Atorvastatin attenuates cognitive deficits and neuroinflammation induced by Aβ1-42 involving modulation of TLR4/TRAF6/NF-κB Pathway
Abstract
Inflammatory damage aggravates the progression of Alzheimer's disease (AD) and the mechanism of inflammatory damage may provide a new therapeutic window for the treatment of AD. Toll-like receptor 4 (TLR4)-mediated signaling can regulate the inflammatory process. However, changes in TLR4 signaling pathway induced by beta-amyloid (Aβ) have not been well characterized in brain, especially in the hippocampus. In the present study, we explored the changes of TLR4 signaling pathway induced by Aβ in the hippocampus and the role of atorvastatin in modulating this signal pathway and neurotoxicity induced by Aβ. Experimental AD rats were induced by intrahippocampal injection of Aβ 1-42 , and the rats were treated with atorvastatin by oral gavage from 3 weeks before to 6 days after injections of Aβ 1-42 . To determine the spatial learning and memory ability of rats in the AD models, Morris water maze (MWM) was performed. The expression of the glial fibrillary acidic protein (GFAP), ionized calcium binding adapter molecule-1 (Iba-1), TLR4, tumor necrosis factor receptor-associated factor 6 (TRAF6), and nuclear transcription factor (NF)-κB (NF-κB) protein in the hippocampus was detected by immunohistochemistry and Western blot. Compared to the control group, increased expression of TLR4, TRAF6, and NF-κB was observed in the hippocampus at 7 days post-injection of Aβ (P < 0.01). Furthermore, atorvastatin treatment significantly ameliorated cognitive deficits of rats, attenuated microglia…
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The fibrillar and oligomeric Aβ-amyloid-induced neuroinflammatory response has been linked to TLR4.
“Similarly, the fibrillar and oligomeric A β -amyloid-induced neuroinflammatory response has been linked to TLR4 as well (Reed-Geaghan et al., 2009; Wang et al., 2018).”
From TET2 Regulates the Neuroinflammatory Response in Microglia (2019) · cites this paper as Wang et al., 2018
Cites
The Rat Brain in Stereotaxic Coordinates
Paxinos, G., & Watson, C. (1983) · Elsevier eBooks · doi:10.1016/c2009-0-63235-9 · Cited by 28,585 · see citing works
The mouse brain in stereotaxic coordinates
Konsman, J. (2003) · Psychoneuroendocrinology · doi:10.1016/s0306-4530(03)00088-x · Cited by 16,796 · see citing works
The Mouse Brain in Stereotaxic Coordinates
Paxinos, G. (2001) · Cited by 12,859 · see citing works
Capiralla, H., Vingtdeux, V., Zhao, H., Sankowski, R., Al‐Abed, Y., Davies, P., & Marambaud, P. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07594.x · Cited by 426 · see citing works
LPS receptor (CD14): a receptor for phagocytosis of Alzheimer's amyloid peptide
Liu, Y., Walter, S., Stagi, M., Cherny, D., Letièmbre, M., Schulz‐Schaeffer, W., Heine, H., Penke, B., Neumann, H., & Fassbender, K. C. (2005) · Brain · doi:10.1093/brain/awh531 · Cited by 344 · see citing works
Durrenberger, P. F., Ettorre, A., Kamel, F. O., Webb, L. V., Sim, M. J. W., Nicholas, R. S., Malik, O., Reynolds, R., Boyton, R. J., & Altmann, D. M. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-1 · Cited by 286 · see citing works
