MicroRNA profiling of mouse cortical progenitors and neurons reveals miR-486-5p as a regulator of neurogenesis
Open accessPublished version of a preprint
Abstract
MicroRNAs (miRNAs) are short (∼22 nt) single-stranded non-coding RNAs that regulate gene expression at the post-transcriptional level. Over recent years, many studies have extensively characterized the involvement of miRNA-mediated regulation in neurogenesis and brain development. However, a comprehensive catalog of cortical miRNAs expressed in a cell-specific manner in progenitor types of the developing mammalian cortex is still missing. Overcoming this limitation, here we exploited a double reporter mouse line previously validated by our group to allow the identification of the transcriptional signature of neurogenic commitment and provide the field with the complete atlas of miRNA expression in proliferating neural stem cells, neurogenic progenitors and newborn neurons during corticogenesis. By extending the currently known list of miRNAs expressed in the mouse brain by over twofold, our study highlights the power of cell type-specific analyses for the detection of transcripts that would otherwise be diluted out when studying bulk tissues. We further exploited our data by predicting putative miRNAs and validated the power of our approach by providing evidence for the involvement of miR-486 in brain development.
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Cites
Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2
Love, M. I., Huber, W., & Anders, S. (2014) · Genome Biology · doi:10.1186/s13059-014-0550-8 · Cited by 95,106 · see citing works
Bartel (2004) · doi:10.1016/s0092-8674(04)00045-5 · Cited by 34,714 · see citing works
The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
Lee, R. C., Feinbaum, R. L., & Ambros, V. (1993) · Cell · doi:10.1016/0092-8674(93)90529-y · Cited by 12,948 · see citing works
miRBase: annotating high confidence microRNAs using deep sequencing data
Kozomara, A., & Griffiths-Jones, S. (2014) · Nucleic Acids Research · doi:10.1093/nar/gkt1181 · Cited by 4,629 · see citing works
Wightman, B., Ha, I., & Ruvkun, G. (1993) · Cell · doi:10.1016/0092-8674(93)90530-4 · Cited by 4,292 · see citing works
The Glial Nature of Embryonic and Adult Neural Stem Cells
Kriegstein, A., & Alvarez-Buylla, A. (2009) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.051508.135600 · Cited by 2,475 · see citing works
Dicer is essential for mouse development
Bernstein, E., Kim, S. Y., Carmell, M., Murchison, E., Alcorn, H. L., Li, M. Z., Mills, A., Elledge, S., Anderson, K., & Hannon, G. (2003) · Nature Genetics · doi:10.1038/ng1253 · Cited by 2,100 · see citing works
MicroRNA biogenesis: coordinated cropping and dicing
Kim, V. N. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1644 · Cited by 2,019 · see citing works
Fast and SNP-tolerant detection of complex variants and splicing in short reads
Wu, T. D., & Nacu, S. (2010) · Bioinformatics · doi:10.1093/bioinformatics/btq057 · Cited by 1,894 · see citing works
A brain-specific microRNA regulates dendritic spine development
Schratt, G. M., Tuebing, F., Nigh, E. A., Kane, C. G., Sabatini, M. E., Kiebler, M., & Greenberg, M. E. (2006) · Nature · doi:10.1038/nature04367 · Cited by 1,786 · see citing works
Self-citationSempere, L. F., Freemantle, S., Pitha-Rowe, I., Moss, E., Dmitrovsky, E., & Ambros, V. (2004) · Genome Biology · doi:10.1186/gb-2004-5-3-r13 · Cited by 1,578 · see citing works
Molecular Basis for the Recognition of Primary microRNAs by the Drosha-DGCR8 Complex
