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The role of SPARC in extracellular matrix assembly
Open accessAbstract
SPARC is a collagen-binding matricellular protein. Expression of SPARC in adult tissues is frequently associated with excessive deposition of collagen and SPARC-null mice fail to generate a robust fibrotic response to a variety of stimuli. This review summarizes recent advancements in the characterization of the binding of SPARC to collagens and describes the results of studies that implicate a function for SPARC in the regulation of the assembly of basal lamina and fibrillar collagen in the ECM. Potential cellular mechanisms that underlie SPARC activity in ECM deposition are also explored.
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Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC
Kucukdereli, H., Allen, N. J., Lee, A. T., Feng, A., Ozlu, M. I., Conatser, L. M., Chakraborty, C., Workman, G., Weaver, M., Sage, E. H., et al. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1104977108 · Cited by 642
Newman, A. C., Nakatsu, M. N., Chou, W., Gershon, P. D., & Hughes, C. C. W. (2011) · Molecular Biology of the Cell · doi:10.1091/mbc.e11-05-0393 · Cited by 489
Metadata
- Authors
- Bradshaw, A. D.
- Venue
- Journal of Cell Communication and Signaling
- Publisher
- Wiley
- Published
- 2009-10-02
- Volume
- 3
- Issue
- 3-4
- Pages
- 239-246
- ISSN
- 1873-9601 (ISSN-L)
- 1873-961X
- OpenAlex
- W2031224113
- Cited by
- 251
- References
- 0
- FWCI
- 8.45
- Type
- journal article
- Language
- en
- Open access
- hybrid
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