Different sourced extracellular vesicles and their potential applications in clinical treatments

Shedding light on the cell biology of extracellular vesicles

van Niel, G., D'Angelo, G., & Raposo, G. (2018) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2017.125 · Cited by 8,369 · see citing works

Extracellular vesicles: Exosomes, microvesicles, and friends

Raposo, G., & Stoorvogel, W. (2013) · Journal of Cell Biology · doi:10.1083/jcb.201211138 · Cited by 8,099 · see citing works

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

Colombo, M., Raposo, G., & Théry, C. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101512-122326 · Cited by 6,186 · see citing works

Biological properties of extracellular vesicles and their physiological functions

Yáñez‐Mó, M., Siljander, P. R. ‐., Andreu, Z., Bedina Zavec, A., Borràs, F. E., Buzas, E. I., Buzas, K., Casal, E., Cappello, F., Carvalho, J., et al. (2015) · Journal of Extracellular Vesicles · doi:10.3402/jev.v4.27066 · Cited by 5,926 · see citing works

Cancer nanomedicine: progress, challenges and opportunities

Shi, J., Kantoff, P. W., Wooster, R., & Farokhzad, O. C. (2017) · Nature Reviews Cancer · doi:10.1038/nrc.2016.108 · Cited by 5,873 · see citing works

Delivery of siRNA to the mouse brain by systemic injection of targeted exosomes

Alvarez-Erviti, L., Seow, Y., Yin, H., Betts, C., Lakhal, S., & Wood, M. J. A. (2011) · Nature Biotechnology · doi:10.1038/nbt.1807 · Cited by 4,930 · see citing works

Extracellular vesicles: biology and emerging therapeutic opportunities

EL Andaloussi, S., Mäger, I., Breakefield, X. O., & Wood, M. J. A. (2013) · Nature Reviews Drug Discovery · doi:10.1038/nrd3978 · Cited by 3,254 · see citing works

Advances and Challenges of Liposome Assisted Drug Delivery

Sercombe, L., Veerati, T., Moheimani, F., Wu, S. Y., Sood, A. K., & Hua, S. (2015) · Frontiers in Pharmacology · doi:10.3389/fphar.2015.00286 · Cited by 2,672 · see citing works

Erythrocyte membrane-camouflaged polymeric nanoparticles as a biomimetic delivery platform

Hu, C. J., Zhang, L., Aryal, S., Cheung, C., Fang, R. H., & Zhang, L. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1106634108 · Cited by 2,449 · see citing works

Toxicity of cationic lipids and cationic polymers in gene delivery

Lv, H., Zhang, S., Wang, B., Cui, S., & Yan, J. (2006) · Journal of Controlled Release · doi:10.1016/j.jconrel.2006.04.014 · Cited by 2,286 · see citing works

Controlled drug delivery vehicles for cancer treatment and their performance

Senapati, S., Mahanta, A. K., Kumar, S., & Maiti, P. (2018) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-017-0004-3 · Cited by 2,167 · see citing works

Animal Communication: When I'm Calling You, Will You Answer Too?

Vickers, N. J. (2017) · Current Biology · doi:10.1016/j.cub.2017.05.064 · Cited by 1,793 · see citing works

Classification, Functions, and Clinical Relevance of Extracellular Vesicles

van der Pol, E., Böing, A. N., Harrison, P., Sturk, A., & Nieuwland, R. (2012) · Pharmacological Reviews · doi:10.1124/pr.112.005983 · Cited by 1,756 · see citing works

Stem Cell Therapies in Clinical Trials: Progress and Challenges

Trounson, A. O., & McDonald, C. A. (2015) · Cell stem cell · doi:10.1016/j.stem.2015.06.007 · Cited by 1,478 · see citing works

Mechanisms involved in the therapeutic properties of mesenchymal stem cells

da Silva Meirelles, L., Fontes, A. M., Covas, D. T., & Caplan, A. I. (2009) · Cytokine & Growth Factor Reviews · doi:10.1016/j.cytogfr.2009.10.002 · Cited by 1,436 · see citing works

Ectosomes and exosomes: shedding the confusion between extracellular vesicles

Cocucci, E., & Meldolesi, J. (2015) · Trends in Cell Biology · doi:10.1016/j.tcb.2015.01.004 · Cited by 1,435 · see citing works

Isolation of multipotent mesenchymal stem cells from umbilical cord blood

Lee, O. K., Kuo, T. K., Chen, W.-M., Lee, K.-D., Hsieh, S.-L., & Chen, T.-H. (2004) · Blood · doi:10.1182/blood-2003-05-1670 · Cited by 1,360 · see citing works

Exosomal-like vesicles are present in human blood plasma

Caby, M.-P., Lankar, D., Vincendeau-Scherrer, C., Raposo, G., & Bonnerot, C. (2005) · International Immunology · doi:10.1093/intimm/dxh267 · Cited by 1,348 · see citing works

Vaccination of metastatic melanoma patients with autologous dendritic cell (DC) derived-exosomes: results of thefirst phase I clinical trial

Escudier, B. J., Dorval, T., Chaput, N., André, F., Caby, M.-P., Novault, S., Flament, C., Leboulaire, C., Borg, C., Amigorena, S., et al. (2005) · Journal of Translational Medicine · doi:10.1186/1479-5876-3-10 · Cited by 1,285 · see citing works

Extracellular Vesicles: Composition, Biological Relevance, and Methods of Study

Zaborowski, M. P., Balaj, L., Breakefield, X. O., & Lai, C. P. (2015) · BioScience · doi:10.1093/biosci/biv084 · Cited by 1,272 · see citing works

Extracellular vesicles for drug delivery.

Vader, P., Mol, E. A., Pasterkamp, G., & Schiffelers, R. M. (2016) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2016.02.006 · Cited by 1,237 · see citing works

Stem-cell therapy for cardiac disease

Segers, V. F. M., & Lee, R. T. (2008) · Nature · doi:10.1038/nature06800 · Cited by 1,180 · see citing works

A phase I study of dexosome immunotherapy in patients with advanced non-small cell lung cancer

Morse, M. A., Garst, J. L., Osada, T., Khan, S., Hobeika, A. C., Clay, T. M., Valente, N., Shreeniwas, R., Sutton, M. A., Delcayre, A. X., et al. (2005) · Journal of Translational Medicine · doi:10.1186/1479-5876-3-9 · Cited by 1,123 · see citing works

Adipose-derived adult stem cells: isolation, characterization, and differentiation potential

Gimble, J. M., & Guilak, F. (2003) · Cytotherapy · doi:10.1080/14653240310003026 · Cited by 1,103 · see citing works

Exosome Secretion: Molecular Mechanisms and Roles in Immune Responses

Bobrie, A., Colombo, M., Raposo, G., & Théry, C. (2011) · Traffic · doi:10.1111/j.1600-0854.2011.01225.x · Cited by 1,102 · see citing works

Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production

Boilard, É., Nigrovic, P. A., Larabee, K. S., Watts, G. F. M., Coblyn, J. S., Weinblatt, M. E., Massarotti, E. M., Remold‐O’Donnell, E., Farndale, R. W., Ware, J. L., et al. (2010) · Science · doi:10.1126/science.1181928 · Cited by 1,088 · see citing works

The Dynamic in vivo Distribution of Bone Marrow-Derived Mesenchymal Stem Cells after Infusion

Gao, J., Dennis, J. E., Muzic, R. F., Lundberg, M., & Caplan, A. I. (2001) · Cells Tissues Organs · doi:10.1159/000047856 · Cited by 952 · see citing works

Mesenchymal stem cells: a new trend for cell therapy

Wei, X., Yang, X. F., Han, Z., Qu, F.-F., Shao, L., & Shi, Y. (2013) · Acta Pharmacologica Sinica · doi:10.1038/aps.2013.50 · Cited by 945 · see citing works

Human saliva, plasma and breast milk exosomes contain RNA: Uptake by macrophages

Lässer, C., Seyed Alikhani, V., Ekström, K., Eldh, M., Torregrosa Paredes, P., Bossios, A., Sjöstrand, M., Gabrielsson, S., Lötvall, J., & Valadi, H. (2011) · Journal of Translational Medicine · doi:10.1186/1479-5876-9-9 · Cited by 899 · see citing works

Exosome-Mediated Transfer of miR-133b from Multipotent Mesenchymal Stromal Cells to Neural Cells Contributes to Neurite Outgrowth

Xin, H., Li, Y., Buller, B., Katakowski, M., Zhang, Y., Wang, X., Shang, X., Zhang, Z. G., & Chopp, M. (2012) · Stem Cells · doi:10.1002/stem.1129 · Cited by 897 · see citing works

Exosomes are released by cultured cortical neurones

Fauré, J., Lachenal, G., Court, M., Hirrlinger, J., Chatellard-Causse, C., Blot, B., Grange, J., Schoehn, G., Goldberg, Y., Boyer, V., et al. (2006) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2005.12.003 · Cited by 896 · see citing works

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

Wollert, T., & Hurley, J. H. (2010) · Nature · doi:10.1038/nature08849 · Cited by 804 · see citing works

Circulating microparticles: pathophysiology and clinical implications

Piccin, A., Murphy, W. G., & Smith, O. P. (2006) · Blood Reviews · doi:10.1016/j.blre.2006.09.001 · Cited by 799 · see citing works

Human bone marrow- and adipose-mesenchymal stem cells secrete exosomes enriched in distinctive miRNA and tRNA species

Baglio, S. R., Rooijers, K., Koppers‐Lalic, D., Verweij, F. J., Pérez-Lanzón, M., Zini, N., Naaijkens, B. A., Perut, F., Niessen, H. W. M., Baldini, N., et al. (2015) · Stem Cell Research & Therapy · doi:10.1186/s13287-015-0116-z · Cited by 766 · see citing works

The role of T helper 17 (Th17) and regulatory T cells (Treg) in human organ transplantation and autoimmune disease

Afzali, B., Lombardi, G., Lechler, R. I., & Lord, G. M. (2007) · Clinical and Experimental Immunology · doi:10.1111/j.1365-2249.2007.03356.x · Cited by 762 · see citing works

Exosome Function: From Tumor Immunology to Pathogen Biology

Schorey, J. S., & Bhatnagar, S. (2008) · Traffic · doi:10.1111/j.1600-0854.2008.00734.x · Cited by 758 · see citing works

Exosomes Derived from Bone Marrow Mesenchymal Stem Cells as Treatment for Severe COVID-19

Sengupta, V., Sengupta, S., Lazo, A., Woods, P., Nolan, A., & Bremer, N. J. (2020) · Stem Cells and Development · doi:10.1089/scd.2020.0080 · Cited by 751 · see citing works

Extracellular vesicles from blood plasma: determination of their morphology, size, phenotype and concentration

Arraud, N., Linares, R., Tan, S., Gounou, C., Pasquet, J., Mornet, S., & Brisson, A. R. (2014) · Journal of Thrombosis and Haemostasis · doi:10.1111/jth.12554 · Cited by 742 · see citing works

Exosome mediated communication within the tumor microenvironment

Milane, L. S., Singh, A., Mattheolabakis, G., Suresh, M., & Amiji, M. M. (2015) · Journal of Controlled Release · doi:10.1016/j.jconrel.2015.06.029 · Cited by 738 · see citing works

Plasma exosomes can deliver exogenous short interfering RNA to monocytes and lymphocytes