Han, J., Lee, Y., Yeom, K., Nam, J., Heo, I., Rhee, J., Sohn, S. Y., Cho, Y., Zhang, B.-T., & Kim, V. N. (2006) · Cell · doi:10.1016/j.cell.2006.03.043 · Cited by 1,552 · see citing works
Discovering microRNAs from deep sequencing data using miRDeep
Friedländer, M. R., Chen, W., Adamidi, C., Maaskola, J., Einspanier, R., Knespel, S., & Rajewsky, N. (2008) · Nature Biotechnology · doi:10.1038/nbt1394 · Cited by 1,189 · see citing works
A microRNA array reveals extensive regulation of microRNAs during brain development
KRICHEVSKY, A. M., KING, K. S., DONAHUE, C. P., KHRAPKO, K., & KOSIK, K. S. (2003) · RNA · doi:10.1261/rna.5980303 · Cited by 1,040 · see citing works
DGCR8 is essential for microRNA biogenesis and silencing of embryonic stem cell self-renewal
Wang, Y., Medvid, R., Melton, C. A., Jaenisch, R., & Blelloch, R. H. (2007) · Nature Genetics · doi:10.1038/ng1969 · Cited by 1,026 · see citing works
Taverna, E., Götz, M., & Huttner, W. Β. (2014) · Annual Review of Cell and Developmental Biology · doi:10.1146/annurev-cellbio-101011-155801 · Cited by 737 · see citing works
A role for the P-body component GW182 in microRNA function
Liu, J., Rivas, F. V., Wohlschlegel, J. A., Yates, J. R., Parker, R., & Hannon, G. J. (2005) · Nature Cell Biology · doi:10.1038/ncb1333 · Cited by 680 · see citing works
Microarray analysis of microRNA expression in the developing mammalian brain
Miska, E. A., Alvarez-Saavedra, E., Townsend, M., Yoshii, A., Šestan, N., Rakic, P., Constantine-Paton, M., & Horvitz, H. R. (2004) · Genome Biology · doi:10.1186/gb-2004-5-9-r68 · Cited by 651 · see citing works
Reciprocal actions of REST and a microRNA promote neuronal identity
Conaco, C., Otto, S., Han, J.-J., & Mandel, G. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511041103 · Cited by 641 · see citing works
A High-Resolution Anatomical Atlas of the Transcriptome in the Mouse Embryo
Diez-Roux, G., Banfi, S., Sultan, M., Geffers, L., Anand, S., Rozado, D., Magen, A., Canidio, E., Pagani, M., Peluso, I., et al. (2011) · PLoS Biology · doi:10.1371/journal.pbio.1000582 · Cited by 638 · see citing works
The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development
Visvanathan, J., Lee, S., Lee, B., Lee, J. W., & Lee, S.-K. (2007) · Genes & Development · doi:10.1101/gad.1519107 · Cited by 579 · see citing works
Lange, C. M., Huttner, W. Β., & Calegari, F. (2009) · Cell stem cell · doi:10.1016/j.stem.2009.05.026 · Cited by 565 · see citing works
Self-citationAn integrated expression atlas of miRNAs and their promoters in human and mouse
The FANTOM Consortium, de Rie, D., Abugessaisa, I., Alam, T., Arner, E., Arner, P., Ashoor, H., Åström, G., Babina, M., Bertin, N., et al. (2017) · Nature Biotechnology · doi:10.1038/nbt.3947 · Cited by 561 · see citing works
Identification of Novel Argonaute-Associated Proteins
Meister, G., Landthaler, M., Peters, L., Chen, P., Urlaub, H., Lührmann, R., & Tuschl, T. (2005) · Current Biology · doi:10.1016/j.cub.2005.10.048 · Cited by 554 · see citing works
Zhao, C., Sun, G., Li, S., & Shi, Y. (2009) · Nature Structural & Molecular Biology · doi:10.1038/nsmb.1576 · Cited by 521 · see citing works
The Long Noncoding RNA RMST Interacts with SOX2 to Regulate Neurogenesis
Ng, S., Bogu, G. K., Soh, B.-S., & Stanton, L. W. (2013) · Molecular Cell · doi:10.1016/j.molcel.2013.07.017 · Cited by 413 · see citing works
Regulation of PI3-kinase/Akt signaling by muscle-enriched microRNA-486
Small, E. M., O'Rourke, J. R., Moresi, V., Sutherland, L. B., McAnally, J., Gerard, R. D., Richardson, J. A., & Olson, E. N. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1000300107 · Cited by 411 · see citing works
