The Physiology of BDNF and Its Relationship with ADHD
Abstract
Brain-derived neurotrophic factor (BDNF) is a major neurotrophin in the central nervous system that plays a critical role in the physiological brain functions via its two independent receptors: tropomyosin-related kinase B (TrkB) and p75, especially in the neurodevelopment. Disrupting of BDNF and its downstream signals has been found in many neuropsychological diseases, including attention-deficit hyperactivity disorder (ADHD), a common mental disorder which is prevalent in childhood. Understanding the physiological functions of BDNF during neural development and its potential relationship with ADHD will help us to elucidate the possible mechanisms of ADHD and to develop therapeutic approaches for this disease. In this review, we summarized the important literatures for the physiological functions of BDNF in the neurodevelopment. We also performed an association study on the functional genetic variation of BDNF and ADHD by a case-control study in the Chinese mainland population and revealed the potential correlation between BDNF and ADHD which needs further research to confirm.
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Disruption of BDNF and its downstream signals has been found in ADHD correlating with severity of ADHD symptoms.
“Disruption of BDNF and its downstream signals has been found in ADHD correlating with severity of ADHD symptoms [218, 219].”
From Molecular Characterisation of the Mechanism of Action of Stimulant Drugs Lisdexamfetamine and Methylphenidate on ADHD Neurobiology: A Review (2022) · cites this paper as [219]
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“found in ADHD correlating with severity of ADHD symptoms [218, 219].”
BackgroundNunes, F., Pochmann, D., Almeida, A. S., Marques, D. M., & Porciúncula, L. D. O. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1000-5 · Cited by 26 · see citing works
- Authors
- Liu, D.-Y., Shen, X.-M., Yuan, F.-F., Guo, O.-Y., Zhong, Y., Chen, J.-G., Zhu, L.-Q., & Wu, J.
- Affiliations
- Huazhong University of Science and Technology (CN)
- Hunan Children's Hospital (CN)
- Corresponding author
- Zhu, Ling-Qiang
- Wu, Jing
- Venue
- Molecular Neurobiology
- Published
- 2014-10-30
- Volume
- 52
- Issue
- 3
- Pages
- 1467-1476
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- OpenAlex
- W1996122997
- Cited by
- 106
- References
- 9
- Citations by year
- 2026: 7 · 2025: 9 · 2024: 13 · 2023: 11 · 2022: 17 · 2021: 10 · 2020: 8 · 2019: 13 · 2018: 6 · 2017: 5 · 2016: 4 · 2015: 3
- FWCI
- 0.55
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Attention Deficit Hyperactivity Disorder
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Nerve injury and regeneration
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetics and Neurodevelopmental Disorders
- Keywords
- brain-derived neurotrophic factor, attention deficit hyperactivity disorder, brain development, TrkB receptor, p75 neurotrophin receptor, genetic association, functional genetic variation, Chinese population
- MeSH terms
- Adult, Animals, Attention Deficit Disorder with Hyperactivity, Brain Chemistry, Child, China, Disease Models, Animal, Gene Expression Regulation, Humans, Hyperkinesis, Learning Disabilities, Nerve Tissue Proteins, Neural Pathways, Signal Transduction, Case-Control Studies, Receptors, Nerve Growth Factor, Mice, Knockout, Brain-Derived Neurotrophic Factor, Amino Acid Substitution, Mutation, Missense, Polymorphism, Single Nucleotide, Receptor, trkB, Asian People, Mice, Rats, Neurogenesis, Rats, Transgenic, Neurodevelopmental Disorders
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