Potential of Extracellular Vesicles in Neurodegenerative Diseases: Diagnostic and Therapeutic Indications
Abstract
Extracellular vesicles (EVs) are membrane-bound vesicles, including exosomes and microvesicles. EVs are nanometer sized, found in physiological fluids such as urine, blood, cerebro-spinal fluid (CSF), with a capacity of transferring various biological materials such as microRNAs, proteins, and lipids among cells without direct cell-to-cell contact. Many cells in the nervous system have been shown to release EVs. These vesicles are involved in intercellular communication and a variety of biological processes such as modulation of immune response, signal transduction, and transport of genetic materials with low immunogenicity; therefore, they have also been recently investigated for the delivery of therapeutic molecules such as siRNAs and drugs in the treatment of diseases. In addition, since EV components reflect the physiological status of the cells and tissues producing them, they can be utilized as biomarkers for early detection of various diseases. In this review, we summarize EV application, in diagnosis as biomarker sources and as a carrier tool for drug delivery in EV-based therapies in neurodegenerative diseases.
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Because of incomplete understanding of the origins of CNS disorders, there is currently no foolproof method for early detection of such disorders.
“For instance, because of the incomplete understanding of the origins of CNS disorders, there is currently no foolproof method for the early detection of such disorders [311, 312].”
From Extracellular vesicles as nanotheranostic platforms for targeted neurological disorder interventions (2024) · cites this paper as [311]
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- Authors
- Izadpanah, M., Seddigh, A., Ebrahimi Barough, S., Fazeli, S. A. S., & Ai, J.
- Affiliations
- Academic Center for Education, Culture and Research (IR)
- University College London Hospitals NHS Foundation Trust (GB)
- University of Science and Culture (IR)
- Tehran University of Medical Sciences (IR)
- Corresponding author
- Ai, Jafar
- Venue
- Journal of Molecular Neuroscience
- Published
- 2018-08-23
- Volume
- 66
- Issue
- 2
- Pages
- 172-179
- ISSN
- 0895-8696 (ISSN-L)
- 1559-1166
- OpenAlex
- W2888752734
- Cited by
- 48
- References
- 3
- Citations by year
- 2026: 5 · 2025: 3 · 2024: 6 · 2023: 9 · 2022: 5 · 2021: 6 · 2020: 7 · 2019: 6 · 2018: 1
- FWCI
- 0.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Journal of Molecular Neuroscience (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Extracellular vesicles in disease
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
- Keywords
- extracellular vesicles, neurodegenerative diseases, exosomes, microvesicles, biomarkers, early diagnosis, drug delivery, EV-based therapeutics, intercellular communication, cerebrospinal fluid, microRNA, siRNA delivery
- MeSH terms
- Extracellular Vesicles, Alzheimer Disease, Amyotrophic Lateral Sclerosis, Animals, Humans, Parkinson Disease
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