Wahlgren, J., Karlson, T. D. L., Brisslert, M., Sani, F. V., Telemo, E., Sunnerhagen, P., & Valadi, H. (2012) · Nucleic Acids Research · doi:10.1093/nar/gks463 · Cited by 716 · see citing works

Extracellular vesicle-based therapeutics: natural versus engineered targeting and trafficking

Murphy, D. E., de Jong, O. G., Brouwer, M., Wood, M. J. A., Lavieu, G., Schiffelers, R. M., & Vader, P. (2019) · Experimental & Molecular Medicine · doi:10.1038/s12276-019-0223-5 · Cited by 715 · see citing works

Coats, Tethers, Rabs, and SNAREs Work Together to Mediate the Intracellular Destination of a Transport Vesicle

Cai, H., Reinisch, K. M., & Ferro‐Novick, S. (2007) · Developmental Cell · doi:10.1016/j.devcel.2007.04.005 · Cited by 686 · see citing works

Exosomes derived from human adipose mensenchymal stem cells accelerates cutaneous wound healing via optimizing the characteristics of fibroblasts

Hu, L., Wang, J., Zhou, X., Xiong, Z., Zhao, J., Yu, R., Huang, F., Zhang, H., & Chen, L. (2016) · Scientific Reports · doi:10.1038/srep32993 · Cited by 678 · see citing works

Efficient RNA drug delivery using red blood cell extracellular vesicles

Usman, W. M., Pham, T. C., Kwok, Y. Y., Vu, L. T., Ma, V., Peng, B., Chan, Y. S., Wei, L., Chin, S. M., Azad, A., et al. (2018) · Nature Communications · doi:10.1038/s41467-018-04791-8 · Cited by 663 · see citing works

ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming

Segura, É., Nicco, C., Lombard, B., Véron, P., Raposo, G., Batteux, F., Amigorena, S., & Théry, C. (2005) · Blood · doi:10.1182/blood-2005-01-0220 · Cited by 614 · see citing works

Microparticles in cardiovascular diseases

VANWIJK, M., VanBavel, E., Sturk, A., & Nieuwland, R. (2003) · Cardiovascular Research · doi:10.1016/s0008-6363(03)00367-5 · Cited by 610 · see citing works

Release of exosomes from differentiated neurons and its regulation by synaptic glutamatergic activity

Lachenal, G. M., Pernet‐Gallay, K., Chivet, M., Hemming, F. J., Belly, A., Bodon, G., Blot, B., Haase, G., Goldberg, Y., & Sadoul, R. (2010) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2010.11.004 · Cited by 595 · see citing works

Sphingolipid-modulated Exosome Secretion Promotes Clearance of Amyloid-β by Microglia

Yuyama, K., Sun, H., Mitsutake, S., & Igarashi, Y. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.324616 · Cited by 591 · see citing works

Recent advancements in the use of exosomes as drug delivery systems

Bunggulawa, E. J., Wang, W., Yin, T., Wang, N., Durkan, C., Wang, Y., & Wang, G. (2018) · Journal of Nanobiotechnology · doi:10.1186/s12951-018-0403-9 · Cited by 590 · see citing works

Mesenchymal Stromal Cell Homing: Mechanisms and Strategies for Improvement

Ullah, M., Liu, D. D., & Thakor, A. S. (2019) · iScience · doi:10.1016/j.isci.2019.05.004 · Cited by 553 · see citing works

Exosomes — beyond stem cells for restorative therapy in stroke and neurological injury

Zhang, Z. G., Buller, B., & Chopp, M. (2019) · Nature Reviews Neurology · doi:10.1038/s41582-018-0126-4 · Cited by 549 · see citing works

Safety of Nanoparticles in Medicine

Wolfram, J., Zhu, M., Yang, Y. P., Shen, J., Gentile, E., Paolino, D., Fresta, M., Nie, G., Chen, C., Shen, H., et al. (2015) · Current Drug Targets · doi:10.2174/1389450115666140804124808 · Cited by 535 · see citing works

The Biology of Cancer Exosomes: Insights and New Perspectives

Ruivo, C. F., Adem, B., Silva, M. G., & Melo, S. A. (2017) · Cancer Research · doi:10.1158/0008-5472.can-17-0994 · Cited by 533 · see citing works

Alzheimer’s disease pathology propagation by exosomes containing toxic amyloid-beta oligomers

Sardar Sinha, M., Ansell-Schultz, A., Civitelli, L., Hildesjö, C., Larsson, M., Lannfelt, L., Ingelsson, M., & Hallbeck, M. (2018) · Acta Neuropathologica · doi:10.1007/s00401-018-1868-1 · Cited by 527 · see citing works

Exosomes derived from platelet-rich plasma promote the re-epithelization of chronic cutaneous wounds via activation of YAP in a diabetic rat model

Guo, S., Tao, S., Yin, W., Qi, X., Yuan, T., & Zhang, C. (2016) · Theranostics · doi:10.7150/thno.16803 · Cited by 519 · see citing works

Technical challenges of working with extracellular vesicles

Ramirez, M. I., de Amorim, M. G., Gadelha, C., Milic, I., Welsh, J. A., Freitas, V. M., Nawaz, M., Akbar, N., Couch, Y., Makin, L., et al. (2017) · Nanoscale · doi:10.1039/c7nr08360b · Cited by 518 · see citing works

Immunosuppression by mesenchymal stem cells: mechanisms and clinical applications

Ghannam, S., Bouffi, C., Djouad, F., Jorgensen, C., & Noël, D. (2010) · Stem Cell Research & Therapy · doi:10.1186/scrt2 · Cited by 507 · see citing works

Umbilical cord mesenchymal stem cells derived extracellular vesicles can safely ameliorate the progression of chronic kidney diseases

Nassar, W., El‐Ansary, M., Sabry, D., Mostafa, M. A., Fayad, T., Kotb, E., Temraz, M., Saad, A.-N., Essa, W. A., & Adel, H. (2016) · Biomaterials Research · doi:10.1186/s40824-016-0068-0 · Cited by 503 · see citing works

Technologies and Standardization in Research on Extracellular Vesicles

Gandham, S. K., Su, X., Wood, J., Nocera, A. L., Alli, S. C., Milane, L. S., Zimmerman, A. J., Amiji, M. M., & Ivanov, A. R. (2020) · Trends in biotechnology · doi:10.1016/j.tibtech.2020.05.012 · Cited by 494 · see citing works

Extracellular vesicles as drug delivery systems: Lessons from the liposome field

van der Meel, R., Fens, M. H. A. M., Vader, P., van Solinge, W. W., Eniola‐Adefeso, O., & Schiffelers, R. M. (2014) · Journal of Controlled Release · doi:10.1016/j.jconrel.2014.07.049 · Cited by 486 · see citing works

Exosomes Derived From Natural Killer Cells Exert Therapeutic Effect in Melanoma

Zhu, L., Kalimuthu, S., Gangadaran, P., Oh, J. M., Lee, H., Baek, S. H., Jeong, S. Y., Lee, S., Lee, J., & Ahn, B. (2017) · Theranostics · doi:10.7150/thno.18752 · Cited by 477 · see citing works

Tetraspanins at a glance

Charrin, S., Jouannet, S., Boucheix, C., & Rubinstein, E. (2014) · Journal of Cell Science · doi:10.1242/jcs.154906 · Cited by 454 · see citing works

Extracellular vesicles shuffling intercellular messages: for good or for bad.

Cicero, A. L., Stahl, P., & Raposo, G. (2015) · Current Opinion in Cell Biology · doi:10.1016/j.ceb.2015.04.013 · Cited by 453 · see citing works

Extracellular vesicles: a new communication paradigm?

Raposo, G., & Stahl, P. D. (2019) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-019-0158-7 · Cited by 443 · see citing works

Extracellular Vesicles and Neurodegenerative Diseases

Hill, A. F. (2019) · The Journal of Neuroscience · doi:10.1523/jneurosci.0147-18.2019 · Cited by 437 · see citing works

Induction of α-synuclein aggregate formation by CSF exosomes from patients with Parkinson’s disease and dementia with Lewy bodies

Stuendl, A., Kunadt, M., Kruse, N., Bartels, C., Moebius, W., Danzer, K. M., Mollenhauer, B., & Schneider, A. (2016) · Brain · doi:10.1093/brain/awv346 · Cited by 428 · see citing works

Direct detection of activated platelets and platelet-derived microparticles in humans

Abrams, C., D, N. E. M., Budzynski, A., & Shattil, S. (1990) · Blood · doi:10.1182/blood.v75.1.128.128 · Cited by 426 · see citing works

Smart drug delivery systems: from fundamentals to the clinic

Alvarez‐Lorenzo, C., & Concheiro, Á. (2014) · Chemical Communications · doi:10.1039/c4cc01429d · Cited by 416 · see citing works

Proteomic Analysis of Microvesicles Derived from Human Mesenchymal Stem Cells

Kim, H.-S., Choi, D., Yun, S. J., Choi, S., Kang, J. W., Jung, J. W., Hwang, D., Kim, K. P., & Kim, D. (2011) · Journal of Proteome Research · doi:10.1021/pr200682z · Cited by 398 · see citing works

Extracellular vesicles: novel promising delivery systems for therapy of brain diseases.

Rufino-Ramos, D., Albuquerque, P. R., Carmona, V., Perfeito, R., Nobre, R. J., & Pereira de Almeida, L. (2017) · Journal of Controlled Release · doi:10.1016/j.jconrel.2017.07.001 · Cited by 395 · see citing works

Dendritic cell-derived exosomes elicit tumor regression in autochthonous hepatocellular carcinoma mouse models

Lu, Z. F., Zuo, B., Jing, R., Gao, X., Rao, Q., Liu, Z., Han, Q., Guo, H., & Yin, H. (2017) · Journal of Hepatology · doi:10.1016/j.jhep.2017.05.019 · Cited by 391 · see citing works

RhoA triggers a specific signaling pathway that generates transforming microvesicles in cancer cells

Li, B., Antonyak, M. A., Zhang, J., & Cerione, R. A. (2012) · Oncogene · doi:10.1038/onc.2011.636 · Cited by 378 · see citing works

Red blood cell-mimicking synthetic biomaterial particles

Doshi, N., Zahr, A. S., Bhaskar, S., Lahann, J., & Mitragotri, S. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0907127106 · Cited by 374 · see citing works

Exosomes secreted by human adipose mesenchymal stem cells promote scarless cutaneous repair by regulating extracellular matrix remodelling

Wang, L., Hu, L., Zhou, X., Xiong, Z., Zhang, C., Shehada, H. M. A., Hu, B., Song, J., & Chen, L. (2017) · Scientific Reports · doi:10.1038/s41598-017-12919-x · Cited by 369 · see citing works

Exosomes from M1-Polarized Macrophages Potentiate the Cancer Vaccine by Creating a Pro-inflammatory Microenvironment in the Lymph Node

Cheng, L., Wang, Y., & Huang, L. (2017) · Molecular Therapy · doi:10.1016/j.ymthe.2017.02.007 · Cited by 364 · see citing works

Imaging extracellular vesicles: current and emerging methods

Chuo, S. T., Chien, J. C.-Y., & Lai, C. P. (2018) · Journal of Biomedical Science · doi:10.1186/s12929-018-0494-5 · Cited by 359 · see citing works