Song, M., Jin, J., Lim, J.-E., Kou, J., Pattanayak, A., Rehman, J. A., Kim, H.-D., Tahara, K., Lalonde, R., & Fukuchi, K.-I. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-92 · Cited by 273 · see citing works
Targeting neuroinflammation in Alzheimer’s disease
Bronzuoli, M. R., Iacomino, A., Steardo, L., & Scuderi, C. (2016) · Journal of Inflammation Research · doi:10.2147/jir.s86958 · Cited by 255 · see citing works
Astrocytes: Conductors of the Alzheimer disease neuroinflammatory symphony
Medeiros, R., & LaFerla, F. M. (2012) · Experimental Neurology · doi:10.1016/j.expneurol.2012.10.007 · Cited by 236 · see citing works
Tang, S.-C., Lathia, J. D., Selvaraj, P. K., Jo, D.-G., Mughal, M. R., Cheng, A., Siler, D. A., Markesbery, W. R., Arumugam, T. V., & Mattson, M. P. (2008) · Experimental Neurology · doi:10.1016/j.expneurol.2008.05.014 · Cited by 232 · see citing works
Screening of innate immune receptors in neurodegenerative diseases: A similar pattern
Letiembre, M., Liu, Y., Walter, S., Hao, W., Pfander, T., Wrede, A., Schulz-Schaeffer, W., & Fassbender, K. (2009) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2007.08.018 · Cited by 228 · see citing works
Choi, S., Aïd, S., Kim, H., Jackson, S. H., & Bosetti, F. (2011) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2011.07572.x · Cited by 222 · see citing works
Xuan, A., Long, D., Li, J., Ji, W., Zhang, M., Hong, L.-P., & Liu, J. (2012) · Journal of Neuroinflammation · doi:10.1186/1742-2094-9-202 · Cited by 211 · see citing works
Biological role of Toll-like receptor-4 in the brain
Trotta, T., Porro, C., Calvello, R., & Panaro, M. A. (2014) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2014.01.014 · Cited by 204 · see citing works
Evidence for benefit of statins to modify cognitive decline and risk in Alzheimer’s disease
Geifman, N., Brinton, R. D., Kennedy, R. E., Schneider, L. S., & Butte, A. J. (2017) · Alzheimer's Research & Therapy · doi:10.1186/s13195-017-0237-y · Cited by 191 · see citing works
Zissimopoulos, J., Barthold, D., Brinton, R. D., & Joyce, G. (2016) · JAMA Neurology · doi:10.1001/jamaneurol.2016.3783 · Cited by 178 · see citing works
Evaluating the role of Toll-like receptors in diseases of the central nervous system.
Carty, M., & Bowie, A. (2011) · Biochemical Pharmacology · doi:10.1016/j.bcp.2011.01.003 · Cited by 154 · see citing works
Toll-Like Receptors in Alzheimer’s Disease: A Therapeutic Perspective
Gambuzza, M., Sofo, V., Salmeri, F., Soraci, L., Marino, S., & Bramanti, P. (2014) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527313666140806124850 · Cited by 131 · see citing works
Calvo-Rodríguez, M., de la Fuente, C., García-Durillo, M., García‐Rodríguez, C., Villalobos, C., & Núñez, L. (2017) · Journal of Neuroinflammation · doi:10.1186/s12974-017-0802-0 · Cited by 123 · see citing works
Ryu, J. K., Cho, T., Choi, H. B., Wang, Y. T., & McLarnon, J. G. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.2888-08.2009 · Cited by 121 · see citing works
Astrocytes and neuroinflammation in Alzheimer's disease
Phillips, E. C., Croft, C. L., Crane, K., O’Neill, M. J., Hutton, M. L., Hanger, D. P., Garwood, C. J., & Noble, W. J. (2014) · Biochemical Society Transactions · doi:10.1042/bst20140155 · Cited by 114 · see citing works