Zhao, C., Sun, G., Li, S., Lang, M., Su, Y., Li, W., & Shi, Y. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0908750107 · Cited by 388 · see citing works
miR-206 and -486 Induce Myoblast Differentiation by Downregulating Pax7
Dey, B. K., Gagan, J. R., & Dutta, A. (2010) · Molecular and Cellular Biology · doi:10.1128/mcb.01009-10 · Cited by 380 · see citing works
The RNAseIII enzyme Drosha is critical in T cells for preventing lethal inflammatory disease
Chong, M. M. W., Rasmussen, J. P., Rudensky, A. Y., & Littman, D. R. (2008) · The Journal of Experimental Medicine · doi:10.1084/jem.20081219 · Cited by 362 · see citing works
Fiore, R., Khudayberdiev, S., Christensen, M., Siegel, G., Flavell, S. W., Kim, T., Greenberg, M. E., & Schratt, G. (2009) · The EMBO Journal · doi:10.1038/emboj.2009.10 · Cited by 348 · see citing works
Self-citationMicroRNAs in neural development: from master regulators to fine-tuners
Rajman, M., & Schratt, G. M. (2017) · Development · doi:10.1242/dev.144337 · Cited by 258 · see citing works
Self-citationKawase‐Koga, Y., Otaegi, G., & Sun, T. (2009) · Developmental Dynamics · doi:10.1002/dvdy.22109 · Cited by 234 · see citing works
A Dynamic Unfolded Protein Response Contributes to the Control of Cortical Neurogenesis
Laguesse, S., Creppe, C., Nedialkova, D. D., Prévôt, P.-P., Borgs, L., Huysseune, S., Franco, B., Duysens, G., Krusy, N., Lee, G., et al. (2015) · Developmental Cell · doi:10.1016/j.devcel.2015.11.005 · Cited by 223 · see citing works
Aprea, J., Prenninger, S., Dori, M., Ghosh, T., Monasor, L. S., Wessendorf, E., Zocher, S., Massalini, S., Alexopoulou, D., Lesche, M., et al. (2013) · The EMBO Journal · doi:10.1038/emboj.2013.245 · Cited by 219 · see citing works
Self-citationSingle-cell sequencing of the small-RNA transcriptome
Faridani, O. R., Abdullayev, I., Hagemann-Jensen, M., Schell, J. P., Lanner, F., & Sandberg, R. (2016) · Nature Biotechnology · doi:10.1038/nbt.3701 · Cited by 219 · see citing works
Wang, N., Zheng, J., Chen, Z., Yang, L., Dura, B., Kwak, M., Xavier-Ferrucio, J. M., Lu, Y.-C., Zhang, M., Roden, C., et al. (2019) · Nature Communications · doi:10.1038/s41467-018-07981-6 · Cited by 183 · see citing works
Regulation of cell-type-specific transcriptomes by microRNA networks during human brain development
Nowakowski, T. J., Rani, N., Golkaram, M., Zhou, H. R., Alvarado, B., Huch, K., West, J. A., Leyrat, A., Pollen, A. A., Kriegstein, A. R., et al. (2018) · Nature Neuroscience · doi:10.1038/s41593-018-0265-3 · Cited by 166 · see citing works
Wang, L., Li, L., Li, L., Chu, S., Shiang, K.-D., Li, M., Sun, H., Xu, J., Xiao, F., Sun, G., et al. (2014) · Blood · doi:10.1182/blood-2014-06-581926 · Cited by 153 · see citing works
Morita, S., Horii, T., Kimura, M., Goto, Y., Ochiya, T., & Hatada, I. (2007) · Genomics · doi:10.1016/j.ygeno.2007.01.004 · Cited by 152 · see citing works
Laneve, P., Gioia, U., Andriotto, A., Moretti, F., Bozzoni, I., & Caffarelli, E. (2010) · Nucleic Acids Research · doi:10.1093/nar/gkq604 · Cited by 119 · see citing works
Artegiani, B., Lindemann, D., & Calegari, F. (2011) · The Journal of Experimental Medicine · doi:10.1084/jem.20102167 · Cited by 116 · see citing works
Self-citationBabiarz, J., Hsu, R., Melton, C. A., Thomas, M. F., Ullian, E. M., & Blelloch, R. H. (2011) · RNA · doi:10.1261/rna.2442211 · Cited by 109 · see citing works
Tan, S.-L., Ohtsuka, T., González, A., & Kageyama, R. (2012) · Genes to Cells · doi:10.1111/gtc.12009 · Cited by 108 · see citing works
MicroRNA 486 is a potentially novel target for the treatment of spinal cord injury
Jee, M. K., Jung, J. S., Choi, J. I., Jang, J. A., Kang, K., Im, Y. B., & Kang, S. K. (2012) · Brain · doi:10.1093/brain/aws047 · Cited by 106 · see citing works