Drug Delivery with Extracellular Vesicles: From Imagination to Innovation

de Jong, O. G., Kooijmans, S. A. A., Murphy, D. E., Jiang, L., Evers, M. J. W., Sluijter, J. P. G., Vader, P., & Schiffelers, R. M. (2019) · Accounts of Chemical Research · doi:10.1021/acs.accounts.9b00109 · Cited by 358 · see citing works

Mesenchymal Stromal/stem Cell-derived Extracellular Vesicles Promote Human Cartilage Regeneration In Vitro

Vonk, L. A., van Dooremalen, S., Liv, N., Klumperman, J., Coffer, P. J., Saris, D. B. F., & Lorenowicz, M. J. (2017) · Theranostics · doi:10.7150/thno.20746 · Cited by 357 · see citing works

Enzyme Loading of Erythrocytes

Ihler, G. M., Glew, R. H., & Schnure, F. W. (1973) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.70.9.2663 · Cited by 350 · see citing works

Neutral sphingomyelinases control extracellular vesicles budding from the plasma membrane

Menck, K., Sönmezer, C., Worst, T. S., Schulz, M., Dihazi, G. H., Streit, F., Erdmann, G., Kling, S., Boutros, M., Binder, C. R., et al. (2017) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2017.1378056 · Cited by 350 · see citing works

Exosomes derived from human platelet-rich plasma prevent apoptosis induced by glucocorticoid-associated endoplasmic reticulum stress in rat osteonecrosis of the femoral head via the Akt/Bad/Bcl-2 signal pathway

Tao, S., Yuan, T., Rui, B., Zhu, Z., Guo, S., & Zhang, C. (2017) · Theranostics · doi:10.7150/thno.17450 · Cited by 347 · see citing works

miR-21 in the Extracellular Vesicles (EVs) of Cerebrospinal Fluid (CSF): A Platform for Glioblastoma Biomarker Development

Akers, J. C., Ramakrishnan, V., Kim, R., Skog, J., Nakano, I., Pingle, S. C., Kalinina, J., Hua, W., Kesari, S., Mao, Y. Q., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0078115 · Cited by 335 · see citing works

Exosome reporter mice reveal the involvement of exosomes in mediating neuron to astroglia communication in the CNS

Men, Y., Yelick, J., Jin, S., Tian, Y., Chiang, M. S. R., Higashimori, H., Brown, E., Jarvis, R., & Yang, Y. (2019) · Nature Communications · doi:10.1038/s41467-019-11534-w · Cited by 331 · see citing works

Red blood cell storage lesion: causes and potential clinical consequences.

Yoshida, T., Prudent, M., & D’Alessandro, A. (1969) · Blood transfusion · doi:10.2450/2019.0217-18 · Cited by 329 · see citing works

Mesenchymal Stem Cells from Human Umbilical Cord Express Preferentially Secreted Factors Related to Neuroprotection, Neurogenesis, and Angiogenesis

Hsieh, J.-Y., Wang, H., Chang, S., Liao, K., Lee, I., Lin, W., Wu, C., Lin, W., & Cheng, S. (2013) · PLoS ONE · doi:10.1371/journal.pone.0072604 · Cited by 319 · see citing works

MiRNA-Sequence Indicates That Mesenchymal Stem Cells and Exosomes Have Similar Mechanism to Enhance Cardiac Repair

Shao, L., Zhang, Y., Lan, B.-B., Wang, J., Zhang, Z., Zhang, L., Xiao, P., Meng, Q., Geng, Y., Yu, X.-Y., et al. (2017) · BioMed Research International · doi:10.1155/2017/4150705 · Cited by 300 · see citing works

Perspectives on the past, present, and future of cancer nanomedicine

Youn, Y. S., & Bae, Y. H. (2018) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2018.05.008 · Cited by 288 · see citing works

Alzheimer’s disease brain-derived extracellular vesicles spread tau pathology in interneurons

Ruan, Z., Pathak, D., Venkatesan Kalavai, S., Yoshii-Kitahara, A., Muraoka, S., Bhatt, N., Takamatsu-Yukawa, K., Hu, J., Wang, Y., Hersh, S., et al. (2021) · Brain · doi:10.1093/brain/awaa376 · Cited by 283 · see citing works

Astrocyte-derived extracellular vesicles: Neuroreparative properties and role in the pathogenesis of neurodegenerative disorders

Upadhya, R., Zingg, W., Shetty, S., & Shetty, A. K. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.04.017 · Cited by 282 · see citing works

Extracellular Vesicles in Cardiovascular Disease

Jansen, F., Nickenig, G., & Werner, N. (2017) · Circulation Research · doi:10.1161/circresaha.117.310752 · Cited by 279 · see citing works

Mitovesicles are a novel population of extracellular vesicles of mitochondrial origin altered in Down syndrome

D’Acunzo, P., Pérez‐González, R., Kim, Y., Hargash, T., Miller, C., Alldred, M. J., Erdjument‐Bromage, H., Penikalapati, S. C., Pawlik, M., Saito, M., et al. (2021) · Science Advances · doi:10.1126/sciadv.abe5085 · Cited by 276 · see citing works

Mutant Copper-Zinc Superoxide Dismutase (SOD1) Induces Protein Secretion Pathway Alterations and Exosome Release in Astrocytes

Basso, M., Pozzi, S., Tortarolo, M., Fiordaliso, F., Bisighini, C., Pasetto, L., Spaltro, G., Lidonnici, D., Gensano, F., Battaglia, E., et al. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.425066 · Cited by 274 · see citing works

The functions and clinical application potential of exosomes derived from adipose mesenchymal stem cells: a comprehensive review

Hong, P., Yang, H., Wu, Y., Li, K., & Tang, Z. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1358-y · Cited by 269 · see citing works

Stem Cell Therapy in Perspective

Strauer, B. E., & Kornowski, R. (2003) · Circulation · doi:10.1161/01.cir.0000057525.13182.24 · Cited by 263 · see citing works

Exosomal microRNA signatures in multiple sclerosis reflect disease status

Ebrahimkhani, S., Vafaee, F., Young, P. E., Hur, S. S. J., Hawke, S. H., Devenney, E. M., Beadnall, H. N., Barnett, M. H., Suter, C. M., & Buckland, M. E. (2017) · Scientific Reports · doi:10.1038/s41598-017-14301-3 · Cited by 263 · see citing works

Exosome-Like Vesicles with Dipeptidyl Peptidase IV in Human Saliva

Ogawa, Y., Kanai‐Azuma, M., Akimoto, Y., Kawakami, H., & Yanoshita, R. (2008) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.31.1059 · Cited by 259 · see citing works

Exosomes derived from umbilical cord mesenchymal stem cells reduce microglia-mediated neuroinflammation in perinatal brain injury

Thomi, G. F., Surbek, D., Haesler, V., Joerger-Messerli, M. S., & Schoeberlein, A. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1207-z · Cited by 257 · see citing works

Exosomes regulate neurogenesis and circuit assembly

Sharma, P., Mesci, P., Carromeu, C., Mcclatchy, D., Schiapparelli, L., Yates, J., Muotri, A., & Cline, H. (2019) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1902513116 · Cited by 257 · see citing works

Extracellular Vesicles from Child Gut Microbiota Enter into Bone to Preserve Bone Mass and Strength

Liu, J., Chen, C., Liu, Z., Luo, Z., Rao, S., Jin, L., Wan, T., Yue, T., Tan, Y., Yin, H., et al. (2021) · Advanced Science · doi:10.1002/advs.202004831 · Cited by 256 · see citing works

Activated CD8+ T cell extracellular vesicles prevent tumour progression by targeting of lesional mesenchymal cells

Seo, N., Shirakura, Y., Tahara, Y., Momose, F., Harada, N., Ikeda, H., Akiyoshi, K., & Shiku, H. (2018) · Nature Communications · doi:10.1038/s41467-018-02865-1 · Cited by 239 · see citing works

Mesenchymal Stem Cell-Derived Extracellular Vesicles as Therapeutics and as a Drug Delivery Platform

Baek, G., Choi, H., Kim, Y., Lee, H.-C., & Choi, C. (2019) · Stem Cells Translational Medicine · doi:10.1002/sctm.18-0226 · Cited by 229 · see citing works

Effects of ceramide and other simple sphingolipids on membrane lateral structure

Goñi, F. M., & Alonso, A. (2008) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2008.09.002 · Cited by 224 · see citing works

Extracellular vesicles derived from human umbilical cord mesenchymal stem cells alleviate rat hepatic ischemia‐reperfusion injury by suppressing oxidative stress and neutrophil inflammatory response

Yao, J., Zheng, J., Cai, J., Zeng, K., Zhou, C., Zhang, J., Li, S., Li, H., Chen, L., He, L., et al. (2018) · The FASEB Journal · doi:10.1096/fj.201800131rr · Cited by 217 · see citing works

Exosomes: novel effectors of human platelet lysate activity

Torreggiani, E., Perut, F., Roncuzzi, L., Zini, N., Baglio, S. R., & Baldini, N. (2014) · European Cells and Materials · doi:10.22203/ecm.v028a11 · Cited by 215 · see citing works

Carrier Erythrocytes: An Overview

Hamidi, M., & Tajerzadeh, H. (2003) · Drug Delivery · doi:10.1080/713840329 · Cited by 215 · see citing works

Engineered red blood cells as carriers for systemic delivery of a wide array of functional probes

Shi, J., Kundrat, L., Pishesha, N., Bilate, A. M. B., Theile, C. S., Maruyama, T., Dougan, S. K., Ploegh, H. L., & Lodish, H. F. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409861111 · Cited by 212 · see citing works

Graft-Versus-Host Disease Amelioration by Human Bone Marrow Mesenchymal Stromal/Stem Cell-Derived Extracellular Vesicles Is Associated with Peripheral Preservation of Naive T Cell Populations

Fujii, S., Miura, Y., Fujishiro, A., Shindo, T., Shimazu, Y., Hirai, H., Tahara, H., Takaori‐Kondo, A., Ichinohe, T., & Maekawa, T. (2017) · Stem Cells · doi:10.1002/stem.2759 · Cited by 209 · see citing works

Extracellular Microvesicles as New Industrial Therapeutic Frontiers

Agrahari, V., Agrahari, V., Burnouf, P., Chew, C. H., & Burnouf, T. P. R. (2019) · Trends in biotechnology · doi:10.1016/j.tibtech.2018.11.012 · Cited by 209 · see citing works

Stem cell-derived extracellular vesicles inhibit and revert fibrosis progression in a mouse model of diabetic nephropathy

Grange, C., Tritta, S., Tapparo, M., Cedrino, M., Tetta, C., Camussi, G., & Brizzi, M. F. (2019) · Scientific Reports · doi:10.1038/s41598-019-41100-9 · Cited by 202 · see citing works

Platelet Microparticles Enhance the Vasoregenerative Potential of Angiogenic Early Outgrowth Cells After Vascular Injury

Mause, S. F., Ritzel, E., Liehn, E. A., Hristov, M., Bidzhekov, K., Müller‐Newen, G., Soehnlein, O., & Weber, C. (2010) · Circulation · doi:10.1161/circulationaha.109.909473 · Cited by 201 · see citing works

Nanoparticles disguised as red blood cells to evade the immune system

Fang, R. H., Hu, C. J., & Zhang, L. (2012) · Expert Opinion on Biological Therapy · doi:10.1517/14712598.2012.661710 · Cited by 174 · see citing works

