ADNP) is an alcohol-responsive gene and negative regulator of alcohol consumption in female mice

Ziv, Y., Rahamim, N., Lezmy, N., Even‐Chen, O., Shaham, O., Malishkevich, A., Giladi, E., Elkon, R., Gozes, I., & Barak, S. (2018) · Neuropsychopharmacology · doi:10.1038/s41386-018-0132-7 · Cited by 22 · see citing works

Exploring the heterogeneity of neural social indices for genetically distinct etiologies of autism

Hudac, C. M., Stessman, H. A. F., DesChamps, T. D., Kresse, A., Faja, S., Neuhaus, E., Webb, S. J., Eichler, E. E., & Bernier, R. (2017) · Journal of Neurodevelopmental Disorders · doi:10.1186/s11689-017-9199-4 · Cited by 23 · see citing works

Single Cell ADNP Predictive of Human Muscle Disorders: Mouse Knockdown Results in Muscle Wasting

Kapitansky, O., Karmon, G., Sragovich, S., Hadar, A., Shahoha, M., Jaljuli, I., Bikovski, L., Giladi, E., Pálovics, R., Iram, T., et al. (2020) · Cells · doi:10.3390/cells9102320 · Cited by 20 · see citing works

ADNP is essential for sex-dependent hippocampal neurogenesis, through male unfolded protein response and female mitochondrial gene regulation

Shapira, G., Karmon, G., Hacohen-Kleiman, G., Ganaiem, M., Shazman, S., Theotokis, P., Grigoriadis, N., Shomron, N., & Gozes, I. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02879-w · Cited by 20 · see citing works

Sexual divergence in activity‐dependent neuroprotective protein impacting autism, schizophrenia, and A lzheimer's disease

Gozes, I. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23808 · Cited by 20 · see citing works

ADNP: in search for molecular mechanisms and innovative therapeutic strategies for frontotemporal degeneration

Gozes, I., & Ivashko‐Pachima, Y. (2015) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2015.00205 · Cited by 18 · see citing works

Characterization of Proteins Present in Isolated Senile Plaques from Alzheimer’s Diseased Brains by MALDI-TOF MS with MS/MS

Kelley, A. R., Perry, G. L., & Bach, S. B. H. (2018) · ACS Chemical Neuroscience · doi:10.1021/acschemneuro.7b00445 · Cited by 18 · see citing works

Somatic Mutations and Alzheimer’s Disease

Downey, J., Lam, J. C. K., Li, V. O. K., & Gozes, I. (2022) · Journal of Alzheimer s Disease · doi:10.3233/jad-220643 · Cited by 17 · see citing works

Avian models for brain mechanisms underlying altered social behavior in autism

Csillag, A., Ádám, Á., & Zachár, G. (2022) · Frontiers in Physiology · doi:10.3389/fphys.2022.1032046 · Cited by 17 · see citing works

Sensitivity to gene dosage and gene expression affects genes with copy number variants observed among neuropsychiatric diseases

Yamasaki, M., Makino, T. T., Khor, S., Toyoda, H., Miyagawa, T., Liu, X., Kuwabara, H., Kano, Y., Shimada, T., Sugiyama, T., et al. (2020) · BMC Medical Genomics · doi:10.1186/s12920-020-0699-9 · Cited by 17 · see citing works

D-SAL and NAP: Two Peptides Sharing a SIP Domain

Gozes, I., Sragovich, S., Schirer, Y., & Idan-Feldman, A. (2016) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0701-8 · Cited by 17 · see citing works

ADNP Regulates Cognition: A Multitasking Protein

Gozes, I. (2018) · Frontiers in Neuroscience · doi:10.3389/fnins.2018.00873 · Cited by 16 · see citing works

Sleep Problems in Children with ASD and Gene Disrupting Mutations

Earl, R. K., Ward, T., Gerdts, J. A., Eichler, E. E., Bernier, R., & Hudac, C. M. (2021) · The Journal of Genetic Psychology · doi:10.1080/00221325.2021.1922869 · Cited by 15 · see citing works

Regulation of UV-B-Induced Inflammatory Mediators by Activity-Dependent Neuroprotective Protein (ADNP)-Derived Peptide (NAP) in Corneal Epithelium

Maugeri, G., D’Amico, A. G., Magrì, B., Giunta, S., Musumeci, G., Saccone, S., Federico, C., Scollo, D., Longo, A., Avitabile, T., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24086895 · Cited by 15 · see citing works

The chromatin remodeler ADNP regulates neurodevelopmental disorder risk genes and neocortical neurogenesis