Nguyen, L. S., Fregeac, J., Bôle‐Feysot, C., Cagnard, N., Iyer, A. M., Anink, J. J., Aronica, E., Alibeu, O., Nitschké, P., & Colleaux, L. (2018) · Molecular Autism · doi:10.1186/s13229-018-0219-3 · Cited by 93 · see citing works
Regulation of miR-34 Family in Neuronal Development
Jauhari, A., Singh, T., Singh, P., Parmar, D., & Yadav, S. (2017) · Molecular Neurobiology · doi:10.1007/s12035-016-0359-4 · Cited by 90 · see citing works
Convergent microRNA actions coordinate neocortical development
Barca‐Mayo, O., & Tonelli, D. D. P. (2014) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-014-1576-5 · Cited by 74 · see citing works
Nielsen, J. A., Lau, P., Maric, D., Barker, J. L., & Hudson, L. D. (2009) · BMC Neuroscience · doi:10.1186/1471-2202-10-98 · Cited by 74 · see citing works
Tonelli, D. D. P., Calegari, F., Fei, J., Nomura, T., Osumi, N., Heisenberg, C., & Huttner, W. Β. (2006) · BioTechniques · doi:10.2144/000112296 · Cited by 63 · see citing works
Self-citationLi, N., You, X. A., Chen, T., Mackowiak, S. D., Friedländer, M. R., Weigt, M., Du, H., Gogol‐Döring, A., Chang, Z., Dieterich, C., et al. (2013) · Nucleic Acids Research · doi:10.1093/nar/gkt072 · Cited by 63 · see citing works
Deep sequencing analysis of the developing mouse brain reveals a novel microRNA
Ling, K., Brautigan, P. J., Hahn, C. N., Daish, T., Rayner, J. R., Cheah, P.-S., Raison, J. M., Piltz, S., Mann, J. R., Mattiske, D. M., et al. (2011) · BMC Genomics · doi:10.1186/1471-2164-12-176 · Cited by 60 · see citing works
Tox: a multifunctional transcription factor and novel regulator of mammalian corticogenesis
Artegiani, B., Domingues, A. M. D. J., Alonso, S. B., Brandl, E., Massalini, S., Dahl, A., & Calegari, F. (2014) · The EMBO Journal · doi:10.15252/embj.201490061 · Cited by 52 · see citing works
Self-citationMarinaro, F., Marzi, M. J., Hoffmann, N., Amin, H., Pelizzoli, R., Niola, F., Nicassio, F., & Tonelli, D. D. P. (2017) · EMBO Reports · doi:10.15252/embr.201642800 · Cited by 52 · see citing works
MiR-34 and MiR-200: Regulator of Cell Fate Plasticity and Neural Development
Jauhari, A., & Yadav, S. (2019) · NeuroMolecular Medicine · doi:10.1007/s12017-019-08535-9 · Cited by 48 · see citing works
Ghosh, T., Aprea, J., Nardelli, J., Engel, H., Selinger, C., Mombereau, C., Lemonnier, T., Moutkine, I., Schwendimann, L., Dori, M., et al. (2014) · Cell Reports · doi:10.1016/j.celrep.2014.05.029 · Cited by 47 · see citing works
Self-citationKoichiro, Tsujimura, K., Nakashima, H., & Nakashima, K. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.m115.705749 · Cited by 43 · see citing works
Holo-Seq: single-cell sequencing of holo-transcriptome
Xiao, Z., Cheng, G., Jiao, Y., Pan, C., Li, R., Jia, D.-M., Zhu, J., Wu, C., Zheng, M., & Jia, J.-L. (2018) · Genome Biology · doi:10.1186/s13059-018-1553-7 · Cited by 39 · see citing works
Expression of miR-145 and Its Target Proteins Are Regulated by miR-29b in Differentiated Neurons
Jauhari, A., Singh, T., & Yadav, S. (2018) · Molecular Neurobiology · doi:10.1007/s12035-018-1009-9 · Cited by 34 · see citing works
Assessment and site-specific manipulation of DNA (hydroxy-)methylation during mouse corticogenesis
Noack, F., Pataskar, A., Schneider, M., Buchholz, F., Tiwari, V., & Calegari, F. (2019) · Life Science Alliance · doi:10.26508/lsa.201900331 · Cited by 23 · see citing works
Self-citationCaronia, G., Anderegg, A., & Awatramani, R. B. (2016) · Neural Development · doi:10.1186/s13064-016-0065-y · Cited by 21 · see citing works