Exosomes Generated From iPSC-Derivatives

Jung, J., Fu, X., & Yang, P. C.-M. (2017) · Circulation Research · doi:10.1161/circresaha.116.309307 · Cited by 174 · see citing works

Immunotherapeutic Potential of Extracellular Vesicles

Zhang, B., Yin, Y., Lai, R. C., & Lim, S. K. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00518 · Cited by 173 · see citing works

Therapeutic effect of exosomes from indoleamine 2,3‐dioxygenase–positive dendritic cells in collagen‐induced arthritis and delayed‐type hypersensitivity disease models

Bianco, N. R., Kim, S. H., Ruffner, M. A., & Robbins, P. D. (2009) · Arthritis & Rheumatism · doi:10.1002/art.24229 · Cited by 171 · see citing works

Extracellular vesicles deposit <i>PCNA</i> to rejuvenate aged bone marrow–derived mesenchymal stem cells and slow age-related degeneration

Lei, Q., Gao, F., Liu, T., Ren, W., Chen, L., Cao, Y., Chen, W., Guo, S., Zhang, Q., Chen, W., et al. (2021) · Science Translational Medicine · doi:10.1126/scitranslmed.aaz8697 · Cited by 170 · see citing works

Natural or Synthetic RNA Delivery: A Stoichiometric Comparison of Extracellular Vesicles and Synthetic Nanoparticles

Murphy, D. E., de Jong, O. G., Evers, M. J. W., Nurazizah, M., Schiffelers, R. M., & Vader, P. (2021) · Nano Letters · doi:10.1021/acs.nanolett.1c00094 · Cited by 169 · see citing works

Global exosome transcriptome profiling reveals biomarkers for multiple sclerosis

Selmaj, I., Cichalewska, M., Namiecińska, M., Gałązka, G., Horzelski, W., Selmaj, K. W., & Mycko, M. P. (2017) · Annals of Neurology · doi:10.1002/ana.24931 · Cited by 168 · see citing works

Extracellular Vesicles from Red Blood Cells and Their Evolving Roles in Health, Coagulopathy and Therapy

Thangaraju, K., Neerukonda, S. N., Katneni, U., & Buehler, P. W. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms22010153 · Cited by 164 · see citing works

Exosomes derived from human umbilical cord mesenchymal stem cells protect against cisplatin-induced ovarian granulosa cell stress and apoptosis in vitro

Sun, L., Li, D., Song, K., Wei, J., Yao, S., Zhao, L., Su, X., Ju, X., Lan, C., Deng, X., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-02786-x · Cited by 164 · see citing works

Adipose-derived stem cell exosomes alleviate pathology of amyotrophic lateral sclerosis in vitro

Lee, M., Ban, J.-J., Kim, K.-Y., Jeon, G. S., Im, W., Sung, J., & Kim, M. (2016) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2016.09.069 · Cited by 156 · see citing works

miRNA contents of cerebrospinal fluid extracellular vesicles in glioblastoma patients

Akers, J. C., Ramakrishnan, V., Kim, R., Phillips, S., Kaimal, V., Mao, Y. Q., Hua, W., Yang, I., Fu, C.-C., Nolan, J. P., et al. (2015) · Journal of Neuro-Oncology · doi:10.1007/s11060-015-1784-3 · Cited by 155 · see citing works

Comparative Study of Extracellular Vesicles from the Urine of Healthy Individuals and Prostate Cancer Patients

Bryzgunova, O. E., Zaripov, M. M., Skvortsova, T. E., Lekchnov, E. A., Grigor’eva, A. E., Zaporozhchenko, I. A., Morozkin, E. S., Ryabchikova, E. I., Yurchenko, Y. B., Voitsitskiy, V. E., et al. (2016) · PLoS ONE · doi:10.1371/journal.pone.0157566 · Cited by 155 · see citing works

Methodologies to Isolate and Purify Clinical Grade Extracellular Vesicles for Medical Applications

Akbar, A., Malekian, F., Baghban, N., Kodam, S. P., & Ullah, M. (2022) · Cells · doi:10.3390/cells11020186 · Cited by 154 · see citing works

Human adipose tissue mesenchymal stromal cells and their extracellular vesicles act differentially on lung mechanics and inflammation in experimental allergic asthma

de Castro, L. L., Xisto, D. G., Kitoko, J. Z., Cruz, F. F., Olsen, P. C., Redondo, P. A. G., Ferreira, T. P. T., Weiss, D. J., Martins, M. A., Morales, M. M., et al. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-017-0600-8 · Cited by 148 · see citing works

TLR-3 stimulation improves anti-tumor immunity elicited by dendritic cell exosome-based vaccines in a murine model of melanoma

Damo, M., Wilson, D. S., Simeoni, E., & Hubbell, J. A. (2015) · Scientific Reports · doi:10.1038/srep17622 · Cited by 145 · see citing works

Self inhibition of phagocytosis: The affinity of ‘marker of self’ CD47 for SIRPα dictates potency of inhibition but only at low expression levels

Tsai, R. K., Rodriguez, P. L., & Discher, D. E. (2010) · Blood Cells Molecules and Diseases · doi:10.1016/j.bcmd.2010.02.016 · Cited by 143 · see citing works

Extracellular vesicles derived from different sources of mesenchymal stem cells: therapeutic effects and translational potential

Cai, J., Wu, J., Wang, J., Li, Y., Hu, X.-B., Luo, S., & Xiang, D. (2020) · Cell & Bioscience · doi:10.1186/s13578-020-00427-x · Cited by 137 · see citing works

Extracellular vesicles from bone marrow-derived multipotent mesenchymal stromal cells regulate inflammation and enhance tendon healing

Shi, Z., Wang, Q., & Jiang, D. (2019) · Journal of Translational Medicine · doi:10.1186/s12967-019-1960-x · Cited by 131 · see citing works

Synergistic Induction of Adaptive Antitumor Immunity by Codelivery of Antigen with α-Galactosylceramide on Exosomes

Gehrmann, U., Hiltbrunner, S., Georgoudaki, A., Karlsson, M. C. I., Näslund, T. I., & Gabrielsson, S. (2013) · Cancer Research · doi:10.1158/0008-5472.can-12-3918 · Cited by 130 · see citing works

Expression of coagulant activity in human platelets: Release of membranous vesicles providing platelet factor 1 and platelet factor 3

Sandberg, H., Bode, A. P., Dombrose, F. A., Hoechli, M., & Lentz, B. R. (1985) · Thrombosis Research · doi:10.1016/0049-3848(85)90122-7 · Cited by 121 · see citing works

Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival

Aiello, S., Rocchetta, F., Longaretti, L., Faravelli, S., Todeschini, M., Cassis, L., Pezzuto, F., Tomasoni, S., Azzollini, N., Mister, M., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-08617-3 · Cited by 120 · see citing works

Oviductal extracellular vesicles interact with the spermatozoon’s head and mid-piece and improves its motility and fertilizing ability in the domestic cat

Ferraz, M. D. A. M. M., Carothers, A., Dahal, R., Noonan, M. J., & Songsasen, N. (2019) · Scientific Reports · doi:10.1038/s41598-019-45857-x · Cited by 120 · see citing works

Astrocyte-derived small extracellular vesicles promote synapse formation via fibulin-2-mediated TGF-β signaling

Patel, M. R., & Weaver, A. M. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108829 · Cited by 120 · see citing works

Extracellular vesicles from human umbilical cord mesenchymal stem cells improve nerve regeneration after sciatic nerve transection in rats

Ma, Y., Dong, L., Zhou, D., Li, L., Zhang, W., Yu, Z., Wang, T., Su, J., Chen, D., Mao, C., et al. (2019) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.14190 · Cited by 119 · see citing works

Tolerance Induction by Exosomes from Immature Dendritic Cells and Rapamycin in a Mouse Cardiac Allograft Model

Li, X., Li, J., Yang, J., Wang, D., Zhao, W., Song, W., Li, W., Wang, J.-F., Han, W., Zhang, Z., et al. (2012) · PLoS ONE · doi:10.1371/journal.pone.0044045 · Cited by 118 · see citing works

Platelet Microparticles Induce Angiogenesis and Neurogenesis after Cerebral Ischemia

Hayon, Y., Dashevsky, O., Shai, E., Brill, A. G., Varon, D., & Leker, R. R. (2012) · Current Neurovascular Research · doi:10.2174/156720212801619018 · Cited by 117 · see citing works

Platelets confound the measurement of extracellular miRNA in archived plasma

Mitchell, A. J., Gray, W. D., Hayek, S. S., Ko, Y., Thomas, S., Rooney, K., Awad, M., Roback, J. D., Quyyumi, A. A., & Searles, C. D. (2016) · Scientific Reports · doi:10.1038/srep32651 · Cited by 117 · see citing works

Extracellular Vesicles As Nanomedicine: Hopes And Hurdles In Clinical Translation

Burnouf, T., Agrahari, V., & Agrahari, V. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s225453 · Cited by 113 · see citing works

Platelet-derived extracellular vesicles to target plaque inflammation for effective anti-atherosclerotic therapy

Ma, Q., Fan, Q., Han, X., Dong, Z., Xu, J., Bai, J., Tao, W., Sun, D., & Wang, C. (2020) · Journal of Controlled Release · doi:10.1016/j.jconrel.2020.11.064 · Cited by 112 · see citing works

Programmed cell death 4 and micro RNA 21 inverse expression is maintained in cells and exosomes from ovarian serous carcinoma effusions

Cappellesso, R., Tinazzi, A., Giurici, T., Simonato, F., Guzzardo, V., Ventura, L., Crescenzi, M., Chiarelli, S. M., & Fassina, A. (2014) · Cancer Cytopathology · doi:10.1002/cncy.21442 · Cited by 111 · see citing works

Exosomes function in cell–cell communication during brain circuit development

Sharma, P., Schiapparelli, L., & Cline, H. T. (2013) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2013.08.005 · Cited by 110 · see citing works

Optimizing preservation of extracellular vesicular miRNAs derived from clinical cerebrospinal fluid

Akers, J. C., Ramakrishnan, V., Yang, I., Hua, W., Mao, Y. Q., Carter, B. S., & Chen, C. C. (2016) · Cancer Biomarkers · doi:10.3233/cbm-160609 · Cited by 109 · see citing works

The Future of Regenerative Medicine: Cell Therapy Using Pluripotent Stem Cells and Acellular Therapies Based on Extracellular Vesicles

Jarrige, M., Frank, E., Herardot, E., Martineau, S., Darle, A., Benabidès, M., Domingues, S., Chose, O., Habeler, W., Lorant, J., et al. (2021) · Cells · doi:10.3390/cells10020240 · Cited by 106 · see citing works

Extracellular Vesicles Carry HIV Env and Facilitate Hiv Infection of Human Lymphoid Tissue

Arakelyan, A., Fitzgerald, W., Zicari, S., Vanpouille, C., & Margolis, L. B. (2017) · Scientific Reports · doi:10.1038/s41598-017-01739-8 · Cited by 103 · see citing works

Platelet-, monocyte-derived and tissue factor-carrying circulating microparticles are related to acute myocardial infarction severity

Chiva‐Blanch, G., Laake, K., Myhre, P. L., Bratseth, V., Arnesen, H., Solheim, S., Badimón, L., & Seljeflot, I. (2017) · PLoS ONE · doi:10.1371/journal.pone.0172558 · Cited by 98 · see citing works

Mesenchymal Stem Cell-Derived Extracellular Vesicles and Their Therapeutic Potential

Zhao, A. G., Shah, K., Cromer, B. A., & Sümer, H. (2020) · Stem Cells International · doi:10.1155/2020/8825771 · Cited by 95 · see citing works

Role of platelet-derived microparticles in angiogenesis and tumor progression.