Li, X.-H., Li, X.-H., Zhang, Y.-Y., Wang, M., & Wang, D. (2013) · Clinical Interventions in Aging · doi:10.2147/cia.s40405 · Cited by 108 · see citing works
Piermartiri, T., Figueiredo, C. P., Rial, D., Duarte, F. S., Bezerra, S. C., Mancini, G., Bem, A. F. D., Prediger, R. D., & Tasca, C. I. (2010) · Experimental Neurology · doi:10.1016/j.expneurol.2010.08.030 · Cited by 106 · see citing works
Reed-Geaghan, E. G., Reed, Q. W., Cramer, P. E., & Landreth, G. E. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.2637-10.2010 · Cited by 104 · see citing works
Xie, T., Wang, W.-P., Mao, Z., Qu, Z., Luan, S.-Q., Jia, L., & Kan, M. (2012) · Neuroscience Letters · doi:10.1016/j.neulet.2012.04.001 · Cited by 102 · see citing works
Song, F., Zeng, K., Liao, L., Yu, Q., Tu, P., & Wang, X. (2016) · PLoS ONE · doi:10.1371/journal.pone.0149991 · Cited by 97 · see citing works
Shi, S., Liang, D., Chen, Y., Xie, Y., Wang, Y., Wang, L., Wang, Z., & Qiao, Z. (2015) · European Journal of Immunology · doi:10.1002/eji.201545855 · Cited by 93 · see citing works
Cholesterol, statins and dementia
Wolozin, B. L. (2004) · Current Opinion in Lipidology · doi:10.1097/00041433-200412000-00007 · Cited by 89 · see citing works
Schmöle, A., Lundt, R., Ternes, S., Albayram, Ö., Ulas, T., Schultze, J. L., Bano, D., Nicotera, P., Alferink, J., & Zimmer, A. (2014) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2014.09.019 · Cited by 87 · see citing works
Ryu, J. K., & McLarnon, J. G. (2007) · Neurobiology of Disease · doi:10.1016/j.nbd.2007.08.019 · Cited by 83 · see citing works
Ameliorative role of Atorvastatin and Pitavastatin in L-Methionine induced vascular dementia in rats
Koladiya, R. U., Jaggi, A. S., Singh, N., & Sharma, B. (2008) · BMC Pharmacology · doi:10.1186/1471-2210-8-14 · Cited by 80 · see citing works
Yamamoto, N., Fujii, Y., Kasahara, R., Tanida, M., Ohora, K., Ono, Y., Suzuki, K., & Sobue, K. (2016) · Glia · doi:10.1002/glia.22974 · Cited by 80 · see citing works
Barone, E., Domenico, F. D., & Butterfield, D. A. (2013) · Biochemical Pharmacology · doi:10.1016/j.bcp.2013.10.030 · Cited by 79 · see citing works
Quan, Q.-K., Wang, J., Li, X., & Wang, Y. (2013) · PLoS ONE · doi:10.1371/journal.pone.0059155 · Cited by 77 · see citing works
Cameron, B., Tse, W., Lamb, R., Li, X., Lamb, B. T., & Landreth, G. E. (2012) · Journal of Neuroscience · doi:10.1523/jneurosci.1729-12.2012 · Cited by 75 · see citing works
Role of neuroinflammation and latent transcription factors in pathogenesis of Parkinson’s disease
Pal, R., Tiwari, P. C., Nath, R., & Pant, K. K. (2016) · Neurological Research · doi:10.1080/01616412.2016.1249997 · Cited by 72 · see citing works
Zhou, J., Zhou, L., Hou, D., Tang, J.-C., Sun, J., & Bondy, S. C. (2011) · Brain Research · doi:10.1016/j.brainres.2011.02.064 · Cited by 70 · see citing works
Involvement of cysteinyl leukotriene receptor 1 in Aβ1–42-induced neurotoxicity in vitro and in vivo
Tang, S., Hong, H., Chen, L., Mei, Z.-L., Ji, M., Xiang, G., Li, N., & Ji, H. (2013) · Neurobiology of Aging · doi:10.1016/j.neurobiolaging.2013.09.036 · Cited by 66 · see citing works
Russo, I., Caracciolo, L., Tweedie, D., Choi, S., Greig, N. H., Barlati, S., & Bosetti, F. (2012) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2012.07846.x · Cited by 65 · see citing works
