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Cited by 109Cancer Mechanisms and TherapyAngiogenesis and VEGF in CancerFibroblast Growth Factor Research

Progranulin and Its Biological Effects in Cancer

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Arechavaleta-Velasco, Fabian, Perez-Juarez, Carlos Eduardo, Gerton, George L., Diaz-Cueto, Laura·2017·Medical Oncology
DOI 10.1007/s12032-017-1054-7PMC PMC5810362
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Abstract

Cancer cells have defects in regulatory mechanisms that usually control cell proliferation and homeostasis. Different cancer cells share crucial alterations in cell physiology, which lead to malignant growth. Tumorigenesis or tumor growth requires a series of events that include constant cell proliferation, promotion of metastasis and invasion, stimulation of angiogenesis, evasion of tumor suppressor factors, and avoidance of cell death pathways. All these events in tumor progression may be regulated by growth factors produced by normal or malignant cells. The growth factor progranulin has significant biological effects in different types of cancer. This protein is a regulator of tumorigenesis because it stimulates cell proliferation, migration, invasion, angiogenesis, malignant transformation, resistance to anticancer drugs, and immune evasion. This review focuses on the biological effects of progranulin in several cancer models and provides evidence that this growth factor should be considered as a potential biomarker and target in cancer treatment.

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  • Catabolism is performed by over 60 diverse acid hydrolases, each contributing to degradation of lipids, proteins, carbohydrates and nucleic acids.

    “Even the canonical role of the lysosome, catabolism, is performed by a highly selective and tightly controlled system of over 60 diverse acid hydrolases, each of which contributes in precise and even unique ways to the degradation of lipids, proteins, carbohydrates and nucleic acids.10”

    From The lysosome and proteostatic stress at the intersection of pediatric neurological disorders and adult neurodegenerative diseases (2025) · cites this paper as [10]

    The Introduction (page unavailable) says that a lysosomal protease, cathepsin L, degrades the protein progranulin in the lysosome. It does not state that lysosomal catabolism involves over 60 acid hydrolases or that they degrade lipids, carbohydrates, and nucleic acids. (LLM, conf=0.78)

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Cited by

Sorted by citations

Authors
Arechavaleta-Velasco, F., Perez-Juarez, C. E., Gerton, G. L., & Diaz-Cueto, L.
Affiliations
  • Mexican Social Security Institute (MX)
  • University of Pennsylvania (US)
ORCID
Venue
Medical Oncology
Publisher
Springer Science and Business Media LLC
Published
2017-11-07
Volume
34
Issue
12
Pages
194-194
ISSN
  • 1357-0560 (ISSN-L)
  • 1559-131X
DOI
10.1007/s12032-017-1054-7
PMC
PMC5810362
OpenAlex
W2767914339
Cited by
109
References
1
Citations by year
2026: 6 · 2025: 10 · 2024: 9 · 2023: 17 · 2022: 14 · 2021: 25 · 2020: 12 · 2019: 9 · 2018: 7
FWCI
1.22
Type
journal article
Language
en
Open access
Licence
www.springer.com/tdm (unspecified)
Locations
  • Medical Oncology (publishedVersion)
  • PubMed (publishedVersion)
  • Europe PMC (PubMed Central) (acceptedVersion)
  • PubMed Central (acceptedVersion)
Funders
National Institute of Environmental Health Sciences (P30ES013508)
Topics
  • Health Sciences › Medicine › Pathology and Forensic Medicine › Cancer Mechanisms and Therapy
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Angiogenesis and VEGF in Cancer
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fibroblast Growth Factor Research
Keywords
progranulin, cancer, carcinogenesis, cell proliferation, metastasis, tumor invasion, angiogenesis, drug resistance, immune evasion, biomarkers, therapeutic target, growth factors
MeSH terms
Progranulins, Animals, Cell Movement, Cell Transformation, Neoplastic, Humans, Neoplasms, Neovascularization, Pathologic, Biomarkers, Tumor, Gene Expression Regulation, Neoplastic, Neovascularization, Physiologic, Drug Resistance, Neoplasm, Intercellular Signaling Peptides and Proteins, Cell Line, Tumor

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