Aprea, J., Lesche, M., Massalini, S., Prenninger, S., Alexopoulou, D., Dahl, A., Hiller, M., & Calegari, F. (2015) · Neurogenesis · doi:10.1080/23262133.2014.995524 · Cited by 13 · see citing works
Self-citationSequence and expression levels of circular RNAs in progenitor cell types during mouse corticogenesis
Dori, M., Alieh, L. H. A., Cavalli, D., Massalini, S., Lesche, M., Dahl, A., & Calegari, F. (2019) · Life Science Alliance · doi:10.26508/lsa.201900354 · Cited by 10 · see citing works
Self-citationLeong, J.-W., Abdullah, S., Ling, K., & Cheah, P.-S. (2016) · Neural Plasticity · doi:10.1155/2016/1951250 · Cited by 5 · see citing works
Kurtenbach, S., Ding, W., Goss, G. M., Hare, J. M., Goldstein, B. J., & Shehadeh, L. A. (2017) · PLoS ONE · doi:10.1371/journal.pone.0187576 · Cited by 2 · see citing works
Flagged first, then by citations
Cited by
Sorted by citations
miRNA-486-5p: signaling targets and role in non-malignant disease
Douvris, A., Viñas, J. L., & Burns, K. D. (2022) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-022-04406-y · Cited by 62 · see citing works
Harrell, C. R., Volarević, V., Djonov, V., & Volarevic, A. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23094487 · Cited by 56 · see citing works
MicroRNAs Instruct and Maintain Cell Type Diversity in the Nervous System
Zolboot, N., Du, J. X., Zampa, F., & Lippi, G. (2021) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2021.646072 · Cited by 48 · see citing works
Lang, H., Zhao, Y., Xiao, R., Sun, J., Chen, Y., Hu, G.-W., & Xu, G. (2022) · Neural Regeneration Research · doi:10.4103/1673-5374.350205 · Cited by 37 · see citing works
Epigenetic Regulation of Neural Stem Cells: The Emerging Role of Nucleoporins
Colussi, C., & Grassi, C. (2021) · Stem Cells · doi:10.1002/stem.3444 · Cited by 22 · see citing works
Todorov, H., Weißbach, S., Schlichtholz, L., Mueller, H., Hartwich, D., Gerber, S., & Winter, J. (2024) · Communications Biology · doi:10.1038/s42003-024-07092-7 · Cited by 15 · see citing works
Mao, S., Lan, T., Sun, Y., Lin, L., Jiang, W., Xu, J., Feng, Y., Hu, H., Fang, Y., Xu, L., et al. (2025) · Stem Cell Research & Therapy · doi:10.1186/s13287-025-04574-1 · Cited by 12 · see citing works
Murtaj, V., Butti, E., Martino, G., & Panina‐Bordignon, P. (2023) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2023.1125785 · Cited by 8 · see citing works
Dynamic miRNA profile of host T cells during early hepatic stages of Schistosoma japonicum infection
Giri, B. R., Li, S., Fang, C., Qiu, L., Yan, S., Pakharukova, M. Y., & Cheng, G. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.911139 · Cited by 5 · see citing works
Kalpachidou, T., Kummer, K. K., Handle, V., Zimmermann, D., Peteinareli, M., Quarta, S., Schiefermeier-Mach, N., Castaldi, L., Heppenstall, P. A., Haberberger, R. V., et al. (2025) · Molecular Therapy — Nucleic Acids · doi:10.1016/j.omtn.2025.102670 · Cited by 4 · see citing works
Qian, J., Dai, X., & Li, Z. (2025) · Neurochemical Research · doi:10.1007/s11064-025-04537-1 · Cited by 4 · see citing works
Fedorová, V., Černá, K. A., Oppelt, J., Pospíšilová, V., Bárta, T., Mráz, M., & Bohačiaková, D. (2023) · Stem Cell Reviews and Reports · doi:10.1007/s12015-023-10524-2 · Cited by 4 · see citing works
Mestres, I., & Calegari, F. (2023) · Development · doi:10.1242/dev.201574 · Cited by 4 · see citing works
Self-citationAlieh, L. H. A., de Toledo, B. C., Hadarovich, A., Tóth-Petróczy, Á., & Calegari, F. (2024) · Biology Open · doi:10.1242/bio.061721 · Cited by 4 · see citing works
Self-citationDifferential microRNA profiling of blood L1CAM and bulk extracellular vesicles in bipolar disorder