Association between the Polymorphisms of TLR4 and CD14 Genes and Alzheimers Disease
Balistreri, C. R., Grimaldi, M., Chiappelli, M., Licastro, F., Castiglia, L., Listı̀, F., Vasto, S., Lio, D., Caruso, C., & Candore, G. (2008) · Current Pharmaceutical Design · doi:10.2174/138161208786264089 · Cited by 65 · see citing works
Clarke, R. M., O'Connell, F., Lyons, A., & Lynch, M. A. (2006) · Neuropharmacology · doi:10.1016/j.neuropharm.2006.07.031 · Cited by 63 · see citing works
de Castro, A. A., Wiemes, B. P., MATHEUS, F. C., Lapa, F. D. R., Viola, G. G., Santos, A. R. S., Tasca, C. I., & Prediger, R. D. (2013) · Brain Research · doi:10.1016/j.brainres.2013.03.029 · Cited by 62 · see citing works
McLarnon, J. G., & Ryu, J. K. (2008) · Current Alzheimer Research · doi:10.2174/156720508785908874 · Cited by 60 · see citing works
Dostal, L. A. (1996) · Fundamental and Applied Toxicology · doi:10.1006/faat.1996.0132 · Cited by 60 · see citing works
Li, Q., Cui, J., Chen, F., Liu, M., Min, G., & Li, L. (2017) · Journal of Alzheimer s Disease · doi:10.3233/jad-170177 · Cited by 53 · see citing works
Zhang, J., Fu, B., Zhang, X., Chen, L., Zhang, L., Zhao, X., Bai, X. H., Zhu, C., Cui, L., & Wang, L. (2013) · Brain Research · doi:10.1016/j.brainres.2013.06.032 · Cited by 51 · see citing works
Self-citationKurata, T., Miyazaki, K., Kozuki, M., Morimoto, N., Ohta, Y., Ikeda, Y., & Abe, K. (2012) · Neurological Research · doi:10.1179/1743132812y.0000000054 · Cited by 49 · see citing works
Zhao, B., Liu, Y., Gao, X., Zhai, H., Guo, J., & Wang, X. (2014) · Molecules · doi:10.3390/molecules191016925 · Cited by 49 · see citing works
Statin use and incident dementia: A nationwide cohort study of Taiwan
Chou, C., Chou, Y., Chou, Y., Yang, Y.-F., & Huang, N. (2014) · International Journal of Cardiology · doi:10.1016/j.ijcard.2014.03.018 · Cited by 47 · see citing works
Zhang, L., Sui, H., Liang, B., Wang, H., Qu, W., Yu, S., & Jin, Y. H. (2014) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.203 · Cited by 43 · see citing works
Costello, D. A., Carney, D. G., & Lynch, M. A. (2015) · Brain Behavior and Immunity · doi:10.1016/j.bbi.2015.01.005 · Cited by 40 · see citing works
Cibičková, Ľ., Hyšpler, R., Stanislav, M., Norbert, C., Živná, H., Daniel, J., Alena, T., Doleželová, E., & Palička, V. (2008) · Steroids · doi:10.1016/j.steroids.2008.08.007 · Cited by 38 · see citing works
Murphy, M. P., Morales, J., Beckett, T. L., Astarita, G., Piomelli, D., Weidner, A. M., Studzinski, C. M., Dowling, A. L. S., Wang, X., LeVine, H., et al. (2010) · Journal of Alzheimer s Disease · doi:10.3233/jad-2010-100639 · Cited by 38 · see citing works
Non-selective NSAIDs improve the amyloid-β-mediated suppression of memory and synaptic plasticity
Mohammadpour, J. D., Hosseinmardi, N., Janahmadi, M., Fathollahi, Y., Motamedi, F., & Rohampour, K. (2015) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2015.02.012 · Cited by 37 · see citing works
Lv, C., Wang, L., Liu, X., Cong, X., Yan, S. S., Wang, Y., & Zhang, W. (2014) · Current Alzheimer Research · doi:10.2174/1567205011666140514111204 · Cited by 34 · see citing works
Lyons, A., Murphy, K. J., Clarke, R. M., & Lynch, M. A. (2011) · Journal of Neuroinflammation · doi:10.1186/1742-2094-8-27 · Cited by 34 · see citing works