Clémot-Dupont, S., Fernandes, J. A. L., Larrigan, S., Sun, X., Medisetti, S., Stanley, R., Hankouri, Z. E., Joshi, S. V., Picketts, D. J., Shekhar, K., et al. (2025) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2405981122 · Cited by 13 · see citing works

ADNP differentially interact with genes/proteins in correlation with aging: a novel marker for muscle aging

Kapitansky, O., & Gozes, I. (2019) · GeroScience · doi:10.1007/s11357-019-00079-x · Cited by 15 · see citing works

Paracrine effects of intraocularly implanted cells on degenerating retinas in mice

Liu, X., Chen, F., Chen, Y., Lü, H., Lu, X., Peng, X., Kaplan, H. J., Dean, D. C., Gao, L., & Liu, Y. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01651-5 · Cited by 15 · see citing works

Increased serum FGF2 levels in first-episode, drug-free patients with schizophrenia

Li, X.-S., Wu, H., Yu, Y., Chen, G.-Y., Qin, X., Zheng, G.-E., Deng, W., & Cheng, Y. (2018) · Neuroscience Letters · doi:10.1016/j.neulet.2018.08.046 · Cited by 15 · see citing works

Microbiota changes associated with ADNP deficiencies: rapid indicators for NAP (CP201) treatment of the ADNP syndrome and beyond

Kapitansky, O., Giladi, E., Jaljuli, I., Bereswill, S., Heimesaat, M. M., & Gozes, I. (2020) · Journal of Neural Transmission · doi:10.1007/s00702-020-02155-5 · Cited by 15 · see citing works

Intranasal NAP (Davunetide): Neuroprotection and circadian rhythmicity

Galushkin, A., & Gozes, I. (2025) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2025.115573 · Cited by 14 · see citing works

Alterations in Activity-Dependent Neuroprotective Protein in Sporadic and Experimental Parkinson’s Disease

Chu, Y., Morfini, G. A., & Kordower, J. H. (2016) · Journal of Parkinson s Disease · doi:10.3233/jpd-160812 · Cited by 14 · see citing works

Sex dimorphism and tissue specificity of gene expression changes in aging mice

Zhu, D., Arnold, M. W., Samuelson, B. A., Wu, J. Z., Mueller, A. L., Sinclair, D. A., & Kane, A. E. (2024) · Biology of Sex Differences · doi:10.1186/s13293-024-00666-4 · Cited by 14 · see citing works

ADNP/ADNP2 expression in oligodendrocytes: implication for myelin-related neurodevelopment

Malishkevich, A., Leyk, J., Goldbaum, O., Richter‐Landsberg, C., & Gozes, I. (2015) · Journal of Molecular Neuroscience · doi:10.1007/s12031-015-0640-4 · Cited by 13 · see citing works

Sex Differences in Mouse Models of Autism Spectrum Disorders: Their Potential to Uncover the Impact of Brain Sexual Differentiation on Gender Bias

Murta, V., Seiffe, A., & Depino, A. M. (2023) · Sexes · doi:10.3390/sexes4030024 · Cited by 12 · see citing works

Tau Diagnostics and Clinical Studies

Gozes, I., Höglinger, G. U., Quinn, J. P., Hooper, N. M., & Höglund, K. (2017) · Journal of Molecular Neuroscience · doi:10.1007/s12031-017-0983-0 · Cited by 12 · see citing works

Animal models of autism: a perspective from autophagy mechanisms

Dana, H., Tahtasakal, R., & Şener, E. F. (2020) · Journal of Translational Genetics and Genomics · doi:10.20517/jtgg.2020.25 · Cited by 12 · see citing works

Tau, ADNP , and sex

Gozes, I. (2023) · Cytoskeleton · doi:10.1002/cm.21776 · Cited by 11 · see citing works

ADNP: A major autism mutated gene is differentially distributed (age and gender) in the songbird brain

Hacohen-Kleiman, G., Barnea, A., & Gozes, I. (2015) · Peptides · doi:10.1016/j.peptides.2015.04.008 · Cited by 11 · see citing works

Activity-Dependent Neuroprotective Protein (ADNP): An Overview of Its Role in the Eye

Maugeri, G., D’Amico, A. G., Magrì, B., Musumeci, G., & D’Agata, V. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232113654 · Cited by 10 · see citing works

Helsmoortel–van der Aa syndrome in a Chinese pediatric patient due to ADNP nonsense mutation: A case report

Chen, L., You, Z.-M., Chen, W.-H., Yang, S., Feng, C.-C., Wang, H., Wang, T., & Zhu, Y. (2023) · Frontiers in Pediatrics · doi:10.3389/fped.2023.1122513 · Cited by 10 · see citing works

Sex-and Region-Dependent Expression of the Autism-Linked ADNP Correlates with Social- and Speech-Related Genes in the Canary Brain

