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The effect of iron depletion on chronic hepatitis C virus infection
Open accessAbstract
Increasing evidence exists that iron overload, a common finding in chronic hepatitis C virus (HCV) infection, plays an important role in the pathophysiology of this disease. The mechanisms by which iron excess induces liver damage along with the benefit of iron depletion via phlebotomy on biochemical and histological outcomes in patients with chronic HCV infection have been discussed in this review. Finally, we focus on the effect of iron reduction on the rate of response to interferon antiviral therapy.
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“Franchini et al.,(2008) reported that chronic HCV infection is the main cause of hyperferritinemia.”
From Iron, Oxidative Stress and Health (2012) · cites this paper as Franchini et al.,(2008)
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Metadata
- Authors
- Franchini, M., Targher, G., Capra, F., Montagnana, M., & Lippi, G.
- Affiliations
- Azienda Ospedaliera Universitaria Integrata Verona (IT)
- University of Verona (IT)
- Corresponding author
- Franchini, Massimo
- Venue
- Hepatology International
- Published
- 2008-05-08
- Volume
- 2
- Issue
- 3
- Pages
- 335-340
- ISSN
- 1936-0533 (ISSN-L)
- 1936-0541
- PMC
- PMC2716881
- OpenAlex
- W1964002000
- Cited by
- 58
- References
- 65
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 9 · 2013: 4 · 2012: 4
- FWCI
- 3.69
- Type
- journal article
- Language
- en
- Update notices
- erratum (2008-08-12)
- Open access
- hybrid
- doi.org
- Licence
- cc-by-nc
- Locations
- Hepatology International (publishedVersion, cc-by-nc)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Hepatology › Hepatitis C virus research
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
- Keywords
- iron depletion, chronic hepatitis C, iron overload, phlebotomy, interferon therapy response, liver injury
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