Griffin, J. M., Kho, D. T., Graham, E. S., Nicholson, L. F. B., & O’Carroll, S. J. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157483 · Cited by 32 · see citing works
Kurata, T., Kawai, H., Miyazaki, K., Kozuki, M., Morimoto, N., Ohta, Y., Ikeda, Y., & Abe, K. (2012) · Journal of the Neurological Sciences · doi:10.1016/j.jns.2012.06.011 · Cited by 31 · see citing works
Regulator of Calcineurin 1 Gene Transcription is Regulated by Nuclear Factor-kappaB
Zheng, L., Liu, H., Wang, P., Song, W., & Sun, X. (2014) · Current Alzheimer Research · doi:10.2174/1567205010666131212114907 · Cited by 26 · see citing works
The effect of statins on rate of cognitive decline in mild cognitive impairment
Smith, K. B., Kang, P. T., Sabbagh, M. N., & Initiative, A. D. N. (2017) · Alzheimer s & Dementia Translational Research & Clinical Interventions · doi:10.1016/j.trci.2017.01.001 · Cited by 24 · see citing works
Neuroprotective effects of sodium hydrosulfide against β-amyloid-induced neurotoxicity
Li, X., Deng, Y., Li, F., Shi, J., & Gong, Q. (2016) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2016.2701 · Cited by 21 · see citing works
Seok, S. M., Park, T. Y., Park, H.-S., Baik, E. J., & Lee, S. (2015) · International Immunopharmacology · doi:10.1016/j.intimp.2015.03.029 · Cited by 20 · see citing works
Zaghi, G. G. D., Godinho, J., Ferreira, E. D. F., Ribeiro, M. H. D. M., Previdelli, I. T. S., de Oliveira, R. M. W., & Milani, H. (2015) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2015.10.004 · Cited by 11 · see citing works
Yoshida, J., Ogasawara, K., Chida, K., Oikawa, K., Matsumoto, Y., Nomura, J.-I., Ogasawara, Y., Fujiwara, S., Kobayashi, M., Yoshida, K., et al. (2016) · Neurological Research · doi:10.1080/01616412.2015.1114291 · Cited by 9 · see citing works
Zhao, L., Zhao, Q., Zhou, Y., Zhao, Y. L. Y., & Wan, Q. (2016) · CNS & Neurological Disorders - Drug Targets · doi:10.2174/1871527315999160111160143 · Cited by 9 · see citing works
Kurata, T., Miyazaki, K., Kozuki, M., Morimoto, N., Matsuzono, K., Ohta, Y., Ikeda, Y., & Abe, K. (2012) · Alzheimer s & Dementia · doi:10.1016/j.jalz.2012.05.527 · Cited by 1 · see citing works
Flagged first, then by citations
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The progress of gut microbiome research related to brain disorders
Zhu, S., Jiang, Y., Xu, K., Cui, M., Ye, W., Zhao, G., Jin, L., & Chen, X. (2020) · Journal of Neuroinflammation · doi:10.1186/s12974-020-1705-z · Cited by 419 · see citing works
Involvement of Lipids in Alzheimer’s Disease Pathology and Potential Therapies
Chew, H., Solomon, V. A., & Fonteh, A. N. (2020) · Frontiers in Physiology · doi:10.3389/fphys.2020.00598 · Cited by 353 · see citing works
TLR4 Targeting as a Promising Therapeutic Strategy for Alzheimer Disease Treatment
Zhou, Y., Chen, Y., Xu, C., Zhang, H., & Lin, C. (2020) · Frontiers in Neuroscience · doi:10.3389/fnins.2020.602508 · Cited by 119 · see citing works
Bagheri, H., Ghasemi, F., Barreto, G. E., Sathyapalan, T., Jamialahmadi, T., & Sahebkar, A. (2019) · BioFactors · doi:10.1002/biof.1597 · Cited by 120 · see citing works
Zhai, L., Shen, H., Sheng, Y., & Guan, Q. (2021) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.16787 · Cited by 115 · see citing works
Self-citationTET2 Regulates the Neuroinflammatory Response in Microglia
