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Expression of miR-145 and Its Target Proteins Are Regulated by miR-29b in Differentiated Neurons

Jauhari, Abhishek, Singh, Tanisha, Yadav, Sanjay·2018·Molecular Neurobiology
DOI 10.1007/s12035-018-1009-9
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Abstract

MicroRNAs (miRNAs) are emerging as the most potential regulator of neuronal development. Recent studies from our lab and elsewhere have demonstrated a direct role of miRNAs in regulating neuronal differentiation and synaptogenesis. MicroRNA-145, a miRNA identified to regulate pluripotency of stem cells, downregulates the protein levels of reprogramming transcription factors (RTFs) like OCT4, SOX2, and KLF4 (cell, 137,647-658,2009). Studies have shown that miR-145 is multifunctional and crucial for fate determination of neurons. In our recently published study, we have identified a set of miRNAs including miR-145 and miR-29b families differentially expressed in SH-SY5Y cells exposed sequentially with retinoic acid + brain-derived neurotrophic factor (RA+BDNF) for differentiation into mature neurons (Mol Neurobiol (2016) doi: https://doi.org/10.1007/s12035-016-0042-9 ). In the present study, we have identified the role of miR-29b in upregulation of miR-145, which is upregulated after exposure of RA+BDNF in a P53-dependent manner. In differentiating SH-SY5Y cells, expression of miR-29b downregulates expression of P85α, a P53 inhibitor, which results in upregulation of miR-145 and downregulation of RTF proteins. Ectopic expression of miR-145 and miR-29b in amounts equivalent to their endogenous expression has induced G1 phase cell cycle arrest. In conclusion, our studies have identified miR-29b as an upstream regulator of miR-145 and targets its RTF genes during differentiation o…

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Metadata

Authors
Jauhari, A., Singh, T., & Yadav, S.
ORCID
Yadav, Sanjay
Venue
Molecular Neurobiology
Publisher
Springer Science and Business Media LLC
Published
2018-04-04
Volume
55
Issue
12
Pages
8978-8990
ISSN
  • 0893-7648
  • 1559-1182
DOI
10.1007/s12035-018-1009-9
Cited by
24
References
2
Language
en
Update notices
correction (2019-07-03)
Licence
Funders
CSIR (mIND BSC-0115)

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CoChat. (2026). Citation check: Expression of miR-145 and Its Target Proteins Are Regulated by miR-29b in Differentiated Neurons. https://app.cochat.ai/papers/10.1007/s12035-018-1009-9
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Jauhari, A., Singh, T., & Yadav, S. (2018). Expression of miR-145 and Its Target Proteins Are Regulated by miR-29b in Differentiated Neurons. Molecular Neurobiology. https://doi.org/10.1007/s12035-018-1009-9