Blood biomarkers in frontotemporal dementia: Review and meta-analysis
Open accessAbstract
Biomarkers in cerebrospinal fluid (CSF) are useful in the differential diagnosis between frontotemporal dementia (FTD) and Alzheimer’s dementia (AD), but require lumbar puncture, which is a moderately invasive procedure that can cause anxiety to patients. Gradually, the measurement of blood biomarkers has been attracting great interest. Testing blood instead of CSF, in order to measure biomarkers, offers numerous advantages because it negates the need for lumbar puncture, it is widely available, and can be repeated, allowing the prediction of disease course. In this study, a systematic review of the existing literature was conducted, as well as meta-analysis with greater emphasis on the most studied biomarkers, p-tau and progranulin. The goal was to give prominence to evidence regarding the use of plasma biomarkers in clinical practice.
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Serum NfL and GFAP can be used as accurate, but less invasive biomarkers than CSF NfL and GFAP.
“This observation strengthens the notion that serum NfL and GFAP can be used as accurate, but less invasive biomarkers than CSF NfL and GFAP [19].”
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- Authors
- Ntymenou, S., Tsantzali, I., Kalamatianos, T., Voumvourakis, K. I., Kapaki, E., Tsivgoulis, G., Stranjalis, G., & Paraskevas, G. P.
- Affiliations
- Evangelismos Hospital (GR)
- National and Kapodistrian University of Athens (GR)
- Department of Neurosurgery, School of Medicine, Evangelismos Hospital, National and Kapodistrian University of Athens, 10676 Athens, Greece
- Corresponding author
- Ntymenou, Sofia
- ORCID
- Venue
- Brain Sciences
- Publisher
- MDPI AG
- Published
- 2021-02-15
- Volume
- 11
- Issue
- 2
- Pages
- 244
- ISSN
- 2076-3425 (ISSN-L)
- PMC
- PMC7919273
- OpenAlex
- W3132159514
- Cited by
- 31
- References
- 55
- Citations by year
- 2026: 3 · 2025: 7 · 2024: 9 · 2023: 7 · 2022: 4 · 2021: 1
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Brain Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Health Sciences › Medicine › Neurology › Amyotrophic Lateral Sclerosis Research
- Keywords
- frontotemporal dementia, blood biomarkers, plasma biomarkers, phosphorylated tau, progranulin, cerebrospinal fluid biomarkers, Alzheimer's disease differential diagnosis, disease progression prediction
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