Carrillo-Jimenez, A., Deniz, Ö., Niklison-Chirou, M. V., Ruiz, R., Bezerra-Salomão, K., Stratoulias, V., Amouroux, R., Yip, P. K., Vilalta, A., Cheray, M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2019.09.013 · Cited by 104 · see citing works
Gut Microbiota in Acute Ischemic Stroke: From Pathophysiology to Therapeutic Implications
Battaglini, D., Pimentel‐Coelho, P. M., Robba, C., dos Santos, C. C., Cruz, F. F., Pelosi, P. P., & Rocco, P. R. M. (2020) · Frontiers in Neurology · doi:10.3389/fneur.2020.00598 · Cited by 99 · see citing works
Atorvastatin prevents lipopolysaccharide-induced depressive-like behaviour in mice
Taniguti, E. H., Ferreira, Y. S., Stupp, I. J. V., Fraga-Junior, E. B., Doneda, D. L., Lopes, L., Rios-Santos, F., Lima, E., Buss, Z. S., Viola, G. G., et al. (2019) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2019.01.018 · Cited by 91 · see citing works
Toll-Like Receptor 4: A Promising Therapeutic Target for Alzheimer’s Disease
Wu, L., Xian, X., Xu, G., Tan, Z., Dong, F., Zhang, M., & Zhang, F. (2022) · Mediators of Inflammation · doi:10.1155/2022/7924199 · Cited by 85 · see citing works
Yue, Q., & Hoi, M. P. M. (2023) · Neural Regeneration Research · doi:10.4103/1673-5374.367832 · Cited by 77 · see citing works
The role and therapeutic potential of nuclear factor κB (NF-κB) in ischemic stroke
Xu, G., Dong, F., Su, L., Tan, Z., Lei, M., Li, L., Wen, D., & Zhang, F. (2024) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2024.116140 · Cited by 72 · see citing works
Toll-like receptors in Alzheimer's disease
Momtazmanesh, S., Perry, G. L., & Rezaei, N. (2020) · Journal of Neuroimmunology · doi:10.1016/j.jneuroim.2020.577362 · Cited by 71 · see citing works
Mechanism of microRNA‐22 in regulating neuroinflammation in Alzheimer’s disease
Han, C., Guo, L., Yang, Y., Guan, Q., Shen, H., Sheng, Y., & Jiao, Q. (2020) · Brain and Behavior · doi:10.1002/brb3.1627 · Cited by 67 · see citing works
Cui, Y., Wang, Y., Zhao, D., Feng, X., Zhang, L., & Liu, C. (2018) · Cell Biology International · doi:10.1002/cbin.11060 · Cited by 68 · see citing works
Innate Immune Functions of Astrocytes are Dependent Upon Tumor Necrosis Factor-Alpha
Rodgers, K. R., Lin, Y., Langan, T. J., Iwakura, Y., & Chou, R. C. (2020) · Scientific Reports · doi:10.1038/s41598-020-63766-2 · Cited by 64 · see citing works
MiR-146a mimic attenuates murine allergic rhinitis by downregulating TLR4/TRAF6/NF-κB pathway
Wang, J., Cui, Z., Liu, L., Zhang, S., Zhang, Y., Zhang, Y., Su, H., & Zhao, Y. (2019) · Immunotherapy · doi:10.2217/imt-2019-0047 · Cited by 50 · see citing works
He, Y., Ruganzu, J. B., Zheng, Q., Wu, X., Jin, H., Peng, X., Ding, B., Lin, C., Ji, S., Ma, Y., et al. (2020) · Molecular Neurobiology · doi:10.1007/s12035-020-01982-7 · Cited by 45 · see citing works
Ronaldson, P. T., & Davis, T. P. (2024) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2024.2306138 · Cited by 40 · see citing works
Zheng, X., Wang, J., Bi, F., Li, Y., Xiao, J., Chai, Z., Li, Y., Miao, Z., & Wang, Y. (2021) · International Journal of Molecular Medicine · doi:10.3892/ijmm.2021.4954 · Cited by 35 · see citing works
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Li, Y., Zhang, L., Zhang, P., & Hao, Z. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.709604 · Cited by 29 · see citing works