Hacohen-Kleiman, G., Moaraf, S., Kapitansky, O., & Gozes, I. (2020) · Journal of Molecular Neuroscience · doi:10.1007/s12031-020-01700-x · Cited by 10 · see citing works

Tracing the invisible mutant ADNP protein in Helsmoortel-Van der Aa syndrome patients

D’Incal, C. P., Cappuyns, E., Choukri, K., Man, K. D., Szrama, K., Konings, A., Bastini, L., Meel, K. V., Buys, A., Gabriele, M., et al. (2024) · Scientific Reports · doi:10.1038/s41598-024-65608-x · Cited by 9 · see citing works

AMBRA1, Autophagy, and the Extreme Male Brain Theory of Autism

Crespi, B. J., Read, S., Ly, A., & Hurd, P. L. (2019) · Autism Research and Treatment · doi:10.1155/2019/1968580 · Cited by 9 · see citing works

Synaptic Deficits in Adnp‐ Mutant Mice Are Ameliorated by Histone Demethylase LSD1 Inhibition

Lin, C., Ren, Y., Tam, K. W., Conrow‐Graham, M., & Yan, Z. (2025) · Autism Research · doi:10.1002/aur.70069 · Cited by 8 · see citing works

Protective inherited mutations in activity-dependent neuroprotective protein (ADNP): the good, the bad, and the ugly

Gozes, I., Shazman, S., Giladi, E., & Levine, J. (2024) · Genomic psychiatry : · doi:10.61373/gp024r.0079 · Cited by 8 · see citing works

A perspective on molecular signalling dysfunction, its clinical relevance and therapeutics in autism spectrum disorder

Purushotham, S. S., Reddy, N. M. N., D’Souza, M. N., Choudhury, N. R., Ganguly, A., Gopalakrishna, N., Muddashetty, R. S., & Clement, J. P. (2022) · Experimental Brain Research · doi:10.1007/s00221-022-06448-x · Cited by 8 · see citing works

Longitudinal Genotype-Phenotype (Vineland Questionnaire) Characterization of 15 ADNP Syndrome Cases Highlights Mutated Protein Length and Structural Characteristics Correlation with Communicative Abilities Accentuated in Males

Levine, J., Lobyntseva, A., Shazman, S., Hakim, F., & Gozes, I. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02189-4 · Cited by 8 · see citing works

VIP/PACAP-Based Drug Development: The ADNP/NAP-Derived Mirror Peptides SKIP and D-SKIP Exhibit Distinctive in vivo and in silico Effects

Sragovich, S., Amram, N., Yeheskel, A., & Gozes, I. (2020) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00589 · Cited by 8 · see citing works

Moderate Physical Activity Increases the Expression of ADNP in Rat Brain

Maugeri, G., D’Amico, A. G., Federico, C., Saccone, S., D’Agata, V., & Musumeci, G. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25084382 · Cited by 7 · see citing works

Neuroprotective Drug Development: The Story of ADNP, NAP (Davunetide), and SKIP

Gozes, I. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-803690-7.00013-2 · Cited by 7 · see citing works

Activity-dependent neuroprotective protein (ADNP): from autism to Alzheimer’s disease

Gozes, I. (2015) · SpringerPlus · doi:10.1186/2193-1801-4-s1-l37 · Cited by 6 · see citing works

Sex-Specific ADNP/NAP (Davunetide) Regulation of Cocaine-Induced Plasticity

Toren, Y., Ziv, Y., Sragovich, S., McKinney, R. A., Barak, S., Shazman, S., & Gozes, I. (2024) · Journal of Molecular Neuroscience · doi:10.1007/s12031-024-02234-2 · Cited by 5 · see citing works

The Overexpression of eIF4E Decreases Oxytocin Levels and Induces Social Cognitive Behavioral Disorders in Mice

Wang, J., Chen, S., Zhao, M., Zheng, L., Huang, X., Hong, X., Kang, J., Ou, P., & Huang, L. (2024) · eNeuro · doi:10.1523/eneuro.0387-24.2024 · Cited by 4 · see citing works

Animal models of autism

Berg, E. L., & Silverman, J. L. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-816393-1.00010-5 · Cited by 4 · see citing works

From circadian sleep disruption to Neuroprotection: The potential of VIP/PACAP in Alzheimer’s disease treatment

Galushkin, A., & Gozes, I. (2024) · Current Research in Biotechnology · doi:10.1016/j.crbiot.2024.100254 · Cited by 4 · see citing works

In Search of the Hidden Protein: Optimization of Detection Strategies for autism-associated Activity-Dependent Neuroprotective Protein (ADNP) mutants.Preprint

