Methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and Alzheimer disease risk: a meta-analysis.
Abstract
Methylenetetrahydrofolate reductase (MTHFR) is key enzyme of folate/homocysteine pathway. Case control association studies on MTHFR C677T polymorphism and Alzheimer's disease (AD) have been repeatedly performed over the last two decades, but the results are inconclusive. The aim of the present study was to assess the risk of MTHFR C677T polymorphism for AD. Forty-one studies were identified by a search of PubMed, Google Scholar, Elsevier, and Springer Link databases, up to January 2015. Odds ratios (ORs) with corresponding 95 % confidence interval (CI) were calculated using fixed effect model or random effect model. The subgroup analyses based on ethnicity were performed. MTHFR C677T polymorphism had a significant association with susceptibility to AD in all genetic models (for T vs C OR = 1.29, 95 % CI = 1.07-1.56, p = 0.003; for TT + CT vs CC OR = 1.29, 95 % CI = 1.19-1.40, p = 0.0004; for TT vs CC OR = 1.31, 95 % CI = 1.16-1.48, p = 0.001; for CT vs CC OR = 1.24, 95 % CI = 1.13-1.35, p < 0.004; and for TT vs CT + CC OR = 1.13, 95 % CI = 1.00-1.28, p = 0.02). Results of present meta-analysis supported that the MTHFR C677T polymorphism was associated with an increased risk of AD.
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Variations in MTHFR, particularly the Mthfr677C>T variant, are associated with cardiovascular diseases, AD, and vascular dementia.
“Variations in MTHFR, particularly the Mthfr677C > T variant, are associated with cardiovascular diseases, AD, and vascular dementia (Liu et al., 2010; Liew and Gupta, 2015; Rai, 2017).”
From Plcg2M28L Interacts With High Fat/High Sugar Diet to Accelerate Alzheimer’s Disease-Relevant Phenotypes in Mice (2022) · cites this paper as Rai, 2017
Cites
Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease
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Meta‐Analysis Of Controlled Clinical Trials
Whitehead, A. (2002) · doi:10.1002/0470854200 · Cited by 827 · see citing works
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Autosomal Recessive Causes Likely in Early-Onset Alzheimer Disease
Wingo, T. S. (2012) · Archives of Neurology · doi:10.1001/archneurol.2011.221 · Cited by 265 · see citing works
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Oblak, A. L., Kotredes, K. P., Pandey, R. S., Reagan, A. M., Ingraham, C., Perkins, B., Lloyd, C., Baker, D., Lin, P. B., Soni, D. M., et al. (2022) · Frontiers in Aging Neuroscience · doi:10.3389/fnagi.2022.886575 · Cited by 23 · see citing works
“Variations in MTHFR, particularly the Mthfr677C > T variant, are associated with cardiovascular diseases, AD, and vascular dementia (Liu et al., 2010; Liew and Gupta, 2015; Rai, 2017).”
Background
- Authors
- Rai, V.
- Affiliations
- Veer Bahadur Singh Purvanchal University (IN)
- Corresponding author
- Rai, Vandana
- ORCID
- Rai, Vandana
- Venue
- Molecular Neurobiology
- Published
- 2016-01-28
- Volume
- 54
- Issue
- 2
- Pages
- 1173-1186
- ISSN
- 0893-7648 (ISSN-L)
- 1559-1182
- OpenAlex
- W2299433408
- Cited by
- 88
- References
- 4
- Citations by year
- 2026: 8 · 2025: 4 · 2024: 7 · 2023: 4 · 2022: 8 · 2021: 12 · 2020: 9 · 2019: 10 · 2018: 11 · 2017: 14 · 2016: 1
- FWCI
- 1.89
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Molecular Neurobiology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- no funding
- Topics
- Health Sciences › Medicine › Rheumatology › Folate and B Vitamins Research
- Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
- Health Sciences › Medicine › Physiology › Alzheimer's disease research and treatments
- Keywords
- MTHFR, MTHFR C677T polymorphism, Alzheimer's disease, genetic susceptibility, folate pathway, homocysteine, genetic association
- MeSH terms
- Alzheimer Disease, Humans, Polymorphism, Genetic, Risk Factors, Case-Control Studies, Genetic Predisposition to Disease, Methylenetetrahydrofolate Reductase (NADPH2)
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