Cited by 58Hepatitis C virus researchIron Metabolism and DisordersLiver Disease Diagnosis and Treatment

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The effect of iron depletion on chronic hepatitis C virus infection

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Franchini, Massimo, Targher, Giovanni, Capra, Franco, Montagnana, Martina, Lippi, Giuseppe·2008·Hepatology International

DOI 10.1007/s12072-008-9076-zPMC PMC2716881

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Abstract

Increasing evidence exists that iron overload, a common finding in chronic hepatitis C virus (HCV) infection, plays an important role in the pathophysiology of this disease. The mechanisms by which iron excess induces liver damage along with the benefit of iron depletion via phlebotomy on biochemical and histological outcomes in patients with chronic HCV infection have been discussed in this review. Finally, we focus on the effect of iron reduction on the rate of response to interferon antiviral therapy.

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Authors: Franchini, M., Targher, G., Capra, F., Montagnana, M., & Lippi, G.
Affiliations: Azienda Ospedaliera Universitaria Integrata Verona (IT)
University of Verona (IT)
Corresponding author: Franchini, Massimo
ORCID: Franchini, Massimo
Targher, Giovanni
Montagnana, Martina
Lippi, Giuseppe
Venue: Hepatology International
Publisher: Springer Science and Business Media LLC
Published: 2008-05-08
Volume: 2
Issue: 3
Pages: 335-340
ISSN: 1936-0533 (ISSN-L)
1936-0541
DOI: 10.1007/s12072-008-9076-z
PMC: PMC2716881
OpenAlex: W1964002000
Cited by: 58
References: 65
Citations by year: 2026: 1 · 2023: 1 · 2022: 3 · 2021: 4 · 2020: 1 · 2019: 3 · 2018: 6 · 2017: 4 · 2016: 1 · 2015: 2 · 2014: 9 · 2013: 4 · 2012: 4
FWCI: 3.69
Type: journal article
Language: en
Update notices: erratum (2008-08-12)
Open access: hybrid
doi.org
Licence: cc-by-nc
Locations: Hepatology International (publishedVersion, cc-by-nc)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hepatology › Hepatitis C virus research
Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
Health Sciences › Medicine › Hepatology › Liver Disease Diagnosis and Treatment
Keywords: iron depletion, chronic hepatitis C, iron overload, phlebotomy, interferon therapy response, liver injury

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The effect of iron depletion on chronic hepatitis C virus infection

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