Li, X., Wang, X., Huang, B., & Huang, R. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.110290 · Cited by 28 · see citing works
Milajerdi, A., Larijani, B. A., & Esmaillzadeh, A. (2019) · Cytokine · doi:10.1016/j.cyto.2019.154752 · Cited by 28 · see citing works
Yue, Q., Zhou, X., Zhang, Z., & Hoi, M. P. M. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23031878 · Cited by 25 · see citing works
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Jia, F., & Fu, L. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04739-2 · Cited by 21 · see citing works
Wang, C., Ye, H., Zheng, Y., Qi, Y., Zhang, M., Long, Y., & Hu, Y. (2022) · NeuroMolecular Medicine · doi:10.1007/s12017-022-08717-y · Cited by 19 · see citing works
Rymbai, E., Sugumar, D., Chakkittukandiyil, A., Kothandan, R., & Selvaraj, D. (2024) · Cell Biochemistry and Function · doi:10.1002/cbf.4014 · Cited by 18 · see citing works
Cheng, Z., Li, X., Ye, X., Yu, R., & Deng, Y. (2022) · Neurochemical Research · doi:10.1007/s11064-022-03752-4 · Cited by 17 · see citing works
Li, Z., Yang, P., & Feng, B. (2020) · Molecular Biology Reports · doi:10.1007/s11033-020-05998-z · Cited by 16 · see citing works
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Li, H., Di, G., Zhang, Y., Liang, J., Wang, X., Xu, Z., & Kong, X. (2021) · Comparative Biochemistry and Physiology Part C Toxicology & Pharmacology · doi:10.1016/j.cbpc.2021.109086 · Cited by 16 · see citing works
The Effects of Atorvastatin on Global Cerebral Ischemia-Induced Neuronal Death
Kho, A. R., Hong, D. K., Kang, B. S., Park, W.-J., Choi, K. C., Park, K., & Suh, S. W. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22094385 · Cited by 16 · see citing works
Sun, C., Chen, Z., Wang, H., & Ding, K. (2018) · Medical Science Monitor · doi:10.12659/msm.910578 · Cited by 14 · see citing works
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Jin, Y., Bao, S.-W., Huang, M.-X., Gao, Y., Lu, H.-J., & Wu, X. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262010174 · Cited by 11 · see citing works
İlgün, A., & Çakır, T. (2025) · Molecular Neurobiology · doi:10.1007/s12035-025-04965-8 · Cited by 11 · see citing works
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Self-citationChen, L., & Zhuang, K. (2023) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12682 · Cited by 7 · see citing works
Liu, Q., Li, X., Zhao, Y., Cao, K., Liu, Y., Xiao, R., Wang, C., Li, Y., Huang, W., & Wang, X. (2019) · Brain Research · doi:10.1016/j.brainres.2019.01.020 · Cited by 7 · see citing works
Li, X., Chen, S., Zheng, G., Yang, Y., Yin, N., Niu, X., Yao, L., & Lv, P. (2023) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207326666230606114448 · Cited by 6 · see citing works
Zhang, T., Wang, J., Wang, Y., He, L., Lv, S., Wang, Y., & Li, W. (2024) · Neuropsychiatric Disease and Treatment · doi:10.2147/ndt.s445636 · Cited by 5 · see citing works
Zhang, H., Huang, H., & Zhao, P. (2025) · Frontiers in Neurology · doi:10.3389/fneur.2025.1526959 · Cited by 5 · see citing works
Min-Kaung-Wint-Mon, & Mitsushima, D. (2025) · Journal of dementia and Alzheimer's disease · doi:10.3390/jdad2030025 · Cited by 5 · see citing works
