The lysosomal function of progranulin, a guardian against neurodegeneration
Open accessAbstract
Progranulin (PGRN), encoded by the GRN gene in humans, is a secreted growth factor implicated in a multitude of processes ranging from regulation of inflammation to wound healing and tumorigenesis. The clinical importance of PGRN became especially evident in 2006, when heterozygous mutations in the GRN gene, resulting in haploinsufficiency, were found to be one of the main causes of frontotemporal lobar degeneration (FTLD). FTLD is a clinically heterogenous disease that results in the progressive atrophy of the frontal and temporal lobes of the brain. Despite significant research, the exact function of PGRN and its mechanistic relationship to FTLD remain unclear. However, growing evidence suggests a role for PGRN in the lysosome-most striking being that homozygous GRN mutation leads to neuronal ceroid lipofuscinosis, a lysosomal storage disease. Since this discovery, several links between PGRN and the lysosome have been established, including the existence of two independent lysosomal trafficking pathways, intralysosomal processing of PGRN into discrete functional peptides, and direct and indirect regulation of lysosomal hydrolases. Here, we summarize the cellular functions of PGRN, its roles in the nervous system, and its link to multiple neurodegenerative diseases, with a particular focus dedicated to recent lysosome-related mechanistic developments.
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Both GRN and TMEM106B are reported to be involved in defective endosome/lysosome trafficking/function, a defect that is also observed in AD.
“Interestingly, both GRN and TMEM106B are reported to be involved in defective endosome/lysosome trafficking/function49,50, a defect that is also observed in AD.”
From New insights into the genetic etiology of Alzheimer’s disease and related dementias (2022) · cites this paper as [49]
The study identified two lysosomal proteins, GRN and TMEM106B, that are associated with frontotemporal dementia but were also identified in the latest AD risk GWAS.
“We also identified two lysosomal proteins, GRN and TMEM106B80,81, that are associated with frontotemporal dementia (FTD)82,83 but were also identified in the latest AD risk GWAS23.”
From Proteogenomic analysis of human cerebrospinal fluid identifies neurologically relevant regulation and implicates causal proteins for Alzheimer’s disease (2024) · cites this paper as [80]
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Saposin A: second cerebrosidase activator protein.
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A Novel Interaction between Perlecan Protein Core and Progranulin
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Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis
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A neurodegenerative disease mutation that accelerates the clearance of apoptotic cells
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Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease
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Progranulin and Its Biological Effects in Cancer
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Progranulin is a chemoattractant for microglia and stimulates their endocytic activity
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“Microglia, the resident immune cells in the brain, especially those which have become reactive following insult or trauma, produce and secrete especially high levels of PGRN [50, 75, 81, 94, 158], and PGRN has been shown to regulate microglial activation, migration, phagocytosis, and synapse pruning [69, 72, 95, 132,…”
InfluentialThe lysosomal protein cathepsin L is a progranulin protease
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Self-citationMouse models of frontotemporal dementia
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Prosaposin is a regulator of progranulin levels and oligomerization
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Association Between Progranulin and Gaucher Disease
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rs5848 polymorphism and serum progranulin level
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Lysosomal processing of progranulin
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Progranulin expression in advanced human atherosclerotic plaque
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The Progranulin Cleavage Products, Granulins, Exacerbate TDP-43 Toxicity and Increase TDP-43 Levels
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- Authors
- Paushter, D. H., Du, H., Feng, T., & Hu, F.
- Affiliations
- Cornell University (US)
- Corresponding author
- Hu, Fenghua
- Venue
- Acta Neuropathologica
- Published
- 2018-05-09
- Volume
- 136
- Issue
- 1
- Pages
- 1-17
- ISSN
- 0001-6322 (ISSN-L)
- 1432-0533
- PMC
- PMC6117207
- OpenAlex
- W2802961407
- Cited by
- 230
- References
- 161
- Citations by year
- 2026: 21 · 2025: 31 · 2024: 33 · 2023: 32 · 2022: 26 · 2021: 45 · 2020: 19 · 2019: 18 · 2018: 3 · 2017: 1
- FWCI
- 2.79
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Acta Neuropathologica (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of Neurological Disorders and Stroke (R01NS088448, R01NS095954)
- Topics
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- progranulin, lysosomes, lysosomal trafficking, frontotemporal lobar degeneration, haploinsufficiency, neuronal ceroid lipofuscinosis, lysosomal storage disease, lysosomal enzymes, neurodegeneration, neurodegenerative diseases
- MeSH terms
- Progranulins, Animals, Humans, Lysosomes, Models, Biological, Mutation, Neurodegenerative Diseases, Protein Transport
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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