Varon, D., & Shai, E. (2009) · PubMed · Cited by 91 · see citing works

Nanovesicles from adipose-derived mesenchymal stem cells inhibit T lymphocyte trafficking and ameliorate chronic experimental autoimmune encephalomyelitis

Farinazzo, A., Angiari, S., Turano, E., Bistaffa, E., Dusi, S., Ruggieri, S., Bonafede, R., Mariotti, R., Constantin, G., & Bonetti, B. (2018) · Scientific Reports · doi:10.1038/s41598-018-25676-2 · Cited by 85 · see citing works

Microparticles in the blood of patients with systemic lupus erythematosus (SLE): phenotypic characterization and clinical associations

Mobarrez, F., Vikerfors, A., Gustafsson, J. T., Gunnarsson, I., Zickert, A., Larsson, A., Pisetsky, D. S., Wallén, H., & Svenungsson, E. (2016) · Scientific Reports · doi:10.1038/srep36025 · Cited by 85 · see citing works

Diagnostic and Therapeutic Potential of Extracellular Vesicles

Kodam, S. P., & Ullah, M. (2021) · Technology in Cancer Research & Treatment · doi:10.1177/15330338211041203 · Cited by 82 · see citing works

Organotropic drug delivery: Synthetic nanoparticles and extracellular vesicles

Busatto, S., Pham, A. N., Suh, A., Shapiro, S. A., & Wolfram, J. (2019) · Biomedical Microdevices · doi:10.1007/s10544-019-0396-7 · Cited by 81 · see citing works

Red Blood Cells-Derived Vesicles for Delivery of Lipophilic Drug Camptothecin

Malhotra, S., Dumoga, S., Sirohi, P., & Singh, N. (2019) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.9b04827 · Cited by 79 · see citing works

GATA-4-expressing mouse bone marrow mesenchymal stem cells improve cardiac function after myocardial infarction via secreted exosomes

He, J., Li, H.-R., Han, J.-X., Li, B., Yan, D., Li, H., Wang, P., & Luo, Y. (2018) · Scientific Reports · doi:10.1038/s41598-018-27435-9 · Cited by 78 · see citing works

Extracellular vesicles from human umbilical cord blood ameliorate bone loss in senile osteoporotic mice

Hu, Y., Xu, R., Chen, C., Rao, S., Xia, K., Huang, J., Yin, H., Wang, Z., Cao, J., Liu, Z., et al. (2019) · Metabolism · doi:10.1016/j.metabol.2019.01.009 · Cited by 75 · see citing works

Exosomes Derived from Immature Bone Marrow Dendritic Cells Induce Tolerogenicity of Intestinal Transplantation in Rats

Yang, X., Song, M., Jiang, H., Zhu, C., & Wen-xi, W. (2010) · Journal of Surgical Research · doi:10.1016/j.jss.2010.05.021 · Cited by 75 · see citing works

The Challenges and Possibilities of Extracellular Vesicles as Therapeutic Vehicles

Melling, G. E., Carollo, E., Conlon, R., Simpson, J. C., & Carter, D. R. F. (2019) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2019.08.009 · Cited by 74 · see citing works

Extracellular Vesicles Derived from Wharton’s Jelly Mesenchymal Stem Cells Prevent and Resolve Programmed Cell Death Mediated by Perinatal Hypoxia-Ischemia in Neuronal Cells

Joerger-Messerli, M. S., Oppliger, B., Spinelli, M., Thomi, G. F., Salvo, I. D., Schneider, P., & Schoeberlein, A. (2018) · Cell Transplantation · doi:10.1177/0963689717738256 · Cited by 73 · see citing works

Neuronally derived extracellular vesicles: an emerging tool for understanding Alzheimer’s disease

Watson, L. S., Hamlett, E. D., Stone, T. D., & Sims‐Robinson, C. (2019) · Molecular Neurodegeneration · doi:10.1186/s13024-019-0317-5 · Cited by 72 · see citing works

Extracellular vesicles and chronic inflammation during HIV infection

Pérez, P. S., Romaniuk, M. A., Duette, G., Zhao, Z., Huang, Y., Jaular, L. M., Witwer, K. W., Théry, C., & Ostrowski, M. (2019) · Journal of Extracellular Vesicles · doi:10.1080/20013078.2019.1687275 · Cited by 72 · see citing works

Intranasal administration of small extracellular vesicles derived from mesenchymal stem cells ameliorated the experimental autoimmune encephalomyelitis

Fathollahi, A., Hashemi, S. M., Hoseini, M. H. M., Tavakoli, S., Farahani, E., & Yeganeh, F. (2020) · International Immunopharmacology · doi:10.1016/j.intimp.2020.107207 · Cited by 71 · see citing works

Potential Application of Extracellular Vesicles of Human Adipose Tissue-Derived Mesenchymal Stem Cells in Alzheimer’s Disease Therapeutics

Katsuda, T., Oki, K., & Ochiya, T. (2014) · Methods in molecular biology · doi:10.1007/7651_2014_98 · Cited by 70 · see citing works

Exosome engineering for efficient and targeted drug delivery: Current status and future perspective

Malekian, F., Shamsian, A., Kodam, S. P., & Ullah, M. (2022) · The Journal of Physiology · doi:10.1113/jp282799 · Cited by 70 · see citing works

Enzyme-responsive multistage vector for drug delivery to tumor tissue

Mi, Y., Wolfram, J., Mu, C., Liu, X., Blanco, E., Shen, H., & Mauro Ferrari, B. (2016) · Pharmacological Research · doi:10.1016/j.phrs.2016.08.024 · Cited by 66 · see citing works

Monitoring Extracellular Vesicle Cargo Active Uptake by Imaging Flow Cytometry

Ofir‐Birin, Y., Karam, P. A., Rudik, A., Giladi, T., Porat, Z., & Regev‐Rudzki, N. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.01011 · Cited by 65 · see citing works

Recent advances of SIRT1 and implications in chemotherapeutics resistance in cancer.

Yousafzai, N. A., Jin, H., Ullah, M., & Wang, X. (2021) · PubMed Central · Cited by 64 · see citing works

Multi-step encapsulation of chemotherapy and gene silencing agents in functionalized mesoporous silica nanoparticles

Shen, J., Liu, H., Mu, C., Wolfram, J., Zhang, W., Kim, H.-C., Zhu, G., Hu, Z., Ji, L.-N., Liu, X., et al. (2017) · Nanoscale · doi:10.1039/c7nr00377c · Cited by 63 · see citing works

Mesenchymal Stem Cell-Derived Extracellular Vesicles Carrying miRNA as a Potential Multi Target Therapy to COVID-19: an In Silico Analysis

Schultz, I. C., Bertoni, A. P. S., & Wink, M. R. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10122-0 · Cited by 62 · see citing works

Small Extracellular Vesicles from adipose derived stromal cells significantly attenuate in vitro the NF-κB dependent inflammatory/catabolic environment of osteoarthritis

Cavallo, C., Merli, G., Borzı̀, R. M., Zini, N., D’Adamo, S., Guescini, M., Grigolo, B., Martino, A. D., Santi, S., & Filardo, G. (2021) · Scientific Reports · doi:10.1038/s41598-020-80032-7 · Cited by 62 · see citing works

Combining Exosomes Derived from Immature DCs with Donor Antigen-Specific Treg Cells Induces Tolerance in a Rat Liver Allograft Model

Ma, B., Yang, J., Song, W., Ding, R., Zhang, Z., Ji, H., Zhang, X., Wang, J., Yang, X., Tao, K., et al. (2016) · Scientific Reports · doi:10.1038/srep32971 · Cited by 59 · see citing works

Post-nano strategies for drug delivery: multistage porous silicon microvectors

Venuta, A., Wolfram, J., Shen, H., & Mauro Ferrari, B. (2016) · Journal of Materials Chemistry B · doi:10.1039/c6tb01978a · Cited by 57 · see citing works

Emerging role of stem cell-derived extracellular microRNAs in age-associated human diseases and in different therapies of longevity

Ullah, M., Ng, N. N., Concepcion, W., & Thakor, A. S. (2019) · Ageing Research Reviews · doi:10.1016/j.arr.2019.100979 · Cited by 57 · see citing works

Platelet-Derived Extracellular Vesicles as Target of Antiplatelet Agents. What Is the Evidence?

Taus, F., Meneguzzi, A., Castelli, M., & Minuz, P. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.01256 · Cited by 56 · see citing works

Transdifferentiation of mesenchymal stem cells-derived adipogenic-differentiated cells into osteogenic- or chondrogenic-differentiated cells proceeds via dedifferentiation and have a correlation with cell cycle arresting and driving genes

Ullah, M., Stich, S., Notter, M., Eucker, J., Sittinger, M., & Ringe, J. (2013) · Differentiation · doi:10.1016/j.diff.2013.02.001 · Cited by 55 · see citing works

Potential of Extracellular Vesicles in Neurodegenerative Diseases: Diagnostic and Therapeutic Indications

Izadpanah, M., Seddigh, A., Ebrahimi Barough, S., Fazeli, S. A. S., & Ai, J. (2018) · Journal of Molecular Neuroscience · doi:10.1007/s12031-018-1135-x · Cited by 48 · see citing works

Adult Stem Cell-Derived Extracellular Vesicles in Cancer Treatment: Opportunities and Challenges

Parfejevs, V., Sagini, K., Buss, A., Soboļevska, K., Llorente, A., Riekstiņa, U., & Ābols, A. (2020) · Cells · doi:10.3390/cells9051171 · Cited by 46 · see citing works

Circulating extracellular vesicles release oncogenic miR-424 in experimental models and patients with aggressive prostate cancer

Albino, D., Falcione, M., Uboldi, V., Temilola, D. O., Sandrini, G., Merulla, J., Civenni, G., Kokanovic, A., Stürchler, A., Shinde, D. A., et al. (2021) · Communications Biology · doi:10.1038/s42003-020-01642-5 · Cited by 45 · see citing works

Stem cell-derived extracellular vesicles: role in oncogenic processes, bioengineering potential, and technical challenges

Ullah, M., Qiao, Y., Concepcion, W., & Thakor, A. S. (2019) · Stem Cell Research & Therapy · doi:10.1186/s13287-019-1468-6 · Cited by 43 · see citing works

Homologous RBC-derived vesicles as ultrasmall carriers of iron oxide for magnetic resonance imaging of stem cells

Chang, M., Hsiao, J., Yao, M., Chien, L., Hsu, S.-C., Ko, B., Chen, S., Liu, H., Chen, Y., Yang, C., et al. (2010) · Nanotechnology · doi:10.1088/0957-4484/21/23/235103 · Cited by 38 · see citing works

Neurons-derived extracellular vesicles promote neural differentiation of ADSCs: a model to prevent peripheral nerve degeneration

Roballo, K. C. S., da Silveira, J. C., Bressan, F. F., de Souza, A. F., Pereira, V. M., Pinzón, J. E., Rós, F. A., Pulz, L. H., Strefezzi, R. D. F., Martins, D. D. S., et al. (2019) · Scientific Reports · doi:10.1038/s41598-019-47229-x · Cited by 37 · see citing works