D’Incal, C. P., Cappuyns, E., Choukri, K., Szrama, K., Man, K. D., der Aa, N. V., Dijck, A. V., Kooy, R. F., & Berghe, W. V. (2022) · Research Square · doi:10.21203/rs.3.rs-1954095/v1 · Cited by 4 · see citing works

Disentangling the role of tau pathology in autism spectrum disorders

Villavicencio-Tejo, F., Olesen, M. A., Moya, M. L., & Quintanilla, R. A. (2025) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2025.111496 · Cited by 3 · see citing works

ADNP Exhibits Methyltransferase Activity in Overexpression Systems and Modulates DNA and Histone Methylation

D’Incal, C. P., Rossem, K. E. V., Cappuyns, E., Dijck, A. V., Elinck, E., Man, K. D., Scott, A., Konings, A., Annear, D. J., & Kooy, R. F. (2025) · Autism Research · doi:10.1002/aur.70132 · Cited by 3 · see citing works

Activity-dependent neuroprotective protein (ADNP)/NAP (CP201): Autism, schizophrenia, and Alzheimer’s disease

Gozes, I. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-814037-6.00001-x · Cited by 3 · see citing works

PACAP, VIP, and ADNP: Autism and Schizophrenia

Gozes, I. (2016) · Current topics in neurotoxicity · doi:10.1007/978-3-319-35135-3_46 · Cited by 2 · see citing works

Profiles of women in science: Illana Gozes, Professor Emerita of Clinical Biochemistry, Tel Aviv University

Helmreich, D. L. (2023) · European Journal of Neuroscience · doi:10.1111/ejn.16061 · Cited by 1 · see citing works

Aging ADNP syndrome mice exhibit mutation/sex-dependent disruption of motor behavior and circadian rhythmicity

Galushkin, A., Giladi, E., & Gozes, I. (2026) · Neurobiology of Disease · doi:10.1016/j.nbd.2026.107509 · Cited by 1 · see citing works

Opposite molecular sex correlations in tauopathy paralleled by motor and cognitive efficacy of davunetide in women

Shapira, G., Blatt, J., Guz, L. S., Shomron, N., & Gozes, I. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03709-x · Cited by 1 · see citing works

Surprising sex differences indicate davunetide-mediated brain protection and clinical efficacy in women suffering from progressive supranuclear palsyPreprint

Gozes, I., Shapira, G., Lobyntseva, A., & Shomron, N. (2023) · Research Square · doi:10.21203/rs.3.rs-2457393/v1 · Cited by 1 · see citing works

Editorial: A Child with ADNP Syndrome: A Case Study of Symptoms, Diagnostic Process and Innovative Behavioral Intervention Modes

Holec, M., & Gozes, I. (2025) · Journal of Molecular Neuroscience · doi:10.1007/s12031-025-02344-5 · Cited by 1 · see citing works

Correction of eIF4E overactivation rescues translatome imbalance and core ASD-like behaviors in valproic acid-induced offspring mice

Huang, M., Ye, H., Xu, Y., Xie, J., Wang, X., Luo, Y., Liu, P., Ma, X.-Y., Zhang, S.-Q., Jiang, B., et al. (2026) · Molecular Psychiatry · doi:10.1038/s41380-026-03517-3 · Cited by 2 · see citing works

Sexual divergence in activity‐dependent neuroprotective protein impacting autism, schizophrenia, and A lzheimer's disease

Gozes, I. (2016) · Journal of Neuroscience Research · doi:10.1002/jnr.23808 · Cited by 20 · see citing works

ADNP is essential for sex-dependent hippocampal neurogenesis, through male unfolded protein response and female mitochondrial gene regulation

Shapira, G., Karmon, G., Hacohen-Kleiman, G., Ganaiem, M., Shazman, S., Theotokis, P., Grigoriadis, N., Shomron, N., & Gozes, I. (2024) · Molecular Psychiatry · doi:10.1038/s41380-024-02879-w · Cited by 20 · see citing works

Sex and the Brain: Novel ADNP Syndrome Mice Are Protected by NAP

Amal, H. (2022) · Biological Psychiatry · doi:10.1016/j.biopsych.2022.03.011 · Cited by 10 · see citing works

Sexual divergence in microtubule function: the novel intranasal microtubule targeting SKIP normalizes axonal transport and enhances memory

Amram, N., Hacohen-Kleiman, G., Sragovich, S., Malishkevich, A., Katz, J., Touloumi, O., Lagoudaki, R., Grigoriadis, N., Giladi, E., Yeheskel, A., et al. (2016) · Molecular Psychiatry · doi:10.1038/mp.2015.208 · Cited by 90 · see citing works

ADNP: A major autism mutated gene is differentially distributed (age and gender) in the songbird brain

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