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Barreto, G. E., González, J., Reiner, Ž., Jamialahmadi, T., Echeverrı́a, V., Ashraf, G. M., & Sahebkar, A. (2021) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2021.109528 · Cited by 4 · see citing works
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Tanwir, S. E., & Kumar, A. (2019) · Open Journal of Medicinal Chemistry · doi:10.4236/ojmc.2019.91001 · Cited by 3 · see citing works
Wang, Y., Li, Y., Chen, Y., Mao, J., Ji, J., Zhang, S., Liu, P., Pronyuk, K., Fisher, D. P., Dang, Y., et al. (2024) · International Journal of Immunopathology and Pharmacology · doi:10.1177/03946320241254083 · Cited by 3 · see citing works
El‐Shafey, M., Mostafa, H. K. K., El-Agawy, M. S. E.-D., Safwat, M. M., El‐Sherbiny, M., Ebrahim, H. A., Hasnaoui-Saadani, R. E., Elsherbiny, N. M., Abomosallam, M., Ibrahim, A. M., et al. (2025) · Tissue and Cell · doi:10.1016/j.tice.2025.103184 · Cited by 1 · see citing works
Yang, Y., Ning, Y., Peng, S., Liao, C., Fu, J., Zhao, J., Ou, C., & Zhang, Y. (2026) · Neuroscience Research · doi:10.1016/j.neures.2026.105022 · Cited by 1 · see citing works
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Wang, J., Yang, Y., Li, W., Wu, S., & Han, C. (2022) · International Immunopharmacology · doi:10.1016/j.intimp.2022.108651
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Wang, Y. (2023) · Highlights in Science Engineering and Technology · doi:10.54097/hset.v36i.6205
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Li, Q., Li, C.-N., & Chen, J. (2023) · IntechOpen eBooks · doi:10.5772/intechopen.1001286
Xu, Y., Zhang, G., Cui, X., & Sun, L. (2026) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2026.1838634
Self-citationHe, X., Zhou, Q., Zhang, M., Wang, D., & Xu, X. (2026) · Frontiers in Medicine · doi:10.3389/fmed.2026.1852942
- Authors
- Wang, S., Zhang, X., Zhai, L., Sheng, X., Zheng, W., Chu, H., & Zhang, G.
- Affiliations
- Second Hospital of Hebei Medical University (CN)
- Corresponding author
- Sheng, Xiaona
- Venue
- Journal of Molecular Neuroscience
- Published
- 2018-02-07
- Volume
- 64
- Issue
- 3
- Pages
- 363-373
- ISSN
- 0895-8696 (ISSN-L)
- 1559-1166
- OpenAlex
- W2787684810
- Cited by
- 52
- References
- 66
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 5 · 2023: 7 · 2022: 6 · 2021: 6 · 2020: 9 · 2019: 7 · 2018: 2
- FWCI
- 4.12
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Molecular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Hebei Natural Science Foundation (C2011206110)
- The key project of Hebei medical science research (20150211)
- Topics
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Life Sciences › Neuroscience › Neurology › Neurological Disease Mechanisms and Treatments
- Keywords
- atorvastatin, Alzheimer's disease, amyloid-beta 42, neuroinflammation, TLR4 signaling, TRAF6, NF-κB, hippocampus, cognitive impairment, microglial activation, astrocyte activation, apoptosis, spatial learning and memory, statins
- MeSH terms
- Atorvastatin, Animals, Anti-Inflammatory Agents, Male, Peptide Fragments, Amyloid beta-Peptides, NF-kappa B, Rats, Sprague-Dawley, Neuroprotective Agents, TNF Receptor-Associated Factor 6, Toll-Like Receptor 4, Rats, Cognitive Dysfunction
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