Prions on the run: How extracellular vesicles serve as delivery vehicles for self-templating protein aggregates

Liu, S., Hossinger, A., Göbbels, S., & Vorberg, I. M. (2017) · Prion · doi:10.1080/19336896.2017.1306162 · Cited by 35 · see citing works

Pulsed focused ultrasound enhances the therapeutic effect of mesenchymal stromal cell-derived extracellular vesicles in acute kidney injury

Ullah, M., Liu, D. D., Rai, S., Razavi, M., Concepcion, W., & Thakor, A. S. (2020) · Stem Cell Research & Therapy · doi:10.1186/s13287-020-01922-1 · Cited by 34 · see citing works

Extracellular vesicles and cardiovascular disease therapy

Amosse, J., Martínez, M. C., & Lay, S. L. (2017) · Stem Cell Investigation · doi:10.21037/sci.2017.11.07 · Cited by 30 · see citing works

Bone Marrow Mesenchymal Stem Cells

Dennis, J. E., & Caplan, A. I. (2004) · doi:10.1007/978-1-59259-411-5_10 · Cited by 30 · see citing works

Pathogenic and protective roles of extracellular vesicles in neurodegenerative diseases

Takeuchi, T. (2020) · The Journal of Biochemistry · doi:10.1093/jb/mvaa131 · Cited by 29 · see citing works

Advances in military, field, and austere transfusion medicine in the last decade

Hess, J. R., Lelkens, C. C. M., Holcomb, J. B., & Scalea, T. M. (2013) · Transfusion and Apheresis Science · doi:10.1016/j.transci.2013.06.015 · Cited by 27 · see citing works

Stability of Erythrocyte-Derived Nanovesicles Assessed by Light Scattering and Electron Microscopy

Božič, D., Hočevar, M., Kisovec, M., Pajnič, M., Pađen, L., Jeran, M., Zavec, A. B., Podobnik, M., Kogej, K., Iglič, A., et al. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222312772 · Cited by 26 · see citing works

Extracellular vesicles from human bone marrow mesenchymal stem cells repair organ damage caused by cadmium poisoning in a medaka model

Matsukura, T., Inaba, C., Weygant, E. A., Kitamura, D., Janknecht, R., Matsumoto, H., Hyink, D. P., Kashiwada, S., & Obara, T. (2019) · Physiological Reports · doi:10.14814/phy2.14172 · Cited by 24 · see citing works

Artificial intelligence and guidance of medicine in the bubble

Akbar, A., Pillalamarri, N., Jonnakuti, S. T., & Ullah, M. (2021) · Cell & Bioscience · doi:10.1186/s13578-021-00623-3 · Cited by 21 · see citing works

Applicability of extracellular vesicles in clinical studies

Vozel, D., Uršič, B., Krek, J. L., Štukelj, R., & Kralj‐Iglič, V. (2017) · European Journal of Clinical Investigation · doi:10.1111/eci.12733 · Cited by 20 · see citing works

Neural-Derived Extracellular Vesicles in Clinical Trials

Dubal, D. B., & Pleasure, S. J. (2019) · JAMA Neurology · doi:10.1001/jamaneurol.2018.4325 · Cited by 20 · see citing works

Small Extracellular Vesicles Control Dendritic Spine Development through Regulation of HDAC2 Signaling

Zhang, L., Lin, T. V., Yuan, Q., Sadoul, R., Lam, T. T., & Bordey, A. (2021) · Journal of Neuroscience · doi:10.1523/jneurosci.0766-20.2021 · Cited by 20 · see citing works

Exosomes are possibly used as a tool of immune regulation during the dendritic cell-based immune therapy against HIV-I

Ellwanger, J. H., Crovella, S., dos Reis, E. C., Pontillo, A., & Chies, J. A. B. (2016) · Medical Hypotheses · doi:10.1016/j.mehy.2016.09.005 · Cited by 18 · see citing works

Advances in innovative exosome-technology for real time monitoring of viable drugs in clinical translation, prognosis and treatment response

Ullah, M., Pek, N. M. Q., & Yannarelli, G. (2021) · Oncotarget · doi:10.18632/oncotarget.27927 · Cited by 17 · see citing works

Clinical Relevance of RNA Editing to Early Detection of Cancer in Human

Ullah, M., & Akbar, A. (2020) · International Journal of Stem cell Research & Therapy · doi:10.23937/2469-570x/1410066 · Cited by 15 · see citing works

Need for Specialized Therapeutic Stem Cells Banks Equipped with Tumor Regression Enzymes and Anti-Tumor Genes

Ullah, M. (2020) · Journal of Biomedical and Allied Research · doi:10.37191/mapsci-2582-4937-2(1)-013 · Cited by 15 · see citing works

Novel Coronavirus (COVID-19) Treatment Options

Ullah, M. (2020) · Biomedical Journal of Scientific & Technical Research · doi:10.26717/bjstr.2020.27.004518 · Cited by 14 · see citing works

Clinical Applications of RNA Editing Technology for the Early Detection of Cancer and Future Directions

Ullah, M., Akbar, A., & Yannarelli, G. (2020) · Technology in Cancer Research & Treatment · doi:10.1177/1533033820964194 · Cited by 14 · see citing works

Heat shock protein 20 promotes sirtuin 1-dependent cell proliferation in induced pluripotent stem cells

Ullah, M., Pek, N. M. Q., Yannarelli, G., & Akbar, A. (2021) · World Journal of Stem Cells · doi:10.4252/wjsc.v13.i6.659 · Cited by 13 · see citing works

Targeting the PANoptosome with miRNA Loaded Mesenchymal Stem Cell Derived Extracellular Vesicles; a New Path to Fight Against the Covid-19?

Çetin, Z. (2021) · Stem Cell Reviews and Reports · doi:10.1007/s12015-021-10166-2 · Cited by 6 · see citing works

Plant-Derived Extracellular Vesicles and Their Exciting Potential as the Future of Next-Generation Drug Delivery

Alzahrani, F. A., Khan, M. I., Kameli, N., Alsahafi, E., & Riza, Y. M. (2023) · Biomolecules · doi:10.3390/biom13050839 · Cited by 143 · see citing works

Global requirements for manufacturing and validation of clinical grade extracellular vesicles

Thakur, A., & Rai, D. (2024) · The Journal of Liquid Biopsy · doi:10.1016/j.jlb.2024.100278 · Cited by 109 · see citing works

Advances in Platelet Rich Plasma-Derived Extracellular Vesicles for Regenerative Medicine: A Systematic-Narrative Review

Anitua, E., Troya, M., Falcón‐Pérez, J. M., López-Sarrio, S., González, E., & Alkhraisat, M. H. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241713043 · Cited by 69 · see citing works

Engineering of MSC-Derived Exosomes: A Promising Cell-Free Therapy for Osteoarthritis

Cheng, J., Sun, Y., Ma, Y., Ao, Y., Hu, X., & Meng, Q. (2022) · Membranes · doi:10.3390/membranes12080739 · Cited by 68 · see citing works

Exploring the bioactivity of MicroRNAs Originated from Plant-derived Exosome-like Nanoparticles (PELNs): current perspectives

Tembo, K. M., Wang, X., Bolideei, M., Liu, Q., Baboni, F., Mehran, M. J., Sun, F., & Wang, C. (2025) · Journal of Nanobiotechnology · doi:10.1186/s12951-025-03602-9 · Cited by 64 · see citing works

Extracellular vesicles as carriers of mRNA: Opportunities and challenges in diagnosis and treatment

Kirian, R. D., Steinman, D., Jewell, C. M., & Zierden, H. C. (2024) · Theranostics · doi:10.7150/thno.93115 · Cited by 46 · see citing works

Exosome Source Matters: A Comprehensive Review from the Perspective of Diverse Cellular Origins

Chen, Y., Qi, W., Wang, Z., & Niu, F. (2025) · Pharmaceutics · doi:10.3390/pharmaceutics17020147 · Cited by 47 · see citing works

Emerging extracellular vesicle-based carriers for glioblastoma diagnosis and therapy

Wang, J., Liu, Y., Liu, F., Gan, S., Roy, S., Hasan, I., Zhang, B., & Guo, B. (2023) · Nanoscale · doi:10.1039/d3nr01667f · Cited by 32 · see citing works

Extracellular Vesicles as Drug Delivery System for Cancer Therapy

Wang, J., Yin, B., Lian, J., & Wang, X. (2024) · Pharmaceutics · doi:10.3390/pharmaceutics16081029 · Cited by 31 · see citing works

Exosomes in transplantation: Role in allograft rejection, diagnostic biomarker, and therapeutic potential

Saravanan, P. B., Kalivarathan, J., Khan, F., Shah, R., Levy, M. F., & Kanak, M. A. (2023) · Life Sciences · doi:10.1016/j.lfs.2023.121722 · Cited by 29 · see citing works

Diverse drug delivery systems for the enhancement of cancer immunotherapy: an overview

Liu, X., Cheng, Y., Mu, Y., Zhang, Z., Tian, D., Liu, Y., Hu, X., & Wen, T. (2024) · Frontiers in Immunology · doi:10.3389/fimmu.2024.1328145 · Cited by 27 · see citing works

Extracellular vesicles: A new frontier in deciphering the mechanisms of traditional Chinese medicine

Wang, K., He, S., Wang, Y., Guo, S., Zhang, F., Wang, Y., Dong, W., Zhang, L., Wang, X., & Yu, L. (2025) · Pharmacological Research · doi:10.1016/j.phrs.2025.107890 · Cited by 26 · see citing works

Small extracellular vesicles derived from four dimensional-culture of mesenchymal stem cells induce alternatively activated macrophages by upregulating IGFBP2/EGFR to attenuate inflammation in the spinal cord injury of rats

Wang, J., Wei, Q.-S., Yang, Y., Che, M., Ma, Y., Peng, L., Yu, H., Shi, H., He, G., Wu, R., et al. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1146981 · Cited by 23 · see citing works

Extracellular vesicles and their cells of origin: Open issues in autoimmune diseases

Haghighitalab, A., Dominici, M., Matin, M. M., Shekari, F., Warkiani, M. E., Lim, R., Ahmadiankia, N., Mirahmadi, M., Bahrami, A. R., & Bidkhori, H. R. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1090416 · Cited by 20 · see citing works

Immunomodulatory function of licensed human bone marrow mesenchymal stromal cell-derived apoptotic bodies

Wang, J., Donohoe, E., Canning, A., Moosavizadeh, S., Buckley, F., Brennan, M. Á., Ryan, A. E., & Ritter, T. (2023) · International Immunopharmacology · doi:10.1016/j.intimp.2023.111096 · Cited by 20 · see citing works

Isolator-based point-of-care manufacturing: a practical solution for GMP-compliant cell and extracellular vesicles therapy production

Chiu, Y.-S., Wang, K.-L., & Wu, K.-L. (2025) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2025.1644318 · Cited by 17 · see citing works

Extracellular Vesicles from Ocular Melanoma Have Pro-Fibrotic and Pro-Angiogenic Properties on the Tumor Microenvironment

Piquet, L., Coutant, K., Mitchell, A., Anes, A. B., Bollmann, E., Schoonjans, N., Bérubé, J., Bordeleau, F., Brisson, A. R., & Landreville, S. (2022) · Cells · doi:10.3390/cells11233828 · Cited by 17 · see citing works