Fries, G. R., Mirza, S. A., Wang, J., Lima, C. N. D. C., Zhang, W., Tamez, M. C. C., Scaini, G., Soares, J. C., & Quevedo, J. (2025) · Epigenomics · doi:10.1080/17501911.2025.2583894 · Cited by 3 · see citing works
MicroRNAs in Umbilical Cord Blood and Development in Full-Term Newborns: A Prospective Study
Wang, L., Tsai, C., Chao, H., Lee, S.-Y., Chen, C., & Li, S. (2024) · Biomarker Insights · doi:10.1177/11772719241258017 · Cited by 2 · see citing works
Wang, W., Xiao, C., Chen, H., Li, F., & Xia, D. (2021) · Advances in Clinical and Experimental Medicine · doi:10.17219/acem/136457 · Cited by 2 · see citing works
Circulating MicroRNAs as a biomarker signature of perinatal asphyxia
Lai, Y.-H., Tu, Y., Chen, C.-H., Chang, J., Hsu, C.-H., Ho, M., Huang, L., Chiu, N., Ho, C., Wang, J.-L., et al. (2024) · Pediatrics & Neonatology · doi:10.1016/j.pedneo.2024.05.002 · Cited by 1 · see citing works
Liu, Y., Ning, Z., Dai, Q., Zhang, X., Xiao, Y., Zhang, Z., Guo, D., Chen, J., Li, Y., Li, W., et al. (2025) · Molecular Therapy · doi:10.1016/j.ymthe.2025.08.024 · Cited by 1 · see citing works
Peregud, D., Pavlova, O., Spektor, V. A., Solovieva, M. G., Nebogina, K., & Pavlov, K. (2025) · Middle East Current Psychiatry · doi:10.1186/s43045-025-00571-5 · Cited by 1 · see citing works
Neocortical temporal patterning by a two-layered regulatory networkPreprint
Yuan, G., Zhao, Z., Dong, X., Xu-wen, W., Zhang, Q., Yu, X., Zhu, M., Yu, J., Zhang, D., Zhang, N., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.64898/2025.12.18.695250 · Cited by 1 · see citing works
Wu, X., Gu, Z., Kong, C., Jiang, X., He, Q., Han, Z., Wu, J., & Wang, J. (2026) · Molecular Neurobiology · doi:10.1007/s12035-026-05796-x
- Authors
- Dori, M., Cavalli, D., Lesche, M., Massalini, S., Alieh, L. H. A., de Toledo, B. C., Khudayberdiev, S., Schratt, G., Dahl, A., & Calegari, F.
- Affiliations
- Center for Regenerative Therapies Dresden (DE)
- DRESDEN-concept Genome Center (DE)
- CRTD – Center for Regenerative Therapies Dresden, School of Medicine, TU Dresden, Fetcherstrasse 105, 01307 Dresden, Germany
- Philipps University of Marburg (DE)
- Corresponding author
- Calegari, Federico
- ORCID
- Venue
- Development
- Publisher
- The Company of Biologists
- Published
- 2020-05-01
- Volume
- 147
- Issue
- 9
- ISSN
- 0950-1991 (ISSN-L)
- 1477-9129
- OpenAlex
- W3016056682
- Semantic Scholar
- ee74682dd6af7e9ede47d47d51c192921dc93f08
- Cited by
- 22
- References
- 65
- Citations by year
- 2026: 1 · 2025: 7 · 2024: 4 · 2023: 3 · 2022: 4 · 2021: 3
- FWCI
- 0.98
- Type
- journal article
- Language
- en
- Open access
- green
- doi.org
- Locations
- Development (publishedVersion)
- bioRxiv (Cold Spring Harbor Laboratory) (acceptedVersion)
- PubMed (publishedVersion)
- HighWire Press Open Archive (submittedVersion)
- Funders
- Zentrum für Regenerative Therapien Dresden
- Technische Universität Dresden
- Deutsche Forschungsgemeinschaft (CA893/9-1)
- Ministero dell'Istruzione, dell'Università e della Ricerca
- Topics
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › MicroRNA in disease regulation
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- miRNA expression profiling, miR-486-5p, neurogenesis, cortical progenitors, neural stem cells, newborn neurons, cortical development, cell type-specific gene expression, brain development
- MeSH terms
- Animals, Female, Immunohistochemistry, Mice, Inbred C57BL, Neurons, Blotting, Northern, In Situ Hybridization, Electroporation, Computational Biology, Gene Expression Profiling, MicroRNAs, Mice, Neurogenesis, Neural Stem Cells, High-Throughput Nucleotide Sequencing
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review