Prospective applications of extracellular vesicle-based therapies in regenerative medicine: implications for the use of dental stem cell-derived extracellular vesicles

Wang, W., Xu, Z., Liu, M., Cai, M., & Liu, X. (2023) · Frontiers in Bioengineering and Biotechnology · doi:10.3389/fbioe.2023.1278124 · Cited by 17 · see citing works

Review on extraction technology and function of plant-derived exosome-like nanoparticles

Cheng, J., & Zhu, Y. (2025) · Frontiers in Medical Technology · doi:10.3389/fmedt.2025.1668738 · Cited by 16 · see citing works

Advances in 3D Culture Models to Study Exosomes in Triple-Negative Breast Cancer

Yousafzai, N. A., Khalki, L. E., Wang, W., Szpendyk, J., & Sossey-Alaoui, K. (2024) · Cancers · doi:10.3390/cancers16050883 · Cited by 19 · see citing works

Artificial Extracellular Vesicles Generated from T Cells Using Different Induction Techniques

Zmievskaya, E., Mukhametshin, S. A., Ganeeva, I., Gilyazova, E., Siraeva, E. T., Кутырева, М. П., Khannanov, A., Yuan, Y., & Bulatov, E. (2024) · Biomedicines · doi:10.3390/biomedicines12040919 · Cited by 15 · see citing works

Therapeutic Effects of Mesenchymal Stem Cell-Derived Extracellular Vesicles in sepsis: a Systematic Review and Meta-Analysis of Preclinical Studies

Aghayan, A. H., Mirazimi, Y., Fateh, K., Keshtkar, A., Rafiee, M., & Atashi, A. (2024) · Stem Cell Reviews and Reports · doi:10.1007/s12015-024-10741-3 · Cited by 15 · see citing works

Unveiling Invisible Extracellular Vesicles: Cutting‐Edge Technologies for Their in Vivo Visualization

Gangadaran, P., Khan, F., Rajendran, R. L., Onkar, A., Goenka, A., & Ahn, B. (2024) · Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology · doi:10.1002/wnan.2009 · Cited by 15 · see citing works

Role of CD9 Sensing, AI, and Exosomes in Cellular Communication of Cancer

Neda, B., Kodam, S. P., & Ullah, M. (2023) · International Journal of Stem cell Research & Therapy · doi:10.23937/2469-570x/1410079 · Cited by 13 · see citing works

Novel microchip electrophoresis–contactless conductivity method for detection and characterization of extracellular vesicles enriched for exosomes and microvesicles

Rui, S., Liu, Y., Huang, H., Wang, H., Wang, L., & You, H. (2022) · Bioanalysis · doi:10.4155/bio-2022-0223 · Cited by 11 · see citing works

Extracellular vesicles in cancer immunotherapy: Therapeutic, challenges and clinical progress

Manoochehri, H., La’ah, A. S., Babaeizad, A., Sheykhhasan, M., Rostamipoor, M., Abbaspoor, M., Nikravesh, F., Khosravi, S. M., Mahaki, H., Tanzadehpanah, H., et al. (2025) · Asian Journal of Pharmaceutical Sciences · doi:10.1016/j.ajps.2025.101065 · Cited by 11 · see citing works

Human bone marrow mesenchymal stem cell-derived extracellular vesicles induce inverse dose-dependent anti-fibrotic effects in human myofibroblast cultures and bleomycin-injured mice with pulmonary fibrosis

Charoenphannathon, J. S., Wong, P. D., Royce, S. G., Jaffar, J., Westall, G. P., Wang, C., Bourke, J. E., & Samuel, C. S. (2025) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2025.118370 · Cited by 11 · see citing works

Therapeutic Potential of Extracellular Vesicles in Oral Inflammation

Farm, Y. R., Chuah, B. H., Law, J. X., Leong, X.-F., Razali, M., & Ng, S. L. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26073031 · Cited by 9 · see citing works

Extracellular vesicles in triple-negative breast cancer: current updates, challenges and future prospects

Tiwari, P. K., Chaudhary, A. A., Gupta, S. K., Chouhan, M., Singh, H. N., Rustagi, S., Khan, S.-U.-D., & Kumar, S. (2025) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2025.1561464 · Cited by 9 · see citing works

Advances in mammalian, plant, and bacterial-derived extracellular vesicles for cancer therapy

Nie, X., Li, Q., Fatima, H., Wang, Y., Meng, F., Xie, J., & Nie, S. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.168637 · Cited by 9 · see citing works

The Fatal Role of Enterohaemorrhagic Escherichia coli Shiga Toxin-associated Extracellular Vesicles in Host Cells

Lee, K., Park, J.-Y., Jeong, Y., & Lee, M. (2023) · The Journal of Microbiology · doi:10.1007/s12275-023-00066-0 · Cited by 9 · see citing works

Stem cell-derived extracellular vesicles: novel therapeutics for cerebral injury following cardiac arrest and potential mechanisms

Zhang, X., Zhang, W., Chen, Z., Zhu, R., Lin, Y., Wu, C., Xu, J., Zhou, G., & Zhang, M. (2025) · Cell & Bioscience · doi:10.1186/s13578-025-01451-5 · Cited by 9 · see citing works

A new route for EV biogenesis

Li, Y. (2023) · Cell Research · doi:10.1038/s41422-022-00747-2 · Cited by 8 · see citing works

Harnessing the Therapeutic Potential of Cell Secretomes and Extracellular Vesicles for Craniofacial Regenerative Applications

Shanbhag, S., Mayol, M., Domic, D., Bobbili, M. R., Grillari, J., Sanz, M., & Gruber, R. (2025) · Journal of Periodontal Research · doi:10.1111/jre.70007 · Cited by 7 · see citing works

Extracellular Vesicles Act as Carriers for Cargo Delivery and Regulate Wnt Signaling in the Hepatocellular Carcinoma Tumor Microenvironment

He, R., Xu, Y., Yu, L., Meng, N.-F., Wang, H.-Y., Cui, Y.-F., & Yam, J. (2023) · Cancers · doi:10.3390/cancers15072088 · Cited by 7 · see citing works

Xenogeneic Transplantation Promoted Human Exosome Sequestration in Rat Specific Organs

Mobarak, H., Mahdipour, M., Ghaffari‐Nasab, A., & Rahbarghazi‬, R. (2023) · Advanced Pharmaceutical Bulletin · doi:10.34172/apb.2024.022 · Cited by 7 · see citing works

Synovial fluid extracellular vesicles as arthritis biomarkers: the added value of lipid-profiling and integrated omics

Varela, L., van de Lest, C. H. A., van Weeren, P. R., & Wauben, M. H. M. (2024) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2024.14 · Cited by 7 · see citing works

The role of extracellular vesicles in the treatment of tendinopathy by regulating the pathological immune microenvironment

Liu, H., Zhu, M., Ding, W., Ning, L., & Qin, T. (2024) · Chemical Engineering Journal · doi:10.1016/j.cej.2024.156489 · Cited by 6 · see citing works

Enhanced quantification and cell tracking of dual fluorescent labeled extracellular vesicles

Sánchez, M. J., Leivar, P., Borrós, S., Fornaguera, C., & Lecina, M. (2024) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2024.124921 · Cited by 6 · see citing works

Extracellular vesicles from platelet-poor plasma possess anti-inflammatory and anti-catabolic effects in chondrocytes stimulated with IL-1β or synovial membrane-conditioned media

Gulová, S., Slovinská, L., Fecskeová, L. K., Bzdilova, J., Matejová, J., Morávek, M., Lacko, M., & Harvanová, D. (2024) · Journal of Orthopaedic Surgery and Research · doi:10.1186/s13018-024-05355-x · Cited by 6 · see citing works

Advances of transdermal drug delivery system based on extracellular vesicles

Qin, H., Zhang, M., Wang, H., Peng, M., Liu, Z., Wang, S., Wang, Z., & Liu, K. (2025) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2025.106647 · Cited by 6 · see citing works

Mesenchymal stem cells and their extracellular vesicles in urological cancers: Prostate, bladder, and kidney

Saadh, M. J., Alhuthali, H. M., Aníbal, O. G., Asenjo‐Alarcón, J. A., Younus, D. G., Alhili, A., Adhab, Z. H., Alsalmi, O. A., Gharib, A. F., Pecho, R. D. C., et al. (2023) · Cell Biology International · doi:10.1002/cbin.12098 · Cited by 6 · see citing works

Comparison of in-vitro immunomodulatory capacity between large and small apoptotic bodies from human bone marrow mesenchymal stromal cells

Wang, J., Moosavizadeh, S., Jammes, M., Tabasi, A., Bach, T., Ryan, A. E., & Ritter, T. (2025) · International Immunopharmacology · doi:10.1016/j.intimp.2025.114480 · Cited by 5 · see citing works

The Role of Extracellular Vesicles as Diagnostic Tools in Gut-Brain Axis Disorders

da Costa, P. M., Nunes, P. I. G., Ciurleo, G. C. V., Junior, J. W. L. T., Neto, P. B., Belayev, L., & Oriá, R. B. (2026) · Molecular Neurobiology · doi:10.1007/s12035-025-05645-3 · Cited by 6 · see citing works

The regulatory landscape for extracellular vesicle therapies: Australian context and future directions

Rudge, C., McClelland, R., Chrzanowski, W., & Davis, R. L. (2026) · Extracellular Vesicles and Circulating Nucleic Acids · doi:10.20517/evcna.2025.129 · Cited by 5 · see citing works

Mechanisms of microRNA export in mammalian cells: From random release to selective secretion

Bhattacharyya, S. N., Ghosh, S., Choudhury, S. H., & Mukherjee, K. (2026) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2026.113299 · Cited by 5 · see citing works

Scalable production and purification of engineered ARRDC1-mediated microvesicles in a HEK293 suspension cell system

Luther, K. M., Navaei, A., Gens, L., Semple, C., Moharil, P., Passalacqua, I., Vyas, K., Wang, Q., Liu, S., Sun, L. R., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-87674-5 · Cited by 5 · see citing works

The future of exosomes bioengineering in precision medicine

Ullah, M. (2022) · The Journal of Physiology · doi:10.1113/jp284018 · Cited by 5 · see citing works

The future of bioorthogonal-chemistry for targeting of exosomes in precision medicine

Ullah, M. (2022) · Oncotarget · doi:10.18632/oncotarget.28323 · Cited by 5 · see citing works

Microvesicles, exosomes and their combinations with cytoplasmic organelles: from their discovery to their innovative roles in clinical medicine

Meldolesi, J. (2026) · Biology Direct · doi:10.1186/s13062-025-00724-w · Cited by 4 · see citing works

Monitoring HEK293 cell extracellular vesicle (EV) production via a polyester capillary-channeled polymer (C-CP) fiber column with HIC modality

Pons, W. F., Beitle, S., Ewonde, R. E., Harcum, S. W., & Marcus, R. K. (2026) · Journal of Chromatography B · doi:10.1016/j.jchromb.2026.124970 · Cited by 4 · see citing works

Red Blood Cell-Derived Extracellular Vesicles for Gene and RNA Therapeutics: Biological, Engineering, and Translational Challenges

Shafiq, T., Khan, N., Kausar, T., Ahmed, W., Zhang, Z., Liang, Y., & Duan, L. (2026) · International Journal of Nanomedicine · doi:10.2147/ijn.s579975 · Cited by 4 · see citing works

The role of extracellular vesicles in intercellular communication within the oral cavity

Semlali, A., Al-zharani, M., & Al-Ansari, J. (2026) · Journal of Oral Microbiology · doi:10.1080/20002297.2026.2673760 · Cited by 4 · see citing works

l-lysine α-oxidase encapsulation in red blood cells - Derived extracellular vesicles as biocompatible nanoplatform for cancer therapy

Qoura, L. A., Babayeva, G. A., Kolpaksidi, A. P., & Pokrovsky, V. S. (2025) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2025.152130 · Cited by 4 · see citing works

Proteolysis targeting chimera extracellular vesicles for therapeutic development treating triple negative breast cancerPreprint

Erwin, N., De, U., Xiao, Y., Wang, L., Maharjan, C. K., Pan, X., Awasthee, N., Zheng, G., Liao, D., Zhang, W., et al. (2024) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2024.08.25.609564 · Cited by 4 · see citing works

Visualizing extracellular vesicles in cancer: from biogenesis to theranostic applications

Deng, D., Wang, L., Zeng, Z., Lu, L., Yang, M., Wang, Y., Shi, X., Lovell, J. F., Zhang, J., & Jin, H. (2026) · Journal of Nanobiotechnology · doi:10.1186/s12951-026-04223-6 · Cited by 3 · see citing works

Extracellular vesicles in cardiovascular disease: Biomarkers, therapeutic applications, and drug delivery strategies

Abuhassan, Q., Salajegheh, A., Muhammad, F. A., Al-Hussainy, A. F., Gajjar, T. B., Hanumanthayya, M., Shukla, S. K., Panigrahi, R., Bainsal, N., Polatova, D., et al. (2026) · Clinica Chimica Acta · doi:10.1016/j.cca.2026.120972 · Cited by 3 · see citing works

Bioengineered MSC-derived extracellular vesicles in intervertebral disc therapeutics: A systematic review

Martins, A. M. V., Pilão, S., dos Santos, S. G., Neidlinger‐Wilke, C., Ignatius, A. A., Gonçalves, R. M., & Teixeira, G. Q. (2026) · Acta Biomaterialia · doi:10.1016/j.actbio.2026.05.036 · Cited by 4 · see citing works

Extracellular vesicles as minimally invasive biomarkers and therapeutic platforms in rare neurological diseases

Phan, N. D., Sharma, R. R., Subramanian, S., & Kartha, R. V. (2026) · Frontiers in Aging · doi:10.3389/fragi.2026.1813553 · Cited by 4 · see citing works

Extracellular Vesicles Produced by the Cardiac Microenvironment Carry Functional Enzymes to Produce Lipid Mediators In Situ

Ong‐Meang, V., Blanzat, M., Savchenko, L., Perquis, L., Guardia, M., Pizzinat, N., & Poinsot, V. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24065866 · Cited by 3 · see citing works

Extracellular Vesicles as Possible Sources of Huntington’s Disease Biomarkers

Ananbeh, H., & Skalníková, H. K. (2023) · Contemporary clinical neuroscience · doi:10.1007/978-3-031-32815-2_3 · Cited by 3 · see citing works

Extracellular vesicles in colorectal cancer: immunomodulation, diagnostics, and therapeutic perspectives

Kumra, R., Rai, R., & Thakur, R. (2026) · Medical Oncology · doi:10.1007/s12032-026-03272-z · Cited by 2 · see citing works

CTLs, NK cells and NK-derived EVs against breast cancer

Parsonidis, P., Mamagkaki, A., & Papasotiriou, I. (2023) · Human Immunology · doi:10.1016/j.humimm.2023.03.001 · Cited by 2 · see citing works

Maximizing oxaliplatin's impact on EGFR + colorectal cancer through targeted extracellular vesicles

Chien, S., Huang, Y.-J., Huang, M., Fang, Y., Chao, S.-W., Li, C.-T., Jhang, W.-Y., Hsu, Y.-H., Wang, S.-H., & Chuang, C.-H. (2024) · Cancer Nanotechnology · doi:10.1186/s12645-024-00284-0 · Cited by 2 · see citing works

Targeting Fibrotic Scars with Extracellular Vesicles Extracted from Mature Aloe vera Gel: Enhanced Antioxidant, Anti-inflammatory, and Antifibrotic Activity through M2 Macrophage Polarization and Inhibition of Myofibroblast DifferentiationPreprint

Ceballos‐Santa, M. C., Babu, J. V., Gaborski, T. R., Schulze, S., & Wuertz‐Kozak, K. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.06.17.660207 · Cited by 2 · see citing works

Exosome-Delivered Factors and their Influence on Angiogenic Processes in Bone Healing

Emami, A., & Oskouie, I. M. (2026) · Regenerative Engineering and Translational Medicine · doi:10.1007/s40883-025-00535-5 · Cited by 1 · see citing works

Engineered extracellular vesicles for combinatorial cancer therapy and imaging

La’ah, A. S., Hosseini, N. F., Kang, C., Ahmadieh-Yazdi, A., Sheykhhasan, M., Yang, P., Ghotaslou, A., Manoochehri, H., Huh, Y. S., Kang, H., et al. (2026) · Acta Pharmaceutica Sinica B · doi:10.1016/j.apsb.2026.03.054 · Cited by 1 · see citing works

Tuning Secretomes for Regenerative Medicine

Buschmann, J. (2026) · Biology · doi:10.3390/biology15120941 · Cited by 1 · see citing works

Brain targeting and trafficking of extracellular vesicles in central nervous system diseases: a therapeutic roadmap

Baker, B., Emerson, S., Tran, T., Mohapatra, N., Wang, D., Zaw, T., Doshi, A. A., Lopez, J.-M., Hassan, D., Kumar, P., et al. (2026) · Nanomedicine · doi:10.1080/17435889.2026.2698782 · Cited by 1 · see citing works

CD9 role in proliferation, rejuvenation, and therapeutic applications

Kodam, S. P., Baghban, N., & Ullah, M. (2023) · Genes & Diseases · doi:10.1016/j.gendis.2023.05.009 · Cited by 1 · see citing works

Pathological biomineralization. Part I: Mineralizing extracellular vesicles in cardiovascular diseases

Buchet, R., Pikuła, S., Strzelecka‐Kiliszek, A., Bottini, M., Ramos, A. P., Ciancaglini, P., Millán, J. L., & Mebarek, S. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-99158-2.00012-7 · Cited by 1 · see citing works

Therapeutic Potential of Extracellular Vesicles from Different Cell Sources

Wang, X., & Li, Z. (2023) · doi:10.1002/9783527842155.ch3

Platelet-rich Plasma-derived Exosomes as Novel Frontier in Regenerative Medicine

Awan, S. J., Idrees, N., Asif, T., Munawar, T., Munawar, M., & Naeem, N. (2025) · Current Cancer Therapy Reviews · doi:10.2174/0115733947399426250911115018

Proteomic identification and validation of novel neuronal EV-based markers for Alzheimer’s disease biomarker discoveryPreprint

Ahmed, W., Nogueras‐Ortiz, C. J., Sagar, R., Dong, D., Boyd, R. J., Yao, P. J., Iliuk, A. B., Lyketsos, C. G., Witwer, K. W., Kapogiannis, D., et al. (2026) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2026.04.26.720870

An overview on mesenchymal stem cells and extracellular vesicles in regenerative medicine

Mendiratta, M., Kashyap, M., & Mohanty, S. (2026) · Elsevier eBooks · doi:10.1016/b978-0-443-45056-3.00019-4

Colostrum Extracellular Vesicle Isolation, Characterization, and Function

Akter, S., Fayez, N., Kumar, M., Sil, S., & Gendelman, H. E. (2026) · Biomedicines · doi:10.3390/biomedicines14071549

Therapeutic Potential of EVs

Pourvali, M., Abroushan, D., Durosini, E., Al-Musawi, S., & Sheykhhasan, M. (2026) · Molecular and translational medicine · doi:10.1007/978-3-032-23810-8_10

Stem Cell-Derived Extracellular Vesicles in Treatment of Disease

Yousefi-Najafabadi, Z., Falahzadeh, K., Taghizadeh, S. H., Sheykhhasan, M., & Aziziyan, F. (2026) · Molecular and translational medicine · doi:10.1007/978-3-032-23810-8_4

Exosome-based nanomedicine for neurological disorders: mechanisms, engineering, and therapeutic potential

Singh, N., Guha, L., & Kumari, A. (2026) · Therapeutic Delivery · doi:10.1080/20415990.2026.2715878

Proteomic and Physicochemical Analysis of Erythrocyte Membrane Vesicles from Fresh and Frozen Blood

Tomić, K., Ivanovski, S., Šribar, J., Čebulj, D., Žvanut, S., Lenassi, M., Fonovič, M., Križaj, I., & Kostevšek, N. (2026) · Journal of Proteome Research · doi:10.1021/acs.jproteome.6c00535

Circulating sEV PD-L1: A dual biomarker and therapeutic target in cancer immune evasion

Pandiarajan, S., Kiran, V., Girigoswami, K., & Girigoswami, A. (2026) · Next Nanotechnology · doi:10.1016/j.nxnano.2026.100859

Designing liposomal EV mimetics by tuning mechanical properties

Lodigiani, G., Garbujo, S., Parisse, P., Casalis, L., Puricelli, L., Santagada, D., Musicò, A., Bombelli, F. B., Gori, A., & Bergamaschi, G. (2026) · Nanoscale · doi:10.1039/d6nr01948j

Targeting Fibrotic Scars With Extracellular Vesicles Extracted From Mature Aloe vera Gel: Enhanced Antioxidant, Anti‐Inflammatory, and Antifibrotic Activity Through M2 Macrophage Polarization and Inhibition of Myofibroblast Differentiation

Ceballos‐Santa, M. C., Babu, J. V., Gaborski, T. R., Schulze, S., & Wuertz‐Kozak, K. (2026) · Advanced Biology · doi:10.1002/adbi.202500421

Extracellular Vesicles As Nanomedicine: Hopes And Hurdles In Clinical Translation

Burnouf, T., Agrahari, V., & Agrahari, V. (2019) · International Journal of Nanomedicine · doi:10.2147/ijn.s225453 · Cited by 113 · see citing works

Extracellular Vesicles for Therapeutic Applications: A Translational Framework Integrating Sources, Administration Routes, Indications, Quality Control, and Regulatory Systems

Zhang, F., Xing, L., Chu, W., Wang, Q., Sun, H., Liu, Y., An, G., & Liang, X. (2026) · DOAJ (DOAJ: Directory of Open Access Journals)

Extracellular Vesicles as Therapeutic Resources in the Clinical Environment

Sanz‐Ros, J., Mas‐Bargues, C., Romero-García, N., Huete-Acevedo, J., Dromant, M., & Borrás, C. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24032344 · Cited by 75 · see citing works

Extracellular Vesicles: The Challenges on the Way and Engineering Perspectives

Attia, N., Ibrahim, H. G., Abdulla, H., Mashal, M., Puras, G., & Pedraz, J. L. (2024) · Springer eBooks · doi:10.1007/978-981-99-7119-0_56 · Cited by 1 · see citing works

Extracellular vesicles for next-gen therapeutics and drug delivery

Khan, N., Ahmadova, Z., Shi, Y., Shafiq, T., Liang, Y., & Duan, L. (2026) · Molecular Biomedicine · doi:10.1186/s43556-026-00571-9 · Cited by 1 · see citing works